Phosphatidylin Suppliers USA
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Product | Description | |
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1,2-Dipalmitoyl phosphatidylinositol 4-phosphate ammonium salt Quick inquiry Where to buy Suppliers range | 1,2-Dipalmitoyl phosphatidylinositol 4-phosphate ammonium salt, a vital phospholipid derivative in signaling pathways associated with immune response and inflammation. This molecule has a multifaceted role, demonstrated by its ability to alter TNF-α activity and regulate T cell activation. Its therapeutic potential extends to autoimmune and inflammatory afflictions; hence, creating an opportunity to target treatments for arthritis and asthma. Synonyms: L-a-Phosphatidyl-(12-dipalmitoyl)-D-myo-inositol 4-monophosphate. CAS No. 57606-15-2. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
1,2-Dipalmitoyl phosphatidylinositol 5-phosphate Quick inquiry Where to buy Suppliers range | 1,2-Dipalmitoyl phosphatidylinositol 5-phosphate is a pivotal phospholipid, involving in intricate signaling pathways governing diverse cellular mechanisms.Its research applications encompass the exploration of lipid metabolism, membrane trafficking, and dynamic cell membrane characteristics. Synonyms: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate); [ (2R) -2-hexadecanoyloxy-3- [hydroxy- [ (1R, 2R, 3R, 4R, 5S, 6R) -2, 3, 4, 6-tetrahydroxy-5-phosphonooxycyclohexyl] oxyphosphoryl] oxypropyl] hexadecanoate; L-alpha-Phosphatidyl-D-myo-inositol 5-monophosphate, dipalmitoyl; PtdIns(5)P; 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate); PtdIns(5)P1; D-myo-PI[5]P; PI5P; PI[5]P;D-myo-Phosphatidylinositol 5-phosphate (PtdIns(5)P); Q27158617; D-myo-Inositol 5-monophosphate, L- alpha -Phosphatidyl-(1,2-dipalmitoyl); D-myo-Inositol 5-monophosphate, L-alpha-Phosphatidyl-(1,2-dipalmitoyl). CAS No. 291527-75-8. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
1,2-Dipalmitoyl-sn-glycero-3-phospho-(1-myoinositol-4-phosphate) Quick inquiry Where to buy Suppliers range | PI(3)P diC16 is a synthetic and purified dipalmitoyl PI(3)P. PI(3)P is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. Synonyms: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'D-myo-inositol-3'-phosphate); PI(3)P diC16; L-alpha-Phosphatidyl-D-myo-inositol 3-monophosphate, dipalmitoyl; D-myo-Inositol, 1-(2R)-2,3-bis(1-oxohexadecyl)oxypropyl hydrogen phosphate 3-(dihydrogen phosphate); Phosphatidylinositol 3-phosphate diC16. Grades: >95%. CAS No. 165689-81-6. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
1,2-Isopropylidene-D,L-myo-inositol Quick inquiry Where to buy Suppliers range | 1,2-Isopropylidene-D,L-myo-inositol is a facilitator in the synthesis of inositol derivatives and phosphatidylinositol. It can be used to maladie encompassing cystic fibrosis, respiratory infringements, and diabetes. Synonyms: (3Ar,4S,5R,6R,7S,7aS)-2,2-dimethyl-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxole-4,5,6,7-tetrol; (3aR,4S,5R,6R,7S,7aS)-2,2-dimethyl-hexahydro-2H-1,3-benzodioxole-4,5,6,7-tetrol; 1, 2-Isopropylidene-D, L-myo-inositol;(3AR, 4S, 5R, 6R, 7S, 7aS)-2, 2-dimethylhexahydrobenzo[d][1, 3]dioxole-4, 5, 6, 7-tetraol; (3aS,4S,5R,6R,7S,7aR)-2,2-dimethyl-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxole-4,5,6,7-tetrol. CAS No. 26276-97-1. Molecular formula: C9H16O6. Mole weight: 220.22. | |
16:0-18:1 PI(4)P Diammonium salt Quick inquiry Where to buy Suppliers range | 16:0-18:1 PI(4)P Diammonium salt, a phosphatidylinositol, is a complex molecule embedded within the cell membrane. It has been closely associated with pathologies such as cancer, Alzheimer's, and diabetes, lending it to extensive biomedical research. The salt is particularly notable for its capacity to regulate specific cellular pathways in drug development. Understanding the complex implications of this molecule requires a multidisciplinary approach, involving the integration of biochemistry, pharmacology, and medical sciences. Synonyms: 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate) (ammonium salt). Grades: >99%. CAS No. 2260795-75-1. Molecular formula: C43H88N2O16P2. Mole weight: 951.11. | |
187-1, N-WASP inhibitor Quick inquiry Where to buy Suppliers range | Acts as inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. It inhibits actin assembly stimulated by phosphatidylinositol 4,5-bisphosphate (pip2), but does not directly inhibit actin. Uses: Peptide Inhibitors. CAS No. 380488-27-7. Product ID: R0915. | |
187-1, N-WASP inhibitor Quick inquiry Where to buy Suppliers range | 187-1, N-WASP inhibitor can inhibit neural Wiskott-Aldrich syndrome protein by stabilizing the autoinhibited state of the protein. It can also block phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly with an IC50 value of~ 2 μM. Synonyms: n-wasp-inhibitor,187-1; cyclo[Gln-Lys-D-Phe-D-Pro-D-Phe-Phe-D-Pro-Gln-Lys-D-Phe-D-Pro-D-Phe-Phe-D-Pro]; cyclo[L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl-L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl]. Grades: >98%. CAS No. 380488-27-7. Molecular formula: C96H122N18O16. Mole weight: 1784.13. | |
187-1, N-WASP inhibitor Quick inquiry Where to buy Suppliers range | Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 uM) but does not directly inhibit actin polymerization. Group: Biochemicals. Grades: Highly Purified. CAS No. 380488-27-7. Pack Sizes: 1mg. Molecular Formula: C96H122N18O16, Sequence: US Biological Life Sciences. | Worldwide |
1-Palmitoyl-2-(L-α-phosphatidylinositol) Sodium Salt Quick inquiry Where to buy Suppliers range | 1-Palmitoyl-2-(L-α-phosphatidylinositol) Sodium Salt is a substrate for phospholipase C that contains mainly linoleic and palmitic acids. Group: Biochemicals. Grades: Highly Purified. CAS No. 383907-36-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C43H78NaO13P, Molecular Weight: 857.04. US Biological Life Sciences. | Worldwide |
20(R)-Ginsenoside Rg3-d6 Quick inquiry Where to buy Suppliers range | 20(R)-Ginsenoside Rg3-d6 is the labelled version of 20(R)-Ginsenoside Rg3, which causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated, relating to in vivo inhibition of tumor angiogenesis of lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C42H66D6O13, Molecular Weight: 791.05. US Biological Life Sciences. | Worldwide |
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile Quick inquiry Where to buy Suppliers range | 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile is used as a reagent in the preparation of imidazo quinoline derivatives, compounds that act as mammalian target of rapamycin (mTOR) an phosphatidylinositol 3-kinase (PI3K-kinase) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 915019-52-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H17BrN4. US Biological Life Sciences. | Worldwide |
2-Amino-4-methylimidazole Quick inquiry Where to buy Suppliers range | 2-Amino-4-methylimidazole is used as a reagent in the synthesis of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel allosteric mGluR5 antagonists. Also used as a reagent in the synthesis of imidazo[1,2-a]pyrimidin-5(1H)-ones as beta isoform selective phosphatidylinositol 3-kinase (PI3K) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6653-42-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C4H7N3, Molecular Weight: 97.12. US Biological Life Sciences. | Worldwide |
2-Amino-6-bromo-3-fluoro-benzoic Acid Quick inquiry Where to buy Suppliers range | 2-Amino-6-bromo-3-fluoro-benzoic Acid is an intermediate used to prepare 2, 4-diaminopyrimidinyl aminoethyl quinazolin-4 (3H) -one derivatives as phosphatidylinositol 3-kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1153974-98-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H5BrFNO2, Molecular Weight: 234.02. US Biological Life Sciences. | Worldwide |
2-?Amino-?6-?methylpyridine Quick inquiry Where to buy Suppliers range | 2-?Amino-?6-?methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Kα). Group: Biochemicals. Grades: Highly Purified. CAS No. 1824-81-3. Pack Sizes: 5g, 25g. Molecular Formula: C6H8N2, Molecular Weight: 108.14. US Biological Life Sciences. | Worldwide |
2-Bromoethyl-1-[2-Fmoc-3-O-tert-butyldimethylsilyl]-D-Erythro-sphingosylphosphate Quick inquiry Where to buy Suppliers range | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
3-O-tert-Butyl di methyl silyl -D-Erythro-sphingosyl phosphoryl choline Quick inquiry Where to buy Suppliers range | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
4-Aminophenyl a-D-mannopyranoside 6-phosphate Quick inquiry Where to buy Suppliers range | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Synonyms: 4-Aminophenyl 6-phospho-alpha-mannopyranoside; 4-Aminophenyl 6-phospho-alpha-D-mannopyranoside. CAS No. 74160-60-4. Molecular formula: C12H18NO9P. Mole weight: 351.25. | |
8-Aminoadenine Quick inquiry Where to buy Suppliers range | 8-Aminoadenine is an adenine receptor agonist with Ki value of 0.0341 μM in HEK293 cells expressing an adenine binding site. It shows 190-fold increased potency at the human binding site over the rat adenine receptor. It inhibits adenine uptake and isoproterenol-stimulated cAMP accumulation. It may be used in the synthetic preparation of purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. It is important in regulating myocardial oxygen consumption and coronary blood flow. It may take part in inflammation and immune responses. Synonyms: 9H-Purine-6,8-diamine; 1H-Purine-6,8-diamine (9CI); 6,8-Diamino-purine (8CI); NSC 21698; NSC21698; NSC-21698. Grades: ≥98% by HPLC. CAS No. 28128-33-8. Molecular formula: C5H6N6. Mole weight: 150.14. | |
AC-55541 Quick inquiry Where to buy Suppliers range | AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Synonyms: AC-55541; AC 55541; AC55541. (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide. Grades: >97 %. CAS No. 916170-19-9. Molecular formula: C25H20BrN5O3. Mole weight: 518.36. | |
Acalisib Quick inquiry Where to buy Suppliers range | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Synonyms: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. | |
Alpelisib Quick inquiry Where to buy Suppliers range | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. | |
Alpelisib, Free Base, 99+% Quick inquiry Where to buy Suppliers range | Alpelisib, also known as BYL719, is a potent and selective phosphatidylinositol-3 kinase [alpha] inhibitor. It inhibited P110[alpha], p110[beta], p110[delta], and p110[gamma] with IC50 values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibited the Akt phosphorylation with IC50 values of 74 nM in Rat1-myr-p110[alpha] cells, 2.2 µM in Rat1-myr-p110[beta] cells, and 1.2 µM in Rat1-myr-p110[delta] cells. Furet P., et al. "Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation." Bioorg. Med. Chem. Lett. 23: 3741-3748 (2013). Group: Biochemicals. Alternative Names: BYL-719; NVP-BYL719; (S)-Pyrrolidine-1,2-dicarboxylic Acid 2-Amide 1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide; (2S) -N1- [4- methyl -5- [2- (2, 2, 2-tri fluoro -1, 1-di methyl ethyl ) -4-pyridinyl ] -2-thiazoly l ] -1, 2-pyrrolidinedicarboxami de . Grades: Highly Purified. CAS No. 1217486-61-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C19H22F3N5O2S, Molecular Weight: 441.47. US Biological Life Sciences. | Worldwide |
AM-8508 Quick inquiry Where to buy Suppliers range | AM-8508 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-8508 exhibits good cellular potency (in vitro pAKT IC50 = 4.6 nM ) and excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibits KLH-specific antibodies in animal models and it may become a drug candidate for the treatment of human inflammatory diseases. Uses: Inflammatory diseases. Synonyms: AM-8508; AM 8508; AM8508. (S)-4-amino-6-((1-(6-fluoro-1-(pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1338483-67-2. Molecular formula: C19H15FN8. Mole weight: 374.14. | |
AM-9635 Quick inquiry Where to buy Suppliers range | AM-9635 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-9635 exhibits good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-9635 can inhibit KLH-specific IgG and IgM in a dosedependent manner and it is well tolerated at all doses. AM-96352 shows significantly reduced IgG and IgM specific antibodies. Synonyms: AM-9635; AM 9635; AM9635. (S)-4-amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1338483-10-5. Molecular formula: C19H14F2N8. Mole weight: 392.36. | |
Amdizalisib Quick inquiry Where to buy Suppliers range | Amdizalisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, an immunomodulator and an antineoplastic. Synonyms: (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 99% by HPLC. CAS No. 1894229-05-0. Molecular formula: C19H15ClN8. Mole weight: 390.83. | |
Apitolisib Quick inquiry Where to buy Suppliers range | Apitolisib, also known as GDC-0980 and RG7422; or GNE390, is a dual PI3 kinase/mTOR inhibitor, is also an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor GDC-0980 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion. Synonyms: GDC-0980; GDC0980; GDC 0980; RG7422; RG-7422; RG 7422; GNE 390; GNE390; GNE-390; Apitolisib. CAS No. 1032754-93-0. Molecular formula: C23H30N8O3S. Mole weight: 498.606. | |
AS-041164 Quick inquiry Where to buy Suppliers range | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a highly potent and selective PI3Kγ inhibitor that inhibits PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ with IC50 values of 240 nM, 1.45 μM, 70 nM and 1.70 μM, respectively. It also blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models. Synonyms: 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione. Grades: ≥98%. CAS No. 6318-41-8. Molecular formula: C11H7NO4S. Mole weight: 249.2. | |
AS-605240 potassium salt Quick inquiry Where to buy Suppliers range | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
BF 738735 Quick inquiry Where to buy Suppliers range | A potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIII&alpha. Broad spectrum enterovirus replication inhibitor. Synonyms: 2-Fluoro-4-[2-methyl-8-[[[3- (methylsulfonyl) phenyl]methyl]amino]imidazo[1, 2-a]pyrazin-3-yl]phenol; BF738735; BF-738735. Grades: ≥98%. CAS No. 1436383-95-7. Molecular formula: C21H19FN4O3S. Mole weight: 426.47. | |
BGT226 Quick inquiry Where to buy Suppliers range | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BGT-226; BGT 226; BGT-226 free base; BGT226 free base; NVP-BGT226; 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-2H-imidazo[4,5-c]quinolin-2-one. Grades: 98%. CAS No. 915020-55-2. Molecular formula: C32H29F3N6O6. Mole weight: 534.54. | |
Bilobalide Quick inquiry Where to buy Suppliers range | Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 33570-04-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C15H18O8. US Biological Life Sciences. | Worldwide |
Carbazochrome Sodium Sulfonate Quick inquiry Where to buy Suppliers range | A Phosphatidylinositol hydrolysis inhibitor in endothelial cells. Group: Biochemicals. Alternative Names: 5-[2- (Aminocarbonyl) hydrazinylidene]-2, 3, 5, 6-tetrahydro-1-methyl-6-oxo-1H-indole-2-Sulfonic Acid Sodium Salt; Adenaron; Adona; Adrenochrome sulfonate Ac 17; Carbazon; Donaseven; Emex; Odanon; Tazin. Grades: Highly Purified. CAS No. 51460-26-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
CAY10505 Quick inquiry Where to buy Suppliers range | CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor, was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505, may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction. Synonyms: CAY10505; CAY 10505; CAY-10505. Grades: 0.98. CAS No. 1218777-13-9. Molecular formula: C14H8FNO3S. Mole weight: 289.28. | |
CAY10626 Quick inquiry Where to buy Suppliers range | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grades: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
Dactolisib Quick inquiry Where to buy Suppliers range | Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; NVP-BEZ235; NVP-BEZ-235; NVP-BEZ 235; Dactolisib. Grades: 0.98. CAS No. 915019-65-7. Molecular formula: C30H23N5O. Mole weight: 469.548. | |
Demethoxyviridiol Quick inquiry Where to buy Suppliers range | It is a mycotoxin produced by the strain of Nodulisporium hinnuleum. It is a fungal metabolite belonging to the wortmannin and viridin classes and an inhibitor of phosphatidylinositol 3-kinase. It affects phospholipid signalling and proliferation of swiss 3T3 cells. Synonyms: Desmethoxyviridiol; Cyclopenta(7,8)phenanthro(10,1-bc)furan-6,9-dione, 1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methyl-, (1R-(1-alpha,3-alpha,11b-alpha))-; (1R,3S,11bR)-1,2,3,7,8,11b-Hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione; [1R-(1α,3α,11bα)]-1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione. Grades: >95% by HPLC. CAS No. 56617-66-4. Molecular formula: C19H16O5. Mole weight: 324.33. | |
D-Erythro-Sphingosyl phosphoryl choline Quick inquiry Where to buy Suppliers range | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium salt Quick inquiry Where to buy Suppliers range | The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents. Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Grades: ≥98%. Molecular formula: C6H12O21P5·5Na. Mole weight: 689.96. | |
D-myo-Inositol-2,4,5-triphosphate sodium salt Quick inquiry Where to buy Suppliers range | D-myo-Inositol-2,4,5-triphosphate sodium salt is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3. Synonyms: Ins(2,4,5)P3 sodium salt; 2,4,5-IP3 sodium salt; D-myo-inositol-2,4,5-tris(hydrogen phosphate), trisodium salt. Grades: ≥98%. Molecular formula: C6H12O15P3·3Na. Mole weight: 486. | |
DNA-PK Inhibitor IV Quick inquiry Where to buy Suppliers range | DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK). It also inhibits the phosphatidylinositol 3-kinase (PI3K) isoforms p110β, p110δ, and p110γ but not p110α or class II PI3Ks, PI4Kβ, ATM, ATR, mTOR, CK2, or GRK2. Synonyms: 2-hydroxy-4-(4-morpholinyl)-benzaldehyde. Grades: ≥98%. CAS No. 70362-07-1. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
Edelfosine Quick inquiry Where to buy Suppliers range | Edelfosine, an orally administered antileishmanial drug, has anti-metastasis effect in experimental tumors. Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. Uses: Phosphodiesterase inhibitors. Synonyms: ALP; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-OMe; ET 18-OCH3; rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine; NSC-324368; (±)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium hydroxide inner salt 4-oxide. Grades: ≥95%. CAS No. 70641-51-9. Molecular formula: C27H58NO6P. Mole weight: 523.73. | |
Ethyl b-D-galactopyranoside Quick inquiry Where to buy Suppliers range | ETHYL β-D-GALACTOPYRANOSIDE, also called AC1NSVA, SCHEMBL2446113, is the β-D-GALACTOPYRANOSIDE type of ethyl galactoside. Studies found it is a potential inhibitor of phosphatidylinositol biosynthesis in mycobacteria. Uses: Used as an indicator ligand to determine k values for nonchromophoric carbohydrates by continuous displacement titrations, measuring either fluorescence or difference in absorption of the indicator; potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria. Synonyms: Ethyl β-D-galactoside; Ethyl β-galactoside; (2R,3R,4S,5R,6R)-2-Ethoxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Grades: ≥ 95%. CAS No. 18997-88-1. Molecular formula: C8H16O6. Mole weight: 208.21. | |
GDC-0879 Quick inquiry Where to buy Suppliers range | GDC-0879, a highly selective, potent, and orally bioavailable RAF small-molecule inhibitor. In GDC-0879-treated mice, both cell line- and patient-derived BRAF(V600E) tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors. Despite the involvement of activated RAF signaling in RAS-induced tumorigenesis, decreased time to progression was observed for some KRAS-mutant tumors following GDC-0879 administration. Moreover, striking differences were noted for RAF and MEK inhibition across a panel of 130 tumor cell lines. Whereas GDC-0879-mediated efficacy was associated strictly with BRAF(V600E) status, MEK inhibition also attenuated proliferation and tumor growth of cell lines expressing wild-type BRAF (81% KRAS mutant, 38% KRAS wild type). The responsiveness of BRAF(V600E) melanoma cells to GDC-0879 could be dramatically altered by pharmacologic and genetic modulation of phosphatidylinositol 3-kinase pathway activity. These data suggest that GDC-0879-induced signaling changes are dependent on the point of oncogenic activation within the RAS network. Taken together, these studies increase our understanding of the molecular determinants for antitumor efficacy resulting from RAF pathway inhibition and have implications for therapeutic intervention in the clinic. Synonyms: GDC0879; GDC-0879; GDC 0879. CAS No. 905281-76-7. Molecular formula: C19H18N4O2. Mole weight: 334.37182. | |
GDC-0941 Bimesylate Quick inquiry Where to buy Suppliers range | Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K). Group: Biochemicals. Alternative Names: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine Methanesulfonate. Grades: Highly Purified. CAS No. 957054-33-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GDC-0941 dimethanesulfonate Quick inquiry Where to buy Suppliers range | GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with modest selectivity against p110β and p110&gamma. It is a novel selective class I phosphatidylinositol-3-kinase (PI3K) inhibitor. It is designed to bind the ATP-binding pocket of PI3K and to prevent formation of phosphatidylinositol-3, 4, 5-triphosphate (PIP3), a second messenger that transmits PI3K downstream signals. It causes growth inhibition in a variety of cancer cell lines, including A2780, MDA-MB-361, PC3, and U87MG. It also inhibits the growth of trastuzumab-sensitive and -resistant HER2-amplied cancer cells which harbor p110( mutations or PTEN loss. It also reduces tumor volume in different xenograft models. Synonyms: GDC-0941 dimethanesulfonate; GDC 0941 dimethanesulfonate; GDC0941 dimethanesulfonate; Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt). Grades: >98%. CAS No. 957054-33-0. Molecular formula: C25H35N7O9S4. Mole weight: 705.85. | |
GDC-0941, Free Base, PI3K Inhibitor Quick inquiry Where to buy Suppliers range | GDC-0941 is a potent inhibitor of p110a and p110d (IC?? = 3nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer." J. Med. Chem. 51: 5522-5532 (2008).GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50's <1 µM. GDC-0941 also demonstrated antitumor activity in preclinical models of breast cancer. Yao, E., et al. "Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab." Clin. Cancer Res. 15: 4147-4156 (2009).The combination of GDC-0941 with trastuzumab is highly efficacious in the treatment of cancer cells in vitro and tumors in vivo. GDC-0941 also has antitumor activity in the treatment of trastuzumab-resistant cells and tumors. Junttila, T.T., et al. "Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941." Cancer Cell 15: 429-440 (2009).GDC-0941 inhibits the activity of recombinant PI3K in vitro with IC50's of 0.003 µM (P110α), 0.033 µM (P110 β), 0.003 µM (P110δ), 0.075 µM (P110γ), 0.58 µM (mTOR) and 1.23 µM (DNA-PK). GDC-0941 inhibited the growth of tumor cells in vitro with IC50's of 0.95 µM (U87MG), 0.07 µM (IGROV-1), 0.15 µM (DETROIT 562), 0.28 µM (PC3) and 0.54 µM (SKOV-3). GDC-0941 also inhibited the growth of U87 MG glioblastoma xenografts and IGROV-1 ovarian cancer xenografts in mice. Raynaud, F.I., et al. "Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941." Mol. Cancer Ther. 8: 1725-1738 (2009). Group: Biochemicals. Alternative Names: 2- (1H-indazol-4-yl) -6- ( (4- (methylsulfonyl) piperazin-1-yl) methyl) -4-morpholinothieno[3, 2-d]pyrimidine; 4-[2- (1H-Indazol-4-yl) -6-[[4- (methylsulfonyl) piperazin-1-yl]methyl]thieno[3, 2-d]pyrimidin-4-yl]morpholine; GDC 0941; GDC 941; GNE 0941; Pictilisib; Pictrelisib. Grades: Highly Purified. CAS No. 957054-30-7. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 513.64. US Biological Life Sciences. | Worldwide |
GSK-2269557 HCl salt Quick inquiry Where to buy Suppliers range | GSK-2269557 is a selective Phosphatidylinositol 3 kinase delta inhibitor originated by GlaxoSmithKline. GSK-2269557 is highly selective for PI3Kδ over the closely related isoforms and is active in a animal model of Th2-driven lung inflammation. Treatment for Asthma and Chronic obstructive pulmonary disease(COPD) is in clinical trials Phase II. Uses: Asthma; chronic obstructive pulmonary disease. Synonyms: GSK-2269557 HCl salt; GSK 2269557 HCl salt; GSK2269557 HCl salt; 6-(1H-indol-4-yl)?-4-[5-[[4-(1-methylethyl)?-1-piperazinyl]?methyl]?-2-oxazolyl]?-1H-indazole, monohydrochloride;1254036-71-9(free base). Grades: 98%. CAS No. 1254036-77-5. Molecular formula: C26H28N6O HCl. Mole weight: 477.01. | |
GSK2292767 Quick inquiry Where to buy Suppliers range | GSK2292767 is a Phosphatidylinositol 3 kinase delta inhibitor applicated for the treatment of respiratory diseases including asthma and COPD in clinical trials. GSK2292767 is highly selective for PI3Kδ over the closely related isoforms and is really active in the animal model of Th2-driven lung inflammation. Uses: Asthma and copd. Synonyms: GSK2292767; GSK-2292767; GSK 2292767. N-[5-[4-[5-[[(2R, 6S)-2, 6-dimethylmorpholin-4-yl]methyl]-1, 3-oxazol-2-yl]-1H-indazol-6-yl]-2-methoxypyridin-3-yl]methanesulfonamide; SCHEMBL173490; ZINC95938263; KB-78330; 1254036-66-2; Methanesulfonamide, N-[5-[4-[5-[[(2R, 6S)-2, 6-dimethyl-4-morpholinyl]methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-methoxy-3-pyridinyl]. Grades: 98%. CAS No. 1254036-66-2. Molecular formula: C24H28N6O5S. Mole weight: 512.58. | |
InSolution Wortmannin Quick inquiry Where to buy Suppliers range | Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 428.43. Catalog: IAR42416420. Assay: ≥95% (HPLC). | |
IPI-549 Quick inquiry Where to buy Suppliers range | IPI-549, a dihydroisoquinolin derivative, has been found to be a phosphatidylinositol 3 kinase gamma inhibitor, could exhibit antineoplastic activity in solid tumors. It is still under Phase I trial. IC50: 16 nM (PI3Kγ), 3.2 μM (PI3Kα), 3.5 μM (PI3Kβ), >8.4 μM (PI3Kδ). Synonyms: IPI-549; IPI 549; IPI549; SCHEMBL16629991; (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide. Grades: 98%. CAS No. 1693758-51-8. Molecular formula: C30H24N8O2. Mole weight: 528.58. | |
ISA-2011B Quick inquiry Where to buy Suppliers range | ISA-2011B is a Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) inhibitor. Research shows that the overexpression of PIP5K1α is associated with poor prognosis in prostate cancer and correlates with an elevated level of the androgen receptor. ISA-2011B can inhibit growth of tumor cells in xenograft mice, which is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways. Uses: Anti-cancer. Synonyms: ISA2011B; ISA 2011B; ISA-2011B; ISA2011-B; ISA 2011-B; ISA-2011-B. (5S,10aS)-5-(5-chloro-1H-indol-3-yl)-9-methyl-8,9,10a,11-tetrahydro-5H-[1,3]dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione. Grades: 98%. CAS No. 1395347-24-6. Molecular formula: C22H18ClN3O4. Mole weight: 423.85. | |
Kijanimicin (Antibiotic Sch 25663) Quick inquiry Where to buy Suppliers range | Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitro-aminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor activity. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. While tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Group: Biochemicals. Alternative Names: Antibiotic Sch 25663. Grades: Highly Purified. CAS No. 78798-08-0. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
L-a-Phosphatidylinositol from Soy bean Quick inquiry Where to buy Suppliers range | L-a-Phosphatidylinositol from Soybean, a naturally occurring phospholipid, boasts a plethora of biomedical applications as it serves as a potent therapeutic agent for an array of ailments including but not limited to cardiovascular diseases, metabolic disorders, and cancer. This compound, with its anti-inflammatory properties, facilitates insulin signaling pathways and preserves cell membranes, hence promoting optimal brain function. The manifold benefits of this compound are a testimony to its profound therapeutic potential. Synonyms: 1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol); Phosphatidylinositols,soya; L-alpha-Phosphatidylinositol from Glycine max (soybean). CAS No. 97281-52-2. Molecular formula: C45H87O13P. Mole weight: 867.1. | |
LB42708 Quick inquiry Where to buy Suppliers range | LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation. Synonyms: LB-42708; LB 42708; (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone. Grades: 98%. CAS No. 226929-39-1. Molecular formula: C30H27BrN4O2. Mole weight: 555.47. | |
Leniolisib Quick inquiry Where to buy Suppliers range | Leniolisib is a PI3K (phosphatidylinositol 3-kinase) inhibitor. No detailed information has been published yet. Synonyms: (S)-1-(3-((6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one;UNII-L22772Z9CP. Grades: 98%. CAS No. 1354690-24-6. Molecular formula: C21H25F3N6O2. Mole weight: 450.46. | |
Luteolin (3',4',5,7-Tetrahydroxyflavone, Luteolol, BRN 0292084, C.I. Natural Yellow 2, Digitoflavone, Flacitran, Flavopurpol, Daphneflavonol, Argemexitin) Quick inquiry Where to buy Suppliers range | Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-y. inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 (PDE1-5). PKC(e) and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator. Phosphatidylinositol 3-kinase (PI3K) / Akt signaling inhibitor. p90 ribosomal S6 kinase (RSK1/RSK2) kinase activity inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-70-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H10O6. US Biological Life Sciences. | Worldwide |
MARCKS Peptide(151-175), Phosphorylated Quick inquiry Where to buy Suppliers range | MARCKS Peptide(151-175), Phosphorylated is a phosphorylated peptide corresponding to the basic effector domain of myristoylated alanine-rich protein kinase C substrate protein (MARCKS). Phosphorylation of MARCKS Peptide (151-175) reverses its inhibition of phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). Uses: Peptide Inhibitors. Product ID: R1503. | |
NIH-12848 Quick inquiry Where to buy Suppliers range | NIH-12848 is putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor (IC50 = 1 μM) but did not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Synonyms: N-(thiophen-2-ylmethyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine; NCGC00012848-02; NIH-12848; NIH 12848; NIH12848, NCGC00012848-02. CAS No. 959551-10-1. Molecular formula: C20H14F3N3S. Mole weight: 385.41. | |
NVP-BEZ 235 Quick inquiry Where to buy Suppliers range | Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Group: Biochemicals. Alternative Names: 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile; 2-Methyl-2- [4- [3-methyl-2-oxo-8- (quinolin-3-yl) -2, 3-dihydroimidazo [4, 5-c] quinolin-1-yl] phenyl] propionitrile; BEZ 235. Grades: Highly Purified. CAS No. 915019-65-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
O-1918 Quick inquiry Where to buy Suppliers range | O-1918 is a cannabidiol analog and a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. It is also an inhibitor of GPR18. It does not bind to CB1 or CB2 receptors at concentrations up to 30 μM. It inhibits endothelium-dependent vasodilation and cell migration induced by abnormal-cannabidiol in vitro and in whole animals. It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells. Synonyms: O-1918; O 1918; O1918; 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene. Grades: ≥97% by HPLC. CAS No. 536697-79-7. Molecular formula: C19H26O2. Mole weight: 286.41. | |
O-Methyl-O-(N-Butylfluorescein)-O-{3-[6-O-(D,L-1-ethoxyethyl)-1,2:4,5-bis-O-(1-methylethylidene)-D,L-myo-inositol]}phosphate Quick inquiry Where to buy Suppliers range | It's an intermediate in the synthesis of Butyl-FLIP as well as a fluorogenic substrate for continuous assay of phosphatidylinositol-specific Phospholipase C. Synonyms: 6-O-(1-Ethoxyethyl)-1,2:4,5-bis-O-(1-methylethylidene)-myo-inositol 6'-Butoxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl Methyl Phosphate. CAS No. 335630-21-2. Molecular formula: C41H49O14P. Mole weight: 796.79. | |
Omipalisib Quick inquiry Where to buy Suppliers range | Omipalisib, also known as GSK2126458, is asmall-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor GSK2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. Synonyms: GSK-2126458; GSK2126458; GSK 2126458; Omipalisib. CAS No. 1086062-66-9. Molecular formula: C25H17F2N5O3S. Mole weight: 505.5. | |
O-(N-Butylfluorescein)-O-{3-[6-O-(D,L-1-ethoxyethyl)-1,2:4,5-bis-O-(1-methylethylidene)-D,L-myo-inositol]}phosphate, Lithium Salt Quick inquiry Where to buy Suppliers range | An intermediatel in the synthesis of Butyl-FLIP, a fluorogenic substrate for continuous assay of phosphatidylinositol-specific Phospholipase C. Synonyms: lithium; (6'-butoxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) [(1R,7S)-8-(1-ethoxyethoxy)-5,5,11,11-tetramethyl-4,6,10,12-tetraoxatricyclo[7.3.0.03,7]dodecan-2-yl] phosphate; O-(N-Butylfluorescein)-O-{3-[6-O-(D,L-1-ethoxyethyl)-1,2:4,5-bis-O-(1-methylethylidene)-D,L-myo-inos; 1792191-32-2. CAS No. 1792191-32-2. Molecular formula: C40H46LiO14P. Mole weight: 788.7. | |
PF-04691502 Quick inquiry Where to buy Suppliers range | PF-04691502 is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. It inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Synonyms: PF04691502; PF 04691502; PF-04691502; PF4691502; PF 4691502; PF-4691502; 2-amino-8-((1R,4R)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Grades: > 98%. CAS No. 1013101-36-4. Molecular formula: C22H27N5O4. Mole weight: 425.489. | |
Phosphatidylinositol-bis-4,5-phosphate sodium salt Quick inquiry Where to buy Suppliers range | Phosphatidylinositol-bis-4,5-phosphate sodium salt. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences. | Worldwide |
Phospholipids Quick inquiry Where to buy Suppliers range | Phospholipids occur as white powders. They are sometimes supplied as clear, nearly colorless chloroform or methylene chloride solutions. Uses: Used for research and manufacturing. Group: Excipients for Liquid Dosage Form. Alternative Names: Coatsome; glycerol phosphatides; Lipoid; phosphatides; phosphatidic acid; phosphatidylcholine; phosphatidylethanolamine; phosphatidylglycerol; phosphatidylinositol; phosphatidylserine; phosphoglycerides; PhosphoLipid; purified egg yolk PC; sphingomyelin. Grades: Pharmceutical Excipients. CAS No. Product ID: PE-0632. | |
PI-103 Quick inquiry Where to buy Suppliers range | PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Synonyms: 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol; PI103; PI-103; PI 103. Grades: >98%. CAS No. 371935-74-9. Molecular formula: C19H16N4O3. Mole weight: 348.362. | |
PI-103 (3-(4-(4-Morpholinyl)pyrido[3, 2:4, 5]furo[3, 2-d]pyrimidin-2-yl)phenol) Quick inquiry Where to buy Suppliers range | A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2 β, p110δ, mTORC2, p110 β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo. Group: Biochemicals. Alternative Names: 3-(4-(4-Morpholinyl)pyrido[3, 2:4, 5]furo[3, 2-d]pyrimidin-2-yl)phenol. Grades: Highly Purified. CAS No. 371935-74-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PI3-Kinase α Inhibitor 2 Quick inquiry Where to buy Suppliers range | PI3-Kinase α (PI3Kα) inhibitor 2 is a potent inhibitor of PI3K p110α (IC50 = 2 nM) with selectivity for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). Synonyms: PI3Kα Inhibitor 2; Phosphatidylinositol 3-Kinase α Inhibitor 2; Compound 15e; 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol. Grades: ≥98%. CAS No. 371943-05-4. Molecular formula: C16H15N3O2S. Mole weight: 313.4. | |
PI3-Kinase α Inhibitor 2 hydrochloride Quick inquiry Where to buy Suppliers range | PI3-Kinase α (PI3Kα) inhibitor 2 is a potent inhibitor of PI3K p110α (IC50 = 2 nM) with selectivity for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). Synonyms: Phosphatidylinositol 3-Kinase α Inhibitor 2; PI3Kα Inhibitor 2; 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol hydrochloride. Grades: ≥98%. CAS No. 1188890-32-5. Molecular formula: C16H15N3O2S·2HCl. Mole weight: 386.3. |