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| Product | Description | |
|---|---|---|
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3. Group: Enzymes. Synonyms: PTEN; MMAC1; phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. Enzyme Commission Number: EC 3.1.3.67. CAS No. 210488-47-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3671; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase; EC 3.1.3.67; 210488-47-4; PTEN; MMAC1; phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. Cat No: EXWM-3671. |  |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4). The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. Group: Enzymes. Synonyms: SHIP1; SHIP2; SHIP; p150Ship. Enzyme Commission Number: EC 3.1.3.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3692; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; EC 3.1.3.86; SHIP1; SHIP2; SHIP; p150Ship. Cat No: EXWM-3692. | |
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase | Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P. Group: Enzymes. Synonyms: inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II. Enzyme Commission Number: EC 3.1.3.66. CAS No. 123644-80-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3670; phosphatidylinositol-3,4-bisphosphate 4-phosphatase; EC 3.1.3.66; 123644-80-4; inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II. Cat No: EXWM-3670. | |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase | The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase). Group: Enzymes. Synonyms: MTMR; PtdIns-3,5-P2 3-Ptase. Enzyme Commission Number: EC 3.1.3.95. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3702; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; EC 3.1.3.95; MTMR; PtdIns-3,5-P2 3-Ptase. Cat No: EXWM-3702. | |
| phosphatidylinositol 3-kinase | One mammalian isoform is known. Group: Enzymes. Synonyms: 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase. Enzyme Commission Number: EC 2.7.1.137. CAS No. 115926-52-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2968; phosphatidylinositol 3-kinase; EC 2.7.1.137; 115926-52-8; 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase. Cat No: EXWM-2968. | |
| phosphatidylinositol-3-phosphatase | This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P. Group: Enzymes. Synonyms: inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase. Enzyme Commission Number: EC 3.1.3.64. CAS No. 124248-47-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3669; phosphatidylinositol-3-phosphatase; EC 3.1.3.64; 124248-47-1; inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase. Cat No: EXWM-3669. | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. Group: Enzymes. Synonyms: type I phosphoinositide 3-kinase. Enzyme Commission Number: EC 2.7.1.153. CAS No. 103843-30-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2983; phosphatidylinositol-4,5-bisphosphate 3-kinase; EC 2.7.1.153; 103843-30-7; type I phosphoinositide 3-kinase. Cat No: EXWM-2983. | |
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P. In humans, the enzyme is localized to late endosomal/lysosomal membranes. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis. Group: Enzymes. Synonyms: phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 . Enzyme Commission Number: EC 3.1.3.78. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3683; phosphatidylinositol-4,5-bisphosphate 4-phosphatase; EC 3.1.3.78; phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase. Cat No: EXWM-3683. | |
| Phosphatidylinositol 4-phosphate, 1,2-dipalmitoyl NH4+ salt | Phospholipids. Alternative Names: D-myo-Inositol, 1-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate] 4-(dihydrogen phosphate), ammonium salt (9CI). CAS No. 127996-98-9. Molecular formula: C41H79O16P2·2NH3. Mole weight: 925.1. Appearance: Solid. Purity: >98%. Catalog: ACM127996989. |  |
| phosphatidylinositol-4-phosphate 3-kinase | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. Group: Enzymes. Synonyms: type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase. Enzyme Commission Number: EC 2.7.1.154. CAS No. 141176-94-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2984; phosphatidylinositol-4-phosphate 3-kinase; EC 2.7.1.154; 141176-94-5; type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase. Cat No: EXWM-2984. | |
| phosphatidylinositol α-mannosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: GDP mannose-phosphatidyl-myo-inositol α-mannosyltransferase; GDPmannose:1-phosphatidyl-myo-inositol α-D-mannosyltransferase; guanosine diphosphomannose-phosphatidyl-inositol α-mannosyltransferase; phosphatidyl-myo-inositol α-mannosyltransferase. Enzyme Commission Number: EC 2.4.1.57. CAS No. 37277-65-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2602; phosphatidylinositol α-mannosyltransferase; EC 2.4.1.57; 37277-65-9; GDP mannose-phosphatidyl-myo-inositol α-mannosyltransferase; GDPmannose:1-phosphatidyl-myo-inositol α-D-mannosyltransferase; guanosine diphosphomannose-phosphatidyl-inositol α-mannosyltransferase; phosphatidyl-myo-inositol α-mannosyltransferase. Cat No: EXWM-2602. | |
| Phosphatidylinositol bis-4,5-phosphate, 1,2-dioctanoyl Na salt | Phospholipids. Alternative Names: D-myo-Inositol, 1-[(2R)-2,3-bis[(1-oxooctyl)oxy]propyl hydrogen phosphate] 4,5-bis(dihydrogen phosphate), sodium salt (1:5). CAS No. 1234574-20-9. Molecular formula: C25H44O19P3·5Na. Mole weight: 861.5. Appearance: Solid. Purity: >98%. Catalog: ACM1234574209. | |
| Phosphatidylinositol bis-4,5-phosphate, 1,2-dipalmitoyl Na salt | Phospholipids. Alternative Names: 1,2-Dipalmitoyl-L-α-phosphatidyl-D-myo-inositol 4,5-bisphosphate. CAS No. 120595-88-2. Molecular formula: C41H78O19P3·3Na. Mole weight: 1036.9. Appearance: Solid. Purity: >98%. IUPACName: [ (2R) -2-hexadecanoyloxy-3- [hydroxy- [ (1R, 2R, 3S, 4R, 5R, 6S) -2, 3, 6-trihydroxy-4, 5-diphosphonooxycyclohexyl] oxyphosphoryl] oxypropyl] hexadecanoate. Canonical SMILES: CCCCCCCCCCCCCCCC (=O)OC[C@H] (COP (=O) (O)O[C@@H]1[C@@H] ([C@@H] ([C@H] ([C@@H] ([C@H]1O)OP (=O) (O)O)OP (=O) (O)O)O)O)OC (=O)CCCCCCCCCCCCCCC. Density: 1.27±0.1 g/cm3(Predicted). Catalog: ACM120595882. | |
| Phosphatidylinositol-bis-4,5-phosphate sodium salt | Phosphatidylinositol-bis-4,5-phosphate sodium salt. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences. |  Worldwide |
| phosphatidylinositol deacylase | This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. Group: Enzymes. Synonyms: phosphatidylinositol phospholipase A2; phospholipase A2. Enzyme Commission Number: EC 3.1.1.52. CAS No. 81604-94-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3480; phosphatidylinositol deacylase; EC 3.1.1.52; 81604-94-6; phosphatidylinositol phospholipase A2; phospholipase A2. Cat No: EXWM-3480. | |
| phosphatidylinositol diacylglycerol-lyase | This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C. Group: Enzymes. Synonyms: monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; 1-phosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming); 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming). Enzyme Commission Number: EC 4.6.1.13. CAS No. 37288-19-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5350; phosphatidylinositol diacylglycerol-lyase; EC 4.6.1.13; 37288-19-0; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; 1-phosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming); 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming). Cat No: EXWM-5350. | |
| phosphatidylinositol N-acetylglucosaminyltransferase | Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups. Group: Enzymes. Synonyms: UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase; uridine diphosphoacetylglucosamine α1,6-acetyl-D-glucosaminyltransferase. Enzyme Commission Number: EC 2.4.1.198. CAS No. 144388-35-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2425; phosphatidylinositol N-acetylglucosaminyltransferase; EC 2.4.1.198; 144388-35-2; UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase; uridine diphosphoacetylglucosamine α1,6-acetyl-D-glucosaminyltransferase. Cat No: EXWM-2425. | |
| Phosphatidylinositols, soya, sodium salts | Phosphatidylinositols, soya, sodium salts is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383907-36-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-139533. |  |
| 1,2-Dipalmitoyl phosphatidylinositol 4-phosphate ammonium salt | 1,2-Dipalmitoyl phosphatidylinositol 4-phosphate ammonium salt, a vital phospholipid derivative in signaling pathways associated with immune response and inflammation. This molecule has a multifaceted role, demonstrated by its ability to alter TNF-α activity and regulate T cell activation. Its therapeutic potential extends to autoimmune and inflammatory afflictions; hence, creating an opportunity to target treatments for arthritis and asthma. Synonyms: L-a-Phosphatidyl-(12-dipalmitoyl)-D-myo-inositol 4-monophosphate. CAS No. 57606-15-2. Molecular formula: C41H80O16P2. Mole weight: 891.01. |  |
| 1,2-Dipalmitoyl phosphatidylinositol 5-phosphate | 1,2-Dipalmitoyl phosphatidylinositol 5-phosphate is a pivotal phospholipid, involving in intricate signaling pathways governing diverse cellular mechanisms.Its research applications encompass the exploration of lipid metabolism, membrane trafficking, and dynamic cell membrane characteristics. Synonyms: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate); [ (2R) -2-hexadecanoyloxy-3- [hydroxy- [ (1R, 2R, 3R, 4R, 5S, 6R) -2, 3, 4, 6-tetrahydroxy-5-phosphonooxycyclohexyl] oxyphosphoryl] oxypropyl] hexadecanoate; L-alpha-Phosphatidyl-D-myo-inositol 5-monophosphate, dipalmitoyl; PtdIns(5)P; 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate); PtdIns(5)P1; D-myo-PI[5]P; PI5P; PI[5]P;D-myo-Phosphatidylinositol 5-phosphate (PtdIns(5)P); Q27158617; D-myo-Inositol 5-monophosphate, L- alpha -Phosphatidyl-(1,2-dipalmitoyl); D-myo-Inositol 5-monophosphate, L-alpha-Phosphatidyl-(1,2-dipalmitoyl). CAS No. 291527-75-8. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
| 1-Palmitoyl-2-(L-α-phosphatidylinositol) Sodium Salt | 1-Palmitoyl-2-(L-α-phosphatidylinositol) Sodium Salt is a substrate for phospholipase C that contains mainly linoleic and palmitic acids. Group: Biochemicals. Grades: Highly Purified. CAS No. 383907-36-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C43H78NaO13P, Molecular Weight: 857.04. US Biological Life Sciences. | Worldwide |
| 1-phosphatidylinositol-3-phosphate 5-kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. This enzyme participates in phosphatidylinositol signaling system and regulation of actin cytoskeleton. Group: Enzymes. Synonyms: type III PIP kinase; phosphatidylinositol 3-phosphate 5-kinase. Enzyme Commission Number: EC 2.7.1.150. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2981; 1-phosphatidylinositol-3-phosphate 5-kinase; EC 2.7.1.150; type III PIP kinase; phosphatidylinositol 3-phosphate 5-kinase. Cat No: EXWM-2981. | |
| 1-phosphatidylinositol 4-kinase | This reaction is catalysed by at least two different isoforms. Group: Enzymes. Synonyms: phosphatidylinositol kinase (phosphorylating); phosphatidylinositol 4-kinase; phosphatidylinositol kinase; type II phosphatidylinositol kinase; PI kinase; PI 4-kinase. Enzyme Commission Number: EC 2.7.1.67. CAS No. 37205-54-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3098; 1-phosphatidylinositol 4-kinase; EC 2.7.1.67; 37205-54-2; phosphatidylinositol kinase (phosphorylating); phosphatidylinositol 4-kinase; phosphatidylinositol kinase; type II phosphatidylinositol kinase; PI kinase; PI 4-kinase. Cat No: EXWM-3098. | |
| 1-phosphatidylinositol-4-phosphate 5-kinase | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known. Group: Enzymes. Synonyms: diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase. Enzyme Commission Number: EC 2.7.1.68. CAS No. 104645-76-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3099; 1-phosphatidylinositol-4-phosphate 5-kinase; EC 2.7.1.68; 104645-76-3; diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase. Cat No: EXWM-3099. | |
| 1-phosphatidylinositol-5-phosphate 4-kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton. Group: Enzymes. Synonyms: type II PIP kinase. Enzyme Commission Number: EC 2.7.1.149. CAS No. 247907-17-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2979; 1-phosphatidylinositol-5-phosphate 4-kinase; EC 2.7.1.149; 247907-17-1; type II PIP kinase. Cat No: EXWM-2979. | |
| glycosylphosphatidylinositol diacylglycerol-lyase | This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors. In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group. In other cases, the diacylglycerol is replaced by ceramide (see Lip-1.4 and Lip-1.5 for definition). The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown. Substitution on O-2 of the inositol b...No. 129070-68-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5351; glycosylphosphatidylinositol diacylglycerol-lyase; EC 4.6.1.14; 129070-68-4; (glycosyl)phosphatidylinositol-specific phospholipase C; GPI-PLC; GPI-specific phospholipase C; VSG-lipase; glycosyl inositol phospholipid anchor-hydrolyzing enzyme; glycosylphosphatidylinositol-phospholipase C; glycosylphosphatidylinositol-specific phospholipase C; variant-surface-glycoprotein phospholipase C; 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming). Cat No: EXWM-5351. | |
| glycosylphosphatidylinositol phospholipase D | This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes. Group: Enzymes. Synonyms: GPI-PLD; glycoprotein phospholipase D; phosphatidylinositol phospholipase D; phosphatidylinositol-specific phospholipase D. Enzyme Commission Number: EC 3.1.4.50. CAS No. 113756-14-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3733; glycosylphosphatidylinositol phospholipase D; EC 3.1.4.50; 113756-14-2; GPI-PLD; glycoprotein phospholipase D; phosphatidylinositol phospholipase D; phosphatidylinositol-specific phospholipase D. Cat No: EXWM-3733. | |
| L-α-Phosphatidylinositol | L-α-Phosphatidylinositol is one of the components of phospholipids, and under limited hydration conditions, it can form curved membrane interfaces [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 97281-52-2. Pack Sizes: 10 mg; 25 mg. Product ID: HY-W020658. | |
| L-a-Phosphatidylinositol from Soy bean | L-a-Phosphatidylinositol from Soybean, a naturally occurring phospholipid, boasts a plethora of biomedical applications as it serves as a potent therapeutic agent for an array of ailments including but not limited to cardiovascular diseases, metabolic disorders, and cancer. This compound, with its anti-inflammatory properties, facilitates insulin signaling pathways and preserves cell membranes, hence promoting optimal brain function. The manifold benefits of this compound are a testimony to its profound therapeutic potential. Synonyms: 1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol); Phosphatidylinositols,soya; L-alpha-Phosphatidylinositol from Glycine max (soybean). CAS No. 97281-52-2. Molecular formula: C45H87O13P. Mole weight: 867.1. | |
| 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1-myoinositol-4-phosphate) | PI(3)P diC16 is a synthetic and purified dipalmitoyl PI(3)P. PI(3)P is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. Synonyms: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'D-myo-inositol-3'-phosphate); PI(3)P diC16; L-alpha-Phosphatidyl-D-myo-inositol 3-monophosphate, dipalmitoyl; D-myo-Inositol, 1-(2R)-2,3-bis(1-oxohexadecyl)oxypropyl hydrogen phosphate 3-(dihydrogen phosphate); Phosphatidylinositol 3-phosphate diC16. Grades: >95%. CAS No. 165689-81-6. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
| 1,2-Isopropylidene-D,L-myo-inositol | 1,2-Isopropylidene-D,L-myo-inositol is a facilitator in the synthesis of inositol derivatives and phosphatidylinositol. It can be used to maladie encompassing cystic fibrosis, respiratory infringements, and diabetes. Synonyms: (3Ar,4S,5R,6R,7S,7aS)-2,2-dimethyl-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxole-4,5,6,7-tetrol; (3aR,4S,5R,6R,7S,7aS)-2,2-dimethyl-hexahydro-2H-1,3-benzodioxole-4,5,6,7-tetrol; 1, 2-Isopropylidene-D, L-myo-inositol;(3AR, 4S, 5R, 6R, 7S, 7aS)-2, 2-dimethylhexahydrobenzo[d][1, 3]dioxole-4, 5, 6, 7-tetraol; (3aS,4S,5R,6R,7S,7aR)-2,2-dimethyl-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxole-4,5,6,7-tetrol. CAS No. 26276-97-1. Molecular formula: C9H16O6. Mole weight: 220.22. | |
| 16:0-18:1 DG | 1-palmitoyl-2-oleoyl-sn-glycerol In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid and is a product of the hydrolysis of the phospholipid PIP2(phosphatidylinositol bisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Group: Neutral lipids. Alternative Names: 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol DG(16:0/18:1(9Z)/0:0). CAS No. 29541-66-0. Molecular formula: C37H70O5. Mole weight: 594.949. Purity: >99%. Catalog: ACM29541660. | |
| 16:0-18:1 PI(4)P Diammonium salt | 16:0-18:1 PI(4)P Diammonium salt, a phosphatidylinositol, is a complex molecule embedded within the cell membrane. It has been closely associated with pathologies such as cancer, Alzheimer's, and diabetes, lending it to extensive biomedical research. The salt is particularly notable for its capacity to regulate specific cellular pathways in drug development. Understanding the complex implications of this molecule requires a multidisciplinary approach, involving the integration of biochemistry, pharmacology, and medical sciences. Synonyms: 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate) (ammonium salt). Grades: >99%. CAS No. 2260795-75-1. Molecular formula: C43H88N2O16P2. Mole weight: 951.11. | |
| 18:0-22:6 DG | 1-stearoyl-2-docosahexaenoyl-sn-glycerol In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid and is a product of the hydrolysis of the phospholipid PIP2(phosphatidylinositol bisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Group: Neutral lipids. Alternative Names: 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol DG(18:0/22:6(4Z, 7Z, 10Z, 13Z, 16Z, 19Z)/0:0). CAS No. 65886-80-8. Molecular formula: C43H72O5. Mole weight: 669.029. Purity: >99%. Catalog: ACM65886808. | |
| 187-1, N-WASP inhibitor | 187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC 50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 380488-27-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1045. | |
| 187-1, N-WASP inhibitor | 187-1, N-WASP inhibitor can inhibit neural Wiskott-Aldrich syndrome protein by stabilizing the autoinhibited state of the protein. It can also block phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly with an IC50 value of~ 2 μM. Synonyms: n-wasp-inhibitor,187-1; cyclo[Gln-Lys-D-Phe-D-Pro-D-Phe-Phe-D-Pro-Gln-Lys-D-Phe-D-Pro-D-Phe-Phe-D-Pro]; cyclo[L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl-L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl]. Grades: >98%. CAS No. 380488-27-7. Molecular formula: C96H122N18O16. Mole weight: 1784.13. | |
| 187-1, N-WASP inhibitor | Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 uM) but does not directly inhibit actin polymerization. Group: Biochemicals. Grades: Highly Purified. CAS No. 380488-27-7. Pack Sizes: 1mg. Molecular Formula: C96H122N18O16, Sequence: US Biological Life Sciences. | Worldwide |
| 187-1, N-WASP INHIBITOR | 187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein. Group: Inhibitors. Alternative Names: CYCLO(LKDFDPDFLFDPLQ)2;187-1, N-WASP INHIBITOR;N-WASP-INHIBITOR, 187-1;M.W. 1784.13 C96H122N18O16. CAS No. 380488-27-7. Molecular formula: C96H122N18O16. Mole weight: 1784.11. Appearance: Solid. Purity: 0.96. IUPACName: 187-1, N-WASP inhibitor. Canonical SMILES: C1CC2C (=O) NC (C (=O) NC (C (=O) N3CCCC3C (=O) NC (C (=O) NC (C (=O) NC (C (=O) N4CCCC4C (=O) NC (C (=O) NC (C (=O) N5CCCC5C (=O) NC (C (=O) NC (C (=O) NC (C (=O) N2C1) CC6=CC=CC=C6) CCCCN) CCC (=O) N) CC7=CC=CC=C7) CC8=CC=CC=C8) CC9=CC=CC=C9) CCCCN) CCC (=O) N) CC1=CC=CC=C1) CC1=CC=CC=C1. Catalog: ACM380488277. | |
| 20(R)-Ginsenoside Rg3-d6 | 20(R)-Ginsenoside Rg3-d6 is the labelled version of 20(R)-Ginsenoside Rg3, which causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated, relating to in vivo inhibition of tumor angiogenesis of lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C42H66D6O13, Molecular Weight: 791.05. US Biological Life Sciences. | Worldwide |
| 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile | 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile is used as a reagent in the preparation of imidazo quinoline derivatives, compounds that act as mammalian target of rapamycin (mTOR) an phosphatidylinositol 3-kinase (PI3K-kinase) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 915019-52-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H17BrN4. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-methylimidazole | 2-Amino-4-methylimidazole is used as a reagent in the synthesis of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel allosteric mGluR5 antagonists. Also used as a reagent in the synthesis of imidazo[1,2-a]pyrimidin-5(1H)-ones as beta isoform selective phosphatidylinositol 3-kinase (PI3K) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6653-42-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C4H7N3, Molecular Weight: 97.12. US Biological Life Sciences. | Worldwide |
| 2-Amino-6-bromo-3-fluoro-benzoic Acid | 2-Amino-6-bromo-3-fluoro-benzoic Acid is an intermediate used to prepare 2, 4-diaminopyrimidinyl aminoethyl quinazolin-4 (3H) -one derivatives as phosphatidylinositol 3-kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1153974-98-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H5BrFNO2, Molecular Weight: 234.02. US Biological Life Sciences. | Worldwide |
| 2-?Amino-?6-?methylpyridine | 2-?Amino-?6-?methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Kα). Group: Biochemicals. Grades: Highly Purified. CAS No. 1824-81-3. Pack Sizes: 5g, 25g. Molecular Formula: C6H8N2, Molecular Weight: 108.14. US Biological Life Sciences. | Worldwide |
| 2-Bromoethyl-1-[2-Fmoc-3-O-tert-butyldimethylsilyl]-D-Erythro-sphingosylphosphate | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 3-O-tert-Butyl di methyl silyl -D-Erythro-sphingosyl phosphoryl choline | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 4-Aminophenyl a-D-mannopyranoside 6-phosphate | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Synonyms: 4-Aminophenyl 6-phospho-alpha-mannopyranoside; 4-Aminophenyl 6-phospho-alpha-D-mannopyranoside. CAS No. 74160-60-4. Molecular formula: C12H18NO9P. Mole weight: 351.25. | |
| 8-Aminoadenine | 8-Aminoadenine is an adenine receptor agonist with Ki value of 0.0341 μM in HEK293 cells expressing an adenine binding site. It shows 190-fold increased potency at the human binding site over the rat adenine receptor. It inhibits adenine uptake and isoproterenol-stimulated cAMP accumulation. It may be used in the synthetic preparation of purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. It is important in regulating myocardial oxygen consumption and coronary blood flow. It may take part in inflammation and immune responses. Synonyms: 9H-Purine-6,8-diamine; 1H-Purine-6,8-diamine (9CI); 6,8-Diamino-purine (8CI); NSC 21698; NSC21698; NSC-21698. Grades: ≥98% by HPLC. CAS No. 28128-33-8. Molecular formula: C5H6N6. Mole weight: 150.14. | |
| AC-55541 | AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Synonyms: AC-55541; AC 55541; AC55541. (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide. Grades: >97 %. CAS No. 916170-19-9. Molecular formula: C25H20BrN5O3. Mole weight: 518.36. | |
| Acalisib | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Synonyms: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. | |
| acyloxyacyl hydrolase | The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms. It consists of diglucosamine, β-D-GlcN-(1? 6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue. Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3. The enzyme from human leucocytes detoxifies the lipid by hydrolysing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS). It also possesses a wide range of phospholipase and acyltransferase activities [e.g. EC 3.1.1.4 (phospholipase A2), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.32 (phospholipase A1) and EC 3.1.1.52 (phosphatidylinositol deacylase)], hydrolysing diacylglycerol and phosphatidyl compounds, but not triacylglycerols. It has a preference for saturated C12-C16 acyl groups. Group: Enzymes. Enzyme Commission Number: EC 3.1.1.77. CAS No. 110277-64-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3505; acyloxyacyl hydrolase; EC 3.1.1.77; 110277-64-0. Cat No: EXWM-3505. | |
| Alpelisib | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. | |
| Alpelisib, Free Base, 99+% | Alpelisib, also known as BYL719, is a potent and selective phosphatidylinositol-3 kinase [alpha] inhibitor. It inhibited P110[alpha], p110[beta], p110[delta], and p110[gamma] with IC50 values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibited the Akt phosphorylation with IC50 values of 74 nM in Rat1-myr-p110[alpha] cells, 2.2 µM in Rat1-myr-p110[beta] cells, and 1.2 µM in Rat1-myr-p110[delta] cells. Furet P., et al. "Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation." Bioorg. Med. Chem. Lett. 23: 3741-3748 (2013). Group: Biochemicals. Alternative Names: BYL-719; NVP-BYL719; (S)-Pyrrolidine-1,2-dicarboxylic Acid 2-Amide 1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide; (2S) -N1- [4- methyl -5- [2- (2, 2, 2-tri fluoro -1, 1-di methyl ethyl ) -4-pyridinyl ] -2-thiazoly l ] -1, 2-pyrrolidinedicarboxami de . Grades: Highly Purified. CAS No. 1217486-61-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C19H22F3N5O2S, Molecular Weight: 441.47. US Biological Life Sciences. | Worldwide |
| AM-8508 | AM-8508 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-8508 exhibits good cellular potency (in vitro pAKT IC50 = 4.6 nM ) and excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibits KLH-specific antibodies in animal models and it may become a drug candidate for the treatment of human inflammatory diseases. Uses: Inflammatory diseases. Synonyms: AM-8508; AM 8508; AM8508. (S)-4-amino-6-((1-(6-fluoro-1-(pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1338483-67-2. Molecular formula: C19H15FN8. Mole weight: 374.14. | |
| AM-9635 | AM-9635 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-9635 exhibits good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-9635 can inhibit KLH-specific IgG and IgM in a dosedependent manner and it is well tolerated at all doses. AM-96352 shows significantly reduced IgG and IgM specific antibodies. Synonyms: AM-9635; AM 9635; AM9635. (S)-4-amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1338483-10-5. Molecular formula: C19H14F2N8. Mole weight: 392.36. | |
| Amdizalisib | Amdizalisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, an immunomodulator and an antineoplastic. Synonyms: (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 99% by HPLC. CAS No. 1894229-05-0. Molecular formula: C19H15ClN8. Mole weight: 390.83. | |
| Apitolisib | Apitolisib, also known as GDC-0980 and RG7422; or GNE390, is a dual PI3 kinase/mTOR inhibitor, is also an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor GDC-0980 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion. Synonyms: GDC-0980; GDC0980; GDC 0980; RG7422; RG-7422; RG 7422; GNE 390; GNE390; GNE-390; Apitolisib. CAS No. 1032754-93-0. Molecular formula: C23H30N8O3S. Mole weight: 498.606. | |
| AS-041164 | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a highly potent and selective PI3Kγ inhibitor that inhibits PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ with IC50 values of 240 nM, 1.45 μM, 70 nM and 1.70 μM, respectively. It also blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models. Synonyms: 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione. Grades: ≥98%. CAS No. 6318-41-8. Molecular formula: C11H7NO4S. Mole weight: 249.2. | |
| AS-605240 potassium salt | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
| BF 738735 | A potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIII&alpha. Broad spectrum enterovirus replication inhibitor. Synonyms: 2-Fluoro-4-[2-methyl-8-[[[3- (methylsulfonyl) phenyl]methyl]amino]imidazo[1, 2-a]pyrazin-3-yl]phenol; BF738735; BF-738735. Grades: ≥98%. CAS No. 1436383-95-7. Molecular formula: C21H19FN4O3S. Mole weight: 426.47. | |
| BGT226 | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BGT-226; BGT 226; BGT-226 free base; BGT226 free base; NVP-BGT226; 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-2H-imidazo[4,5-c]quinolin-2-one. Grades: 98%. CAS No. 915020-55-2. Molecular formula: C32H29F3N6O6. Mole weight: 534.54. | |
| Bilobalide | Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 33570-04-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C15H18O8. US Biological Life Sciences. | Worldwide |
| Carbazochrome Sodium Sulfonate | A Phosphatidylinositol hydrolysis inhibitor in endothelial cells. Group: Biochemicals. Alternative Names: 5-[2- (Aminocarbonyl) hydrazinylidene]-2, 3, 5, 6-tetrahydro-1-methyl-6-oxo-1H-indole-2-Sulfonic Acid Sodium Salt; Adenaron; Adona; Adrenochrome sulfonate Ac 17; Carbazon; Donaseven; Emex; Odanon; Tazin. Grades: Highly Purified. CAS No. 51460-26-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| CAY10505 | CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor, was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505, may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction. Synonyms: CAY10505; CAY 10505; CAY-10505. Grades: 0.98. CAS No. 1218777-13-9. Molecular formula: C14H8FNO3S. Mole weight: 289.28. | |
| CAY10626 | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grades: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase | This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system. Group: Enzymes. Synonyms: CDP-diglyceride-inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosph. Enzyme Commission Number: EC 2.7.8.11. CAS No. 9027-1-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3311; CDP-diacylglycerol-inositol 3-phosphatidyltransferase; EC 2.7.8.11; 9027-01-4; CDP-diglyceride-inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase; CDP-DG:inositol transferase; cytidine diphosphodiglyceride-inositol phosphatidyltransferase; CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase; CDP-diglyceride-inositol transferase; cytidine diphosphoglyceride-inositol phosphatidyltransferase; cytidine diphosphoglyceride-inositol transferase. Cat No: EXWM-3311. | |
| CMPD101 | CMPD101 is a novel, potent and selective G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor (IC50 values are 35 and 32 nM at GRK2 and GRK3 respectively). CMPD101 exhibits selectivity for GRK2/3 over GRK1/5 and reduces DAMGO-induced desensitization and internalization of μ-opioid receptors. CMPD101 has been shown to potentiate phosphatidylinositol 4,5-bisphosphate (PIP2) depletion and slow agonist-induced desensitization of protease-activated receptor 2 (PAR2). Group: Inhibitors. Alternative Names: CMPD101; CMPD 101; CMPD-101; Takeda101; Takeda-101; Takeda 101. CAS No. 865608-11-3. Molecular formula: C24H21F3N6O. Mole weight: 466.47. Appearance: Solid powder. Purity: >98%. IUPACName: 3-[[[4-Methyl-5- (4-pyridinyl) -4H-1, 2, 4-triazol-3-yl]methyl]amino]-N-[[2- (trifluoromethyl) phenyl]methyl]benzamide. Canonical SMILES: O=C (NCC1=CC=CC=C1C (F) (F)F)C2=CC=CC (NCC3=NN=C (C4=CC=NC=C4)N3C)=C2. Catalog: ACM865608113. | |
| cyclopropane-fatty-acyl-phospholipid synthase | The enzyme adds a methylene group across the 9,10 position of a Δ9-olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol, forming a cyclopropane derivative (cf. EC 2.1.1.16 methylene-fatty-acyl-phospholipid synthase). Group: Enzymes. Synonyms: cyclopropane synthetase; unsaturated-phospholipid methyltransferase; cyclopropane synthase; cyclopropane fatty acid synthase; cyclopropane fatty acid synthetase; CFA synthase. Enzyme Commission Number: EC 2.1.1.79. CAS No. 51845-48-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1980; cyclopropane-fatty-acyl-phospholipid synthase; EC 2.1.1.79; 51845-48-8; cyclopropane synthetase; unsaturated-phospholipid methyltransferase; cyclopropane synthase; cyclopropane fatty acid synthase; cyclopropane fatty acid synthetase; CFA synthase. Cat No: EXWM-1980. | |
| Dactolisib | Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; NVP-BEZ235; NVP-BEZ-235; NVP-BEZ 235; Dactolisib. Grades: 0.98. CAS No. 915019-65-7. Molecular formula: C30H23N5O. Mole weight: 469.548. | |
| Demethoxyviridiol | It is a mycotoxin produced by the strain of Nodulisporium hinnuleum. It is a fungal metabolite belonging to the wortmannin and viridin classes and an inhibitor of phosphatidylinositol 3-kinase. It affects phospholipid signalling and proliferation of swiss 3T3 cells. Synonyms: Desmethoxyviridiol; Cyclopenta(7,8)phenanthro(10,1-bc)furan-6,9-dione, 1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methyl-, (1R-(1-alpha,3-alpha,11b-alpha))-; (1R,3S,11bR)-1,2,3,7,8,11b-Hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione; [1R-(1α,3α,11bα)]-1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione. Grades: >95% by HPLC. CAS No. 56617-66-4. Molecular formula: C19H16O5. Mole weight: 324.33. | |
| D-Erythro-Sphingosyl phosphoryl choline | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
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