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Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Phospholipids, phosphatidylserines; Serine glycerophosphatides. CAS No. 1446756-47-3. Pack Sizes: 5 mg (50 mg/mL * 100 μL in Chloroform); 10 mg (50 mg/mL * 200 μL in Chloroform); 25 mg (50 mg/mL * 500 μL in Chloroform). Product ID: HY-A0183.
Phosphatidylserine 50% Powder
Phosphatidylserine 50% Powder.
CA, FL & NJ
phosphatidylserine decarboxylase
A pyridoxal-phosphate protein. In Escherichia coli, the prosthetic group is a pyruvoyl group. Group: Enzymes. Synonyms: PS decarboxylase; phosphatidyl-L-serine carboxy-lyase. Enzyme Commission Number: EC 4.1.1.65. CAS No. 9054-78-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4812; phosphatidylserine decarboxylase; EC 4.1.1.65; 9054-78-8; PS decarboxylase; phosphatidyl-L-serine carboxy-lyase. Cat No: EXWM-4812.
Phosphatidylserine Powder
Phosphatidylserine Powder. Applications: 1. phosphatidylserine powder can be applied in food field, it is added into kinds of beverage, liquor and foods as functional food additive;2. phosphatidylserine powder can be applied in health product field, it is widely added into various kinds of health products to prevent chronic diseases or relief symptom of climacteric syndrome.3. phosphatidylserine powder can be applied in cosmetics field, it is widely added into the cosmetics with the function of delaying aging and compacting skin, thus make skin much smooth and delicate.4. phosphatidylserine powder owning estrogenic effect and reliefing symptom of climacteric syndrome. Group: Others. Purity: 20%, 50%. Phosphatidylserine Powder. Cat No: EXTC-166.
Phosphatidylserines (bovine)
Phosphatidylserine is a naturally occurring phospholipid that is enriched in the central nervous system and makes up cell membrane. Synonyms: PtdSers (bovine). Grades: ≥98%. CAS No. 1446756-47-3. Molecular formula: C42H78NO10P (foroleoyl). Mole weight: 788.1.
Phosphatidyl-L-Serine (Phosphatidylserine)
Phosphatidylserine is an important phospholipid membrane component which plays a key role in cell cycle signaling, specifically in relationship to apoptosis. Phosphatidylserine is a fatty molecule, a phospholipid, which contains both amino and fatty acids. The fatty acids include omega-3 and omega-6 fatty acid molecules. Phosphatidylserine is widely used as nutritional supplement. Group: Biochemicals. Alternative Names: 1,2-Diacyl-sn-glycero-3-phospho-L-serine. Grades: Purified. CAS No. 51446-62-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C42H82NO10P, Molecular Weight: 792.07. US Biological Life Sciences.
Worldwide
Soybean P.E. 70% Phosphatidylserine HPLC
Soybean P.E. 70% Phosphatidylserine HPLC.
CA, FL & NJ
1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine sodium salt
DPPS (1,2-Dipalmitoyl-sn-glycero-3-phosphoserine, sodium salt) is a form of phosphatidylserine (PS), a negatively charged phospholipid located in the inner leaflet of the cell membrane. Synonyms: L-Serine, (2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate (ester), monosodium salt; L-Serine, 2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate (ester), monosodium salt, (R)-; 4,6,10-Trioxa-5-phosphahexacosanoic acid, 2-amino-5-hydroxy-11-oxo-8-[(1-oxohexadecyl)oxy]-, 5-oxide, sodium salt (1:1), (2S,8R)-; Coatsome MS 6060LS; 1,2-Dipalmitoyl-sn-glycero-3-phosphoserine sodium salt; L-α-Dipalmitoylphosphatidylserine sodium salt; DPPS sodium salt; monosodium mono (O- ( ( (R) -2, 3-bis (palmitoyloxy) propoxy) oxidophosphoryl) -L-serinate). Grades: ≥98%. CAS No. 145849-32-7. Molecular formula: C38H73NO10P.Na. Mole weight: 758.00.
3-Ketodihydrosphingosine
3-Ketodihydrosphingosine is derived from N-Boc-L-Serine (B667355), which is an N-Boc-protected form of L-Serine (S270975). L-Serine is a non-essential amino acid that is required for the synthesis of sphinogolipids and phosphatidylserine, compounds that are important for central nervous system neuronal survival. L-Serine is also important in intermediary metabolism in eukaryotic cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 18944-28-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H37NO2, Molecular Weight: 299.49. US Biological Life Sciences.
Worldwide
Bavituximab
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human Phosphatidylserine Recombinant Antibody. CAS No. 648904-28-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99279.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism. Group: Enzymes. Synonyms: phosphatidylserine synthase; CDPdiglyceride-serine O-phosphatidyltransferase; PS synthase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase; phosphatidylserine synthetase; CDP-di. Enzyme Commission Number: EC 2.7.8.8. CAS No. 9068-48-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3346; CDP-diacylglycerol-serine O-phosphatidyltransferase; EC 2.7.8.8; 9068-48-8; phosphatidylserine synthase; CDPdiglyceride-serine O-phosphatidyltransferase; PS synthase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase; phosphatidylserine synthetase; CDP-diacylglycerol-L-serine O-phosphatidyltransferase; cytidine diphosphoglyceride-serine O-phosphatidyltransferase; CDP-diglyceride-L-serine phosphatidyltransferase; CDP-diglyceride:serine phosphatidyltransferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase; CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase. Cat No: EXWM-3346.
Fmoc-L-serine
N-Fmoc-L-serine is an N-Fmoc-protected form of L-Serine. L-Serine is a non-essential amino acid that is required for the synthesis of sphingolipids and phosphatidylserine, compounds that are important for central nervous system neuronal survival. L-Serine is also important in intermediary metabolism in eukaryotic cells. Synonyms: Fmoc-L-Ser-OH; Fmoc-L-β-hydroxyalanine(S)-Fmoc-2-amino-3-hydroxypropionic acid; FMOC-SER-OH; N-Fmoc-L-serine-OH; N-FMOC-L-SERINE; FMOC-SERINE; FMOC-SER. Grades: ≥ 99.5% (Chiral HPLC). CAS No. 73724-45-5. Molecular formula: C18H17NO5. Mole weight: 327.30.
GW-4869 HCl
GW-4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM). GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GW4869; GW-4869; GW 4869; GW554869A; GW-554869A; GW 554869A; GW69A; GW-69A; GW 69A; GW-4869 HCl. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.51. Purity: >98%. IUPACName: (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride. Canonical SMILES: O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5.[H]Cl.[H]Cl. Product ID: ACM6823694-1. Alfa Chemistry ISO 9001:2015 Certified.
KC01
KC01 is a covalent inhibitor of ABHD16A. ABHD16A is a phosphatidylserine (PS) lipase that generates lyso-PS in mammalian systems. KC01 can deplete lysoPSs from cells, including lymphoblasts derived from subjects with PHARC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KC01; K C01; K-C01. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1646795-59-6. Molecular formula: C22H39NO3. Mole weight: 365.56. Purity: >98%. IUPACName: (Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide. Canonical SMILES: O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O. Product ID: ACM1646795596. Alfa Chemistry ISO 9001:2015 Certified. Categories: KC-17.
lipid IVA palmitoyltransferase
Isolated from the bacteria Escherichia coli and Salmonella typhimurium. The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. The enzyme also acts on Kdo-(2?4)-Kdo-(2?6)-lipid IVA. Group: Enzymes. Synonyms: PagP; crcA (gene name). Enzyme Commission Number: EC 2.3.1.251. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2201; lipid IVA palmitoyltransferase; EC 2.3.1.251; PagP; crcA (gene name). Cat No: EXWM-2201.
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine. Group: Enzymes. Synonyms: phosphatidylserine synthase 2; serine-exchange enzyme II; PTDSS2 (gene name). Enzyme Commission Number: EC 2.7.8.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3328; L-serine-phosphatidylethanolamine phosphatidyltransferase; EC 2.7.8.29; phosphatidylserine synthase 2; serine-exchange enzyme II; PTDSS2 (gene name). Cat No: EXWM-3328.
Native Bovine Phospholipase A2
Phospholipase A2 (PLA2) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. It aggressively attacks phospholipids in membranes of intact cells. PLA2 specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Group: Enzymes. Synonyms: Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-84-7. PLA2. Activity: > 20 units/mg protein. Storage: -20°C. Form: lyophilized powder; Contains Tris buffer salts. Source: Bovine pancreas. Species: Bovine. Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Cat No: NATE-0583.
Phospholipase A2 (PLA2) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. It aggressively attacks phospholipids in membranes of intact cells. PLA2 specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Group: Enzymes. Synonyms: Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-84-7. PLA2. Activity: ~1,500 units/mg protein. Storage: -20°C. Source: Naja mossambica mossambica. Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Cat No: NATE-0586.
Native Porcine Phospholipase A2
Phospholipase A2 (PLA2) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. It aggressively attacks phospholipids in membranes of intact cells. PLA2 specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Group: Enzymes. Synonyms: Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-84-7. PLA2. Activity: Type I, > 600 units/mg protein. Storage: -20°C. Form: Type I, ammonium sulfate suspension; Suspension in 3.2 M (NH4)2SO4 solution, pH 5.5; Type II, suspension, off-white. Source: Porcine pancreas. Species: Porcine. Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Cat No: NATE-0587.
Native Rat Protein Kinase C Catalytic Subunit
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and &theta. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Does not require ca2+ or phosphatidylserine for its activity. Group: Enzymes. Synonyms: PKC-M, PKM; PKCM; Protein Kinase C Catalytic Subunit. Purity: > 90% (SDS-PAGE). PKC. Activity: > 800 units/mg protein. Stability: -70°C. Source: rat brain. Species: Rat. PKC-M, PKM; PKCM; Protein Kinase C Catalytic Subunit. Pack: vial of 200 ng. Cat No: NATE-0578.
Phospholipase A2 (PLA2) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. It aggressively attacks phospholipids in membranes of intact cells. PLA2 specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Applications: Phospholipase a 2 is an enzyme used to hydrolyze phospholipids. it is used to study the release of arachidonic acid from various cell types such as neutrophils, gastric mucosal cells and kidney cells. Group: Enzymes. Synonyms: Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-84-7. PLA2. Activity: > 10 units/mg solid. Storage: -20°C. Form: Lyophilized powder containing mannitol and Tris buffer. Source: Streptomyces violaceoruber. Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Cat No: NATE-0588.
O-Phospho-L-serine
O-Phospho-L-serine, a molecule which resembles phosphatidylserine head group, is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A. Synonyms: Dexfosfoserine; Phosphoserine; L-O-Phosphoserine; O-Phosphoserine; L-SOP; Fosforina. Grades: ≥ 99% (Titration). CAS No. 407-41-0. Molecular formula: C3H8NO6P. Mole weight: 185.07.
Phospholipids
Phospholipids occur as white powders. They are sometimes supplied as clear, nearly colorless chloroform or methylene chloride solutions. Synonyms: Coatsome; glycerol phosphatides; Lipoid; phosphatides; phosphatidic acid; phosphatidylcholine; phosphatidylethanolamine; phosphatidylglycerol; phosphatidylinositol; phosphatidylserine; phosphoglycerides; PhosphoLipid; purified egg yolk PC; sphingomyelin. Product ID: PE-0632. Category: Anionic Surfactant; Cationic Surfactant; Dispersing Agents; Emulsifying Agents; Emulsion Stabilizer; Nonionic Surfactant; Solubilizing Agents; Suspending Agents; Wetting Agents. Product Keywords: Excipients for Liquid Dosage Form; Surfactant Excipients; PE-0632; Phospholipids; Anionic Surfactant; Cationic Surfactant; Dispersing Agents; Emulsifying Agents; Emulsion Stabilizer; Nonionic Surfactant; Solubilizing Agents; Suspending Agents; Wetting Agents. UNII: NA. Grade: Pharmceutical Excipients. Administration route: Oral, otic, buccal, vaginal, topical, epidural, intravenous, intramuscular, and inhalation aerosol. Dosage Form: oral, otic, buccal, vaginal, topical, epidural, intravenous, intramuscular, and inhalation aerosol. Stability and Storage Conditions: Phospholipids are stable in the solid state if protected from oxygen, heat, and light. Chloroform or dichloromethane solutions are also stable. Both the solid-state and solution forms should be stored at -20°C. Liposomal phospholipids are k
phospholipid-translocating ATPase
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme moves phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine from one membrane face to the other ('flippase'). Group: Enzymes. Synonyms: Mg2+-ATPase; flippase; aminophospholipid-transporting ATPase. Enzyme Commission Number: EC 7.6.2.1 (Formerly EC 3.6.3.1). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4646; phospholipid-translocating ATPase; EC 3.6.3.1; Mg2+-ATPase; flippase; aminophospholipid-transporting ATPase. Cat No: EXWM-4646.
Protein Kinase Activator SC-10 (N- (n-heptyl) -5-chloro-1-naphthalene sulfonamide)
An activator of protein kinase C in a Ca2+-dependent manner, via a mechanism similar to that of phosphatidylserine. Group: Biochemicals. Alternative Names: N- (n-heptyl) -5-chloro-1-naphthalene sulfonamide. Grades: Molecular Biology Grade. CAS No. 102649-79-6. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Protein Kinase Activator SC-9 (N- (6-phenylhexyl) -5-chloro-1-naphthalene sulfonamide)
Activates protein kinase C in a Ca2+-dependent manner, via a mechanism similar to that of phosphatidylserine. Group: Biochemicals. Alternative Names: N- (6-phenylhexyl) -5-chloro-1-naphthalene sulfonamide. Grades: Molecular Biology Grade. CAS No. 102649-78-5. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences.
Worldwide
Z-FA-FMK
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (1S)-Z-FA-FMK. CAS No. 197855-65-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0109A.
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