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| Product | Description | |
|---|---|---|
| Chemical phosphorylation reagent II | Chemical phosphorylation recompound II is a potent instrument utilized within the realm of biomedical industry, serving as a pivotal component for the intricate phosphorylation reactions. This indispensable recompound orchestrates the modification and activation of select biomolecules encompassing proteins, peptides and nucleotides. Its versatility extends to diverse fields including drug development, signal transduction research and researchs targeting anomalous phosphorylation processes underlying numerous pathologies. Synonyms: 2-[ (4, 4'-Dimethoxytrityloxy) methyl]-2-[[ (diisopropylamino) (2-cyanoethoxy) phosphinooxy]methyl]malonic acid diethyl ester. Grades: >95% by HPLC. Molecular formula: C39H51N2O9P. Mole weight: 722.82. |  |
| MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, Biotin (HRP) | MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, Biotin (HRP). Group: Molecular Biology. Grades: Affinity Purified. Pack Sizes: 100ul. US Biological Life Sciences. |  Worldwide |
| MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, MAP Kinase Kinase 3,6 (MKK3,6) Nonphosphorylated Control Cell Extract | Nonphosphorylated Control Cell Extract for M2363-15A. Total cell extracts from NIH/3T3 cells, prepared without treatment, serve as a negative control. Group: Molecular Biology. Pack Sizes: 80ul. US Biological Life Sciences. | Worldwide |
| MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, MAP Kinase Kinase 3,6 (MKK3,6) Phosphorylated Control Cell Extract | Phosphorylated Control Cell Extract for M2363-15A. Total cell extracts from NIH/3T3 cells, prepared with UV light treatment, serve as a positive control. Group: Molecular Biology. Pack Sizes: 80ul. US Biological Life Sciences. | Worldwide |
| Solid Chemical phosphorylation reagent II | Solid Chemical phosphorylation reagent II is a crucial tool in biomedical research for selectively introducing phosphorylation onto target proteins or peptides. It is widely used in drug discovery and the study of various diseases involving abnormal protein phosphorylation, including cancer, Alzheimers disease, and diabetes. Synonyms: Chemical phosphorylation amidite. Grades: >95% by HPLC. CAS No. 202284-84-2. Molecular formula: C37H49N4O7P. Mole weight: 692.79. | |
| SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) | A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 10-DEBC hydrochloride | 10-DEBC hydrochloride is a selective and reversible Akt/PKB inhibitor suppressing the IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), and inhibiting downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. 10-DEBC hydrochloride inhibits cell growth (IC50 ~ 2-6 μM) and leads to apoptosis in rhabdomyosarcoma cells. Synonyms: 10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1); Akt Inhibitor X; 2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride; 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride; 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 925681-41-0. Molecular formula: C20H25N2OCl.HCl. Mole weight: 381.34. | |
| 10-DEBC hydrochloride | Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5uM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6uM) and induces apoptosis in rhabdomyosarcoma cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 925681-41-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H25N2OCl.HCl, Method for Determining. US Biological Life Sciences. | Worldwide |
| 10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride | 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)- β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF- β1-induced myofibroblast differentiation of dermal fibroblasts and TGF- β2-induced endothelial cell differentiation in iPSCs (1,2). Group: Biochemicals. Grades: Highly Purified. CAS No. 521984-48-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C28H28ClN3O3, Molecular Weight: 489.99. US Biological Life Sciences. | Worldwide |
| 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine | 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine with lauric acid. Phosphatidylethanolamine is a phospholipid found in all living organisms, particularly in nervous tissue. It serves as a precursor of phosphatidylcholine, and promotes membrane fusion, oxidative phosphorylation, mitochondrial biogenesis, and autophagy. Synonyms: DLEA; DLPE; Dilauroyl phosphatidylethanolamine; PE(12:0/12:0); 1,2-didodecanoyl-sn-glycero-3-phosphoethanolamine. Grades: ≥98%. CAS No. 42436-56-6. Molecular formula: C29H58NO8P. Mole weight: 579.76. | |
| 12(S)-HETE | 12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 54397-83-0. Pack Sizes: 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-124404A. |  |
| 1- (8-Chloro-5-isoquinolinesulfonyl) piperazine, Dihydrochloride (HA-156) | Inhibits both Ca2+ dependent myosin phosphorylation by MLC-Kinase and protein kinase C. Group: Biochemicals. Alternative Names: HA-156. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl-2-acetyl-sn-glycerol | 1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of the PKC-activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. Activator of phospholipid-dependent protein kinase C and stimulator of secretion and aggregation in blood platelets. Synonyms: 18:1-2:0 DG; 1-(9Z-octadecenoyl)-2-acetoyl-sn-glycerol; DG(18:1(9Z)/2:0/0:0); OAG; 2-Acetyl-1-oleoyl-sn-glycerol; 1-O-Octadecenoyl-2-O-acetylglycerol. Grades: ≥90%. CAS No. 86390-77-4. Molecular formula: C23H42O5. Mole weight: 398.58. | |
| 1-Oleoyl lysophosphatidic acid | 1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase. Synonyms: 1-Oleoyl-sn-glycerol 3-phosphate; Oleoyl LPA; 18:1 LPA; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate; LysoPA(18:1). Grades: ≥95%. CAS No. 65528-98-5. Molecular formula: C21H41O7P. Mole weight: 436.50. | |
| (1r, 4r) -4- ( (2- (Butylamino) -5- (5- (morpholinomethyl) pyridin-2-yl) pyrimidin-4-yl) amino) cyclohexanol | (1r, 4r) -4- ( (2- (Butylamino) -5- (5- (morpholinomethyl) pyridin-2-yl) pyrimidin-4-yl) amino) cyclohexanol inhibits steady-state phosphorylation of endogenous Mer and blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. (1r, 4r) -4- ( (2- (Butylamino) -5- (5- (morpholinomethyl) pyridin-2-yl) pyrimidin-4-yl) amino) cyclohexanol also decreases colony-forming potential in rhabdoid and NSCLC tumor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1493694-70-4. Pack Sizes: 5mg, 50mg. Molecular Formula: C24H36N6O2. US Biological Life Sciences. | Worldwide |
| 1-Stearo-2-linolein | 1-Stearo-2-linolein is used in the study of the influence of platelet-derived growth factor (PDGF) on diacylglycerol phosphorylation in Swiss 3T3 cells. It is also a possible protein kinase C activator. Group: Biochemicals. Grades: Highly Purified. CAS No. 27095-10-9. Pack Sizes: 10mg, 100mg. Molecular Formula: C39H72O5, Molecular Weight: 620.99. US Biological Life Sciences. | Worldwide |
| 1-Stearo-2-linolein-d5 | 1-Stearo-2-linolein-d5 is labelled 1-Stearo-2-linolein (S686465) which is used in the study of the influence of platelet-derived growth factor (PDGF) on diacylglycerol phosphorylation in Swiss 3T3 cells. It is also a possible protein kinase C activator. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C39H67D5O5, Molecular Weight: 626.02. US Biological Life Sciences. | Worldwide |
| 1-Stearoyl-2-linoleoyl-sn-glycerol | 1-Stearoyl-2-linoleoyl-sn-glycerol is used in the study of the influence of platelet-derived growth factor (PDGF) on diacylglycerol phosphorylation in Swiss 3T3 cells. It is also a possible protein kinase C activator. Group: Biochemicals. Grades: Highly Purified. CAS No. 34487-26-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C39H72O5, Molecular Weight: 620.99. US Biological Life Sciences. | Worldwide |
| 1-Stearoyl-sn-glycero-3-phosphocholine | 1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 19420-57-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-125771. | |
| 2,6-Di-tert-butyl-4-nitrophenol | 2,6-Di-tert-butyl-4-nitrophenol is a potentially powerful uncoupler of ATP-generating oxidative phosphorylation that has been reported to be a contaminant in submarines and indoor spaces, causing a number of objects to turn yellow (even human skin). Group: Biochemicals. Grades: Highly Purified. CAS No. 728-40-5. Pack Sizes: 500mg, 1g. Molecular Formula: C14H21NO3. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3-hydroxypropanal | 2-Chloro-3-hydroxypropanal is a versatile building block used in organic synthesis. It was used as a reactant in the study of phosphorylation effect on reaction rate of unnatural electrophiles with ketodeoxyphosphoglucon ate aldolase. Group: Biochemicals. Grades: Highly Purified. CAS No. 28598-66-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C3H5ClO2, Molecular Weight: 108.52. US Biological Life Sciences. | Worldwide |
| 2-Chlorophenyl N-Phenyl chlorophosphoramidate | 2-Chlorophenyl N-Phenyl chlorophosphoramidate is a reagent used in the phosphorylation of adenosine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 69320-80-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H10Cl2NO2P, Molecular Weight: 302.089999999999. US Biological Life Sciences. | Worldwide |
| 2'-C-Methylcytidine | A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication. Synonyms: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one; 1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one; 2'-C-methylcytidine; valopicitabine; Cytidine,2'-C-methyl. Grades: ≥ 95%. CAS No. 20724-73-6. Molecular formula: C10H15N3O5. Mole weight: 257.24. | |
| 2-Cyanobenzaldehyde | This compound can act as a crosslinker to protein kinase, which is responsible for thousands of phosphorylation events in the phosphoproteome. Group: Biochemicals. Alternative Names: 2-Formylbenzonitrile; o-Cyanobenzaldehyde; Phthalaldehydonitrile. Grades: Highly Purified. CAS No. 7468-67-9. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| (2-cyanoethyl) (2,2-bis(ethoxycarbonyl)-3-(4,4'-dimethoxytrityloxy)propyl-1) N,N-diisopropylphosphoramidite | N,N-diisopropylphosphoramidite, a catalytic compound, is an essential building block for oligonucleotide synthesis used in various therapeutic domains such as antisense therapy, siRNA, and gene editing. This efficient and highly pure chemical ensures the production of top-quality therapeutic oligonucleotides. Synonyms: Chemical phosphorylation reagent for oligonucleotide synthesis;Propanedioic acid, [[bis (4-methoxyphenyl) phenylmethoxy]methyl][[[[bis (1-methylethyl) amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester; CP?; CPRII; 2-[ (4, 4'-Dimethoxytrityloxy) methyl]-2-[[ (diisopropylamino) (2-cyanoethoxy) phosphinooxy]methyl]malonic acid diethyl ester; Diethyl {[bis (4-methoxyphenyl) (phenyl) methoxy]methyl} ({[ (2-cyanoethoxy) (diisopropylamino) phosphino]oxy}methyl) malonate. Grades: ≥97% by HPLC. CAS No. 171285-25-9. Molecular formula: C39H51N2O9P. Mole weight: 722.80. | |
| 2'-Deoxyadenosine-5'-O-(1-Thiotriphosphate) | 2'-Deoxyadenosine-5'-O-(1-Thiotriphosphate) - a specialized nucleotide - is typically employed in biochemical assays that evaluate the functioning of enzymes, including kinases and GTPases. Its inclusion in such assays is aimed at exploring the intricate mechanics of protein phosphorylation and nucleotide exchange in the aforementioned enzymes. Synonyms: Alpha Thiol dATP; 1-Thio-dATP. Grades: ≥95% by AX-HPLC. Molecular formula: C10H16N5O11P3S. Mole weight: 507.25. | |
| 2-Deoxy-D-glucose | 2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models. Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose; 2-DG; 2 DG; 2DG. Grades: >98%. CAS No. 154-17-6. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 2-Ethoxybenzamide | 2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects [1]. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ethenzamide. CAS No. 938-73-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1428. | |
| 2-Fluoro-3, 4-methylenedioxyphenyl Boronic acid | 2-Fluoro-3, 4-methylenedioxyphenyl Boronic acid is used in the synthetic preparation of potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Group: Biochemicals. Grades: Highly Purified. CAS No. 943830-75-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C7H6BFO4, Molecular Weight: 183.93. US Biological Life Sciences. | Worldwide |
| 2-Methoxyestradiol | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. Group: Biochemicals. Grades: Highly Purified. CAS No. 362-07-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| 2-Methyl-4-isothiazolin-3-one Hydrochloride (MIT) | MIT is used to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites. 2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-containing solution. Group: Biochemicals. Alternative Names: 2-Methyl-2H-isothiazol-3-one; 2-Methyl-3(2H)-isothiazolone Hydrochloride; 2-Methyl-3-isothiazolone Hydrochloride; 2-Methyl-4-isothiazolin-3-one Hydrochloride; 2-Methyl-4-isothiazoline-3-ketone Hydrochloride; 2-Methyl-4-isothiazoline-3-one Hydrochloride; KB 838 Hydrochloride; Kathon CG 243 Hydrochloride; Kordek 50 Hydrochloride; Kordek 50C Hydrochloride; Kordek 573F Hydrochloride; Kordek MLX Hydrochloride; MIT Hydrochloride; MIT (biocide) Hydrochloride; Methylisothiazolinone Hydrochloride; Microcare MT; N-Methylisothiazolin-3-one Hydrochloride; N-Methylisothiazolone Hydrochloride; Neolone Hydrochloride; Neolone 950 Hydrochloride; Neolone CapG Hydrochloride; Neolone M 10 Hydrochloride; Neolone M 50 Hydrochloride; Neolone PE Hydrochloride; Optiphen MIT Hydrochloride; ProClin 950 Hydrochloride. Grades: Highly Purified. CAS No. 26172-54-3. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C?H?ClNOS, Molecular Weight: 151.61. US Biological Life Sciences. | Worldwide |
| 2-(S)-Isobutyl-pyrrolidine Hydrochloride | 2-(S)-Isobutyl-pyrrolidine Hydrochloride can be prepared from asymmetric synthesis of pyrrolidines from benzotri azolyl phenyl oxazolopyrrolidine via allylation, alkylation, and phosphorylation. (R)-isomer of (R)?-2-?(2-?Methylpropyl)?-pyrrolidine (M330115). Group: Biochemicals. Grades: Highly Purified. CAS No. 222314-40-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C8H17N; HCl, Molecular Weight: 127.233645999999. US Biological Life Sciences. | Worldwide |
| 3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3`-Deoxy-5`-thymidylic Acid | 3`-Deoxy-5`-thymidylic Acid has been shown to complex with human thymidylate kinase via hydrogen bonding between Arg97 residues and phosphate groups. This interaction leads to the closed P-loop conformation in human thymidylate kinase, which promotes phosphorylation of nucleotides and has the potential as a model for novel compounds as a result of structure-based design studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 3715-64-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H15N2O7P, Molecular Weight: 306.211. US Biological Life Sciences. | Worldwide |
| [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase | A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. Simultaneously dephosphorylates and activates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), that has been inactivated by phosphorylation. Group: Enzymes. Synonyms: branched-chain oxo-acid dehydrogenase phosphatase; branched-chain 2-keto acid dehydrogenase phosphatase; branched-chain α-keto acid dehydrogenase phosphatase; BCKDH; [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase; [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase. Enzyme Commission Number: EC 3.1.3.52. CAS No. 87244-20-0, 88086-29-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3657; [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase; EC 3.1.3.52; 87244-20-0, 88086-29-7; branched-chain oxo-acid dehydrogenase phosphatase; branched-chain 2-keto acid dehydrogenase phosphatase; branched-chain α-keto acid dehydrogenase phosphatase; BCKDH; [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase; [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase. Cat No: EXWM-3657. |  |
| [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase | The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). Group: Enzymes. Synonyms: BCK; BCKD kinase; BCODH kinase; branched-chain α-ketoacid dehydrogenase kinase; branched-chain 2-oxo acid dehydrogenase kinase; branched-chain keto acid dehydrogenase kinase; branched-chain oxo acid dehydrogenase kinase (phosphorylating); STK2. Enzyme Commission Number: EC 2.7.11.4. CAS No. 82391-38-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3155; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase; EC 2.7.11.4; 82391-38-6; BCK; BCKD kinase; BCODH kinase; branched-chain α-ketoacid dehydrogenase kinase; branched-chain 2-oxo acid dehydrogenase kinase; branched-chain keto acid dehydrogenase kinase; branched-chain oxo acid dehydrogenase kinase (phosphorylating); STK2. Cat No: EXWM-3155. | |
| 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase | The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. O-Polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit. The dual kinase/methylase WbdD also catalyses the preceding phosphorylation of α-D-Man-(1?2)-α-D-Man-(1?2)-α-D-Man-(1?3)-α-D-Man-(1?3)-[α-D-Man-(1?2)-α-D-Man-(1?2)-α-D-Man-(1?3)-α-D-Man-(1?3)]n-α-D-Man-(1?3)-α-D-Man-(1?3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.7.1.181, α-D-Man-(1?2)-α-D-Man-(1?3)-α-D-Man-(1?3)-α-D-Man-diphospho-ditrans,octacis-undecaprenol 3-kinase). Group: Enzymes. Synonyms: WbdD. Enzyme Commission Number: EC 2.1.1.294. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1901; 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase; EC 2.1.1.294; WbdD. Cat No: EXWM-1901. | |
| 3-? (Trifluoromethyl) ?phenyl Isocyanate | 3-? (Trifluoromethyl) ?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 329-01-1. Pack Sizes: 500mg, 1g. Molecular Formula: C8H4F3NO, Molecular Weight: 187.12. US Biological Life Sciences. | Worldwide |
| 4-methoxy-3-(3-morpholinopropoxy)-2-nitrobenzonitrile | 4-methoxy-3-(3-morpholinopropoxy)-2-nitrobenzonitrile is an impurity of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 17. Grades: 98%. CAS No. 1006378-06-8. Molecular formula: C15H19N3O5. Mole weight: 321.33. | |
| 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide | 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide is an impurity of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 22. CAS No. 861453-16-9. Molecular formula: C15H21N3O6. Mole weight: 339.34. | |
| 4-Methoxylonchocarpin | 4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model [1]. Uses: Scientific research. Group: Natural products. CAS No. 51589-67-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11768. | |
| 4-Nitro-3-(trifluoromethyl)phenol | 4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide that is toxic to lampreys (P. marinus) (LC 50 values are 1.97-2.11 for cysts, 2.05-2.21 for fry, 1.6-2.45 for juveniles, and 1.6-1.63 for adults, respectively). 4-Nitro-3-(trifluoromethyl)phenol is also toxic to juvenile lake sturgeons (A. fulvescens) less than 100 mm, but is nontoxic to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (50 μM) dissociates oxidative phosphorylation by 22% and 28% in isolated livers of lampreys and rainbow trout (O. mykiss), respectively. 4-Nitro-3-(trifluoromethyl)phenol can be used to control lamprey larval populations. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3-(Trifluoromethyl)-4-Nitrophenol; TFM. CAS No. 88-30-2. Pack Sizes: 1 g; 5 g. Product ID: HY-W014566. | |
| 4-Nitrophenyl phosphate potassium salt | 4-Nitrophenyl phosphate potassium salt, an indispensable reagent in the field of biomedicine, plays a pivotal role in the study of protein phosphorylation. With its distinctive characteristics, this compound serves as a substrate for a diverse range of kinases, notably including alkaline phosphatases. Its multifunctionality extends to the exploration of signal transduction pathways and the elucidation of enzymatic activities implicated in afflictions such as cancer and metabolic disorders. Synonyms: pNP-Phos K. CAS No. 208651-58-5. Molecular formula: C6H5NO6P.K. Mole weight: 257.18. | |
| 4-phosphopantoate-β-alanine ligase | The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphorylation (EC 6.3.2.1 [pantoate-β-alanine ligase] and EC 2.7.1.33 [pantothenate kinase], respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme. Group: Enzymes. Synonyms: phosphopantothenate synthetase; TK1686 protein. Enzyme Commission Number: EC 6.3.2.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5753; 4-phosphopantoate-β-alanine ligase; EC 6.3.2.36; phosphopantothenate synthetase; TK1686 protein. Cat No: EXWM-5753. | |
| 5'-O-(2-Amino-2-deoxy-D-glucopyranosyl)-thymidine | 5'-O-(2-Amino-2-deoxy-D-glucopyranosyl)-thymidine is a significant compound employed in the biomedical sector to counter viral infections triggered by thymidine kinase-dependent viruses. Its profound impact lies in its function as a substrate for viral thymidine kinase, thereby leading to phosphorylation and subsequent disruption of viral DNA research and development. Molecular formula: C16H25N3O9. Mole weight: 403.38. | |
| 5-O-Methylvisammioside | 4-O- β-D-Glucosyl-5-O-methyllvisamminol is a novel epigenetic suppressor of histone H3 phosphorylation. Potent anti-inflammatory and anti-carcinogenic agent. Group: Biochemicals. Alternative Names: 4-O- β-D-Glucosyl-5-O-methyllvisamminol; (S)-2-[1-( β-D-Glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-4-methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one. Grades: Highly Purified. CAS No. 84272-85-5. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C22H28O10, Molecular Weight: 452.45. US Biological Life Sciences. | Worldwide |
| 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one | 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is an intermediate of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 12; 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one. CAS No. 199327-61-2. Molecular formula: C16H21N3O4. Mole weight: 319.36. | |
| 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - ATTO-MB2 | ATTO-MB2 is a cutting-edge compound, revolutionizing the research landscape by skillfully manipulating cellular signaling pathways. This game-changing compound ingeniously homes in on distinct pivotal enzymes responsible for adenosine phosphorylation. Aptly deployed, it showcases astonishing prowess in studying various ailments spawned from distorted adenosine metabolism, encompassing the likes of malignancies and inflammatory afflictions. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with ATTO-MB2, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C35H48N10O11P2S (free acid). Mole weight: 878.83 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - Biotin | 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - Biotin, a biomolecule utilized for cellular signal transduction pathway examinations, has shown promising results in assaying the effects of adenosine phosphorylation on tyrosine kinase intricate signaling pathways. In addition to its well-established utilization in biochemical research, this compound has also exhibited significant potential for the treatment of specific oncological conditions. Grades: ≥ 95% by HPLC. Molecular formula: C26H43N9O12P2S (free acid). Mole weight: 767.68 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-ATP - 5/6-TAMRA | 8-[(6-Amino)hexyl]-amino-ATP - 5/6-TAMRA, a fluorescent probe widely used in biomedical research, is an invaluable tool for investigating the activity of kinases. By monitoring protein phosphorylation and assessing protein-ATP interaction, this product allows for a deeper understanding of the molecular mechanisms of cellular signaling pathways. Additionally, the detection of abnormal kinase activity, a hallmark of many diseases including cancer, makes this probe a crucial component in the development of innovative diagnostic and therapeutic strategies. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-5'-triphosphate, labeled with 5/6-TAMRA, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C41H50N9O17P3 (free acid). Mole weight: 1033.81 (free acid). | |
| 8-Azidoadenosine 5'-triphosphate tetralithium salt | 8-Azidoadenosine 5'-triphosphate tetralithium salt, a pivotal agent in the field of biomedicine, serves as an indispensable resource for the investigation of kinase activity and phosphorylation occurrences. Through its utilization as a photoaffinity probe, this compound facilitates the identification and characterization of proteins that bind to adenosine triphosphate (ATP). Its remarkably potent nature renders it a valuable asset in the realm of drug discovery and development. Grades: 85%. Molecular formula: C10H15N8O13P3. Mole weight: 548.19. | |
| 8-Bromo-2'-deoxy-N6-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite | 8-Bromo-2'-deoxy-N6-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite is an imperative compound, serving as an indispensable phosphorylation recompound engendering the amalgamation of oligonucleotides. Its pervasive utilization in the research of pharmacological exploration, primarily within the domain of nucleotide-based therapeutics spanning antisense oligonucleotides and siRNA. Synonyms: 8-Bromo-2'-deoxy-N6-DMF-5'-O-DMT-D-adenosine 3'-CE phosphoramidite; 8-Bromo-N6-DMF-5'-O-DMT-2'-deoxyadenosine 3'-CE phosphoramidite. Molecular formula: C43H52BrN8O6P. Mole weight: 887.82. | |
| 8-Chloroadenosine | 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 8-Cl-Ado. CAS No. 34408-14-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103400. | |
| 8-?Prenylnaringenin | 8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus , with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 53846-50-7. Pack Sizes: 5 mg. Product ID: HY-N2787. | |
| A 1070722 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders. Uses: Potential treatment of neurodegenerative disorders. Synonyms: A 1070722; A1070722; A-1070722; 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea. Grades: ≥99% by HPLC. CAS No. 1384424-80-9. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. | |
| A431+ Calyculin A (30min) Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 Calyculin A Control Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431+ EGF (5min) Lysate | A431 cells express approximately 10e6 epidermal growth factor (EGF) receptors at the cell surface. Upon stimulation with EGF, A431 cells exhibit a dramatic increase in phosphorylation of EGF receptors followed by activation of major cell signaling pathways, such as PKB/Akt and MAP kinase pathways. Downstream of these cell signaling pathways, a variety of cytoskeletal, cytoplasmic, and nuclear proteins become phosphorylated at different time points after EGF stimulation. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 EGF Control Lysate | A431 cells express approximately 10e6 epidermal growth factor (EGF) receptors at the cell surface. Upon stimulation with EGF, A431 cells exhibit a dramatic increase in phosphorylation of EGF receptors followed by activation of major cell signaling pathways, such as PKB/Akt and MAP. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by Western blotting using anti-Phosphotyrosine. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of A431 cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A-443654 | A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines. It inhibits Akt-dependent signal transduction in cells and in vivo in a dose-responsive manner. Synonyms: A443564; A-443564; A 443564. Grades: >98%. CAS No. 552325-16-3. Molecular formula: C24H23N5O. Mole weight: 397.47. | |
| A 484954 | A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. Synonyms: A-484954; A 484954; A484954; 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide. Grades: ≥98% by HPLC. CAS No. 142557-61-7. Molecular formula: C13H15N5O3. Mole weight: 289.29. | |
| A-674563 | Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBalpha, beta, gamma) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki =11nM for Akt1). It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families. A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4uM.1 In vivo, 40mg/kg/day A-674563 in combination with 15mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model. Group: Biochemicals. Alternative Names: (αS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]- benzeneethanamine). Grades: Highly Purified. CAS No. 552325-73-2. Pack Sizes: 500ug, 1mg, 5mg, 10mg. Molecular Formula: C22H22N4O. US Biological Life Sciences. | Worldwide |
| A-83-01 | A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Synonyms: A8301; A 8301; A-8301. Grades: 98%. CAS No. 909910-43-6. Molecular formula: C25H19N5S. Mole weight: 421.52. | |
| AAL-993 | AAL-993 is a VEGFR tyrosine kinase inhibitor that possesses dual inhibition of VEGFR signaling and HIF-1α expression through ERK inhibition without affecting Akt phosphorylation. Synonyms: AAL 993; AAL993; 2-((4-pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide. Grades: >98%. CAS No. 269390-77-4. Molecular formula: C20H16F3N3O. Mole weight: 371.36. | |
| ABC294640 | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Synonyms: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. Grades: 0.98. CAS No. 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. | |
| Abituzumab | Abituzumab (DI17E6) is a humanised anti- integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK , Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: EMD 525797; DI17E6. CAS No. 1105038-73-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99183. | |
| Abn-CBD | Abn-CBD is a neurobehaviorally inactive cannabinoid and acts as a selective and potent agonist for GPR55 with EC50 value of 2.5 μM. It increases migration and phosphorylation of protein kinases in human umbilical vein endothelial cells. Synonyms: 1,3-Benzenediol, 4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; 1,3-Benzenediol, 4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, trans-(-)-; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; Resorcinol, 4-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)-; Abnormal Cannabidiol; (1'R,2'R)-5'-methyl-6-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,4-diol; trans-(-)-4-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; trans-(-)-4-[3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Grades: ≥97% by HPLC. CAS No. 22972-55-0. Molecular formula: C21H30O2. Mole weight: 314.47. | |
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