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2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGF β/Smad inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 50607-30-2. Pack Sizes: 250mg, 1g. Molecular Formula: C5H7NO2, Molecular Weight: 113.11. US Biological Life Sciences.
3-(4-Amino-1,3-dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is a related compound of Lenalidomide (L328000), an immunomodulatory drug and an analog of Thalidomide. Group: Biochemicals. Grades: Highly Purified. CAS No. 1421593-78-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C13H13N3O4, Molecular Weight: 275.26. US Biological Life Sciences.
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3-Amino-2,6-piperidinedione
3-Amino-2,6-piperidinedione is a synthetic intermediate that has been used to design antitumor compounds [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2353-44-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-34590.
3-Amino-2,6-piperidinedione 2,2,2-Trifluoroacetate is an intermediate in the synthesis of Thalidomide-d4 (T338852), a labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Grades: Highly Purified. CAS No. 590365-46-1. Pack Sizes: 1g, 10g. Molecular Formula: C7H9F3N2O4, Molecular Weight: 242.15. US Biological Life Sciences.
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3-amino-2,6-piperidinedione hydrochloride
3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation. Synonyms: 3-Amino-2,6-piperidinedione Monohydrochloride; 2-Amino-glutarimide Hydrochloride; 3-Amino-2,6-dioxopiperidine Hydrochloride; 3-Aminopiperidine-2,6-dione Monohydrochloride; DL-Glutamic Acid Imide Hydrochloride; Glutamimide Hydrochloride; 2,6-dioxopiperidine-3-ammonium chloride; Glutamic acid imide hydrochloride; Glutamic acid imide-DL-hydrochloride; ACMC-20a23n; (+-)-3-Amino-2,6-piperidinedione monohydrochloride; AMPD00004; 3-Aminopiperidine-2,6-dione, HCl. Grades: > 99 %. CAS No. 24666-56-6. Molecular formula: C5H9ClN2O2. Mole weight: 164.59.
4-(4-Chlorophenyl)-2,6-piperidinedione. Group: Biochemicals. Grades: Highly Purified. CAS No. 84803-46-3. Pack Sizes: 100mg. US Biological Life Sciences.
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4-(4-Chlorophenyl)-2,6-piperidinedione-d4
4-(4-Chlorophenyl)-2,6-piperidinedione-d4. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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4-beta-D-Ribofuranosyl-2,6-piperidinedione
4-beta-D-Ribofuranosyl-2,6-piperidinedione is a crucial compound pervasively utilized in the research of tackling an array of ailments encompassing cancer, viral infections and autoimmune disorders. CAS No. 120129-78-4. Molecular formula: C10H15NO6. Mole weight: 245.23.
An aromatase inhibitor. Also blocks adrenal steroidogenesis. Group: Biochemicals. Alternative Names: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
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N-Boc-2,4-piperidinedione
N-Boc-2,4-piperidinedione. Group: Biochemicals. Grades: Highly Purified. CAS No. 845267-78-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C10H15NO4. US Biological Life Sciences.
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R-(+)-Aminoglutethimide Tartrate Salt (R-(+)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt)
An aromatase inhibitor. Also blocks adrenal steroidogenesis. Group: Biochemicals. Alternative Names: R-(+)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
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(R,S)-Lenalidomide, Free Base (3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, CC-5013, CDC-501, ENMD-0997, Revamid, Revimid)
Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting Tumor Necrosis Factor-a (TNF-a). Displays potent anti-tumor and anti-inflammatory effects as well as modulates and potentiates host immune responses against multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 191732-72-6. Pack Sizes: 25mg. US Biological Life Sciences.
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S-(-)-Aminoglutethimide Tartrate Salt (S-(-)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt)
An aromatase inhibitor. Also blocks adrenal steroidogenesis. Group: Biochemicals. Alternative Names: S-(-)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Isopropylidene-Lyxofuranosyl Piperidine-2,6-dione's unique structure and pharmacological properties make it a suitable candidate for drug development targeting specific cellular pathways involved in diseases like cancer, inflammation, and neurodegenerative disorders. Extensive research is ongoing to unravel the therapeutic potential and mechanism of action of this compound in treating these conditions. Synonyms: 5-deoxy-2,3-O-isopropylidene-5-((2,6-piperidinedione-4-yl)propane-2-on-1-yl)-D-lyxofuranose. Molecular formula: C16H23NO8. Mole weight: 357.36.
4-Nitro lenalidomide
4-Nitro lenalidomide. Group: Biochemicals. Alternative Names: 3-(1,3-Dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione. Grades: Highly Purified. CAS No. 827026-45-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C13H11N3O5. US Biological Life Sciences.
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Aminoglutethimide
Aminoglutethimide. Group: Biochemicals. Alternative Names: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione. Grades: Highly Purified. CAS No. 125-84-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C13H16N2O2. US Biological Life Sciences.
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ARV-471
ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. Grades: ≥95%. CAS No. 2229711-68-4. Molecular formula: C45H49N5O4. Mole weight: 723.90.
Cycloheximide
Cycloheximide is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes, resulting in inhibition of protein synthesis leading to cell growth, cell arrest and cell death. CHX is widely used for selection of CHX resistant yeast and fungi strains; controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression; apoptosis induction or facilitation of apoptosis induction of death receptors. Group: Biochemicals. Alternative Names: 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione; 3- [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide; Naramycin A; Acti-Aid; Acti-dione; Acti-dione BR; Acti-dione PM; Acti-dione TGF; Actidion; CHX; Cicloheximide; FT 3422-2; NSC 185; Naramycin; Naramycin Microcapsule D 80; Naramycin NM-MCU 80; TZA; U 4527; β - [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide. Grades: Molecular Biology Grade. CAS No. 66-81-9. Pack Sizes: 500mg, 1g, 5g, 25g. Molecular Formula: C15H23NO4, Molecular Weight: 281.35. US Biological Life Sciences.
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Cycloheximide Solution 50mg/ml
Cycloheximide is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes, resulting in inhibition of protein synthesis leading to cell growth, cell arrest and cell death. CHX is widely used for selection of CHX resistant yeast and fungi strains; controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression; apoptosis induction or facilitation of apoptosis induction of death receptors.Prepared from C8500 Cycloheximide. Group: Biochemicals. Alternative Names: 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione; 3- [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide; Naramycin A; Acti-Aid; Acti-dione; Acti-dione BR; Acti-dione PM; Acti-dione TGF; Actidion; CHX; Cicloheximide; FT 3422-2; NSC 185; Naramycin; Naramycin Microcapsule D 80; Naramycin NM-MCU 80; TZA; U 4527; β - [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide. Grades: Molecular Biology Grade. CAS No. 66-81-9. Pack Sizes: 20ml, 5x20ml. Molecular Formula: C15H23NO4, Molecular Weight: 281.35. US Biological Life Sciences.
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Epiderstatin
Epiderstatin is a glutarimide antibiotic produced by Streptomyces pulveraceus sub sp. epiderstagenes. It has the activity of inhibiting the filamentous division induced by epidermal growth factor (EGF), but does not inhibit EGF-receptor kinase (EGF-receptor kinase). It has only weak antifungal activity and no antibacterial effect. Synonyms: 4-(3-(3,5-Dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl)-2,6-piperidinedione. CAS No. 126602-16-2. Molecular formula: C15H20N2O4. Mole weight: 292.33.
Gabapentin Impurity 1
Gabapentin Impurity 1 is a piperidinedione derivative. Synonyms: 2,4-Dioxo-3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile; 8,10-Diketo-9-Azaspiro[5.5]Undecane-7,11-Dicarbonitrile; Nsc169442; α,α'-Dicyano-1,1-cyclohexanediacetamide; NSC 408757. Grades: > 95%. CAS No. 4355-15-1. Molecular formula: C12H13N3O2. Mole weight: 231.26.
Gepirone
Gepirone is an antidepressant and anxiolytic drug of the azapirone group that has been under development for the treatment of depression for a number of years but has yet to be marketed. It acts as a selective partial agonist of the 5-HT1A receptor. Synonyms: 4,4-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione; 2,6-Piperidinedione, 4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-; Gepirona. Grades: ≥95%. CAS No. 83928-76-1. Molecular formula: C19H29N5O2. Mole weight: 359.48.
Lenalidomide
Lenalidomide is an immunomodulatory drug; analog of Thalidomide. Group: Biochemicals. Alternative Names: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; CC-5013. Grades: Highly Purified. CAS No. 191732-72-6. Pack Sizes: 10mg. US Biological Life Sciences.
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Lenalidomide Impurity B
An impurity of Lenalidomide, a medication used for the treatment of myelodysplastic syndrome (MDS), multiple myeloma, and mantle cell lymphoma (MCL). Synonyms: 3-(1,3-Dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 4-Nitro Lenalidomide. Grades: > 95%. CAS No. 827026-45-9. Molecular formula: C13H11N3O5. Mole weight: 289.25.
Labeled Lenalidomide. Immunomodulatory drug; analog of Thalidomide. Group: Biochemicals. Alternative Names: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-13C5; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline-13C5; CC-5013-13C5. Grades: Highly Purified. CAS No. 1219332-91-8. Pack Sizes: 1mg. US Biological Life Sciences.