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2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGF β/Smad inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 50607-30-2. Pack Sizes: 250mg, 1g. Molecular Formula: C5H7NO2, Molecular Weight: 113.11. US Biological Life Sciences.
ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: 3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-. CAS No. 2229711-08-2. Molecular formula: C45H49N5O4. Mole weight: 723.90.
3-(4-Amino-1,3-dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is a related compound of Lenalidomide (L328000), an immunomodulatory drug and an analog of Thalidomide. Group: Biochemicals. Grades: Highly Purified. CAS No. 1421593-78-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C13H13N3O4, Molecular Weight: 275.26. US Biological Life Sciences.
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3-Amino-2,6-piperidinedione
3-Amino-2,6-piperidinedione is a synthetic intermediate that has been used to design antitumor compounds [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2353-44-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-34590.
3-Amino-2,6-piperidinedione 2,2,2-Trifluoroacetate is an intermediate in the synthesis of Thalidomide-d4 (T338852), a labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Grades: Highly Purified. CAS No. 590365-46-1. Pack Sizes: 1g, 10g. Molecular Formula: C7H9F3N2O4, Molecular Weight: 242.15. US Biological Life Sciences.
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3-Amino-2,6-piperidinedione hydrochloride
3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation. Synonyms: 3-Amino-2,6-piperidinedione Monohydrochloride; 2-Amino-glutarimide Hydrochloride; 3-Amino-2,6-dioxopiperidine Hydrochloride; 3-Aminopiperidine-2,6-dione Monohydrochloride; DL-Glutamic Acid Imide Hydrochloride; Glutamimide Hydrochloride; 2,6-dioxopiperidine-3-ammonium chloride; Glutamic acid imide hydrochloride; Glutamic acid imide-DL-hydrochloride; ACMC-20a23n; (+-)-3-Amino-2,6-piperidinedione monohydrochloride; AMPD00004; 3-Aminopiperidine-2,6-dione, HCl. Grade: > 99 %. CAS No. 24666-56-6. Molecular formula: C5H9ClN2O2. Mole weight: 164.59.
4-(4-Chlorophenyl)-2,6-piperidinedione
4-(4-Chlorophenyl)-2,6-piperidinedione. Group: Biochemicals. Grades: Highly Purified. CAS No. 84803-46-3. Pack Sizes: 100mg. US Biological Life Sciences.
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4-(4-Chlorophenyl)-2,6-piperidinedione-d4
4-(4-Chlorophenyl)-2,6-piperidinedione-d4. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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4-beta-D-Ribofuranosyl-2,6-piperidinedione
4-beta-D-Ribofuranosyl-2,6-piperidinedione is a crucial compound pervasively utilized in the research of tackling an array of ailments encompassing cancer, viral infections and autoimmune disorders. Synonyms: 2,6-Piperidinedione, 4-β-D-ribofuranosyl-; 4-β-D-Ribofuranosyl-2,6-piperidinedione. CAS No. 120129-78-4. Molecular formula: C10H15NO6. Mole weight: 245.23.
An aromatase inhibitor. Also blocks adrenal steroidogenesis. Group: Biochemicals. Alternative Names: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
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N-Boc-2,4-piperidinedione
N-Boc-2,4-piperidinedione. Group: Biochemicals. Grades: Highly Purified. CAS No. 845267-78-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C10H15NO4. US Biological Life Sciences.
Worldwide
R-(+)-Aminoglutethimide Tartrate Salt (R-(+)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt)
An aromatase inhibitor. Also blocks adrenal steroidogenesis. Group: Biochemicals. Alternative Names: R-(+)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
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(R,S)-Lenalidomide, Free Base (3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, CC-5013, CDC-501, ENMD-0997, Revamid, Revimid)
Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting Tumor Necrosis Factor-a (TNF-a). Displays potent anti-tumor and anti-inflammatory effects as well as modulates and potentiates host immune responses against multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 191732-72-6. Pack Sizes: 25mg. US Biological Life Sciences.
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S-(-)-Aminoglutethimide Tartrate Salt (S-(-)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt)
An aromatase inhibitor. Also blocks adrenal steroidogenesis. Group: Biochemicals. Alternative Names: S-(-)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione Tartrate Salt. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Isopropylidene-Lyxofuranosyl Piperidine-2,6-dione's unique structure and pharmacological properties make it a suitable candidate for drug development targeting specific cellular pathways involved in diseases like cancer, inflammation, and neurodegenerative disorders. Extensive research is ongoing to unravel the therapeutic potential and mechanism of action of this compound in treating these conditions. Synonyms: 5-deoxy-2,3-O-isopropylidene-5-((2,6-piperidinedione-4-yl)propane-2-on-1-yl)-D-lyxofuranose. Molecular formula: C16H23NO8. Mole weight: 357.36.
4-Isobutylpiperidine-2,6-dione
4-Isobutylpiperidine-2,6-dione is a highly significant compound in the research of biomedical exploration, garnering immense attention for its multifaceted characteristics. Notably, this compound's synthetic analogs have assumed a pivotal role in the creation of groundbreaking anti-cancer agents, innovative tools for neurodegenerative infirmities and interventions for psychiatric conditions. Synonyms: 4-(2-Methylpropyl)-2,6-piperidinedione; 3-Isobutylglutarimide; 4-Isobutyl-2,6-dioxopiperidine; 2,6-Piperidinedione, 4-(2-methylpropyl)-; 4-Isobutyl-2,6-piperidinedione. Grade: >95%. CAS No. 916982-10-0. Molecular formula: C9H15NO2. Mole weight: 169.22.
4-Nitro lenalidomide
4-Nitro lenalidomide. Group: Biochemicals. Alternative Names: 3-(1,3-Dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione. Grades: Highly Purified. CAS No. 827026-45-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C13H11N3O5. US Biological Life Sciences.
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Actidione
Actidione, an inhibitor of eukaryotic protein synthesis, is an antibiotic isolated from the beers of Streptomycin-producing strains of Streptomyces griseus. Actidione is used as a fungicide and anticancer drug. Synonyms: 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide; Naramycin A; Acti-Aid; Acti-dione; Acti-dione BR; Acti-dione PM; Acti-dione TGF; Actidion; CHX; Cicloheximide; NSC 185; Naramycin; Naramycin Microcapsule D 80; Naramycin NM-MCU 80; TZA; U 4527; Cycloheximide; [1S-[1α(S*),3α,5β]]-4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione. Grade: ≥95%. CAS No. 66-81-9. Molecular formula: C15H23NO4. Mole weight: 281.35.
Aminoglutethimide
Aminoglutethimide. Group: Biochemicals. Alternative Names: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione. Grades: Highly Purified. CAS No. 125-84-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C13H16N2O2. US Biological Life Sciences.
Worldwide
ARV-471
ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. Grade: ≥95%. CAS No. 2229711-68-4. Molecular formula: C45H49N5O4. Mole weight: 723.90.
CFT7455
CFT7455 is an orally bioavailable MonoDAC targeting IKZF1/3 for the treatment of multiple myeloma (MM) and non-Hodgkin's lymphomas (NHL), including peripheral T-cell lymphoma (PTCL) and mantle cell lymphoma (MCL). Synonyms: Cemsidomide; CFT-7455; CFT 7455; (3S)-3-(6-((4-(Morpholin-4-ylmethyl)phenyl)methyl)-2-oxobenzo(cd)indol-1-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-(6-((4-(4-morpholinylmethyl)phenyl)methyl)-2-oxobenz(cd)indol-1(2H)-yl)-, (3S)-; (3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione; GTPL11961; GLXC-26095; (S)-CFT7455; EX-A6043; NSC840579; AKOS040758857; NSC-840579; BP-28982; MS-28680; HY-144841; CS-0435593; EN300-43393872; (3S)-3-(6-{[4-(morpholin-4-ylmethyl)phenyl]methyl}-2-oxobenz[cd]indol-1(2H)-yl]piperidine-2,6-dione; (3S)-3-[9-({4-[(morpholin-4-yl)methyl]phenyl}methyl)-3-oxo-2-azatricyclo[6.3.1.0,4,12]dodeca-1(12),4,6,8,10-pentaen-2-yl]piperidine-2,6-dione. CAS No. 2504235-67-8. Molecular formula: C28H27N3O4. Mole weight: 469.53.
Cycloheximide
Cycloheximide is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes, resulting in inhibition of protein synthesis leading to cell growth, cell arrest and cell death. CHX is widely used for selection of CHX resistant yeast and fungi strains; controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression; apoptosis induction or facilitation of apoptosis induction of death receptors. Group: Biochemicals. Alternative Names: 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione; 3- [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide; Naramycin A; Acti-Aid; Acti-dione; Acti-dione BR; Acti-dione PM; Acti-dione TGF; Actidion; CHX; Cicloheximide; FT 3422-2; NSC 185; Naramycin; Naramycin Microcapsule D 80; Naramycin NM-MCU 80; TZA; U 4527; β - [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide. Grades: Molecular Biology Grade. CAS No. 66-81-9. Pack Sizes: 500mg, 1g, 5g, 25g. Molecular Formula: C15H23NO4, Molecular Weight: 281.35. US Biological Life Sciences.
Worldwide
Cycloheximide Solution 50mg/ml
Cycloheximide is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes, resulting in inhibition of protein synthesis leading to cell growth, cell arrest and cell death. CHX is widely used for selection of CHX resistant yeast and fungi strains; controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression; apoptosis induction or facilitation of apoptosis induction of death receptors.Prepared from C8500 Cycloheximide. Group: Biochemicals. Alternative Names: 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione; 3- [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide; Naramycin A; Acti-Aid; Acti-dione; Acti-dione BR; Acti-dione PM; Acti-dione TGF; Actidion; CHX; Cicloheximide; FT 3422-2; NSC 185; Naramycin; Naramycin Microcapsule D 80; Naramycin NM-MCU 80; TZA; U 4527; β - [2- (3, 5-Dimethyl-2-oxocyclohexyl) -2-hydroxyethyl] glutarimide. Grades: Molecular Biology Grade. CAS No. 66-81-9. Pack Sizes: 20ml, 5x20ml. Molecular Formula: C15H23NO4, Molecular Weight: 281.35. US Biological Life Sciences.
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Epiderstatin
Epiderstatin is a glutarimide antibiotic produced by Streptomyces pulveraceus sub sp. epiderstagenes. It has the activity of inhibiting the filamentous division induced by epidermal growth factor (EGF), but does not inhibit EGF-receptor kinase (EGF-receptor kinase). It has only weak antifungal activity and no antibacterial effect. Synonyms: 4-(3-(3,5-Dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl)-2,6-piperidinedione. CAS No. 126602-16-2. Molecular formula: C15H20N2O4. Mole weight: 292.33.
FPFT-2216
FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), Ikaros (IKZF1) and Aiolos (IKZF3) zinc finger transcription factors, and casein kinase 1α (CK1α). Synonyms: 2,6-Piperidinedione, 3-[4-(4-methoxy-3-thienyl)-1H-1,2,3-triazol-1-yl]-. CAS No. 2367619-87-0. Molecular formula: C12H12N4O3S. Mole weight: 292.31.
Gabapentin Impurity 1
Gabapentin Impurity 1 is a piperidinedione derivative. Synonyms: 2,4-Dioxo-3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile; 8,10-Diketo-9-Azaspiro[5.5]Undecane-7,11-Dicarbonitrile; Nsc169442; α,α'-Dicyano-1,1-cyclohexanediacetamide; NSC 408757. Grade: > 95%. CAS No. 4355-15-1. Molecular formula: C12H13N3O2. Mole weight: 231.26.
Lenalidomide
Lenalidomide is an immunomodulatory drug; analog of Thalidomide. Group: Biochemicals. Alternative Names: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; CC-5013. Grades: Highly Purified. CAS No. 191732-72-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Lenalidomide-[13C5]
Lenalidomide is a labelled Lenalidomide. Lenalidomide is a cereblon binder, which induces ubiquitination and degradation of CK1a and transcription factors IKZF1, IKZF3 and SALL4 by E3 ubiquitin ligase. Uses: Labelled lenalidomide (l328000). immunomodulatory drug; analog of thalidomide. Synonyms: Lenalidomide 13C5; 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-13C5. Grade: 95% atom 13C. CAS No. 1219332-91-8. Molecular formula: C8[13C]5H13N3O3. Mole weight: 264.22.
N-Chlorosuccinimide
N-Chlorosuccinimide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-Chloro-2,5-piperidinedione;1-chloro-5-pyrrolidinedione;5-Pyrrolidinedione,1-chloro-2;imide,n-chloro-succinicaci;n-chloro-succinimid;Pyrrolidinedione, 1-chloro-;Succinic N-chloroimide;succinicn-chloroimide. Product Category: Heterocyclic Organic Compound. CAS No. 128-09-6. Molecular formula: C4H4ClNO2. Mole weight: 133.53. Density: 1,65 g/cm³. Product ID: ACM128096. Alfa Chemistry ISO 9001:2015 Certified.
N-Ethylglutarimide
N-Ethylglutarimide. Group: Biochemicals. Alternative Names: 1-Ethyl-2,6-piperidinedione. Grades: Highly Purified. CAS No. 25115-65-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C7H11NO2. US Biological Life Sciences.
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Phenglutarimide
Phenglutarimide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: phenglutarimide;GLUTARIMIDE,2-((2-DIETHYLAMINO)ETHYL)-2-PHENYL-;ATURBANE;3-[2-(Diethylamino)ethyl]-3-phenyl-2,6-piperidinedione;Aturban;Ciba-10870;Phenglutarimid;1674-96-0 (Hydrochloride). Product Category: Heterocyclic Organic Compound. CAS No. 1156-05-4. Molecular formula: C17H24N2O2. Mole weight: 288.389. Density: 1.072g/cm³. Product ID: ACM1156054. Alfa Chemistry ISO 9001:2015 Certified.
(Rac)-Antineoplaston A10
(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10 which is an Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Synonyms: 3-Phenylacetylamino-2,6-piperidinedione; N-(2,6-Dioxopiperidin-3-yl)benzeneacetamide. CAS No. 77658-84-5. Molecular formula: C13H14N2O3. Mole weight: 246.26.
rac Lenalidomide-13C5
Labeled Lenalidomide. Immunomodulatory drug; analog of Thalidomide. Group: Biochemicals. Alternative Names: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-13C5; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline-13C5; CC-5013-13C5. Grades: Highly Purified. CAS No. 1219332-91-8. Pack Sizes: 1mg. US Biological Life Sciences.
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R-(+)-Aminoglutethimide L-tartrate salt
R-(+)-Aminoglutethimide L-tartrate salt. Group: Biochemicals. Alternative Names: R-(+)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione L-tartrate salt; d-Aminoglutethimide L-tartrate. Grades: Highly Purified. CAS No. 57344-88-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C17H22N2O8. US Biological Life Sciences.
Worldwide
S-(-)-Aminoglutethimide D-tartrate salt
S-(-)-Aminoglutethimide D-tartrate salt. Group: Biochemicals. Alternative Names: S-(-)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione L-tartrate salt; l-Aminoglutethimide L-tartrate. Grades: Highly Purified. CAS No. 57288-04-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C17H22N2O8. US Biological Life Sciences.
Worldwide
Vellosimine
Vellosimine is a natural alkaloid found in the herbs of Rauvolfia verticillata. Synonyms: 4-ethyl-4-phenyl-piperidine-2,6-dione; 2,6-Piperidinedione,4-ethyl-4-phenyl. Grade: >95%. CAS No. 6874-98-2. Molecular formula: C19H20N2O. Mole weight: 292.4.
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