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PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC 50 of 2.7 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5334-30-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108484.
PP 3
PP 3. Group: Biochemicals. Grades: Purified. CAS No. 5334-30-5. Pack Sizes: 10mg. US Biological Life Sciences.
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PP 3
PP 3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2. It inhibits EGFR kinase (IC50 = 2.7 μM). Synonyms: PP 3; PP3; PP-3; 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 5334-30-5. Molecular formula: C11H9N5. Mole weight: 211.22.
1-(2,6-Difluorophenyl)-3-(2-hydroxyphenyl)-3-ppropanedione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(2,6-difluorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione, 623944-98-9, Maybridge3_005097, AC1MBL85, SureCN12532290, HMS1445H15, IDI1_016484, AK136763, KB-33207, 3-Propanedione,1-(2,6-difluorophenyl)-3-(2-hydroxyphenyl)-. Product Category: Heterocyclic Organic Compound. CAS No. 623944-98-9. Molecular formula: C15H12F2O2. Mole weight: 276.234906 [g/mol]. Purity: 0.96. IUPACName: 1-(2,6-difluorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione. Canonical SMILES: C1=CC=C(C(=C1)C(=O)CC(=O)C2=C(C=CC=C2F)F)O. Product ID: ACM623944989. Alfa Chemistry ISO 9001:2015 Certified.
2,2,2-Trifluoroethyl methacrylate (30-50ppm 4-Methoxyphenol as stabiliser)
25g Pack Size. Group: Building Blocks, Fluorinated Products, Organics, Reagents, Research Organics & Inorganics. Formula: C6H7F3O2. CAS No. 352-87-4. Prepack ID 20890465-25g. Molecular Weight 168.11. See USA prepack pricing.
2,2,3,3-Tetrafluoropropyl methacrylate, 97%, contains 50 ppm BHT as stabilizer
3MB-PP1 is a bulky purine analog that acts as a selective, ATP-competitive, analog-sensitive polo-like kinase 1 (Plk1) allele inhibitor. Synonyms: 1-Tert-Butyl-3-(3-Methylbenzyl)-1h-Pyrazolo[3,4-D]pyrimidin-4-amine. Grades: ≥98%. CAS No. 956025-83-5. Molecular formula: C17H21N5. Mole weight: 295.4.
A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NM-PP1. Grades: Highly Purified. CAS No. 221244-14-0. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H21N5, Molecular Weight: 331.41. US Biological Life Sciences.
A highly potent (IC-50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NA-PP1. Grades: Highly Purified. CAS No. 2121243-82-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H19N5, Molecular Weight: 317.39. US Biological Life Sciences.
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Acrylonitrile (stabilized with 35-45 ppm 4-hydroxy anisole)
Acrylonitrile (stabilized with 35-45 ppm 4-hydroxy anisole). Group: Biochemicals. Alternative Names: Acrylon; Carbacryl; Cyanoethene; Cyanoethylene; Fumigrain; Propenenitrile; Vinyl Cyanide; NSC 6362. Grades: Highly Purified. CAS No. 107-13-1. Pack Sizes: 10ml. US Biological Life Sciences.
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Anti-phospho-PP2A-? (pTyr307) antibody produced in rabbit
DIM-C-pPhOCH3 is a Nur77 agonist. It was shown to induce apoptosis in cancer cell lines in vitro, enhance long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model. Synonyms: DIM-C-pPhOCH3; DIM C pPhOCH3; DIM-C-pPhOMe; DIM C pPhOMe; 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane; 3-[1H-indol-3-yl-(4-methoxyphenyl)methyl]-1H-indole. Grades: ≥98% by HPLC. CAS No. 33985-68-1. Molecular formula: C24H20N2O. Mole weight: 352.43.
DIM-C-pPhOCH3
DIM-C-pPhOCH3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DIM-C-pPhOCH3, AGN-PC-007RQG, SureCN2546810, CHEMBL2376692, STK975724, 1H-Indole, 3,3-[(4-methoxyphenyl)methylene]bis-, 3,3-[(4-methoxyphenyl)methanediyl]bis(1H-indole), 1,1-bis(3 inverted exclamation marka-Indolyl)-1-(p-methoxyphenyl)methane; 3,3 inverted exclamation marka-[(4-Methoxyphenyl)methylene]bis-1H-indole, 33985-68-1. Product Category: Heterocyclic Organic Compound. CAS No. 33985-68-1. Molecular formula: C24H20N2O. Mole weight: 352.43. Purity: 0.96. IUPACName: 3-[1H-indol-3-yl-(4-methoxyphenyl)methyl]-1H-indole. Canonical SMILES: COC1=CC=C(C=C1)C(C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54. Product ID: ACM33985681. Alfa Chemistry ISO 9001:2015 Certified.
The successive addition of three glucose residues by EC 2.4.1.267 (dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol α-1,3-glucosyltransferase), EC 2.4.1.265 and EC 2.4.1.256 (dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol α-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly. Group: Enzymes. Synonyms: ALG8; Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase; dolichyl β-D-glucosyl phosphate:D-Glc-α-(1?3)-D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?6)]-D-Man-α-(1?6)]-D-M. Enzyme Commission Number: EC 2.4.1.265. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2496; dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol α-1,3-glucosyltransferase; EC 2.4.1.265; ALG8; Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase; dolichyl β-D-glucosyl phosphate:D-Glc-α-(1?3)-D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?6)]-D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α-1,3-glucosyltransferase. Cat No: EXWM-2496.
The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase) and EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol α-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly. Group: Enzymes. Synonyms: ALG6; Dol-P-Glc:Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase; dolichyl β-D-glucosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?6)]-D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α. Enzyme Commission Number: EC 2.4.1.267. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2498; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol α-1,3-glucosyltransferase; EC 2.4.1.267; ALG6; Dol-P-Glc:Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase; dolichyl β-D-glucosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?6)]-D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α-1,3-glucosyltransferase. Cat No: EXWM-2498.
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl β-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3. Group: Enzymes. Synonyms: Man5GlcNAc2-PP-Dol mannosyltr. Enzyme Commission Number: EC 2.4.1.258. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2488; dolichyl-P-Man:Man5GlcNAc2-PP-dolichol α-1,3-mannosyltransferase; EC 2.4.1.258; Man5GlcNAc2-PP-Dol mannosyltransferase; ALG3; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Not56-like protein; Alg3 α-1,3-mannosyl transferase; Dol-P-Man:Man5GlcNAc2-PP-Dol α-1,3-mannosyltransferase; dolichyl β-D-mannosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α-1,3-mannosyltransferase. Cat No: EXWM-2488.
fac-Ir(ppy)3
fac-Ir(ppy)3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: fac-Tris(2-phenylpyridine)iridium(III). Product Category: Organic Light Emitting Diode (OLED). CAS No. 94928-86-6. Molecular formula: C33H24IrN3. Mole weight: 654.78 g/mol. Product ID: ACM94928866. Alfa Chemistry ISO 9001:2015 Certified.
Isolated from the bacterium Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. Group: Enzymes. Synonyms: PglI. Enzyme Commission Number: EC 2.4.1.293. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2527; GalNAc5-diNAcBac-PP-undecaprenol β-1,3-glucosyltransferase; EC 2.4.1.293; PglI. Cat No: EXWM-2527.
Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. Group: Enzymes. Synonyms: PglH. Enzyme Commission Number: EC 2.4.1.292. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2526; GalNAc-α-(1?4)-GalNAc-α-(1?3)-diNAcBac-PP-undecaprenol α-1,4-N-acetyl-D-galactosaminyltransferase; EC 2.4.1.292; PglH. Cat No: EXWM-2526.
The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an α1,3-mannosylation of D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol, followed by an α1,6-mannosylation (cf. EC 2.4.1.257), to form the first branched pentasaccharide intermediate of the dolichol pathway. Group: Enzymes. Synonyms: Alg2 mannosyltransferase (ambiguous); ALG2 (gene name, ambiguous); glycolipid 3-α-mannosyltransferase; GDP-mannose:glycolipid 3-&alph. Enzyme Commission Number: EC 2.4.1.132. CAS No. 81181-76-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2357; GDP-Man:Man1GlcNAc2-PP-dolichol α-1,3-mannosyltransferase; EC 2.4.1.132; 81181-76-2; Alg2 mannosyltransferase (ambiguous); ALG2 (gene name, ambiguous); glycolipid 3-α-mannosyltransferase; GDP-mannose:glycolipid 3-α-D-mannosyltransferase; GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase; GDP-D-mannose:D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol 3-α-mannosyltransferase. Cat No: EXWM-2357.
The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in α(1?2) linkages to the nascent oligosaccharide. Group: Enzymes. Synonyms: ALG11; AL. Enzyme Commission Number: EC 2.4.1.131. CAS No. 74506-43-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2356; GDP-Man:Man3GlcNAc2-PP-dolichol α-1,2-mannosyltransferase; EC 2.4.1.131; 74506-43-7; ALG11; ALG11 mannosyltransferase; LEW3 (gene name); At2G40190 (gene name); gmd3 (gene name); galactomannan deficiency protein 3; GDP-mannose:glycolipid 1,2-α-D-mannosyltransferase; glycolipid 2-α-mannosyltransferase; GDP-mannose:glycolipid 2-α-D-mannosyltransferase; GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase; GDP-α-D-mannose:D-Man-α-(1?3)-[D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol 2-α-D-mannosyltransferase. Cat No: EXWM-2356.
Ir[FCF3(CF3)ppy]2(dtbbpy)PF6 is a versatile photocatalyst that can be used for a variety of synthetic transformations including the α-arylation of alcohols. Uses: Transition metal catalysts. Synonyms: Bis[2-(2-fluoro-4-(trifluoromethyl)phenyl)-5-(trifluoromethyl)pyridine][4,4'-di-tert-butyl-2,2'-bipyridine] iridium(III) hexafluorophosphate; Iridium(1+), [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-κN1,κN1']bis[3-fluoro-5-(trifluoromethyl)-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC]-, (OC-6-33)-, hexafluorophosphate(1-) (1:1). Grades: ≥95%. CAS No. 2222402-20-0. Molecular formula: C44H34F14IrN4.F6P. Mole weight: 1221.93.
Ir(Fppy)3
Ir(Fppy)3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Tris(2-(4,6-difuorophenyl)pyridine)iridium(III). Product Category: Organic Light Emitting Diode (OLED). CAS No. 387859-70-3. Molecular formula: C33H18F6IrN3. Mole weight: 762.72 g/mol. Product ID: ACM387859703-5. Alfa Chemistry ISO 9001:2015 Certified. Categories: Tris[2-(2,4-difluorophenyl)pyridine]iridium(III), Ir(ppy)3.
Ir(ppy)3-Bp
Ir(ppy)3-Bp. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Tris[3- (2- pyridinyl- kN) [1, 1':4', 1''- terphenyl] - 4- yl- kC] - iridium(III). Product Category: Organic Light Emitting Diode (OLED). CAS No. 1404192-47-7. Molecular formula: C69H48IrN3. Mole weight: 1111.36 g/mol. Product ID: ACM1404192477. Alfa Chemistry ISO 9001:2015 Certified.
Ir(ppz)3
Ir(ppz)3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Tris(phenylpyrazole)iridium. Product Category: Organic Light Emitting Diode (OLED). CAS No. 562824-31-1. Molecular formula: C27H21N6Ir. Mole weight: 621.71 g/mol. Product ID: ACM562824311. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ir(ppy)3.
m7(3'OMeG)(5')ppp(5')(2'OMeA)pG
Used for in vitro transcription of 5'-capped mRNA to produce a Cap 1 structure. EZ Cap reagent AG 3'OMe should be used with the specific starting sequence 5'AG 3'. Synonyms: EZ Cap Reagent AG (3'OMe)[m7 (3'OMeG) (5')ppp (5') (2'OMeA)pG]. Grades: ≥95% by AX-HPLC. Molecular formula: C33H45N15O24P4 (free acid). Mole weight: 1159.71 (free acid).
Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses. Group: Biochemicals. Alternative Names: 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-26-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
PP1 Analog III, 3-MB-PP1 - CAS 956025-83-5
PP1 Analog III, 3-MB-PP1 primarily used in Inhibition. Group: Fluorescence/luminescence spectroscopy.
PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog)
A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C16H18IN5, Molecular Weight: 407.3. US Biological Life Sciences.
Worldwide
PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor)
A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. US Biological Life Sciences.
A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC?? = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242 is a more effective mTORC1 inhibitor than Rapamycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 1092351-67-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
PP2 (4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879)
Highly potent and selective Scr family tyrosine kinase inhibitor. Reduces cancer metastasis. Apoptotic. Antitumor compound. RIP2 inhbitor. Blocks TGF-beta-mediated cellular responses. Autophagy modulator. Group: Biochemicals. Alternative Names: 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.8. US Biological Life Sciences.
A negative control for the Src family kinase inhibitor PP2. Inhibits the activity of EGFR kinase at an IC50 = 2.7uM. Group: Biochemicals. Alternative Names: 4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine; NSC 1401. Grades: Purified. CAS No. 5334-30-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PPAR? Antagonist III, G3335 - CAS 36099-95-3
The PPAR? Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPAR?. Group: Fluorescence/luminescence spectroscopy.
PPAR-beta/delta Antagonist II, GSK3787 (4-Chloro-N-(2-((5-trifluoromethyl)-2-pyridyl) sulfonyl) ethyl) benzamide, PPARb Antagonist I, PPARd Antagonist I)
A cell-permeable pyridylsulfone that acts as a selective, high affinity PPARb (PPARd) ligand (IC50 in PPAR ligand displacement assays=200nM against human PPARb and >10uM against PPARa or PPARg) and effectively antagonizes agonist-induced, but not basal, PPARb transcription activity both in cultures in vitro (IC50=126nM in CV-1 cells) and in mice in vivo (82% and 71% inhibition of 10mg/kg GW0742-induced Adr and Angptl4 mRNA upregulation, respectively, in colon epithelium; 10mg/kg GSK3787; p.o.) by covalently modifying PPARb at Cys249. GSK3787 is also shown to exhibit weak agonistic activity toward PPARg (1.2-fold increase above basal level by 1uM GSK3787), and effectively block the more potent agonist GW1929 from further stimulation (1.5 and 3.5-fold above basal by 0.3uM GW1929 in the presence or absence of 1uM GSK3787, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 188591-46-0. Pack Sizes: 10mg. US Biological Life Sciences.
A cell-permeable, diaryl sulfonamide PPARb/d subtype-specific pure competitive antagonist with an IC50 of 98nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARb/d specific agonist-induced transcriptional activity in cell cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR beta/delta receptor (IC50=93nM). Enhances the interaction of the PPARb/d ligand-binding domain with the co-repressor, SMRT-ID2 (EC50=10nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARb/d- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated gamma (PPAR-g) receptor (Ki=29nM; IC50=80nM), but does not exhibit any transcriptional agonism. Unlike TZD compounds, it does not induce weight gain or diminish hematocrit. Shown to effectively block CDK-5-mediated phosphorylation of Ser273 of PPAR-gamma in adipose tissue. Supresses hepatic glucose production, reduces plasma free fatty acid levels, and improves insulin sensitivity of adipose tissue. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?, Molecular Weight: 547.6. US Biological Life Sciences.
Worldwide
ppg-3 methyl ether
Polypropylene glycol methyl ether is an odorless colorless liquid. Mixes with water. (USCG, 1999). Group: Polymers. CAS No. 37286-64-9. Product ID: 1-(1-methoxypropan-2-yloxy)propan-2-ol. Molecular formula: 148.2g/mol. Mole weight: C7H16O3. CC(COC(C)COC)O. InChI=1S/C7H16O3/c1-6 (8)4-10-7 (2)5-9-3/h6-8H, 4-5H2, 1-3H3. WGYZMNBUZFHYRX-UHFFFAOYSA-N.
PTK/PI 3-K/mTOR Inhibitor, PP121 - CAS 1092788-83-4
The PTK/PI 3-K/mTOR Inhibitor, PP121, also referenced under CAS 1092788-83-4, controls the biological activity of PTK/PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
Same activities as rosaglitazone but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs). Group: Biochemicals. Grades: Highly Purified. CAS No. 155141-29-0. Pack Sizes: 25mg, 100mg, 1g. Molecular Formula: C18H19N3O3S. C4H4O4. US Biological Life Sciences.
Worldwide
SLU-PP-332
SLU-PP-332 is a pan- Estrogen Receptor/ERR agonist with EC 50 values of 98, 230 and 430 nM for ERRα , ERRβ and ERRγ , respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 303760-60-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155673.
10-Nitrolinoleate
10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Alteratively, nitrolinoleates can act independently of NO/cGMP and PPARγ signaling to suppress neutrophil and macrophage functions. Synonyms: LNO2; 10-nitro-9,12-octadecadienoic acid. Grades: ≥95%. CAS No. 774603-04-2. Molecular formula: C18H31NO4. Mole weight: 325.4.
10-Nitrolinoleic acid
10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [ 3 H]Rosiglitazone for binding to PPAR-γ, with an IC 50 of 0.22 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 774603-04-2. Pack Sizes: 100 μg (3.07 mM * 100 μL in Ethanol). Product ID: HY-113473.
10-Nitrooleate
Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 μM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 μM. Uses: Anti-inflammatory agents. Synonyms: 9-Octadecenoic acid, 10-nitro-, (9E)-; (9E)-10-Nitro-9-octadecenoic acid; (E)-10-Nitro-octadec-9-enoic acid; CXA 10; IMR 261; 10-Nitro Oleic Acid; (9E)-10-nitrooctadecenoic acid; 10-nitro-9E-octadecenoic acid. Grades: ≥98%. CAS No. 875685-46-4. Molecular formula: C18H33NO4. Mole weight: 327.46.
1,2,3,4,6-Penta-O-trimethylsilyl-D-mannopyranose
1,2,3,4,6-Penta-O-trimethylsilyl-D-mannopyranose is a compound utilized extensively in the realm of biomedicine, serving as a pivotal reagent for synthesizing therapeutic agents and advancing drug development methodologies. Displaying a distinctive and intricate configuration, it enables the manipulation of mannose-based molecules, exerting impacts in anti-inflammatory and antiviral medicinal investigations. Synonyms: 1,2,3,4,6-Penta-O-trimethylsilyl-D-mannopyranoside; D-Mannopyranose, 1,2,3,4,6-pentakis-O-(trimethylsilyl)-; trimethyl-[[(2R,3R,4S,5S)-3,4,5,6-tetrakis(trimethylsilyloxy)oxan-2-yl]methoxy]silane; ( ( (3S, 4S, 5R, 6R) -6- ( ( (Trimethylsilyl) oxy) methyl) tetrahydro-2H-pyran-2, 3, 4, 5-tetrayl) tetrakis (oxy) ) tetrakis (trimethylsilane) ; 1,2,3,4,6-Pentakis-O-(trimethylsilyl)hexopyranose #; D-Mannopyranose, 5TMS derivative; PPFHNIVPOLWPCF-AUGMSIGLSA-N. CAS No. 55529-69-6. Molecular formula: C21H52O6Si5. Mole weight: 541.06.
1,2-DLPC
1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα -dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα -mediated inflammation in muscle cells [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dilauroyl-sn-glycero-3-phosphocholine. CAS No. 18194-25-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-107737.
1,3-Bis[2-(7-chloro-2-quinolyl)vinyl]benzene
1,3-Bis[2-(7-chloro-2-quinolyl)vinyl]benzene is an impurity of Montelukast, which is a leukotriene receptor antagonist indicated for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1,3-Bis[(E)-2-(7-chloroquinoline-2-yl)vinyl]benzene; 2,2'-{1,3-Phenylenedi[(E)ethene-2,1-diyl]}bis(7-chloroquinoline); (E, E) -2, 2'- (1, 3-Pphenylenedi- 2, 1- ethenediyl) bis[7- chloro-quinoline]; Montelukast Impurity 18. Grades: ≥95%. CAS No. 120578-04-3. Molecular formula: C28H18Cl2N2. Mole weight: 453.36.
Labeled 1,3-Dipalmitoyl-2-chloropropanediol is used in the synthesis of some prodrugs of Piroxicam and Lornoxicam to improve their bioavailability. Group: Biochemicals. Alternative Names: Hexadecanoic Acid 2-Chloro-1,3-propanediyl-d5 Ester; 1,3-Bispalmitoyl-2-chloropropanediol-d5; PP-2-MCPD-d5. Grades: Highly Purified. CAS No. 1426395-62-1. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
1-(4-Bromophenyl)-2-phenylbenzimidazole
1-(4-Bromophenyl)-2-phenylbenzimidazole. Group: Small molecule semiconductor building blockssemiconductor blocks. CAS No. 760212-58-6. Product ID: 1-(4-bromophenyl)-2-phenylbenzimidazole. Molecular formula: 349.23. Mole weight: C19H13BrN2. C1=CC=C (C=C1)C2=NC3=CC=CC=C3N2C4=CC=C (C=C4)Br. InChI=1S/C19H13BrN2/c20-15-10-12-16 (13-11-15)22-18-9-5-4-8-17 (18)21-19 (22)14-6-2-1-3-7-14/h1-13H. PPYIZNYOMNYZCG-UHFFFAOYSA-N. >98.0%(GC)(T).
1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one is an intermediate in synthesizing GFT-505 (G368870), which is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 824932-89-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C18H18O2S. US Biological Life Sciences.
Worldwide
15-deoxy-Δ12,14-Prostaglandin D2
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation ( EC 50 =8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 ( SRC-1 ) to peroxisome proliferator-activated receptor γ ( PPARγ ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells ( IC 50 =0.3 μg/ml) and inhibits ADP-induced platelet aggregation ( IC 50 =320 ng/mL). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 15-Deoxy-Δ12,14-PGD2. CAS No. 85235-11-6. Pack Sizes: 1 mg (2.99 mM * 1 mL in Methyl acetate). Product ID: HY-116028.
15-deoxy-Δ12,14-Prostaglandin J2
15-deoxy-Δ12,14-Prostaglandin J2 is a TRPA1 agonist and an endogenous PPARγ ligand that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM). Uses: Immunologic factors. Synonyms: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid. Grades: ≥95% by HPLC. CAS No. 87893-55-8. Molecular formula: C20H28O3. Mole weight: 316.44.
15-Deoxy-delta12,14-Prostaglandin J2
15-Deoxy-delta12,14-Prostaglandin J2 is an endogenous PPARγ ligand and TRPA1 agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 87893-55-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H28O3, Molecular Weight: 316.44. US Biological Life Sciences.
Worldwide
15-Deoxy-Δ-12,14-prostaglandin J2
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ ( EC 50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC 50 of 7 μM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2. CAS No. 87893-55-8. Pack Sizes: 1 mg (3.16 mM * 1 mL in Methyl acetate). Product ID: HY-108568.
15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester
15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 μM in a murine chimera system. Synonyms: 15-deoxy-Δ12,14-PGJ2-2-glycerol ester; 1,3-dihydroxypropan-2-yl (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoate. Grades: ≥98%. Molecular formula: C23H34O5. Mole weight: 390.5.
15-keto-Prostaglandin E2
15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 15-keto-PGE2. CAS No. 26441-05-4. Pack Sizes: 500 μg; 1 mg. Product ID: HY-113205.
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