Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| PP2 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PP2 | PP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PP2; PP-2; PP 2; AG 1879; AG-1879; AG1879. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 172889-27-9. Molecular formula: C15H16ClN5. Mole weight: 301.77. Purity: >98%. IUPACName: 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Canonical SMILES: NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(Cl)C=C3)=NC=N1. Product ID: ACM172889279. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PP2 | PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Synonyms: PP-2; PP 2; AG 1879; AG-1879; AG1879. CAS No. 172889-27-9. Molecular formula: C15H16ClN5. Mole weight: 301.77. |  |
| PP2 | PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC 50 s of 4 and 5 nM for Lck and Fyn , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGL 1879. CAS No. 172889-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13805. |  |
| PP242 | PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 μM for p110α, p110β, p110δ, p110γ and DNA-PK, respectively. Synonyms: PP 242; PP-242; Torkinib. CAS No. 1092351-67-1. Molecular formula: C16H16N6O. Mole weight: 308.345. | |
| PP242 (2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol) | A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC?? = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242 is a more effective mTORC1 inhibitor than Rapamycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 1092351-67-1. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| PP242 hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| PP2 (4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879) | Highly potent and selective Scr family tyrosine kinase inhibitor. Reduces cancer metastasis. Apoptotic. Antitumor compound. RIP2 inhbitor. Blocks TGF-beta-mediated cellular responses. Autophagy modulator. Group: Biochemicals. Alternative Names: 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.8. US Biological Life Sciences. | Worldwide |
| PP2A Activating Ligand, ITH12246 | A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences. | Worldwide |
| PP2A-?, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PP2C-?, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PP2 - CAS 172889-27-9 | PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC?? = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-PP2A-? (pTyr307) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-PP2A/ PPP2R1A antibody produced in goat | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Grammistin Pp2a | Grammistin Pp2a has antibacterial activity. The source of Grammistin Pp2a is Pogonoperca punctata [Clown grouper]. Synonyms: Grammistin Pp2a. Grades: >95% by HPLC. Molecular formula: C73H122N16O14. Mole weight: 1447.84. | |
| InSolution PP2 | PP2, 172889-27-9, is a 10 mM solution of PP2 (Cat. No. 529573) in DMSO. A potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases. Group: Fluorescence/luminescence spectroscopy. | |
| MonoclonalAnti-PP2A, C subunit antibody produced in mouse | ~1.0 mg/mL, clone 7A6, purified immunoglobulin. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-PP2A subunit B isoform B56-? antibody produced in mouse | ~1.0 mg/mL, clone H5D12, purified immunoglobulin. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-PP2A subunit B isoform PR55-? antibody produced in mouse | ~1.0 mg/mL, clone 2G9, purified immunoglobulin. Group: Fluorescence/luminescence spectroscopy. | |
| mTOR Inhibitor III, PP242 | The mTOR Inhibitor III, PP242 controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Protein Phosphatase 2A, Serine, Threonine (PP2A Ser/Thr), Dilution Buffer | Protein Phosphatase 2A, Serine, Threonine (PP2A Ser/Thr), Dilution Buffer. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| 1,4-Dimethylendothall | 1,4-Dimethylendothall is an endothall analog with no PP2A inhibition activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 109282-27-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H14O5, Molecular Weight: 214.22. US Biological Life Sciences. | Worldwide |
| (2Z,4E)-5-[(1S)-3-(Hexylthio)-1-hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl]-3-methyl-2,4-pentadienoic Acid | (2Z,4E)-5-[(1S)-3-(Hexylthio)-1-hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl]-3-methyl-2,4-pentadienoic Acid, an analog of Abscisic Acid (A110000), is designed as an antagonist of PYL-PP2C receptor interactions. Group: Biochemicals. Grades: Highly Purified. CAS No. 1609660-14-1. Pack Sizes: 5mg, 50mg. Molecular Formula: C21H32O4S. US Biological Life Sciences. | Worldwide |
| A431+ Calyculin A (30min) Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 Calyculin A Control Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| AMZ30 | AMZ30, a PME-1 inhibitor, could inhibit PME-1 irreversiblely and be significant in the pharmacological study of determinating the demethylated PP2A function. IC50: 600 nM. Uses: Amz30 is a pme-1 inhibitor that could inhibit pme-1 irreversiblely and be significant in the pharmacological study of determinating the demethylated pp2a function. Synonyms: AMZ30; AMZ 30; AMZ-30; CHEMBL1550905; ML136; ML 136; ML-136; MLS002699139; SCHEMBL16194668; SCHEMBL16194670. Grades: 98%. CAS No. 1313613-09-0. Molecular formula: C19H12FN3O6S2. Mole weight: 461.44. | |
| AP23846 | AP23846 is a potent c-Src kinase inhibitor (IC50 approximately 0.5 nmol/L in vitro, approximately 10-fold more potent than PP2, the most widely used commercially available Src family kinase inhibitor). Synonyms: AP-23846; (4-((2-cyclopentyl-9-ethyl-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grades: >98%. CAS No. 878654-51-4. Molecular formula: C20H16FN3O2. Mole weight: 439.53. | |
| Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| b-Catenin/Tcf Inhibitor V, BC21 (Copper, di-u-chlorobis[1-[(1-piperidinyl-kN)methyl]-2-naphthalenolato-kO]di-(9Cl), Wnt Pathway Inhibitor XV) | A cell-permeable dimeric copper complex that competitively binds b-catenin and disrupts b-catenin/Tcf4 interaction reversibly (IC50=5.0uM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in b-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤10uM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 691005-38-6. Pack Sizes: 10mg. Molecular Formula: C32H36Cl2Cu2N2O2, Molecular Weight: 678.6. US Biological Life Sciences. | Worldwide |
| C2 Ceramide | C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis , inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ceramide 2. CAS No. 3102-57-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101180. | |
| CaMKP inhibitor sodium | CaMKP inhibitor sodium (compound 5) is an inhibitor of Ca 2+ /neutral protein-dependent protein concentration (CaMKP) and its nuclear type (CaMKP-N) (IC50: 6.4 μM, CaMKP; 6.6 μM, CaMKP-N). CaMKP is one type of Ser/Thr protein, which can be passed through to remove the oxidized oxidized protein (CaMK). CaMKP inhibitor sodium inhibits CaMKP mediated phospho-CaMKI hydrolysis, unaffectes protein phosphoric acid 2C (PP2C) and calcineurin (CaN) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 52789-62-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11000A. | |
| Cantharidic acid sodium salt | Cantharidic acid is an inhibitor of protein phosphatases, which is first isolated from Chinese blister beetles. Cantharidic acid is a hydrolysis product of cantharidin, it can inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 μM, respectively. Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation. Synonyms: Disodium cantharidin; Cantharidin disodium; 1465-77-6; Disodium cantharidate; 8OIF7X5MK8; Cantharidic Acid (sodium salt); disodium (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate; disodium; (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate; 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, disodium salt, (exo,exo)-; UNII-8OIF7X5MK8. Grades: ≥95%. CAS No. 1465-77-6. Molecular formula: C10H12O5·2Na. Mole weight: 258.2. | |
| Carnosic Acid (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic Acid, CA) | Carnosic acid is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective and neuroprotective activities. It modulates Akt/IKK/NF-B signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C20H28O4, Molecular Weight: ~332.43. US Biological Life Sciences. | Worldwide |
| Cyclosporin A | Potent immunosuppressant (same as FK-506 and rapamycin). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phos- phatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits n Group: Biochemicals. Alternative Names: Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A; Sandimmun; Sandimmune; Neoral; Optimmune; Restasis; OL 27-400. Grades: Highly Purified. CAS No. 59865-13-3. Pack Sizes: 5g, 10g. US Biological Life Sciences. | Worldwide |
| Cyclosporin A (Standard) | Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM [3]. Cyclosporin A also inhibits CD11a/CD18 adhesion [8]. Uses: Scientific research. Group: Natural products. CAS No. 59865-13-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0579R. | |
| Cytostatin | Cytostatin is a potent and selective inhibitor of protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), but it doesn't have effect against PP1, PP2B, or PP5. Synonyms: 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, (5S,6S)-; (5S,6S)-5,6-Dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one; 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl]-5-methyl-, (5S,6S)-; (+)-Cytostatin; Antibiotic MJ 654NF4; NSC 675266. Grades: ≥75%. CAS No. 682329-63-1. Molecular formula: C21H33O7P. Mole weight: 428.46. | |
| Cytostatin (5,6-Dihydro-6-(6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl)-5-methyl-2H-pyran-2-one) | Potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Antitumor agent. Antimetastatic. Apoptosis inducer. Group: Biochemicals. Grades: Purified. CAS No. 156856-30-3. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Cytostatin sodium salt | Cytostatin is a potent and selective inhibitor of protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), but it doesn't have effect against PP1, PP2B, or PP5. Synonyms: 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, sodium salt (1:1), (5S,6S)-; 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl]-5-methyl-, monosodium salt, (5S,6S)-; (+)-Cytostatin sodium salt; NSC 675266 sodium salt. Grades: ≥75%. CAS No. 457070-06-3. Molecular formula: C21H32NaO7P. Mole weight: 450.44. | |
| D-erythro-Sphingosine | D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC 50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine. CAS No. 123-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101047. | |
| D-erythro-Sphingosine-d7 | D-erythro-Sphingosine-d 7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7. CAS No. 1246304-34-6. Pack Sizes: 500 μg. Product ID: HY-101047S. | |
| Endothall | Endothall (Endothal) is a protein phosphatase 2A ( PP2A ) inhibitor with IC 50 s of 90 nM and 5 μM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Endothal. CAS No. 145-73-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113976A. | |
| Fenvalerate | Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC 50 of 2-4 nM for PP2B-A&alpha. Fenvalerate is a pyrethroid ester insecticide and acaricide [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51630-58-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B2006. | |
| Fostriecin | The most fully characterised member of a family of phosphate esters of a triene antibiotic; a topoisomerase II inhibitor; selective inhibition of protein phosphatase PP2A. Synonyms: (1E,7E,9E,11E)-3,6,13-trihydroxy-3-methyl-1-(6-oxo-3,6-dihydro-2H-pyran-2-yl)trideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate; 2H-Pyran-2-one, 5,6-dihydro-6-[3,6,13-trihydroxy-3-methyl- 4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-, monosodiumsalt. Grades: >95% by HPLC. CAS No. 87810-56-8. Molecular formula: C19H27O9P. Mole weight: 430.39. | |
| Fostriecin sodium salt | Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect on topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM). Fostriecin is found in Streptomyces pulveraceous. Uses: Enzyme inhibitors. Synonyms: Fostriecin Sodium; Antibiotic CI 920 sodium salt; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt. Grades: ≥98% by HPLC. CAS No. 87860-39-7. Molecular formula: C19H26O9PNa. Mole weight: 452.37. | |
| IQ-1 (2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide) | Cell-permeable. Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents β-catenin from switching coactivator usage from CBP to p300. The increase in β-cateinin/CBP mediated transcription at the expense of β- cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency. Group: Biochemicals. Alternative Names: 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide. Grades: Highly Purified. CAS No. 331001-62-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Lambda Protein Phosphatase (GST), Recombinant | Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. Full-length, recombinant lambda protein phosphatase (l-ppase) with a n- terminal gst-tag, l-ppase is a mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosine. Applications: Phosphatase assays. Group: Enzymes. Synonyms: Protein pho. Purity: Glutathione agarose affinity chromatography. λ-PPase. Storage: 6 months at -70°C. Source: E. coli. Protein phosphatase 1F; PPM1F; CAMKP; CaMKPase; FEM-2; POPX2; hFEM-2; Lambda Protein Phosphatase; λ-Ppase. Cat No: NATE-0856. |  |
| LB-100 | LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC 50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1632032-53-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18597. | |
| Microcystin-LA | Microcystin is a class of cyclic heptapeptide toxins produced by cyanobacteria. Microcystin-LA is an analog of the major microcystin-LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with IC50 value of 0.3 nM. Synonyms: Cyanoginosin-LA; Toxin BE4. Grades: ≥95%. CAS No. 96180-79-9. Molecular formula: C46H67N7O12. Mole weight: 910.06. | |
| Microcystin-LR | Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Uses: Enzyme inhibitors. Synonyms: Microcystin LR; Microcystin; Microcystin-a; MicrocystinLR; Cyanoginosin-LR; Toxin T 17; cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]; 5-L-Arginine-microcystin LA; cyclo(Ala-Leu-MAsp-Arg-Adda-isoGlu-Mdha). Grades: >95%. CAS No. 101043-37-2. Molecular formula: C49H74N10O12. Mole weight: 995.17. | |
| Microcystin-RR | It is produced by the strain of Microcystis aeruginosa. Microcystin-RR inhibits PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively. Synonyms: Cyanoginosin RR; Microcystin-RR; Cyanoginosin-RR; (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid; Cyanoginosin LA, 3-arginyl-5-arginine-; MCYST-RR; MC-RR; Cyanoginosin LA, 3-L-arginyl-5-L-arginine; Cyanoginosin LA, 3-L-arginine-5-L-arginine-; MCRR; Microcystin-RR, Microcystis aeruginosa; Microcystin-RR solution; Microcystin RR from algae. Grades: ≥95%. CAS No. 111755-37-4. Molecular formula: C49H75N13O12. Mole weight: 1038.21. | |
| Native Bovine Protein Phosphatase 2A1 | Protein Phosphatase 2A1 is a trimer consisting of the A, B, and C subunits of the PP2A family. It has a total molecular weight of 192 kDa. Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with mictotubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity. Applications: Protein phosphatase 2a1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dis-regulation in cancer. the enzyme is involved in regulating numerous cellular processes and is used to study cell cycle, growth, and differentiation. the protein phosphatase 2a1 has been used to treat human fibroblast cells prior to western blot analysis. Group: Enzymes. Synonyms: Protein Phosphatase 2A1; PP2A1; PPA2A1. Purity: >90% (SDS-PAGE). Protein Phosphatase. Activity: > 1500 units/mg protein. Stability: -70°C. Form: Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol. Source: Bovine. Protein Phosphatase 2A1; PP2A1; PPA2A1. Pack: vial of 1 μg. Cat No: NATE-0616. | |
| Native Bovine Protein Phosphatase 2A2 | Protein phosphatase 2A (PP2A) is a specific protamine-kinase-inactivating phosphatase, one common physiological form of which is PP2A2. Protein Phosphatase 2A2 from bovine kidney was shown to be a unique inhibitor of protamine kinase while other phosphatases in the same family including PP1, PP2B, PP2C did not show any inhibition. Protein phosphatase 2a (pp2a) is a specific protamine-kinase-inactivating phosphatase, one common physiological form of which is pp2a2. Applications: Protein phosphatase 2a2 has been used in a study to investigate two heat-stable protein inhibitors. it has also been used in a study to describe the purification and properties of a protamine kinase from bovine kidney microsomes. Group: Enzymes. Synonyms: Protein Phosphatase 2A2; PP2A2. Protein Phosphatase. Activity: ~2.0 U/vial. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protein Phosphatase 2A2; PP2A2. Cat No: NATE-0617. | |
| Native Bovine Protein Phosphatase 2Ac | Divalent cation-independent catalytic subunit of protein phosphatase 2A. Useful for functional studies of the A and B subunit of the phosphatase. Group: Enzymes. Synonyms: Protein Phosphatase 2Ac; PP2Ac. Protein Phosphatase. Activity: ~2 U/vial. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protein Phosphatase 2Ac; PP2Ac. Cat No: NATE-0618. | |
| Native Bovine Protein Phosphatase 2C | Protein Phosphatase 2C is a Mg2+-dependent serine/threonine protein phosphatase with a molecular mass of 42-45 kDa, involved in regulating numerous cellular processes. It is ubiquitously expressed and has been isolated from many mammalian tissues including liver, brain, skeletal muscle, retina, and blood platelets. There are two major isotypes associated with this enzyme, 2C1 and 2C2, also known as 2Ca and 2Cb, respectively. Both isozymes appear to be equally Mg2+-dependent and respond similarly to specific substrates. Both are monomers that demonstrate ~75% sequence homology. The molecular masses are similar; 44 kDa and 42 kDa for 2C1 and 2C2, respectively. Additional Type 2C serine/threonine protein phosphatases include 2Cg, 2Cd, Wip1, and NERPP2C, many of which have multiple isozyme members. Group: Enzymes. Synonyms: Protein Phosphatase 2C; PP2C. Protein Phosphatase. Activity: ~1000 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protein Phosphatase 2C; PP2C. Pack: vial of 1 μg. Cat No: NATE-0619. | |
| Nodularin | Nodularin is a pentapeptide toxin produced by the cyanobacterium Nodularia spumigena. It acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. Synonyms: Nodularin; Nodularin R; Nodularin-R; UNII-0979BIK2QU; 0979BIK2QU; HSDB 7749; DTXSID60880022; (2Z,5R,6S,9S,12S,13S,16R)-9-[3-(diaminomethylideneamino)propyl]-2-ethylidene-12-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid; Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl); Nodularin, cyanotoxin. Grades: ≥95%. CAS No. 118399-22-7. Molecular formula: C41H60N8O10. Mole weight: 825. | |
| Nodularin (in ethanol) | Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026nm, respectively. It inhibits PP2B only at higher concentrations (IC50=1.8uM). Group: Biochemicals. Alternative Names: Cyclo[(2S, 3S, 4E, 6E, 8S, 9S)-3-amino-9-methoxy-2, 6, 8-trimethyl-10-phenyl-4, 6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D- β-aspartyl-L-arginyl]; Cyclo[(Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D- β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-γ-glutamyl]; 1, 4, 8, 11, 15-Pentaazacyclononadecan e Cyclic Peptide Deriv.; Nodularin R. Grades: Highly Purified. CAS No. 118399-22-7. Pack Sizes: 100ug. Molecular Formula: C??H??N?O??, Molecular Weight: 824.96. US Biological Life Sciences. | Worldwide |
| Norcantharidin | It is an antitumor drug and a PP1 and PP2A inhibitor. It is a modified product of the natural antitumor drug cantharidin. It reduces its urinary system toxicity but not its antitumor efficacy after is demethylated. It induces cell apoptosis and acts as an antineoplastic. Synonyms: rel-(3aR,4S,7R,7aS)-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; 7-Oxabicyclo[2.2.1]heptane-exo-cis-2,3-dicarboxylic anhydride; Demethylcantharidin; Isocantharidin; NSC 59023; NCTD; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (3aR,4S,7R,7aS)-rel-; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (3aα, 4β, 7β, 7aα)-; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride, exo-; exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid anhydride. Grades: ≥98%. CAS No. 29745-04-8. Molecular formula: C8H8O4. Mole weight: 168.15. | |
| Okadaic acid | Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A ( IC 50 =0.1-0.3 nM), and inhibits PP1 ( IC 50 =15-50 nM), PP3 ( IC 50 =3.7-4 nM), PP4 ( IC 50 =0.1 nM), PP5 ( IC 50 =3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 78111-17-8. Pack Sizes: 25 μg (124.2 μM * 250 μL in Ethanol). Product ID: HY-N6785. | |
| Okadaic Acid | Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1, both isoforms of PP2A and PP3. It is a very weak inhibitor of PP2B and does not inhibit PP2C or other phosphatases. Synonyms: AA8227800; 9,10-Deepithio-9,10-didehydroacanthifolicin. Grades: 95% by HPLC. CAS No. 78111-17-8. Molecular formula: C44H68O13. Mole weight: 805.00. | |
| Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
| Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Phosphotrienin (Fostriecin, Antibiotic CI 920, Antibiotic CL 1565A, Antibiotic PD 110161, NSC 339638), Sodium Salt | Fostriecin is the most fully characterized member of a family of phosphate esters of a triene antibiotic. The antitumor potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A. Group: Biochemicals. Alternative Names: Fostriecin, Phosphotrienin, Antibiotic CI 920, Antibiotic CL 1565A,Antibiotic PD 110161, NSC 339638. Grades: Highly Purified. CAS No. 87810-56-8. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| PME-1 Inhibitor, AMZ-30 | A cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50=600nM and 2.5uM in human cell lysates and in HEK 293T cells, (respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20uM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?S?, Molecular Weight: 462.6. US Biological Life Sciences. | Worldwide |
| PP 2 | PP 2. Group: Biochemicals. Alternative Names: AGL 1879; PP 2 (enzyme inhibitor); Src kinase inhibitor PP2; 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.77. US Biological Life Sciences. | Worldwide |
| PP 3 | PP 3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2. It inhibits EGFR kinase (IC50 = 2.7 μM). Synonyms: PP 3; PP3; PP-3; 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 5334-30-5. Molecular formula: C11H9N5. Mole weight: 211.22. | |
| PP3 (4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine; NSC 1401) | A negative control for the Src family kinase inhibitor PP2. Inhibits the activity of EGFR kinase at an IC50 = 2.7uM. Group: Biochemicals. Alternative Names: 4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine; NSC 1401. Grades: Purified. CAS No. 5334-30-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPM1A-IN-1 | PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2919466-30-9. Pack Sizes: 1 mg. Product ID: HY-164220. | |
| Protein Phosphatase 2Ac from Human, Recombinant | Divalent cation-independent catalytic subunit of protein phosphatase 2A. Useful for functional studies of the A and B subunit of the phosphatase. Human recombinant pp2a catalytic subunit expressed in insect cells with an n-terminal octahistidine-tag followed by a streptactin-tag. the c-terminal leucine 309 was deleted. Applications: Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and to evaluate the effects of test substances on the activity of the phosphatase. Group: Enzymes. Synonyms: Protein Phosphatase 2Ac; PP2Ac. Purity: >90% estimated by SDS-PAGE. Protein Phosphatase. Mole weight: 38.6 kDa. Stability: As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly. Storage: at -80°C. Source: Insect cells. Species: Human. Protein Phosphatase 2Ac; PP2Ac. Cat No: NATE-1398. | |
Our database is helping our users find suppliers everyday.
