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Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor , inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication [1] [2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 3β-Hydroxy-5-pregnen-20-one. CAS No. 145-13-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0151.
Pregnenolone
Pregnenolone. Categories: pregnenolone; 145-13-1.
CA, FL & NJ
Pregnenolone
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. Group: Biochemicals. Alternative Names: (3 β)-3-Hydroxy-pregn-5-en-20-one; (3 β)-3-Hydroxypregn-5-en-20-one; 5-Pregnenolone; Arthenolone; Bina-Skin; Enelone; NSC 1616; Pregnolon; Prenolon; Regnosone; Skinostelon. Grades: Highly Purified. CAS No. 145-13-1. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C??H??O?, Molecular Weight: 316.48. US Biological Life Sciences.
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Pregnenolone 16-acetonitrile
Heterocyclic Organic Compound. CAS No. 102812-95-3. Catalog: ACM102812953.
Pregnenolone 16α-carbonitrile
Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P450 3A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1434-54-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-131723.
Pregnenolone-3-sulfate Sodium Salt. Group: Biochemicals. Alternative Names: 3-(Sulfooxy)pregn-5-en-20-one Sodium Salt (1:1); (3 β-3-(Sulfooxy)pregn-5-en-20-one Sodium Salt; 3 β-Hydroxypregn-5-en-20-one Hydrogen Sulfate Sodium Salt; Pregnenolone Sulfate Sodium Salt. Grades: Highly Purified. CAS No. 1852-38-6. Pack Sizes: 25mg. Molecular Formula: C21H31NaO5S, Molecular Weight: 418.52. US Biological Life Sciences.
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Pregnenolone Acetate
Pregnenolone derivative, a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. Group: Biochemicals. Alternative Names: (3 β)-3-(Acetyloxy)-pregn-5-en-20-one; 3 β-Acetoxy-5-pregnen-20-one; 3 β-Acetoxy-Δ5-pregnen-20-one; 3 β-Hydroxypregn-5-en-20-one Acetate; 3 β-Pregn-5-enol-20-one Acetate; 5-Pregnen-3 β-ol-20-one Acetate; 5-Pregnene-3 β-acetoxy-20-one; Antofin; Artivis; Enescorb; NSC 64827; Pregenolone Acetate; Pregnenolone Acetate; Pregnenolone-3-acetate; Previsone; Sharmone. Grades: Highly Purified. CAS No. 1778-02-5. Pack Sizes: 25mg. US Biological Life Sciences.
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Pregnenolone Carbonitrile
Pregnenolone carbonitrile (PCN) is a derivative of pregnenolone and acts as an agonist of the rodent pregnane X receptor (PXR). Synonyms: PCN; Pregnenolone 16α-carbonitrile; SC-4674; (3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile. Grades: ≥98%. CAS No. 1434-54-4. Molecular formula: C22H31NO2. Mole weight: 341.5.
Pregnenolone-d4
Pregnenolone-d4. Group: Biochemicals. Alternative Names: (3 β)-. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C21H28D4O2, Molecular Weight: 320.27. US Biological Life Sciences.
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Pregnenolone (Standard)
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor , inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication [1] [2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 3β-Hydroxy-5-pregnen-20-one (Standard). CAS No. 145-13-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0151R.
Pregnenolone sulfate sodium salt
Pregnenolone sulfate, a metabolite of the natural steroid hormone pregnenolone, is a neurosteroid that has been demonstrated to antagonize the GABAA receptor chloride channel. Synonyms: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt; (3β-3-(Sulfooxy)pregn-5-en-20-one Sodium Salt; 3β-Hydroxypregn-5-en-20-one Hydrogen Sulfate Sodium Salt; Pregnenolone Sulfate Sodium Salt. CAS No. 1852-38-6. Molecular formula: C21H31NaO5S. Mole weight: 418.52.
16-Dehydropregnenolone Acetate is the dehydration product of Pregnenolone Acetate. 16-Dehydropregnenolone Acetate is used in the preparation of pregnane derivatives and its glycosides as potential anticancer agents. Group: Biochemicals. Alternative Names: (3 β)-3-(Acetyloxy)pregna-5,16-dien-20-one; 3 β-Hydroxypregna-5,16-dien-20-one Acetate; (-)-16-Dehydropregnenolone Acetate; 16,17-Didehydropregnenolone Acetate; 16-DPA; 16-Dehydropregnenolone-3 β-acetate; 20-Oxopregna-5,16-dien-3 β-yl Acetate; 3 β-Acetoxypregna-5,16-dien-20-one; 3 β-Acetyloxy-pregna-5,16-dien-20-one; NSC 37741; Pregnadienolone Acetate. Grades: Highly Purified. CAS No. 979-02-2. Pack Sizes: 10g. US Biological Life Sciences.
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17a-Acetoxy pregnenolone
17a-Acetoxy pregnenolone. Group: Biochemicals. Alternative Names: (3b)-17-(Acetyloxy)-3-hydroxypregn-5-en-20-one; 3b,17-Dihydroxypregn-5-en-20-one 17-acetate. Grades: Highly Purified. CAS No. 2381-45-5. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C23H34O4. US Biological Life Sciences.
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17Alpha-hydroxypregnenolone-21,21,21-d3
Heterocyclic Organic Compound. Alternative Names: 17ALPHA-HYDROXYPREGNENOLONE-21,21,21-D3;17a-Hydroxypregnenolone-21,21,21-d3;17a-Hydroxypregnenolone-d3;5-Pregnen-3b,17a-diol-20-one;17α-Hydroxypregnenolone-21,21,21-D3;5-Pregnen-3,17a-diol-20-one;17α-Hydroxy Pregnenolone-d3. CAS No. 105078-92-0. Molecular formula: C21H29D3O3. Mole weight: 335.5. Appearance: White Solid. Purity: 97-98 atom % D. Catalog: ACM105078920.
17-Hydroxy Pregnenolone
17-Hydroxy Pregnenolone. Group: Biochemicals. Alternative Names: (3 β)-3,17-dihydroxypregn-5-en-20-one; 17-Hydroxy-Δ5-pregnenolone; 17α-Hydroxypregnenolone; 3 β,17-Dihydroxy-5-pregnen-20-one; 3 β,17α-Dihydroxypregn-5-en-20-one; 5-Pregnen-3 β,17α-diol-20-one; NSC 63853. Grades: Highly Purified. CAS No. 387-79-1. Pack Sizes: 100mg. Molecular Formula: C21H32O3, Molecular Weight: 332.48. US Biological Life Sciences.
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20a-Dihydro pregnenolone
20a-Dihydro pregnenolone. Group: Biochemicals. Alternative Names: (3b,20S)-Pregn-5-ene-3,20-diol; Pregn-5-ene-3b,20a-diol; Pregnenediol. Grades: Highly Purified. CAS No. 901-56-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C21H34O2. US Biological Life Sciences.
Worldwide
20a-Dihydro pregnenolone 3-sulfate sodium salt
20a-Dihydro pregnenolone 3-sulfate sodium salt. Group: Biochemicals. Alternative Names: (3b,20S)-Pregn-5-ene-3,20-diol 3-(hydrogen sulfate) sodium; Pregn-5-ene-3b,20a-diol 3-(hydrogen sulfate) sodium; 5-Pregnene-20a-ol 3b-sulfate sodium. Grades: Highly Purified. CAS No. 131320-06-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C21H33NaO5S. US Biological Life Sciences.
Worldwide
20b-Dihydro pregnenolone
20b-Dihydro pregnenolone. Group: Biochemicals. Alternative Names: (3b,20R)-Pregn-5-ene-3,20-diol; Pregn-5-ene-3b,20b-diol; (20R)-Pregn-5-ene-3b,20-diol. Grades: Highly Purified. CAS No. 901-57-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C21H34O2. US Biological Life Sciences.
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3-tert-Butyldimethylsilyloxy pregnenolone
3-tert-Butyldimethylsilyloxy pregnenolone. Group: Biochemicals. Alternative Names: 3b- (tert-Butyldimethylsiloxy) pregn-5-en-20-one; (3b) -3- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] pregn-5-en-20-one. Grades: Highly Purified. CAS No. 58701-45-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C27H46O2Si. US Biological Life Sciences.
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7,8-Dehydro pregnenolone
7,8-Dehydro pregnenolone. Group: Biochemicals. Alternative Names: (3b,9b)-3-Hydroxy-pregna-5,7-dien-20-one. Grades: Highly Purified. CAS No. 1158830-87-5. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C21H30O2. US Biological Life Sciences.
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7-Bromo-3-O-acetyl Pregnenolone
DHEA (De hydroepiandrosterone) derivative, useful due to their cosmetic use. Group: Biochemicals. Alternative Names: (3 β)-3-(Acetyloxy)-7-bromo-pregn-5-en-20-one; 7-Bromo-3 β-hydroxy-pregn-5-en-20-one Acetate. Grades: Highly Purified. CAS No. 114417-65-1. Pack Sizes: 10mg. US Biological Life Sciences.
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Abiraterone Related Compound 1 (Pregnenolone-16-ene Acetate)
Cas No. 979-02-2.
Abiraterone Related Compound 3 (Pregnenolone-16-ene Acetate Oxime)
Pregnenolone-16-ene Acetate Oxime is used in the synthesis of pegnange derivatives as antioxidant and anti-dyslipidemic agents. Synonyms: Abiraterone Impurity 3,Pregnenolone-16-ene Acetate Oxime. Grades: > 95%. CAS No. 2174-13-2. Molecular formula: C23H33NO3. Mole weight: 371.52.
Micronized Pregnenolone
Micronized Pregnenolone.
CA, FL & NJ
17α-hydroxyprogesterone deacetylase
A microsomal cytochrome P-450 (heme-thiolate) protein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3β-hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis. The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome. The enzymes from different organisms differ in their substrate specificity. While the enzyme...son do not accept the former, and the enzyme from guinea pig does not accept the latter. Group: Enzymes. Synonyms: C-17/C-20 lyase; 17α-hydroxyprogesterone acetaldehyde-lyase; CYP17; CYP17A1 (gene name); 17α-hydroxyprogesterone 17,20-lyase. Enzyme Commission Number: EC 1.14.14.32. CAS No. 62213-24-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0930; 17α-hydroxyprogesterone deacetylase; EC 1.14.14.32; 62213-24-5; C-17/C-20 lyase; 17α-hydroxyprogesterone acetaldehyde-lyase; CYP17; CYP17A1 (gene name); 17α-hydroxyprogesterone 17,20-lyase. Cat No: EXWM-0930.
17-MethyI-18-norandrosta-5,13(17)-dien-3 β-ol 3-Acetate s an impurity of Pregnenolone (P712200) which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. Group: Biochemicals. Grades: Highly Purified. CAS No. 23930-63-4. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C21H30O2. US Biological Life Sciences.
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17-Methyl-18-norandrosta-5,13(17)-dien-3 β-ol
17-Methyl-18-norandrosta-5,13(17)-dien-3 β-ol is an intermediate in the synthesis of Pregnenolone (P712200) related compounds. Group: Biochemicals. Grades: Highly Purified. CAS No. 23930-65-6. Pack Sizes: 5mg, 25mg. Molecular Formula: C19H28O. US Biological Life Sciences.
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3β-hydroxy-Δ5-steroid dehydrogenase
This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Δ5-3-hydroxy steroids to a Δ4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3β-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced coenzyme, which remains attached to the enzyme, activates the isomerization of the Δ5 form to a Δ4 form (cf. EC 5.3.3.1, steroid Δ-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (co...5-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0049; 3β-hydroxy-Δ5-steroid dehydrogenase; EC 1.1.1.145; 9044-85-3; progesterone reductase; Δ5-3β-hydroxysteroid dehydrogenase; 3β-hydroxy-5-ene steroid dehydrogenase; 3β-hydroxy steroid dehydrogenase/isomerase; 3β-hydroxy-Δ5-C27-steroid dehydrogenase/isomerase; 3β-hydroxy-Δ5-C27-steroid oxidoreductase; 3β-hydroxy-5-ene-steroid oxidoreductase; steroid-Δ5-3β-ol dehydrogenase; 3β-HSDH; 5-ene-3-β-hydroxysteroid dehydrogenase; 3β-hydroxy-5-ene-steroid d
5-PREGNEN-3β-OL-20-ONE GLUCOSIDURONATE, SODIUM SALT
5-PREGNEN-3β-OL-20-ONE GLUCOSIDURONATE, SODIUM SALT. Group: Biochemicals. Alternative Names: PREGNENOLONE GLUCURONIDE, SODIUM SALT. US Biological Life Sciences.
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5-PREGNEN-3β-OL-20-ONE HEMISUCCINATE
5-PREGNEN-3β-OL-20-ONE HEMISUCCINATE. Group: Biochemicals. Alternative Names: PREGNENOLONE HEMISUCCINATE. US Biological Life Sciences.
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5-PREGNEN-3β-OL-20-ONE METHYL ETHER
5-PREGNEN-3β-OL-20-ONE METHYL ETHER. Group: Biochemicals. Alternative Names: PREGNENOLONE METHYL ETHER. US Biological Life Sciences.
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Allopregnandiol 20-(Hydrogen Sulfate) Sodium Salt
(3 β,5α,20R)-Pregnane-3,20-diol, 20-Sulfate Sodium Salt is sulfate conjugated metabolite of Allopregnandiol (CAS#516-33-0). (3 β,5α,20R)-Pregnane-3,20-diol, 20-Sulfate Sodium Salt can be obtained from 5α-Pregnan-3 β-ol-20-one 3 β-Acetate (P711315) which is a derivative of Pregnenolone (P712200); a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. Group: Biochemicals. Grades: Highly Purified. CAS No. 215855-82-6. Pack Sizes: 1mg, 10mg. Molecular Formula: C21H35NaO5S, Molecular Weight: 422.55. US Biological Life Sciences.
Worldwide
Allopregnandiol 3-(Hydrogen Sulfate) Sodium Salt
Allopregnandiol 3-(Hydrogen Sulfate) Sodium Salt is sulfate conjugated metabolite of Allopregnandiol (CAS#516-33-0). (3 β,5α,20R)-Pregnane-3,20-diol, 20-Sulfate Sodium Salt can be obtained from 5α-Pregnan-3 β-ol-20-one 3 β-Acetate (P711315) which is a derivative of Pregnenolone (P712200); a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. Group: Biochemicals. Grades: Highly Purified. CAS No. 215855-85-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H35NaO5S, Molecular Weight: 422.55. US Biological Life Sciences.
Worldwide
Atamestane
Atamestane is a synthetic steroidal substance with antineoplastic activity. Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Uses: Enzyme inhibitors. Synonyms: Atamestanum; Atamestano; Biomed-777; Biomed 777; Biomed777; CCRIS 6528; CCRIS6528; CCRIS-6528; SH-489; SH 489; SH489. CAS No. 96301-34-7. Molecular formula: C20H26O2. Mole weight: 298.43.
Dehydroepiandrosterone sulfate sodium salt
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Sodium prasterone sulfate. CAS No. 1099-87-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-B0765.
Δ4-Pregnene-3,20-diol
Intermediate in the preparation of Pregnenolone and its derivatives. Group: Biochemicals. Alternative Names: 3-Hydroxy-4-pregnen-20-ol; 3,20-Dihydroxypregn-4-ene. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
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MAP4343
MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 511-26-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107116.
steroid 17α-monooxygenase
Requires NADPH and EC 1.6.2.4, NADPH-hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17α-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17α-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 4.1.2.30, 7α-hydroxyprogesterone aldolase). The ratio of the 17α-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones. Group: Enzymes. Synonyms: steroid 17α-hydroxylase; cytochrome P-450 17α; cytochrome P-450 (P-450 17α,lyase); 17α-hydroxylase-C17,20 lyase; CYP17; CYP17A1 (gene name). Enzyme Commission Number: EC 1.14.14.19. CAS No. 9029-67-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0916; steroid 17α-monooxygenase; EC 1.14.14.19; 9029-67-8; steroid 17α-hydroxylase; cytochrome P-450 17α; cytochrome P-450 (P-450 17α,lyase); 17α-hydroxylase-C17,20 lyase; CYP17; CYP17A1 (gene name). Cat No: EXWM-0916.
steryl-sulfatase
Also acts on some related steryl sulfates. Group: Enzymes. Synonyms: arylsulfatase; steroid sulfatase; sterol sulfatase; dehydroepiandrosterone sulfate sulfatase; arylsulfatase C; steroid 3-sulfatase; steroid sulfate sulfohydrolase; dehydroepiandrosterone sulfatase; pregnenolone sulfatase; phenolic steroid sulfatase; 3-β-hydroxysteroid sulfate sulfatase. Enzyme Commission Number: EC 3.1.6.2. CAS No. 9025-62-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3753; steryl-sulfatase; EC 3.1.6.2; 9025-62-1; arylsulfatase; steroid sulfatase; sterol sulfatase; dehydroepiandrosterone sulfate sulfatase; arylsulfatase C; steroid 3-sulfatase; steroid sulfate sulfohydrolase; dehydroepiandrosterone sulfatase; pregnenolone sulfatase; phenolic steroid sulfatase; 3-β-hydroxysteroid sulfate sulfatase. Cat No: EXWM-3753.
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