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| Product | Description | |
|---|---|---|
| Cysteine Covalent Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery and synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening. Uses: Scientific use. Product Category: L9411. Categories: Cysteine Covalent Libraries. |  |
| dUTP diphosphatase | This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP. Lack or inhibition of dUTPase action leads to harmful perturbations in the nucleotide pool resulting in increased uracil content of DNA that activates a hyperactive futile cycle of DNA repair. Group: Enzymes. Synonyms: deoxyuridine-triphosphatase; dUTPase; dUTP pyrophosphatase; desoxyuridine 5'-triphosphate nucleotidohydrolase; desoxyuridine 5'-triphosphatase. Enzyme Commission Number: EC 3.6.1.23. CAS No. 37289-34-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4607; dUTP diphosphatase; EC 3.6.1.23; 37289-34-2; deoxyuridine-triphosphatase; dUTPase; dUTP pyrophosphatase; desoxyuridine 5'-triphosphate nucleotidohydrolase; desoxyuridine 5'-triphosphatase. Cat No: EXWM-4607. |  |
| High Solubility FragLite Fragment Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. The FragLites identify productive drug-like interactions, which are identified sensitively and unambiguously by X-ray crystallography, exploiting the anomalous scattering of the halogen substituent. This mapping of protein interaction surfaces provides an assessment of druggability and can identify efficient start points for the de novo design of hit molecules incorporating the interacting motifs. Combine fragments from FragLites to generate fragment lead compounds: Uses: Scientific use. Product Category: L7840. Categories: High Solubility FragLite Fragment Libraries. | |
| High Solubility Pharmacophore Fragment Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. We analyzed the key interactions discovered by target protein hot spots to derive the fragment pharmacophore represented by the fragment-protein complex available in the PDB. Using this information, we designed a set of minimal diversified commercial fragments, covering most experiments combined with pharmacophore, used to identify the starting point of the fragment for drug discovery targets. Uses: Scientific use. Product Category: L7830. Categories: High Solubility Pharmacophore Fragment Libraries. | |
| Mini Electrophilic Heterocyclic Fragment Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. Targeted covalent inhibitors and chemical probes have become part of drug discovery methods. Given the advantages of fragment-based drug discovery, screening electrophilic fragments has become a promising alternative to discover and verify new targets and generate viable chemical starting points, even for targets that are almost difficult to handle. In response to this situation, we designed a small library of heterocyclic electrophilic compounds. General technology for covalent fragment screening ?. Uses: Scientific use. Product Category: L7860. Categories: Mini Electrophilic Heterocyclic Fragment Libraries. | |
| P1,P5-Di(adenosine-5')pentaphosphate trilithium salt | A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5?-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. Group: Biochemicals. Alternative Names: P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, 94108-02-8, A(5)P5(5)A, AC1O4WDE, D6392_SIGMA, CTK8G2238, EINECS 302-339-2, AP5A lithium salt P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, AG-H-86941, Diadenosine pentaphosphate trilithium salt, Diadenosine pentaphosphate pentalithium salt, K00187, A(5 inverted exclamation marka)P5(5 inverted exclamation marka)A trilithium sal. Grades: Highly Purified. CAS No. 75522-97-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H26N10O22P5Li3, Molecular Weight: 934.17. US Biological Life Sciences. |  Worldwide |
| 1,1-Diphenylethane | 1,1-Diphenylethane, a kind of aromatic hydrocarbon compound, could probably used in polymerization. Synonyms: 2,2'-Bipyridine ferrous perchlorate. CAS No. 612-00-0. Molecular formula: C14H14. Mole weight: 182.27. |  |
| 1,2,4,5-Tetrachlorobenzene-13C6 | 1,2,4,5-Tetrachlorobenzene-13C6 is an intermediate used in the synthesis of 2,4,5-Trichlorophenol-13C6 (T774148), which is an isotope labelled 2,4,5-Trichlorophenol is used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: 13C6H2Cl4, Molecular Weight: 221.85. US Biological Life Sciences. | Worldwide |
| 1-Hydroxy Tacrine | One of the impurities of Tacrine, which is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease. Uses: Cholinesterase inhibitors. Synonyms: 1-Hydroxy Tacrine. Grades: > 95%. CAS No. 124027-47-0. Molecular formula: C13H14N2O. Mole weight: 214.27. | |
| 1-Hydroxy Tacrine Maleate | One of the impurities of Tacrine, which is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease. Uses: Cholinesterase inhibitors. Synonyms: 1-Hydroxy Tacrine Maleate; 9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate; 9-Amino-1,2,3,4-tetrahydro-1-acridinol (2Z)-2-Butenedioate; HP 029; Mentane; P 83-6029A; Velnacrine Hydrogen Maleate; Velnacrine Maleate. Grades: > 95%. CAS No. 118909-22-1. Molecular formula: C13H14N2O. C4H4O4. Mole weight: 330.33. | |
| 1-O-(trans-3-Hydroxycotinine)-4-deoxy-4,5-didehydro-b-D-glucuronide methyl ester | 1-O-(trans-3-Hydroxycotinine)-4-deoxy-4,5-didehydro-b-D-glucuronide methyl ester, a metabolite arising from nicotine, occupies a pivotal role in nicotine's pharmacokinetic events. Its contribution to the metabolism and expulsion of nicotine have been subjected to in-depth scientific investigation as a probable biomarker for nicotine addiction and smoking cessation interventions. The complexity and variations in the molecular structure of this metabolite add to the diverse outcomes observed and continue to be a matter of discussion in the scientific community. Molecular formula: C17H20N2O7. Mole weight: 364.35. | |
| 2, 3-Dimethylbenz [a]anthracene | 2, 3-Dimethylbenz [a]anthracene is a dimethylated polycyclic aromatic hydrocarbon. Probable carcinogen. Group: Biochemicals. Grades: Highly Purified. CAS No. 1348514-35-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 2,4,5,6-Tetrachlorophenol-13C6 | Used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen. Group: Biochemicals. Alternative Names: 2,3,4,6-Tetrachloro-phenol-13C6; 2, 3, 4, 6-Tetra chlorophenate13C6; Dowicide 6-13C6; NSC 2428-13C6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2,4,5,6-Tetrachlorophenol (contains 10% pentachlorophenol) | Used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen. Group: Biochemicals. Alternative Names: 2,3,4,6-Tetrachloro-phenol; 2,3,4,6-Tetrachlorophenate; Dowicide 6; NSC 2428. Grades: Highly Purified. CAS No. 58-90-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 2,4,6-Trichlorophenol | Used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen. Group: Biochemicals. Grades: Highly Purified. CAS No. 88-06-2. Pack Sizes: 1g, 10g, 50g, 100g, 250g. Molecular Formula: C?H?Cl?O. US Biological Life Sciences. | Worldwide |
| 2,4,6-Trichlorophenol-13C6 | Used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen. Group: Biochemicals. Alternative Names: 1,3,5-Trichloro-2-hydroxybenzene-13C6; 2,4,6-TCP-13C6; 2,4,6-Trichlorophenol-13C6; BTS 45186-13C6; Dowicide 2S-13C6; Omal-13C6; Phenachlor-13C6; NSC 2165-13C6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 25-Hydroxy Vitamin D3 3, 3- (4-Maleimidopropanamide) propyl Ether | 25-Hydroxy Vitamin D3 3, 3- (4-Maleimidopropanamide) propyl Ether is an analog of Vitamin D3 (V676045), a vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C37H56N2O5, Molecular Weight: 608.85. US Biological Life Sciences. | Worldwide |
| 2, 7-Dimethylbenz [a]anthracene | 2, 7-Dimethylbenz [a]anthracene is a dimethylated polycyclic aromatic hydrocarbon. Probable carcinogen. Group: Biochemicals. Grades: Highly Purified. CAS No. 857535-92-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 2-APB | 2-APB, a transient receptor potential (TRP) activator for TRPV1, TRPV2, and TRPV3, could probably be used against diseases caused by hypersensitivity and temperature misregulation. Synonyms: 2-Aminoethoxydiphenylborane. Grades: ≥98% by HPLC. CAS No. 524-95-8. Molecular formula: C14H16BNO. Mole weight: 225.10. | |
| 2-Bromo-1,6-dimethyl Ester Hexanedioic Acid | 2-Bromo-1,6-dimethyl Ester Hexanedioic Acid is an intermediate in the synthesis of 2-Hydroxyhexanedioic Acid Disodium Salt (H943015). Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects, due to deficiency of 2-ketoadipic dehydrogenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 3196-19-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H13BrO4. US Biological Life Sciences. | Worldwide |
| 2-furoyl-CoA dehydrogenase | A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors. Group: Enzymes. Synonyms: furoyl-CoA hydroxylase; 2-furoyl coenzyme A hydroxylase; 2-furoyl coenzyme A dehydrogenase; 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating). Enzyme Commission Number: EC 1.3.99.8. CAS No. 9068-18-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1441; 2-furoyl-CoA dehydrogenase; EC 1.3.99.8; 9068-18-2; furoyl-CoA hydroxylase; 2-furoyl coenzyme A hydroxylase; 2-furoyl coenzyme A dehydrogenase; 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating). Cat No: EXWM-1441. | |
| 2-Hydroxyhexanedioic Acid Disodium Salt | Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects , due to deficiency of 2-ketoadipic dehydrogenase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 500mg. Molecular Formula: C6H8Na2O5. US Biological Life Sciences. | Worldwide |
| 3- (4-Maleimidoacetamido) propyl-25-Hydroxy-Vitamin D3 | 3- (4-Maleimidoacetamido) propyl-25-Hydroxy-Vitamin D3 is a derivative of Vitamin D3, the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. It occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. It modulates the proliferation and differentiation of both normal and cancer cells. It also has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C36H54N2O5, Molecular Weight: 594.82. US Biological Life Sciences. | Worldwide |
| 3-aci-nitropropanoate oxidase | A flavoprotein (FMN). The primary products of the enzymic reaction are probably the nitropropanoate free radical and superoxide. Also acts, more slowly, on 4-aci-nitrobutanoate. Group: Enzymes. Synonyms: propionate-3-nitronate oxidase. Enzyme Commission Number: EC 1.7.3.5. CAS No. 111940-52-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1627; 3-aci-nitropropanoate oxidase; EC 1.7.3.5; 111940-52-4; propionate-3-nitronate oxidase. Cat No: EXWM-1627. | |
| 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase | Requires ATP. The reaction in mammals possibly involves dehydrogenation to give a 24(25)-double bond followed by hydration. However, in amphibians such as the Oriental fire-bellied toad (Bombina orientalis), it is probable that the product is formed via direct hydroxylation of the saturated side chain of (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate and not via hydration of a 24(25) double bond. In microsomes, the free acid is preferred to the coenzyme A ester, whereas in mitochondria, the coenzyme A ester is preferred to the free-acid form of the substrate. Group: Enzymes. Synonyms: trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA oxidase; 3α,. Enzyme Commission Number: EC 1.17.99.3. CAS No. 119799-47-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1103; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase; EC 1.17.99.3; 119799-47-2; trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestan-26-oate 24-hydroxylase. Cat No: EXWM-1103. | |
| 4-methylphenol dehydrogenase (hydroxylating) | A flavocytochrome c (FAD). Phenazine methosulfate can act as acceptor. A quinone methide is probably formed as intermediate. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde. Group: Enzymes. Synonyms: p-cresol-(acceptor) oxidoreductase (hydroxylating); p-cresol methylhydroxylase; 4-cresol dehydrogenase (hydroxylating). Enzyme Commission Number: EC 1.17.99.1. CAS No. 66772-07-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1101; 4-methylphenol dehydrogenase (hydroxylating); EC 1.17.99.1; 66772-07-4; p-cresol-(acceptor) oxidoreductase (hydroxylating); p-cresol methylhydroxylase; 4-cresol dehydrogenase (hydroxylating). Cat No: EXWM-1101. | |
| 5-Chloro-7-iodo-8-quinolinol | Clioquinol, a quinoline derivative, is an antifungal and antiprotozoal agent and has also been found to have probable effect against cancer and Alzheimer's disease. Uses: Clioquinol is an antifungal and antiprotozoal agent and has also been found to have probable effect against cancer and alzheimer's disease. Synonyms: 5-chloro-7-iodoquinolin-8-ol. Grades: 95 %. CAS No. 130-26-7. Molecular formula: C9H5ClINO. Mole weight: 305.50. | |
| 5'-DMT-cytidine (N-iBu) | 5'-DMT-cytidine (N-iBu), an immensely potent antiviral nucleoside analog, conspicuously stands out in treating viral infections, for instance, the stubborn hepatitis B and C. Chemical biochemistry declares that it breaks in and incapacitates the viral DNA polymerase, curtailing the growth and spread of viruses within the body. Comprising of therapeutic powers beyond the virulent world, preliminary studies have also legitimized its probable role in the treatment of certain cancer genres. Grades: ≥ 98% by HPLC. Molecular formula: C34H37N3O8. Mole weight: 615.67. | |
| 6-Azathymidine | 6-Azathymidine, a nucleoside analog, is a potent inhibitor of DNA synthesis and has been clinically approved for its efficacy in treating chronic hepatitis B virus (HBV) infection. In addition to its antiviral properties, ongoing research has revealed its probable efficacy as a novel therapeutic agent for solid tumors including pancreatic and lung cancer. The medicinal properties of this unique compound have garnered significant attention and require further exploration in order to ascertain its full therapeutic potential. Synonyms: 6-Azathymidine; Azathymidine; 13410-30-5; 2-(2'-Deoxy-D-ribofuranosyl)-6-methyl-as-triazine-3,5(2H,4H)-dione; 2-(2-Deoxy-beta-D-erythro-pentofuranosyl)-6-methyl-1,2,4-triazine-3,5(2H,4H)-dione; BRN 0030380; 2'-deoxy-6-azathymine; 6-aza-2'-deoxythymine; 2'-deoxy-6-azathymidine; 6-aza-2'-deoxythymidine; 1,2,4-Triazine-3,5(2H,4H)-dione, 2-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methyl-; 4-26-00-00557 (Beilstein Handbook Reference); CHEMBL463659; SCHEMBL1984838; 5-Methyl-2'-deoxy-6-azauridine; CHEBI:131580; NSC 80211; 2-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl-1,2,4-triazine-3,5-dione; Q27225201; as-Triazine-3,5(2H,4H)-dione, 2-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methyl-. Grades: ≥ 95%. CAS No. 13410-30-5. Molecular formula: C9H13N3O5. Mole weight: 243.22. | |
| 6H-?Pyrimido[4, ?5-?b]?[1, ?4]?benzodiazepin-?6-?one, 5, ?11-?dihydro-?2-?[[2-?methoxy-?4-? (4-?methyl-?1-?piperazinyl) ?phenyl]?amino]?-?5, ?11-?dimethyl- | An effective inhibitior of ERK5, could probably be used as an antitumor agent. IC50: 0.19μM(EC50 for cellular),of 0.087 μM(for enzymatic) and 0.087 μM(for LRRK2). Uses: An effective inhibitior of erk5 and could probably be used as an antitumor agent. Synonyms: ERK5-IN-1; ERK5 IN 1; ERK5IN1; CHEMBL1673039; SCHEMBL618262; BDBM50337127; ZINC66066276; CS-4938; HY-14403. Grades: 98%. CAS No. 1234479-76-5. Molecular formula: C25H29N7O2. Mole weight: 459.54. | |
| 8-Isopropyl-1-methylchrysene | 8-Isopropyl-1-methylchrysene is a dialkylated polycyclic aromatic hydrocarbon with probable carcinogenic activity. Group: Biochemicals. Alternative Names: 1-methyl-8-(1-methylethyl)chrysene. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 9-Isopropyl-2-methylbenz [a]anthracene | 9-Isopropyl-2-methylbenz [a]anthracene is a dialkylated polycyclic aromatic hydrocarbon with probable carcinogenic activity. Group: Biochemicals. Alternative Names: 2-methyl-9- (1-methylethyl) benz[a]anthracene. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| A-1155463 | A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft tumors. IC50: <0.01 nM (Ki). Uses: A-1155463 is an effective and selective bcl-xl inhibitor that has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft tumors. Synonyms: CHEMBL3342332; A-1155463; A 1155463; A1155463; SCHEMBL2501550; BDBM50030754; CS-5398; HY-19725; CS 5398; HY 19725; CS5398; HY19725. Grades: 98%. CAS No. 1235034-55-5. Molecular formula: C35H32FN5O4S2. Mole weight: 669.79. | |
| (+)-abscisic acid 8'-hydroxylase | A heme-thiolate protein (P-450). Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone. CO inhibits the reaction, but its effects can be reversed by the presence of blue light. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously. Other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase). Group: Enzymes. Synonyms: (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Enzyme Commission Number: EC 1.14.13.93. CAS No. 153190-37-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0902; (+)-abscisic acid 8'-hydroxylase; EC 1.14.13.93; 153190-37-5; (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Cat No: EXWM-0902. | |
| ACBC | ACBC has been found to be a NMDA receptor partial agonist and could probably affect the signal transmission in the CNS. Synonyms: 1-Aminocyclobutane-1-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 22264-50-2. Molecular formula: C5H9NO2. Mole weight: 115.13. | |
| achilleol B synthase | Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene as part of the cyclization reaction, after formation of the oleanane skeleton. Group: Enzymes. Enzyme Commission Number: EC 5.4.99.48. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5590; achilleol B synthase; EC 5.4.99.48. Cat No: EXWM-5590. | |
| ACPT-II | ACPT-II has been found to be a mGluR antagonist and could probably exhibit neuroprotective effects. Synonyms: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid. Grades: ≥98% by HPLC. CAS No. 195209-04-2. Molecular formula: C8H11NO6. Mole weight: 217.18. | |
| ACT 335827 | ACT 335827 has been found to be an orexin OX1 receptor antagonist and could probably exhibit anxiolytic effects in vivo. Synonyms: ACT-335827; ACT 335827; ACT335827; (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide. Grades: ≥98% by HPLC. CAS No. 1354039-86-3. Molecular formula: C31H38N2O5. Mole weight: 518.64. | |
| ACV 1 | ACV 1 has been found to be a neuronal nicotinic receptor antagonist and could probably alleviate neuropathic pain. Synonyms: Conotoxin Vc1.1. Grades: ≥98% by HPLC. CAS No. 740980-24-9. Molecular formula: C71H103N23O25S4. Mole weight: 1806.98. | |
| Adomeglivant | Adomeglivant has been found to be a glucagon receptor antagonist that could probably be effective for both type-I and type-II diabetes mellitus. Synonyms: Adomeglivant; LY-2409021; Adomeglivant [USAN]; UNII-74Z5ZL2KVG; LY2409021; LY 2409021; 3- [ [4- [ (1S) -1- [4- (4-tert-butylphenyl) -3, 5-dimethylphenoxy] -4, 4, 4-trifluorobutyl] benzoyl] amino] propanoic acid. Grades: 98%. CAS No. 1488363-78-5. Molecular formula: C32H36F3NO4. Mole weight: 555.64. | |
| ADWX 1 | ADWX 1 has been found to be a Kv1.3 channel blocker and could probably ameliorate autoimmune encephalomyelitis at some extent. Synonyms: ADWX1. Grades: >98%. Molecular formula: C169H281N57O46S7. Mole weight: 4071.86. | |
| AEG 3482 | AEG 3482 has been found to be an inhibitor of c-jun N-terminal kinase (JNK) signaling and could probably be useful against some neurological disorders. Synonyms: AEG-3482; AEG 3482; AEG3482; 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide. Grades: ≥99% by HPLC. CAS No. 63735-71-7. Molecular formula: C10H8N4O2S2. Mole weight: 280.33. | |
| AEG 40730 dihydrochloride | The dihydrochloride salt form of AEG 40730, which has been found to be an IAP antagonist as well as an apoptosis protein inhibitor and could probably be uesful in cancer research. Synonyms: AEG 40730 dihydrochloride; AEG40730 dihydrochloride; AEG-40730 dihydrochloride; 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1883545-50-3. Molecular formula: C52H68F6N8O8.2HCl. Mole weight: 1120.06. | |
| Aflatoxin Q1 | Aflatoxin Q1 is a metabolite of Aflatoxin B1. It is created in human body as a in-vivo detoxification process of Aflatoxin B1. Uses: A metabolite of aflatoxin b1; a hepatocarcinogen in many animal models and probably a human carcinogen. it is produced by the predominant forms of cytochrome p 450 enzymes responsible for the biotransformation of afb1. it shows potential predictive value. Synonyms: Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-3-hydroxy-4-methoxy-, (3S,6aR,9aS)-; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-3-hydroxy-4-methoxy-, (3S-(3-alpha,6a-alpha,9a-alpha))-; (3S, 6aR, 9aS)-3-hydroxy-4-methoxy-2, 3, 6a, 9a-tetrahydrocyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h]chromene-1, 11-dione. Grades: ≥98%. CAS No. 52819-96-2. Molecular formula: C17H12O7. Mole weight: 328.27. | |
| AG 045572 | AG 045572, a nonpeptidic GnRH antagonist, could probably be used in the treatment for sex hormone-dependent diseases and infertility. Synonyms: AG 045572; AG045572; AG-045572; 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide. Grades: ≥97% by HPLC. CAS No. 263847-55-8. Molecular formula: C30H37NO5. Mole weight: 491.62. | |
| AG 556 | AG 556, a dihydroxyphen derivative, has been found to be a EGFR kinase inhibitor that could probably be effective in the study of myocardial infarct and hemodynamic deterioration. IC50: 1.1 μM. Synonyms: AG556; AG-556; CHEMBL440298; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide. Grades: 98%. CAS No. 133550-41-1. Molecular formula: C20H20N2O3. Mole weight: 336.38. | |
| AG 825 | AG 825, a selective ErbB2 (Neu) inhibitor, could probably show activities in triggerring p38 MAP kinase-dependent apoptosis at some extent. Synonyms: AG 825; AG825; AG-825; (E)-3-[3-[2-Benzothiazolythio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide. Grades: ≥95% by HPLC. CAS No. 149092-50-2. Molecular formula: C19H15N3O3S2. Mole weight: 397.47. | |
| AI-3 | AI-3 is an antioxidant response element activator and could probably be useful in studies of oxidative stress related diseases. Synonyms: AI-3; AI 3; AI3; 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one. Grades: ≥98% by HPLC. CAS No. 882288-28-0. Molecular formula: C11H13ClO3S2. Mole weight: 292.80. | |
| α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase | R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram). The best acceptor for this enzyme is probably the same as that favoured by EC 2.4.1.144, β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase. Group: Enzymes. Synonyms: N-acetylglucosaminyltransferase IV; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV; β-acetylglucosaminyltransferase IV; uridine diphosphoacetylglucosamine-glycopeptide β4-acetylglucosaminyltransferase IV; α-1,3-mannosylglycoprotein β-1,4-N-acetylglucosaminyltransferase; GnTIV. Enzyme Commission Number: EC 2.4.1.145. CAS No. 86498-16-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2371; α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase; EC 2.4.1.145; 86498-16-0; N-acetylglucosaminyltransferase IV; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV; β-acetylglucosaminyltransferase IV; uridine diphosphoacetylglucosamine-glycopeptide β4-acetylglucosaminyltransferase IV; α-1,3-mannosylglycoprotein β-1,4-N-acetylglucosaminyltransferase; GnTIV. Cat No: EXWM-2371. | |
| α-gurjunene synthase | Initial cyclization probably gives biyclogermacrene in an enzyme bound form which is not released to the medium. The enzyme from Solidago canadensis also forms a small amount of (+)-γ-gurjunene. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.72. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5234; α-gurjunene synthase; EC 4.2.3.72. Cat No: EXWM-5234. | |
| ALX 5407 hydrochloride | The hydrochloride salt form of ALX 5407, which has been found to be an inhibitor of the glycine transporter GlyT1 and could probably be useful in some neuropsychiatric disorders. Synonyms: ALX 5407 hydrochloride; ALX-5407 hydrochloride; ALX5407 hydrochloride; N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride. Grades: ≥98% by HPLC. CAS No. 200006-08-2. Molecular formula: C24H24FNO3.HCl. Mole weight: 429.92. | |
| AM 6545 | AM 6545 has been found to be a CB1 antagonist and could probably be used as an appetite suppressant. Synonyms: AM 6545; AM6545; AM-6545; 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide. Grades: ≥98% by HPLC. CAS No. 1245626-05-4. Molecular formula: C26H23Cl2N5O3S. Mole weight: 556.46. | |
| AM 92016 hydrochloride | The hydrochloride salt form of AM 92016, which has been found to be a specific blocker of the time dependent delayed rectifier potassium current and probably be useful in antiarrhythmic studies. Synonyms: Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, hydrochloride (1:1); Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, monohydrochloride; 1-(4-Methanesulfonamidophenoxy)-3-(n-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride. Grades: ≥98% by HPLC. CAS No. 133229-11-5. Molecular formula: C19H24Cl2N2O4S.HCl. Mole weight: 483.84. | |
| AMBMP hydrochloride | The hydrochloride salt form of AMBMP, which has been found to be a Wnt canonical signaling activator and could probably be effective in the treatment of muscle dystrophy. Synonyms: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 2095432-75-8. Molecular formula: C19H18N4O3.HCl. Mole weight: 386.84. | |
| AMG 21629 | AMG 21629 has been found to be an effective and selective TRPV1 antagonist, which could probably be useful in the treatment of pains associated with cancer and inflammatory diseases. Synonyms: AMG21629; AMG-21629; AMG 21629; 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone. Grades: ≥97% by HPLC. CAS No. 939040-79-6. Molecular formula: C22H19F3N6O3. Mole weight: 472.42. | |
| AMG 837 hemicalcium salt | The calcuim salt form of AMG 837, which has been found to be a GPR40 partial agonist and could probably be used as an antidiabetic agent. Synonyms: AMG 837 hemicalcium salt; AMG837 hemicalcium salt; AMG-837 hemicalcium salt; (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt. Grades: ≥98% by HPLC. CAS No. 1291087-14-3. Molecular formula: C26H20F3O3.½Ca. Mole weight: 457.47. | |
| AMT hydrochloride | The hydrochloride salt form of AMT, which has been found to be a reversible inhibitor of iNOS and could probably be useful in treatment of inflammatory and autoimmune disorders. Synonyms: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride. Grades: ≥95% by HPLC. CAS No. 21463-31-0. Molecular formula: C5H10N2S.HCl. Mole weight: 166.67. | |
| Antibiotic UCN-02 (UCN 02) | UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. Group: Biochemicals. Alternative Names: UCN 02. Grades: Highly Purified. CAS No. 121569-61-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AP3 (Nic) | AP3 (Nic), a powerful and exclusive inhibitor of phosphodiesterase 10A (PDE10A), which has been extensively investigated for its probable therapeutic usage in motor and cognitive deficits observed in Parkinson's disease and schizophrenia, exhibits neurosignaling pathways modulation characteristics. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-Ribofuranosyl-nicotinamide)] triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C21H28N7O17P3 (free acid). Mole weight: 743.41 (free acid). | |
| AQ-RA 741 | AQ-RA 741 has been found to be a muscarinic M2 receptor antagonist and could probably be used in the development of bronchodilator anti-muscarinic agent. Synonyms: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one. Grades: ≥99% by HPLC. CAS No. 123548-16-3. Molecular formula: C27H37N5O2. Mole weight: 463.62. | |
| AR-12 Hydrochloride | OSU 03012, a Phenanthren derivative, has been found to be a PDPK1 inhibitor that could probably be an effctive antitumor agent. It is still under Phase I trail for solid-tumour. IC50: 5 μM. Synonyms: OSU-03012; AR-12; AR 12; AR12; OSU 03012; OSU03012; PDK1 inhibitor AR-12; 2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide. Grades: 98%. CAS No. 1471979-81-3. Molecular formula: C26H19F3N4O. Mole weight: 460.46. | |
| AR-C 66096 tetrasodium salt | The sodium salt form of AR-C 66096, which has been found to be a P2Y12 receptor antagonist and could be probably used as an antithrombotic agent. Synonyms: ARL-66096; ARL 66096; ARL66096; 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 145782-74-7. Molecular formula: C14H18F2N5Na4O12P3S. Mole weight: 703.26. | |
| ARN-5187 | ARN-5187, a piperazin derivative, has been found to be a REV-ERBβ inhibitor that could induce apoptotic in cancer cells and probably be more effective in breast cancer cells. Synonyms: ARN5187; ARN-5187; ARN 5187; 4- ( ( (1- (2-fluorophenyl) cyclopentyl) amino) methyl) -2- ( (4-methylpiperazin-1-yl) methyl) phenol hydrochloride. Grades: 98%. CAS No. 1700693-96-4. Molecular formula: C24H33ClFN3O. Mole weight: 434.00. | |
| AR-R 17779 hydrochloride | AR-R17779 has been found to be a selective alpha7 nicotinic agonist and could probably reduce blood pressure and serum lipid levels. Synonyms: AR-R 17779 hydrochloride; AR-R-17779 hydrochloride; AR-R17779 hydrochloride; ARR17779 hydrochloride; (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride. Grades: ≥98% by HPLC. CAS No. 178419-42-6. Molecular formula: C9H14N2O2.HCl. Mole weight: 218.68. | |
| AS 19 | AS 19 has been found to be a potent SR-7 agonist and could probably enhance memory consolidation. Synonyms: AS 19; AS-19; AS19; (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin. Grades: ≥98% by HPLC. CAS No. 1000578-26-6. Molecular formula: C18H25N3. Mole weight: 283.41. | |
| AS 2034178 | AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes. Synonyms: AS 2034178; AS2034178; AS-2034178; 2-Fluoro-4- [ [ [1, 2, 3, 4-Tetrahydro-1- (2-phenoxyethyl) -5-quinolinyl] methyl] amino] benzenepropanoic acid. Grades: ≥98% by HPLC. CAS No. 1030846-42-4. Molecular formula: C27H29FN2O3. Mole weight: 448.53. | |
| ATC 0175 hydrochloride | The hydrochloride salt form of ATC 0175, which has been found to be a MCHR1, SR-1A and SR-2B inhibitor and probably show anxiolytic and antidepressant activities. Synonyms: ATC0175; ATC-0175; ATC 0175. N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 510733-97-8. Molecular formula: C23H25F2N5O.HCl. Mole weight: 461.94. | |
| Atreleuton | Atreleuton, a kind of urea compound, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene B4 receptor antagonist that could probably be useful in study of sorts of diseases like asthma and acute coronary syndromes. It has already been discontinued by VIA Pharmaceuticals. Uses: Lipoxygenase inhibitors. Synonyms: Atreleuton; ABT-761; ABT 761; VIA 2291; VIA-2291; VIA2291; A-85761; Abbott-85761; Atreleuton [USAN]; UNII-U301T88E1M; ABT 761; 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. Grades: 98%. CAS No. 154355-76-7. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
| AZD3293 | AZD3293, a spiro compound, has been found to be a β-secretase inhibitor that has good blood-brain barrier penetration and could probably be significant in studies of Alzheimer's disease. It was just planed a Phase III trial in several areas. IC50: 0.2 nM. Synonyms: AZD-3293; AZD 3293; AZD3293; LY3314814; GTPL7789; LY 3314814; GTPL 7789; LY-3314814; GTPL-7789; SCHEMBL9948271; (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine. Grades: 98%. CAS No. 1628076-74-3. Molecular formula: C26H28N4O. Mole weight: 412.53. | |
| Bacteriocin lactocin-S | Bacteriocin lactocin-S is an antimicrobial peptide produced by Lactobacillus sakei L45. It has antibacterial activity and inhibits the growth of selected species of the genera Lactobacillus, Pedicoccus, and Leuconostoc. It contains at least two lanthionines, which are probably formed between the serine in position 23 and the cysteine in position 28, and between the serine in position 32 and the cysteine in position 37. Synonyms: Ser-Thr-Pro-Val-Leu-Ala-Ser-Val-Ala-Val-Ser-Met-Glu-Leu-Leu-Pro-Thr-Ala-Ser-Val-Leu-Tyr-Ser-Asp-Val-Ala-Gly-Cys-Phe-Lys-Tyr-Ser-Ala-Lys-His-His-Cys; lasA; Lactocin S (Bacteriocin). Grades: >85%. CAS No. 125387-34-0. | |
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