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PS 48. Group: Biochemicals. Grades: Purified. CAS No. 1180676-32-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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PS 48
PS 48 has been shown to be a PKB Kinase (phosphoinositide-dependent protein kinase-1, PDK1) activator (Kd = 10.3 μM). Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). This is a distinct region separate from the ATP binding site. Applications: A phosphoinositide-dependent protein kinase-1 (pdk1) activator. Group: Coenzymes. Synonyms: (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid. CAS No. 1180676-32-7. Mole weight: 286.76. Form: Solid. (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid; PS 48; 1180676-32-7. Cat No: COEC-117.
11-O-Propionyl Halobetasol
11-O-Propionyl Halobetasol is an impurity of Halobetasol (H102290); an anti-inflammatory drug that is used to treat various dermatological conditions which mainly consist of various forms of psoriasis. Group: Biochemicals. Grades: Highly Purified. CAS No. 181527-42-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C25H31ClF2O5, Molecular Weight: 484.96. US Biological Life Sciences.
1-C-[2,4-Bis(1,1-dimethylethoxy)-5-pyrimidinyl]-5-O-(1-methoxy-1-methylethyl)-2,3-O-(1-methylethylidene)-α-D-ribofuranose is an intermediate in the synthesis of β-Pseudouridine, an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. CAS No. 631920-67-7. Molecular formula: C24H40N2O8. Mole weight: 484.58.
2,4-Bis[4-(N,N-diphenylamino)-2,6-dihydroxyphenyl]squaraine (DPSQ) is a symmetric squaraine that can be used as a green light absorbing donor. The characteristic absorption peak is at 720 nm. It can be used for a variety of electrochemical applications. Uses: Dpsq based dyes can be used for potential application in polymeric solar cells (pscs), and organic photovoltaic cells (opvs). Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. CAS No. 1345272-10-7. Pack Sizes: 1 g in glass bottle. Oc1cc (cc (O)c1[C]2[C+] ([O-])[C] ([C+]2[O-])c3c (O)cc (cc3O)N (c4ccccc4)c5ccccc5)N (c6ccccc6)c7ccccc7. 1S/C40H28N2O6/c43-31-21-29 (41 (25-13-5-1-6-14-25) 26-15-7-2-8-16-26) 22-32 (44) 35 (31) 37-39 (47) 38 (40 (37) 48) 36-33 (45) 23-30 (24-34 (36) 46) 42 (27-17-9-3-10-18-27) 28-19-11-4-12-20-28/h1-24, 43-46H. FXAALAVLRJSKEQ-UHFFFAOYSA-N.
((2R,3R,4R,5R)-3-(Benzoyloxy)-4-fluoro-5-(4-methoxy-2-oxopyrimidin-1(2H)-yl)-4-methyltetrahydrofuran-2-yl)methyl Benzoate is an intermediate in synthesizing PSI 6130, which is an experimental treatment for hepatitis C. PSI 6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI 6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B. Molecular formula: C25H23FN2O7. Mole weight: 482.46.
3-Methylcatechol
3-Methylcatechol is a building block in the chemical synthesis produced by Pseudomonas putida MC2 [1]. Uses: Scientific research. Group: Natural products. CAS No. 488-17-5. Pack Sizes: 10 mM * 1 mL; 250 mg. Product ID: HY-W012815.
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target:In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways.In vivo: Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 523-50-2. Molecular formula: C11H6O3. Mole weight: 186.16. Purity: 0.9986. Canonical SMILES: O=C1C=CC2=CC=C(OC=C3)C3=C2O1. Product ID: ACM523502. Alfa Chemistry ISO 9001:2015 Certified.
Aripiprazole N,N-Dioxide
An impurity of Aripiprazole, which is an atypical antipsychotic used to treat schizophrenia. Uses: A metabolite of anti-psychotic drug, aripiprazole (a771000). Synonyms: 7-[4-[4-(2,3-Dichlorophenyl)-1,4-dioxido-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone; Aripiprazole Di-N-Oxide. CAS No. 573691-13-1. Molecular formula: C23H27Cl2N3O4. Mole weight: 480.38.
Azlocillin sodium salt
Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa and, in contrast to most cephalosporins, exhibits activity against enterococci. Uses: Anti-bacterial agents. Synonyms: Bayer Brand of Azlocillin; Sodium Azlocillin; Securopen; Bay-e 6905; Baye 6905; Bay e 6905; Azlocillin; Azlocillin Bayer Brand. Grade: >98%. CAS No. 37091-65-9. Molecular formula: C20H23N5O6SNa. Mole weight: 484.48.
Bagougeramine A
Bagougeramine A is produced by the strain of Bacillus circulans TB-2125. Both of A and B have activities against gram-positive bacteria and negative bacteria, and B has higher activity than A, except for Pseudomonas aeruginosa A3. Synonyms: beta-D-Glucopyranuronamide, 4-((3-((aminoiminomethyl)amino)-N-(N-methylglycyl)-D-alanyl)amino)-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,4-dideoxy-. CAS No. 104840-35-9. Molecular formula: C17H28N10O7. Mole weight: 484.47.
Naturally occurring analog of psoralen and isomer of methoxsalen. Found in a wide variety of plants. Antipsoriatic. Group: Biochemicals. Alternative Names: 4-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 5-Methoxypsoralen; Bergaptan; Bergaptene; Heraclin; Majudin;5-MOP, Psoraderm-5. Grades: Highly Purified. CAS No. 484-20-8. Pack Sizes: 1g. US Biological Life Sciences.
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Bergaptol
A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 and 42.93 μM, respectively. Recent studies suggest that it may have antiproliferative and anticancer properties. Group: Biochemicals. Alternative Names: 4-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-one; 4-Hydroxybergapten; 5-Hydroxy-6,7-furanocoumarin; 5-Hydroxypsoralen; NSC 341958. Grades: Highly Purified. CAS No. 486-60-2. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Bifeprunox mesylate
Bifeprunox mesylate is a dopamine D2 and 5-HT1A partial agonist developed as an atypical antipsychotic for the treatment of schizophrenia and other psychotic indications. Uses: Atypical antipsychotic. Synonyms: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-1,3-benzoxazol-2-one mesylate. Grade: 98%. CAS No. 350992-13-1. Molecular formula: C24H23N3O2.CH4O3S. Mole weight: 481.56.
Bongkrekic acid
Bongkrekic acid is an acid-labile toxin produced by Pseudomonas cocoveneans. Uses: Anti-bacterial agents. Synonyms: (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(Carboxymethyl)-6-methoxy-2,5,17-trimethyl-2,4,8,10,14,18,20-docosaheptaenedioic Acid; (-)-Bongkrekic Acid; BA; Flavotoxin A. Grade: ≥98%. CAS No. 11076-19-0. Molecular formula: C28H38O7. Mole weight: 486.60.
Byakangelicin
Byakangelicin is an effective inhibitor of sex hormones and affects the catabolism of endogenous hormones. It directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes. It is an inhibitor of aldose reductase used in the treatment of diabetic cataracts. Byakangelicin is a natural coumarin compound found in Murraya koenigii, Triphasia trifoliata, and other organisms. Synonyms: 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxy-; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-, (R)-; 9-[(2R)-2,3-Dihydroxy-3-methylbutoxy]-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one; Biacangelicin; (+)-Byakangelicin; 5-Methoxy-8-(2,3-dihydroxy-3-methylbutoxy)psoralene; Bjacangelicin; Bjakangelicin; Byankagelicine. Grade: >98%. CAS No. 482-25-7. Molecular formula: C17H18O7. Mole weight: 334.32.
Cathepsin S inhibitor
Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. Synonyms: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor. Grade: >98%. CAS No. 1373215-15-6. Molecular formula: C25H29FN4O5. Mole weight: 484.52.
DUPA(OtBu)-OH
DUPA(OtBu)-OH is a PEG linker for antibody-drug-conjugation (ADC). DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. Synonyms: (S)-5-tert-Butoxy-4-(3-((s)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic Acid; L-Glutamic acid, N-[[[(1S)-3-carboxy-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-, 1,5-bis(1,1-dimethylethyl) ester; 2-[3-(1,3-bis-tert-butoxycarbonylpropyl)ureido]pentanedioic acid 1-tert-butyl ester. Grade: 95%. CAS No. 1026987-94-9. Molecular formula: C23H40N2O9. Mole weight: 488.57.
Elemicin
A constituent of the essential oil of nutmeg and is responsible for the psychoactive effects of nutmeg. Also a minor constituent of the oleoresin and essential oil of Manila elemi (Canarium luzonicum). Exhibits anticholinergic-like effects in humans. Group: Biochemicals. Alternative Names: 1,2,3-Trimethoxy-5-(2-propen-1-yl)-benzene; 5-Allyl-1,2,3-trimethoxybenzene; 1-(3,4,5-Trimethoxyphenyl)-2-propene; 3, 4, 5-Trimethoxyallyl Benzene ; 5-(Prop-2-enyl)-1,2,3-trimethoxybenzene; 5-Allyl-1,2,3-trimethoxybenzene. Grades: Highly Purified. CAS No. 487-11-6. Pack Sizes: 1g. US Biological Life Sciences.
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Fexofenadine EP Impurity E
Fexofenadine EP Impurity E is an impurity of Fexofenadine, which is a histamine H1 receptor antagonist used for the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria. Synonyms: Fexofenadine Hydrochloride EP impurity E; Azacyclonol; MER 17; MDL 4829; MER17; MDL4829; MER-17; MDL-4829; 4-Piperidinemethanol, α,α-diphenyl-; α,α-Diphenyl-4-piperidinemethanol; 4-(Diphenylhydroxymethyl)piperidine; 4-(Hydroxydiphenylmethyl)piperidine; Ataractan; Calmeran; Diphenyl-4-piperidylmethanol; Frenoton; Psychosan; α-(4-Piperidyl)benzhydrol; γ-Pipradol. Grade: >98%. CAS No. 115-46-8. Molecular formula: C18H21NO. Mole weight: 267.37.
Fludioxonil
Fludioxonil is a phenylpyrrole fungicide used to control a range of diseases, including Fusarium, Rhizoctonia, and Alternaria. It also inhibits glucose transport-related phosphorylation and reduces mycelial growth. Synonyms: 1H-Pyrrole-3-carbonitrile, 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-; Beret Gold; Celeste; CGA 173506; Fludioxonil; Geoxe; Maxim; Maxim (pesticide); Maxim 4FS; Maxim PSP; Maxin XL; Saphire; Savior; Scholar; Seibia; Spirato; Spirato 480 FS. Grade: 95%. CAS No. 131341-86-1. Molecular formula: C12H6F2N2O2. Mole weight: 248.19.
Fmoc-Ile-Ser[Psi(Me,Me)Pro]-OH is used as a reactant in the synthesis of peptides and receptor targeting ligands. Synonyms: Fmoc-Ile-Ser[Psi(Me,Me)Pro]-OH; (S)-3-[N-(9-Fluorenylmethyloxycarbonyl)-L-isoleucinyl]-2,2-dimethyloxazolidine-4-carboxylic acid; Fmoc-Ile-Ser(Psime,Mepro)-OH; 6904AH; (4S)-3-[(2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid. Grade: 99-101% (Assay by titration). CAS No. 1147996-34-6. Molecular formula: C27H32N2O6. Mole weight: 480.56.
Fmoc-Leu-Ser(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Leu-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Leu-Ser(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 339531-50-9. Mole weight: 480.55. Product ID: ACM339531509. Alfa Chemistry ISO 9001:2015 Certified.
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Val-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Val-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 168216-05-5. Mole weight: 480.55. Product ID: ACM168216055-1. Alfa Chemistry ISO 9001:2015 Certified.
It is originally isolated from Nocardia uniformis subsp. tsuyamanensis. FR-29038 has anti-Bacillus, Escherichia, Klebsiella, Pseudomonas, Salmonella, Shigella and other family bacteria activities. Synonyms: Antibiotic FR 29038; BRN 3578863; O-{4-[1-Amino-2-({1-[carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl}imino)-2-hydroxyethyl]phenyl}homoserine. CAS No. 59511-12-5. Molecular formula: C23H26N4O8. Mole weight: 486.47.
Monoacetylphloroglucinol is a small molecular weight phenolic metabolite that belongs to the phloroglucinol (1,3,5-trihydroxybenzene) family produced by bacteria (including Pseudomonas strains). It exhibits a wide range of biological activities, although the potency is mostly low. Synonyms: 2,4,6-trihydroxyacetophemone. Grade: >95% by HPLC. CAS No. 480-66-0. Molecular formula: C8H8O4. Mole weight: 186.15.
N, N, N', N'-Tetra([1, 1'-biphenyl]-4-yl)[1, 1':4', 1''-terphenyl]-4, 4''-diamine
N,N,N',N'-Tetraphenylbenzidine (purified by sublimation)
N,N,N',N'-Tetraphenylbenzidine (purified by sublimation). Group: other material building blocksorganic light-emitting diode (oled) materials perovskite solar cell (psc) materials. Alternative Names: 4,4'-Bis(diphenylamino)biphenyl TPB. CAS No. 15546-43-7. Product ID: N,N-diphenyl-4-[4-(N-phenylanilino)phenyl]aniline. Molecular formula: 488.63. Mole weight: C36H28N2. C1=CC=C (C=C1)N (C2=CC=CC=C2)C3=CC=C (C=C3)C4=CC=C (C=C4)N (C5=CC=CC=C5)C6=CC=CC=C6. InChI=1S/C36H28N2/c1-5-13-31 (14-6-1) 37 (32-15-7-2-8-16-32) 35-25-21-29 (22-26-35) 30-23-27-36 (28-24-30) 38 (33-17-9-3-10-18-33) 34-19-11-4-12-20-34/h1-28H. DCZNSJVFOQPSRV-UHFFFAOYSA-N. >98.0%GC.
Pseudomonic Acid C
Pseudomonic Acid C. Group: Biochemicals. Alternative Names: (2E)-5,9-Anhydro-2,3,4,8-tetradeoxy-8-(5-hydroxy-4-methyl-2-hexen-1-yl)-3-methyl-L-talo-Non-2-enonic Acid 8-Carboxyoctyl Ester; [2E,8(2E,4R,5S)]-5,9-Anhydro-2,3,4,8-tetradeoxy-8-(5-hydroxy-4-methyl-2-hexenyl)-3-methyl-L-talo-non-2-enonic Acid 8-Carboxyoctyl Ester; (+)-Pseudomonic acid C. Grades: Highly Purified. CAS No. 71980-98-8. Pack Sizes: 10mg. Molecular Formula: C26H44O8, Molecular Weight: 484.62. US Biological Life Sciences.
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Pseudouridimycin
Pseudouridimycin is a C-nucleoside analogue that selectively inhibits bacterial RNA polymerase. Pseudouridimycin is an antibiotic found in Streptomyces albus that has activity against Gram-positive and Gram-negative bacteria. Synonyms: PUM; 2,4(1H,3H)-Pyrimidinedione, 5-(5-((N-(aminoiminomethyl)glycyl-N2-hydroxy-L-glutaminyl)amino)-5-deoxy-beta-D-ribofuranosyl)-; (1S)-1,4-Anhydro-5-[(N-carbamimidoylglycyl-N2-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol; D-Ribitol, 5-[[N-(aminoiminomethyl)glycyl-N2-hydroxy-L-glutaminyl]amino]-1,4-anhydro-5-deoxy-1-C-(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)-, (1S)-. Grade: ≥95%. CAS No. 1566586-52-4. Molecular formula: C17H26N8O9. Mole weight: 486.44.
(R)-(+)-SLV 319 is a less active enantiomer of SLV 319, which is a central cannabinoid (CB1) receptor antagonist. SLV 319 has the potential to treat neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. Synonyms: (R)-SLV 319; (R)-SLV319; (R)-SLV-319; (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide. Grade: 99%. CAS No. 656827-86-0. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.4.
SBSstandard 2D cryopreservation tube(Three yards in one)
SBS tubes preset QR bar, the tube cap designs of integrated sealing ring,which is in perfect airtightness to prevent liquid leakage.The grillage is designed for multi-replay function, and easily unlocked by the clasp.The grillage is designed for multi-replay function, and easily unlocked by the clasp. Product ID: PM-052. Category: cryopreservation tube. Product Keywords: Plastic Packaging; SBSstandard 2D cryopreservation tube(Three yards in one); PM-052; cryopreservation tube;. Administration route: SBS grillage and SBS tubes are perfectly fit, which is convenient for high-throughput automation workstation. Dosage Form: 96 psc/box x 36 boxes, 48 psc/box x 36 boxes.
SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340)
A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.