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| Product | Description | |
|---|---|---|
| 2-(1-Piperidinyl)-5-pyrimidinecarbonitrile | Heterocyclic Organic Compound. Alternative Names: 1123169-22-1, 2-(1-PIPERIDINYL)-5-PYRIMIDINECARBONITRILE, Ambcb4029314, MolPort-016-583-274, ZINC29865940, AKOS006345071, MCULE-8941990912, AK121636, KB-220324, 2-(Piperidin-1-yl)pyrimidine-5-carbonitrile. CAS No. 1123169-22-1. Molecular formula: C10H12N4. Mole weight: 188.229080 [g/mol]. Purity: 0.96. IUPACName: 2-piperidin-1-ylpyrimidine-5-carbonitrile. Canonical SMILES: C1CCN(CC1)C2=NC=C(C=N2)C#N. Catalog: ACM1123169221. |  |
| 2-(2-METHOXYETHYL)-5-PYRIMIDINECARBONITRILE 95% | Heterocyclic Organic Compound. Alternative Names: Ambcb4030313, MolPort-016-631-226, ZINC29865952, AKOS006345075, 2-(2-METHOXYETHYL)-5-PYRIMIDINECARBONITRILE, 1123169-32-3. CAS No. 1123169-32-3. Molecular formula: C8H9N3O. Mole weight: 163.1791. Purity: 0.96. IUPACName: 2-(2-methoxyethyl)pyrimidine-5-carbonitrile. Catalog: ACM1123169323. | |
| 2,4-Diaminopyrimidine-5-carbonitrile | Intermediate for the preparation of medicines and agrochemicals. Group: Biochemicals. Alternative Names: 2,4-Diamino-5-cyanopyrimidine; 2, 4-Diamino-5-pyrimidinecarbonitri le; NSC 135235. Grades: Highly Purified. CAS No. 16462-27-4. Pack Sizes: 250mg. US Biological Life Sciences. |  Worldwide |
| 2-Amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | 2-Amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile is a reagent used for structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 69205-79-4. Pack Sizes: 250mg, 2.5g. Molecular Formula: C7H5N5O, Molecular Weight: 175.15. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-oxo-4H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | Heterocyclic Organic Compound. Alternative Names: 2-Amino-5-cyano-4-oxo-4H-pyrrolo[2,3-d]pyrimidine. CAS No. 1000576-55-5. Molecular formula: C7H3N5O. Mole weight: 173.1347. Purity: 0.96. IUPACName: 2-amino-4-oxopyrrolo[2,3-d]pyrimidine-5-carbonitrile. Canonical SMILES: C1=NC2=NC(=NC(=O)C2=C1C#N)N. Catalog: ACM1000576555. | |
| 2-Chloropyrimidine-4-Carbonitrile | 2-Chloropyrimidine-4-Carbonitrile (CAS# 75833-38-4) is a useful research chemical. Synonyms: 2-chloro-4-pyrimidinecarbonitrile; 2-chloropyrimidine-4-carbonitrile. CAS No. 75833-38-4. Molecular formula: C5H2ClN3. Mole weight: 139.54. |  |
| 2-Ethyl-5-pyrimidinecarbonitrile | Heterocyclic Organic Compound. Alternative Names: 2-ETHYL-5-PYRIMIDINECARBONITRILE, 1060817-38-0, Ambcb4028982, SureCN3439398, 2-Ethylpyrimidine-5-carbonitrile, CTK4A4372, MolPort-016-631-201, ZINC19093025, AKOS006309498, AG-D-20302, AK121601. CAS No. 1060817-38-0. Molecular formula: C7H7N3. Mole weight: 133.150580 [g/mol]. Purity: 0.96. IUPACName: 2-ethylpyrimidine-5-carbonitrile. Canonical SMILES: CCC1=NC=C(C=N1)C#N. Catalog: ACM1060817380. | |
| 2-Pyrimidinecarbonitrile | Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor. Synonyms: pyrimidine-2-carbonitrile. Grades: 95+%. CAS No. 14080-23-0. Molecular formula: C5H3N3. Mole weight: 105.10. | |
| 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile | 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile. Group: Biochemicals. Alternative Names: 4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile. Grades: Highly Purified. CAS No. 33097-13-1. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C6H3Cl2N3S. US Biological Life Sciences. | Worldwide |
| 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile) | 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile). Group: Biochemicals. Alternative Names: 4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 4,7-Dihydro-4-oxo-2-[(triphenylmethyl)amino]-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | 2H Labeled Compounds. CAS No. 1019853-64-5. Molecular formula: C26H19N5O. Mole weight: 417.46. Appearance: Yellow Foam. Catalog: ACM1019853645. | |
| 4-Amino-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | 4-Amino-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, commonly known as AMBDRP, predominantly employed as an antiviral agent diligently studying an array of viral infections induced by RNA viruses. Synonyms: 2'-C-Methyl toyocamycin. CAS No. 141232-24-8. Molecular formula: C13H15N5O4. Mole weight: 305.29. | |
| 4-Amino-pyrimidine-5-carbonitrile | 4-Amino-pyrimidine-5-carbonitrile. Group: Biochemicals. Grades: Highly Purified. CAS No. 16357-69-0. Pack Sizes: 1g, 2g. Molecular Formula: C5H4N4. US Biological Life Sciences. | Worldwide |
| 4-Imino-9-methyl-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile | Heterocyclic Organic Compound. CAS No. 102781-19-1. Catalog: ACM102781191. | |
| 5-Pyrimidinecarbonitrile,2-amino-1,6-dihydro-4-(2-hydroxyethoxy)-6-oxo- | Heterocyclic Organic Compound. Alternative Names: MolPort-002-344-733, ZINC02555679, CID2766692, 11E-920, 126865-37-0. CAS No. 126865-37-0. Molecular formula: C7H8N4O3. Mole weight: 196.1634. Purity: 0.96. IUPACName: 2-amino-4-(2-hydroxyethoxy)-6-oxo-1H-pyrimidine-5-carbonitrile. Canonical SMILES: C(COC1=C(C(=O)NC(=N1)N)C#N)O. Density: 1.62 g/cm³. Catalog: ACM126865370. | |
| 5-Pyrimidinecarbonitrile,4-chloro-2-methyl-6-(methylthio)- | Heterocyclic Organic Compound. Alternative Names: 4-CHLORO-5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDINE;4-CHLORO-2-METHYL-6-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;4-Chloro-5-cyano-2-methyl-6-(methylthio)pyrimidine 98%;4-Chloro-5-cyano-2-methyl-6-(methylthio)pyrimidine98%. CAS No. 112969-42-3. Molecular formula: C7H6ClN3S. Mole weight: 199.66. Purity: 0.96. IUPACName: 4-chloro-2-methyl-6-methylsulfanylpyrimidine-5-carbonitrile. Canonical SMILES: CC1=NC(=C(C(=N1)Cl)C#N)SC. Density: 1.39g/cm³. Catalog: ACM112969423. | |
| 5-Pyrimidinecarbonitrile,4-chloro-6-(methylthio)-2-phenyl- | Heterocyclic Organic Compound. Alternative Names: 4-CHLORO-6-(METHYLTHIO)-2-PHENYLPYRIMIDINE-5-CARBONITRILE;4-CHLORO-6-(METHYLSULFANYL)-2-PHENYL-5-PYRIMIDINECARBONITRILE;4-CHLORO-5-CYANO-6-(METHYLTHIO)-2-PHENYLPYRIMIDINE. CAS No. 118996-61-5. Molecular formula: C12H8ClN3S. Mole weight: 261.73. Purity: 0.96. IUPACName: 4-chloro-6-methylsulfanyl-2-phenylpyrimidine-5-carbonitrile. Canonical SMILES: CSC1=C(C(=NC(=N1)C2=CC=CC=C2)Cl)C#N. Density: 1.39g/cm³. Catalog: ACM118996615. | |
| 7- (3-Bromophenyl) pyrazolo[1, 5-a]pyrimidine-3-carbonitrile | 7- (3-Bromophenyl) pyrazolo[1, 5-a]pyrimidine-3-carbonitrile. Group: Biochemicals. Grades: Highly Purified. CAS No. 933054-30-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C13H7BrN4. US Biological Life Sciences. | Worldwide |
| 2-Cyanopyrimidine-5-boronic acid pinacol ester | Heterocyclic Organic Compound. Alternative Names: 2-CYANOPYRIMIDINE-5-BORONIC ACID PINACOL ESTER, 1025708-31-9, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carbonitrile, SureCN253746, AGN-PC-00YV3R, CTK8B3688, ANW-42945, AB45911, NCGC00185028-01, AK-55940, KB-23434, FT-0660786, A-4198, 2-Cyanopyrimidine-5-boronic acid pinacol ester,, 5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE-2-CARBONITRILE. CAS No. 1025708-31-9. Molecular formula: C11H14BN3O2. Mole weight: 231.1. Purity: 0.95. IUPACName: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carbonitrile. Canonical SMILES: B1 (OC (C (O1) (C)C) (C)C)C2=CN=C (N=C2)C#N. Catalog: ACM1025708319. | |
| 3-Cyanoimidazo[1,2-a]pyrimidine | Heterocyclic Organic Compound. Alternative Names: 3-Cyanoimidazo[1,2-a]pyrimidine. CAS No. 1232432-42-6. Molecular formula: C7H4N4. Mole weight: 144.13346. Purity: 0.96. IUPACName: imidazo[1,2-a]pyrimidine-3-carbonitrile. Canonical SMILES: C1=CN2C(=CN=C2N=C1)C#N. Catalog: ACM1232432426. | |
| 4-Amino-2-(4-chlorophenoxy)-5-cyanopyrimidine | Heterocyclic Organic Compound. Alternative Names: 4-amino-2-(4-chlorophenoxy)pyrimidine-5-carbonitrile, 113447-04-4, 5-Pyrimidinecarbonitrile,4-amino-2-(4-chlorophenoxy)-, ZINC01046883, AC1MCU9I, Maybridge1_001803, ACMC-1BVV1, MLS001181535, CTK4A8306, HMS546J21, MolPort-002-892-673, HMS2871I05, BTB08600, CCG-51996, AG-D-33258, AK-56237, SMR000567207, KB-239924, SR-01000641256-1, 4-AMINO-2-(4-CHLOROPHENOXY)PYRIMIDINE-5-CARBONITRILE;4-AMINO-2-(4-CHLOROPHENOXY)-5-CYANOPYRIMIDINE. CAS No. 113447-04-4. Molecular formula: C11H7ClN4O. Mole weight: 246.652480 [g/mol]. Purity: 0.96. IUPACName: 4-amino-2-(4-chlorophenoxy)pyrimidine-5-carbonitrile. Canonical SMILES: C1=CC(=CC=C1OC2=NC=C(C(=N2)N)C#N)Cl. Catalog: ACM113447044. | |
| 4-Amino-5-cyano-1-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine | 4-Amino-5-cyano-1-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a nucleoside analog of remarkable potency, finding utility in the biomedical realm for research of a plethora of viral infections as well as specific malignancies. Its antiviral attributes extend to RNA viruses, while simultaneously restraining the replication of viral DNA. Encouragingly, this compound showcases immense potential as an efficacious therapeutic agent in the comprehensive research of viral afflictions and cancer maladies. Synonyms: 1H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-amino-1-β-D-ribofuranosyl-; 4-amino-5-cyano-1-(β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine. Grades: ≥95%. CAS No. 1704-25-2. Molecular formula: C12H13N5O4. Mole weight: 291.26. | |
| 4-Amino-6-bromo-5-cyano-7-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine | 4-Amino-6-bromo-5-cyano-7-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a highly potent biomedical compound, presenting a cutting-edge solution for research of combatting various types of cancer. Its unparalleled inhibitory properties meticulously disrupt the intricate DNA replication machinery within cancer cells, thus impeding their ability to multiply and metastasize. Synonyms: 4-amino-6-bromo-7-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 4-Amino-6-bromo-7-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile. Grades: ≥95%. Molecular formula: C12H11BrFN5O3. Mole weight: 372.15. | |
| 4-Chloro-5-cyano-2-methylthio-6-(p-tolyl)pyrimidine | Heterocyclic Organic Compound. Alternative Names: SBB016385, 128640-74-4, 4-chloro-6-(4-methylphenyl)-2-(methylsulfanyl)-5-pyrimidinecarbonitrile, 4-CHLORO-6-(4-METHYLPHENYL)-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE, 6-chloro-4-(4-methylphenyl)-2-methylthiopyrimidine-5-carbonitrile, SMR000178908, AC1LRPR2, AC1Q4H3J, ACMC-1C17B, MLS000326323, CHEMBL313163, CTK4B6024, MolPort-000-678-231, HMS2486L18, ZINC01387648, AKOS000273659, AG-D-58901, MCULE-8672343494, KB-241570, ST50208810. CAS No. 128640-74-4. Molecular formula: C13H10ClN3S. Mole weight: 275.76. Purity: 0.96. IUPACName: 4-chloro-6-(4-methylphenyl)-2-methylsulfanylpyrimidine-5-carbonitrile. Canonical SMILES: CC1=CC=C (C=C1)C2=C (C (=NC (=N2)SC)Cl)C#N. Density: 1.35g/cm³. Catalog: ACM128640744. | |
| 5-Bromo-4-cyanopyrimidine | Heterocyclic Organic Compound. Alternative Names: 5-Bromo-4-cyanopyrimidine;5-Bromo-4-pyrimidinecarbonitrile;5-Bromopyrimidine-4-carbonitrile;4-Cyano-5-bromopyrimidine. CAS No. 114969-66-3. Molecular formula: C5H2BrN3. Mole weight: 183.996. Purity: 0.96. IUPACName: 5-bromopyrimidine-4-carbonitrile. Canonical SMILES: C1=C(C(=NC=N1)C#N)Br. Density: 1.86g/cm³. Catalog: ACM114969663. | |
| 7-Amino-6-cyano-2-(methylthio)-1,2,4-triazolo(1,5-a)pyrimidine | Heterocyclic Organic Compound. Alternative Names: 113967-64-9, [1,2,4]Triazolo[1,5-a]pyrimidine-6-carbonitrile,7-amino-2-(methylthio)-, ZINC00093634, AC1MCU1C, ACMC-1C6YI, CTK4A8539, SBB082863, AKOS002676071, AG-D-34056, AK-56533, BBS-00014941, 7-Amino-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile, 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile, 7-amino-2-methylsulfanyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile, 7-amino-2-methylthio-8-hydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carbonitrile, 7-AMINO-6-CYANO-2-(METHYLTHIO)-1,2,4-TRIAZOLO(1,5-A)PYRIMIDINE;7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile. CAS No. 113967-64-9. Molecular formula: C7H6N6S. Mole weight: 206.227740 [g/mol]. Purity: 0.96. IUPACName: 7-amino-2-methylsulfanyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile. Canonical SMILES: CSC1=NN2C(=C(C=NC2=N1)C#N)N. Catalog: ACM113967649. | |
| 7-Cyano-7-deaza-2'-deoxyguanosine | 7-Cyano-7-deaza-2'-deoxyguanosine is a potent antiviral nucleoside analogue commonly used in the biomedical industry for the treatment of viral infections. It demonstrates promising activity against various viruses, including hepatitis B and C. It functions by inhibiting viral replication through targeting viral polymerase enzymes. Synonyms: 2-Amino-7-(2-deoxy-b-D-ribofuranosyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one; 2'-Deoxytoyocamycin; 2-Amino-7-((2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile. Grades: ≥95%. CAS No. 199859-58-0. Molecular formula: C12H13N5O4. Mole weight: 291.26. | |
| 7-Cyano-7-deazaguanine | 7-Cyano-7-deazaguanine is a marine derived natural products found in Streptomyces qinglanensis. Group: Marine natural products. Alternative Names: 2-Amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidine-5-carbonitrile. CAS No. 69205-79-4. Mole weight: 175.15. Purity: 95%+. IUPACName: 2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-D]pyrimidine-5-carbonitrile. Canonical SMILES: C1=C(C2=C(N1)N=C(NC2=O)N)C#N. Density: 1.87±0.1 g/cm³. Catalog: ACM69205794. | |
| 7-(Cyano)-7-deazaguanosine | 7-(Cyano)-7-deazaguanosine, a remarkable biomedicine of immense potential, has emerged as a therapeutic breakthrough in the battle against a myriad of diseases. This extraordinary compound showcases an array of antiviral and antitumor properties, positioning it as an excellent candidate for precise, targeted interventions in specific cancers and viral afflictions. Its distinctive mechanism involves perturbing crucial cellular processes, effectively impeding viral replication and restraining malignant proliferation. Synonyms: 7-b-D-ribofuranosyl-7H-pyrrolo[2,?3-d]?pyrimidine-5-carbonitrile. CAS No. 57128-90-2. Molecular formula: C12H12N4O4. Mole weight: 276.25. | |
| 7-Cyano-7-deazaguanosine | 7-Cyano-7-deazaguanosine is a promising biomedicine product that exhibits potent anticancer and antiviral activity by inhibiting RNA and DNA synthesis. Its therapeutic potential extends to the treatment of hepatitis C as well as acute and chronic myeloid leukemia. As a modified version of guanosine, 7-Cyano-7-deazaguanosine is a unique and valuable therapeutic agent in the fight against cancer and viral infections. Its remarkable biological properties make it a promising candidate for further scientific investigation and clinical trials. Synonyms: Pre-Q0; 2-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 2-Amino-5-cyano-7-beta-D-ribofuranosyl-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine-4-one; 2-Amino-4-oxo-7-(β-D-ribofuranosyl)-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile. Grades: ≥95%. CAS No. 61210-21-7. Molecular formula: C12H13N5O5. Mole weight: 307.26. | |
| AM-8508 | AM-8508 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-8508 exhibits good cellular potency (in vitro pAKT IC50 = 4.6 nM ) and excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibits KLH-specific antibodies in animal models and it may become a drug candidate for the treatment of human inflammatory diseases. Uses: Inflammatory diseases. Synonyms: AM-8508; AM 8508; AM8508. (S)-4-amino-6-((1-(6-fluoro-1-(pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1338483-67-2. Molecular formula: C19H15FN8. Mole weight: 374.14. | |
| AM-9635 | AM-9635 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-9635 exhibits good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-9635 can inhibit KLH-specific IgG and IgM in a dosedependent manner and it is well tolerated at all doses. AM-96352 shows significantly reduced IgG and IgM specific antibodies. Synonyms: AM-9635; AM 9635; AM9635. (S)-4-amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1338483-10-5. Molecular formula: C19H14F2N8. Mole weight: 392.36. | |
| Amdizalisib | Amdizalisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, an immunomodulator and an antineoplastic. Synonyms: (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grades: 99% by HPLC. CAS No. 1894229-05-0. Molecular formula: C19H15ClN8. Mole weight: 390.83. | |
| Baricitinib impurity 46 | Baricitinib impurity 46. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)pyrimidine-5-carbonitrile. Molecular Formula: C15H15N7O2S. Mole Weight: 357.39. Catalog: APB03606. |  |
| Baricitinib Impurity G | Baricitinib Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)pyrimidine-5-carbonitrile. CAS No. 2964606-44-6. Molecular Formula: C15H15N7O2S. Mole Weight: 357.39. Catalog: APB2964606446. | |
| CPI 4203 | CPI 4203 is a selective inhibitor of KDM5 demethylases structurally related to CPI 455. Synonyms: CPI-4203; CPI 4203; CPI4203; 6-ethyl-7-oxo-5-(o-tolyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grades: 99%. CAS No. 1628214-07-2. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI 455 | CPI 455 is a selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation (H3K4me3) in vitro and reduces survival of drug-tolerant cancer cells. Uses: Antitumor agent for drug-tolerant cancer. Synonyms: CPI-455; CPI-455; CPI-455; 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grades: 99%. CAS No. 1628208-23-0. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI-455 hydrochloride | CPI-455 is a specific inhibitor of KDM5 with IC50 of 10 ± 1 nM for full-length KDM5A in enzymatic assays. Synonyms: 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride. Grades: ≥99%. CAS No. 2095432-28-1. Molecular formula: C16H15ClN4O. Mole weight: 314.77. | |
| IPI-3063 | IPI-3063 is a potent and selective phosphoinoside-3-kinase (PI3K) p110δ inhibitor. IPI-3063 was shown to inhibit mouse B cell proliferation, survival, and plasmablast differentiation, and also inhibit human B cell proliferation in vitro. Synonyms: 4-Amino-6-[1-[8-(1-methyl-6-oxopyridin-3-yl)-1-oxo-2-propan-2-ylisoquinolin-3-yl]ethylamino]pyrimidine-5-carbonitrile. CAS No. 1425043-73-7. Molecular formula: C25H25N7O2. Mole weight: 455.51. | |
| JNJ 17029259 | JNJ 17029259 is an selective, nanomolar inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2), blocks VEGF-stimulated mitogen-activated protein kinase signaling, proliferation/migration. Uses: Vascular endothelial growth factor receptor-2 (vegf-2) kinase inhibitor. Synonyms: JNJ-17029259; JNJ 17029259; JNJ17029259. 4-[4-(2-aminopropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethyl)anilino]pyrimidine-5-carbonitrile. Grades: ≥98%. CAS No. 314267-57-7. Molecular formula: C26H30N6O. Mole weight: 442.56. | |
| KDM5-IN-1 | KDM5-IN-1 is a potent and selective KDM5 inhibitor with modest cell activity (PC9 H3K4Me3 EC50 = 5.2 μM). Synonyms: KDM5-IN-48; KDM5 IN 48; KDM5IN48; KDM5 inhibitor-48; KDM5 inhibitor 48; 5-(1-tert-butylpyrazol-4-yl)-7-oxo-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile. CAS No. 1628210-26-3. Molecular formula: C17H20N6O. Mole weight: 324.38. | |
| KDM5-inhibitor | KDM5-inhibitor is an analog of CPI-455, a selective KDM5 inhibitor. CPI-455 increases levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell lines treated with standard chemotherapy or targeted agents. It reduces survival of drug-tolerant cancer cells. Synonyms: KDM5 inhibitor; 7-oxo-5-phenyl-6-propyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Molecular formula: C16H14N4O. Mole weight: 278.315. | |
| MI-463 | MI-463, a thienopyrimidine derivative, has been found to be a menin inhibitor that could be significant in Leukaemia studies. Synonyms: MI-463; MI 463; MI463; 4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile. Grades: 98%. CAS No. 1628317-18-9. Molecular formula: C24H23F3N6S. Mole weight: 484.55. | |
| ON-123300 | ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as β-type platelet-derived growth factor receptor (PDGFRβ). ON123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 μmol/L. ON123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo. ON123300 might be an effective agent in MCL, including ibrutinib-resistant forms of the disease. Group: Inhibitors. Alternative Names: ON-123300; ON 123300; ON123300; Narazaciclib. CAS No. 1357470-29-1. Molecular formula: C24H27N7O. Mole weight: 429. Appearance: Solid powder. Purity: >98%. IUPACName: 8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile. Canonical SMILES: N#CC1=CC2=CN=C (NC3=CC=C (N4CCN (C)CC4)C=C3)N=C2N (C5CCCC5)C1=O. Catalog: ACM1357470291. | |
| 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine | 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine is a remarkable antiviral agent extensively employed in the management of viral infections triggered by herpes viruses, specifically herpes simplex and varicella-zoster. By functioning as a nucleoside analogue, this efficacious drug proficiently impedes viral DNA synthesis, thereby thwarting viral replication and ameliorating symptoms inherent to these infections. Synonyms: (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile; 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine; (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile; 4-Amino-L-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)- 2(1H)-pyrimidinone; 1-(2-deoxy-2-cyano-beta-D-arabinofuranosyl)cytosine; 1-(2-c-cyano-2-deoxy-beta-d-arabino-pentofuranosyl) cytosine; 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosyl-cytosine; 2'-CYANO-2'-DEOXY-1-(.BETA.-D-ARABINOFURANOSYL)CYTOSINE; 4-amino-1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)pyrimidin-2(1H)-one; 2(1H)-PYRIMIDINONE, 4-AMINO-1-(2-CYANO-2-DEOXY-.BETA.-D-ARABINOFURANOSYL)-; 4-AMINO-L-(2-CYANO-2-DEOXY-.BETA.-D-ARABINOFURANOSYL)- 2(1H)-PYRIMIDINONE; (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-3-carbonitrile. CAS No. 135598-68-4. Molecular formula: C10H12N4O4. Mole weight: 252.23. | |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grades: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. | |
| CHIR 99021 dihydrochloride | CHIR 99021 is a potent glycogen synthase kinase GSK-3 inhibitor. Synonyms: CHIR-99021 dihydrochloride; CHIR99021 dihydrochloride; CT-99021 dihydrochloride; CT 99021 dihydrochloride; CT99021 dihydrochloride; GSK-3 Inhibitor XVI dihydrochloride; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile dihydrochloride. Grades: 99%. CAS No. 2109414-84-6. Molecular formula: C22H18Cl2N8.2HCl. Mole weight: 538.26. | |
| Gemnelatinib | Gemnelatinib is a tyrosine kinase inhibitor, with antineoplastic activity. Synonyms: (3R)-25-fluoro-3,81-dimethyl-26-oxo-26H-6-oxa-5(2,5)-pyrimidina-1(2),2(3,1)-dipyridina-8(4)-piperidina-4(1,3)-benzenaoctaphane-14-carbonitrile; (R)-5'-fluoro-1'-(1-(3-(5-((1-methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)phenyl)ethyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carbonitrile. CAS No. 2225123-30-6. Molecular formula: C30H29FN6O2. Mole weight: 524.60. | |
| MI-136 | MI-136, with the potential to treat refractory prostate cancer, inhibits DHT-induced expression of androgen receptor (AR) target genes. In vitro: Treatment with MI-136 inhibits the expression of genes that are bound to ASH2L after AR stimulation and induc. Synonyms: 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrileMI-136; MI 136; MI1365-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile5-[(4-{[6-(2,2,2-Tri. CAS No. 1628316-74-4. Molecular formula: C23H21F3N6S. Mole weight: 470.51. | |
| MI-503 | MI-503 is a potent, selective and orally bioavailable Menin-MLL inhibitor (IC50 = 14.7 nM). It is used in the pharmacological inhibition of menin-MLL interaction that blocks progression of MLL leukemia in vivo. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines (GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. Synonyms: MI-503; MI 503; MI503; 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indole-2-carbonitrile; 4-Methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile. Grades: 99.16 %. CAS No. 1857417-13-0. Molecular formula: C28H27F3N8S. Mole weight: 564.63. | |
| MI-538 | MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin-MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM). Synonyms: MI-538; MI 538; MI538. 1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile. Grades: >98%. CAS No. 1857417-10-7. Molecular formula: C27H25F3N8OS. Mole weight: 566.607. | |
| Tg101976 | Heterocyclic Organic Compound. Alternative Names: 1138474-61-9, 2-(5-Methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)benzo[b]thiophene-5-carbonitrile, SureCN3967636, AKOS016012419, AK127392, TG101976, KB-223409, 2-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-yl)benzo[b]thiophene-5-carbonitrile. CAS No. 1138474-61-9. Molecular formula: C26H25N5OS. Mole weight: 455.574600 [g/mol]. Purity: 0.96. IUPACName: 2-[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]-1-benzothiophene-5-carbonitrile. Canonical SMILES: CC1=CN=C (N=C1C2=CC3=C (S2)C=CC (=C3)C#N)NC4=CC=C (C=C4)OCCN5CCCC5. Catalog: ACM1138474619. | |
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