Rapamycin Suppliers USA
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Product | Description | |
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Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant. Group: Biobased Products. Alternative Names: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution. Grades: 98%. CAS No. 53123-88-9. Product ID: BBC53123889. Molecular formula: C51H79NO13. Mole weight: 914.18. IUPAC Name: (1R, 9S, 12S, 15R, 16E, 18R, 19R, 21R, 23S, 24E, 26E, 28E, 30S, 32S, 35R)-1, 18-dihydroxy-12-[(2R)-1-[(1S, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19, 30-dimethoxy-15, 17, 21, 23, 29, 35-hexamethyl-11, 36-dioxa-4-azatricyclo[30.3.1.04, 9]hexatriaconta-16, 24, 26, 28-tetraene-2, 3, 10, 14, 20-pentone. Appearance: Powder. Density: 1.035 g/ml. SMILES: C[C@@H]1CC[C@H]2C[C@@H] (/C (=C/C=C/C=C/[C@H] (C[C@H] (C (=O)[C@@H] ([C@@H] (/C (=C/[C@H] (C (=O)C[C@H] (OC (=O)[C@@H]3CCCCN3C (=O)C (=O)[C@@]1 (O2)O)[C@H] (C)C[C@@H]4CC[C@H] ([C@@H] (C4)OC)O)C)/C)O)OC)C)C)/C)OC. | |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Uses: Antifungal and antineoplastic agent. Synonyms: Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A. Grades: >98%. CAS No. 53123-88-9. Molecular formula: C51H79NO13. Mole weight: 914.19. | |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin Inhibitor. Uses: Scientific use. Product Category: T1537. CAS No. 53123-88-9. | |
Rapamycin Quick inquiry Where to buy Suppliers range | 100mg Pack Size. Group: Biochemicals, Organics, Research Organics & Inorganics. Formula: C51H79NO13. CAS No. 53123-88-9. Prepack ID 41676136-100mg. Molecular Weight 914.17. See USA prepack pricing. | |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. Uses: API. CAS No. 53123-88-9. Product ID: Z10-101-156. | |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin. Group: Molecular Biology. Grades: Highly Purified. CAS No. 53123-88-9. Pack Sizes: 25mg. Molecular Formula: C51H79NO13. US Biological Life Sciences. | Worldwide |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin. CAS No. 53123-88-9. Ebrator Biochemicals provides scientists around the global scientific community with a wide range of high purity Life Science products & Fine Chemicals. Categories: Rapamycin. | |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin. CAS No. 53123-88-9. Categories: Rapamycin. | |
Rapamycin-13C,d3 (contains d0) Technical Grade Quick inquiry Where to buy Suppliers range | Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, RapaÂNui. Used as an immunosuppressant; antirestenotic. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C5013CH76D3NO13, Molecular Weight: 918.18. US Biological Life Sciences. | Worldwide |
Rapamycin-13C,d3 (contains d0) Technical Grade Quick inquiry Where to buy Suppliers range | Rapamycin-13C,d3 (contains d0) Technical Grade. Uses: For analytical and research use. Group: Chiral Molecules. Catalog: APS002920. Format: Neat. Product Type: Stable Isotope Labelled. | |
Rapamycin-d3 (contains d0) Technical Grade Quick inquiry Where to buy Suppliers range | Rapamycin-d3 (contains d0) Technical Grade. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: (-)-Rapamycin-d3,Rapamycin-d3. CAS No. 392711-19-2. Molecular formula: C512H3H76NO13. Mole weight: 917.19. Catalog: APS392711192. SMILES: [2H]C ([2H]) ([2H])O[C@H]1C[C@@H]2CC[C@@H] (C)[C@@] (O) (O2)C (=O)C (=O)N3CCCC[C@H]3C (=O)O[C@@H] (CC (=O)[C@H] (C)\C=C (/C)\[C@@H] (O)[C@@H] (OC)C (=O)[C@H] (C)C[C@H] (C)\C=C\C=C\C=C\1/C)[C@H] (C)C[C@@H]4CC[C@@H] (O)[C@@H] (C4)OC. Format: Neat. Product Type: Stable Isotope Labelled. | |
Rapamycin Dialdehyde Quick inquiry Where to buy Suppliers range | Rapamycin Dialdehyde is an impurity of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus and a useful immunosuppressant to prevent rejection in organ transplantation. Group: Biochemicals. Grades: Highly Purified. CAS No. 500733-49-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H79NO15, Molecular Weight: 946.17. US Biological Life Sciences. | Worldwide |
Rapamycin Impurity 1 Quick inquiry Where to buy Suppliers range | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Grades: > 95%. Molecular formula: C51H79NO13. Mole weight: 914.2. | |
Rapamycin Impurity 2 Quick inquiry Where to buy Suppliers range | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Grades: > 95%. Molecular formula: C50H77NO13. Mole weight: 900.17. | |
Rapamycin Impurity 3 Quick inquiry Where to buy Suppliers range | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Grades: > 95%. CAS No. 157054-84-7. Molecular formula: C52H81NO13. Mole weight: 928.22. | |
Rapamycin Impurity 4 (Sirolimus-31,42-Diester Impurity) Quick inquiry Where to buy Suppliers range | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Grades: > 95%. Molecular formula: C61H95NO19. Mole weight: 1146.43. | |
Rapamycin, seco, Sodium Salt (FRAP, mTOR Inhibitor, Sirolimus) Quick inquiry Where to buy Suppliers range | A metabolite of Sirolimus. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Rapamycin (Sirolimus) Quick inquiry Where to buy Suppliers range | Cas No. 53123-88-9. | |
(19E/Z)-seco-[4-O-[2-Hydroxy(ethyl)-d4]] Rapamycin Sodium Salt Quick inquiry Where to buy Suppliers range | A labelled metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C53H78D4NNaO14, Molecular Weight: 984.23. US Biological Life Sciences. | Worldwide |
(19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Quick inquiry Where to buy Suppliers range | (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin is a metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000). Group: Biochemicals. Grades: Highly Purified. CAS No. 1062122-63-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C53H83NO14. US Biological Life Sciences. | Worldwide |
(19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt Quick inquiry Where to buy Suppliers range | Metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin. Group: Biochemicals. Alternative Names: (2S)-1-[2-oxo-2-[(2R, 3R, 6S)-tetrahydro-2-hydroxy-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19E/Z, 21R)-14-hydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15, 19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Sodium Salt; seco Everolimus Sodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC) Quick inquiry Where to buy Suppliers range | (19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC). Uses: For analytical and research use. Group: Chiral Molecules. Pack Sizes: 10MG. Catalog: APS003603. Format: Neat. Shipping: Dry ice. | |
(19Z)-seco-[4-O-(2-hydroxyethyl)] rapamycin sodium salt Quick inquiry Where to buy Suppliers range | (19Z)-seco-[4-O-(2-hydroxyethyl)] rapamycin sodium salt. Group: Biochemicals. Alternative Names: (2S)-1-[2-oxo-2-[(2R, 3R, 6S)-tetrahydro-2-hydroxy-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19Z, 21R)-14-hydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15, 19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic acid sodium salt; seco everolimus sodium salt. Grades: Highly Purified. CAS No. 220127-31-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C53H82NNaO14. US Biological Life Sciences. | Worldwide |
27-O-Desmethyl Rapamycin (27-O-Desmethyl Sirolimus) Quick inquiry Where to buy Suppliers range | A metabolite of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Grades: > 95%. Molecular formula: C50H77NO13. Mole weight: 900.17. | |
28-epi-Rapamycin Quick inquiry Where to buy Suppliers range | An epimer of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Synonyms: 28-epi-Rapamycin; (31S)-Rapamycin. Grades: > 95%. CAS No. 253431-35-5. Molecular formula: C51H79NO13. Mole weight: 914.2. | |
28-Ethyl-d4-hydroxy Rapamycin Quick inquiry Where to buy Suppliers range | 28-Ethyl-d4-hydroxy Rapamycin is the labeled analogue of 28-Ethylhydroxy Rapamycin (E678640), an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C53H79D4NO14, Molecular Weight: 962.25. US Biological Life Sciences. | Worldwide |
28-O-Methyl-rapamycin Quick inquiry Where to buy Suppliers range | 28-O-Methyl-rapamycin is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, RapaNui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. Group: Biochemicals. Grades: Highly Purified. CAS No. 159351-88-9. Pack Sizes: 1mg. Molecular Formula: C52H81NO13. US Biological Life Sciences. | Worldwide |
28-O-Methyl-rapamycin Quick inquiry Where to buy Suppliers range | 28-O-Methyl-rapamycin. Uses: For analytical and research use. Group: Chiral Molecules. Catalog: APS00327. Format: Neat. | |
42-O-[2-[[Hydroxy (2-bromoethoxy) phosphinyl]oxy]ethyl] Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin derivative. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
42-O- [2- [ [Hydroxy [2- (trimethylammonio) ethoxy] phosphinyl] oxy] ethyl] Rapamycin Inner Salt Quick inquiry Where to buy Suppliers range | A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin. Group: Biochemicals. Alternative Names: ATG 181. Grades: Highly Purified. CAS No. 1062645-51-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
42-O-[2-[[Hydroxy[2- (trimethylammonio) ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt >75% Quick inquiry Where to buy Suppliers range | 42-O-[2-[[Hydroxy[2- (trimethylammonio) ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt >75%. Uses: For analytical and research use. Group: Chiral Molecules; Pharmaceutical Toxicology. Catalog: APS00468. Format: Neat. | |
42-O-tert-Butyldi methyl silyloxyethyl-d4 Rapamycin Quick inquiry Where to buy Suppliers range | Intermediate to make Everolimus-d4. Group: Biochemicals. Alternative Names: 42-O- [2- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] ethyl-d4] rapamycin; Everolimus-d4 tert-Butyldimethylsilyl Ether. Grades: Highly Purified. CAS No. 1356839-88-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-O-Demethyl Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin metabolite. Group: Biochemicals. Alternative Names: 7-O-Demethyl Cypher; 7-O-Demethyl Rapammune; 7-O-Demethyl Sirolimus. Grades: Highly Purified. CAS No. 151519-50-5. Pack Sizes: 1mg. Molecular Formula: C??H??NO??, Molecular Weight: 900.15. US Biological Life Sciences. | Worldwide |
7-O-Desmethyl Rapamycin Quick inquiry Where to buy Suppliers range | A metabolite of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Synonyms: 7-O-Demethyl Cypher; 7-O-Demethyl Rapammune; 7-O-Demethyl Sirolimus. Grades: > 95%. CAS No. 151519-50-5. Molecular formula: C50H77NO13. Mole weight: 900.17. | |
Demethoxy Rapamycin Quick inquiry Where to buy Suppliers range | A derivative of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Synonyms: Demethoxyrapamycin; Rapamycin, 32-demethoxy-; Desmethoxyrapamycin; 83482-58-0; AY 24668; (16E, 24E, 26E, 28E)-1, 18-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)propan-2-yl]-30-methoxy-15, 17, 21, 23, 29, 35-hexamethyl-11, 36-dioxa-4-azatricyclo[30.3.1.04, 9]hexatriaconta-16, 24, 26, 28-tetraene-2, 3, 10, 14, 20-pentone; AY-24668; 19-O-Desmethoxy rapamycin. Grades: > 95%. CAS No. 83482-58-0. Molecular formula: C50H77NO12. Mole weight: 884.17. | |
InSolution Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin, CAS 53123-88-9, is a 5 mM (500 μg/109 μl) solution of Rapamycin (Cat. No. 553210) in DMSO. Selectively inhibits mTOR and blocks activation of p70 S6 Kinase (IC50 = 50 pM). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG, 1MG. Mole weight: 914.17. Catalog: IAR42415229. Assay: ≥98% (TLC). | |
InSolution Rapamycin in EtOH Quick inquiry Where to buy Suppliers range | The Rapamycin, also referenced under CAS 53123-88-9, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 914.17. Catalog: IAR42415230. Assay: ≥98% (HPLC). | |
Seco Rapamycin (sodium salt) Quick inquiry Where to buy Suppliers range | Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin which is a natural macrolide immunosuppressant. Seco-rapamycin inhibits the ChT-L (D) and PGPH (E) peptidases, and activate the T-L (F) peptidase and poorly activates mTOR. IC50: ChT-L. Uses: A decomposition product of rapamycin (r124000). Synonyms: sodium;(2S)-1-[2-[(2R,3R,6S)-2-hydroxy-6-[(2S,9S,11R,13R,14R,17R,21R)-14-hydroxy-22-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaenyl]-3-methyloxan-2-yl]-2-oxoacetyl]piperidine-2-c. Grades: > 95%. CAS No. 148554-65-8. Molecular formula: C51H78NNaO13. Mole weight: 936.15. | |
SMER28 (Small-Molecule Enhancer of Rapamycin-28, 6-Bromo-4-allylaminoquinazoline) Quick inquiry Where to buy Suppliers range | Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntingtons Disease (HD). Group: Biochemicals. Grades: Highly Purified. CAS No. 307538-42-7. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Temsirolimus (Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate, CCL-779) Quick inquiry Where to buy Suppliers range | Ester analog of rapamycin. Group: Biochemicals. Alternative Names: Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate; CCL-779. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Wortmannin-Rapamycin Conjugate Quick inquiry Where to buy Suppliers range | Wortmannin is a potent inhibitor of PI3K enzymes, and rapamycin blocks mTOR. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Synonyms: Wortmannin-Rapamycin Conjugate; 1067892-47-0; AKOS040755180. Grades: ≥98%. CAS No. 1067892-47-0. Molecular formula: C88H131N3O23. Mole weight: 1598.9. | |
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile Quick inquiry Where to buy Suppliers range | 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile is used as a reagent in the preparation of imidazo quinoline derivatives, compounds that act as mammalian target of rapamycin (mTOR) an phosphatidylinositol 3-kinase (PI3K-kinase) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 915019-52-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H17BrN4. US Biological Life Sciences. | Worldwide |
2,4-Dichloro-5,7-dihydro-7,7-dimethylfuro[3,4-d]pyrimidine Quick inquiry Where to buy Suppliers range | 2,4-Dichloro-5,7-dihydro-7,7-dimethylfuro[3,4-d]pyrimidine is used for preparation and study of pharmacokinetics, and antitumor activity of dihydrofuro[3,4-d]pyrimidines as inhibitors of mammalian target of rapamycin kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1260088-72-9. Pack Sizes: 25mg, 50mg. Molecular Formula: C8H8Cl2N2O, Molecular Weight: 219.07. US Biological Life Sciences. | Worldwide |
28-Epirapamycin Quick inquiry Where to buy Suppliers range | 28-Epirapamycin is an epimer of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, RapaNui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. Group: Biochemicals. Grades: Highly Purified. CAS No. 253431-35-5. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C51H79NO13. US Biological Life Sciences. | Worldwide |
28-Ethylhydroxy Everolimus-d4 Impurity Quick inquiry Where to buy Suppliers range | 28-Ethylhydroxy Everolimus-d4 Impurity is a deuterium labelled 28-Ethylhydroxy-everolimus Impurity (E945435). It is also an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C55H83D4NO15, Molecular Weight: 1006.3. US Biological Life Sciences. | Worldwide |
28-Ethylhydroxy Everolimus Impurity Quick inquiry Where to buy Suppliers range | 28-Ethylhydroxy Everolimus Impurity is an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C55H87NO15, Molecular Weight: 1002.28. US Biological Life Sciences. | Worldwide |
2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate Quick inquiry Where to buy Suppliers range | 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate is an intermediate in the synthesis of 28-Ethylhydroxy Rapamycin (E678640), which is an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H20Cl3NO2Si. US Biological Life Sciences. | Worldwide |
ABTL-0812 Quick inquiry Where to buy Suppliers range | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Synonyms: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. Grades: 98%. CAS No. 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. | |
Apitolisib Quick inquiry Where to buy Suppliers range | Apitolisib, also known as GDC-0980 and RG7422; or GNE390, is a dual PI3 kinase/mTOR inhibitor, is also an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor GDC-0980 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion. Synonyms: GDC-0980; GDC0980; GDC 0980; RG7422; RG-7422; RG 7422; GNE 390; GNE390; GNE-390; Apitolisib. CAS No. 1032754-93-0. Molecular formula: C23H30N8O3S. Mole weight: 498.606. | |
Autophinib Quick inquiry Where to buy Suppliers range | Autophinib is a novel potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin with IC50 values of 0.04 μM and 0.09 μM, respectively. Synonyms: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine. CAS No. 1644443-47-9. Molecular formula: C14H11ClN6O3. Mole weight: 346.73. | |
AZD-2014 Quick inquiry Where to buy Suppliers range | AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Synonyms: AZD2014, AZD-2014, AZD 2014, Vistusertib. Grades: 0.98. CAS No. 1009298-59-2. Molecular formula: C25H30N6O3. Mole weight: 462.554. | |
AZD-8055 Quick inquiry Where to buy Suppliers range | AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. Synonyms: AZD8055; AZD-8055; AZD 8055. Grades: 0.98. CAS No. 1009298-09-2. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
AZD8055 Quick inquiry Where to buy Suppliers range | A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Group: Biochemicals. Alternative Names: 5- [2, 4-Bis [ (3S) -3-methyl-4-morpholinyl] pyrido [2, 3-d] pyrimidin-7-yl] -2-methoxy Benzene methanol; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]- 2-methoxyphenyl] methanol; AZD 8055; [5- [2, 4-Bis ( (3S) -3-methylmorpholin-4-yl) pyrido [5, 6-e] pyrimidin-7-yl] -2-methoxyphenyl] methanol. Grades: Purified. CAS No. 1009298-09-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Compound 401 Quick inquiry Where to buy Suppliers range | Compound 401, a pyrimido-isoquinolinone compound, is a selective and cell-permeable inhibitor that has an reversible function on DNA-dependent protein kinase (DNA-PK). It is also a mammalian target of rapamycin (mTOR) with little affinity for 43 other com. Synonyms: 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-oneCompound 401; Compound-401; Compound401;168425-64-72-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-oneCHEMBL1792422-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-oneSCHEMBL10092321CTK4D2994S-7713; S 7713; S77132-(morpholin-4-yl)pyrimido[2,1-a]iso. Grades: >99 %. CAS No. 168425-64-7. Molecular formula: C16H15N3O2. Mole weight: 281.31. | |
Cyclosporin A Quick inquiry Where to buy Suppliers range | Potent immunosuppressant (same as FK-506 and rapamycin). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phos- phatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits n Group: Biochemicals. Alternative Names: Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A; Sandimmun; Sandimmune; Neoral; Optimmune; Restasis; OL 27-400. Grades: Highly Purified. CAS No. 59865-13-3. Pack Sizes: 5g, 10g. US Biological Life Sciences. | Worldwide |
Elaiophylin (Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846I, Gopalamicin, Salbomycin, Azalomycin B, SNA 4606-3) Quick inquiry Where to buy Suppliers range | Antibiotic. Active against Gram-positive bacteria, protozoa and tumors. Testosterone 5alpha-reductase inhibitor. Nitric oxide synthase (NOS) inhibitor. Immunosuppressive and enhances the antifungal activity of rapamycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 37318-06-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Elaiophyllin (Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846 I, Antibiotic SNA 4606-3, Azalomycin B, Gopalamicin, Salbomycin) Quick inquiry Where to buy Suppliers range | Elaiophyllin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophyllin inhibits testosterone 5-reductase. It has synergistic antifungal activity with its co-metabolite rapamycin. It has also been found to have anthelminthic and immunosuppressive activity and to inhibit nitric oxide synthesis. Elaiophyllin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumor cells. Group: Biochemicals. Alternative Names: Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846 I, Antibiotic SNA 4606-3, Azalomycin B, Gopalamicin, Salbomycin. Grades: Highly Purified. CAS No. 37318-06-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Everolimus Quick inquiry Where to buy Suppliers range | Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that can prevent allograft rejection, and may demonstrate activity in both the prevention and treatment of PTLDs in transplant patients. Group: Biochemicals. Alternative Names: Afinitor, Certican, RAD-001, Zortress; 40-O- (2-Hydroxyethyl) rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; RAD; RAD 001; SDZ-RAD; XIENCE V. Grades: Highly Purified. CAS No. 159351-69-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Everolimus Quick inquiry Where to buy Suppliers range | Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Synonyms: RAD-001; RAD001; RAD 001; Afinitor; Certican; Zortress; RAD001; SDZ-RAD. Grades: >98%. CAS No. 159351-69-6. Molecular formula: C53H83NO14. Mole weight: 958.24. | |
Everolimus 28-Ethylhydroxy Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 28-Ethylhydroxy Rapamycin. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
Everolimus, Cyclosporine and Tacrolimus Mix Standard Quick inquiry Where to buy Suppliers range | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
Everolimus-d4 Quick inquiry Where to buy Suppliers range | Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Alternative Names: 40-O-(2-Hydroxyethyl-d4)rapamycin; 42-O-(2-Hydroxy)ethyl-d4 Rapamycin; Afinitor-d4; Certican-d4; RAD-d4; RAD 001-d4; SDZ-RAD-d4; XIENCE V-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Everolimus O-Silyl Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin; 42-O-[2-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]ethyl]rapamycin. Grades: > 95%. CAS No. 159351-68-5. Molecular formula: C59H97NO14Si. Mole weight: 1072.52. | |
KU-55933 Quick inquiry Where to buy Suppliers range | KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. Synonyms: KU 55933; KU-55933; KU55933. CAS No. 587871-26-9. Molecular formula: C21H17NO3S2. Mole weight: 395.49. | |
L-Leucine-d3 Quick inquiry Where to buy Suppliers range | Labeled L-Leucine used as tracers to study human apolipoprotein B metabolism. L-Leucine is an essential amino acid. L-Leucine acts as a nutrient signal to stimulate protein synthesis. It has also activates the mammalian target of rapamycin kinase that regulates cell growth. Group: Biochemicals. Alternative Names: (2S)-2-Amino-4-methylpentanoic Acid-d3; (S)-(+)-Leucine-d3; (S)-2-Amino-4-methylpentanoic Acid-d3; (S)-2-Amino-4-methylvaleric Acid-d3; (S)-Leucine-d3; L-(+)-Leucine-d3; L-2-Amino-4-methylpentanoic Acid-d3; L-α-Aminoisocaproic Acid-d3; NSC 46709-d3. Grades: Highly Purified. CAS No. 87828-86-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
L-Leucine (L-Leu-OH) (non-animal) Quick inquiry Where to buy Suppliers range | L-Leucine is an essential amino acid. L-Leucine acts as a nutrient signal to stimulate protein synthesis. It has also activates the mammalian target of rapamycin kinase that regulates cell growth. Group: Biochemicals. Alternative Names: L-Leucine; (2S)-2-Amino-4-methylpentanoic Acid; (S)-(+)-Leucine; (S)-2-Amino-4-methylpentanoic Acid; (S)-2-Amino-4-methylvaleric Acid; (S)-Leucine; L-(+)-Leucine; L-2-Amino-4-methylpentanoic Acid; L-Norvaline, 4-methyl-; L-α-Aminoisocaproic Acid; Leu; Leucine; NSC 46709; (S)-2-Amino-4-methyl-Pentanoic Acid. Grades: Cell Culture Grade. CAS No. 61-90-5. Pack Sizes: 100g, 250g, 500g, 1Kg. Molecular Formula: C?H??NO?, Molecular Weight: 131.17. US Biological Life Sciences. | Worldwide |
ME-344 Quick inquiry Where to buy Suppliers range | ME-344 is an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Synonyms: ME344; ME 344. Grades: >98%. CAS No. 1374524-55-6. Molecular formula: C22H20O4. Mole weight: 348.39. | |
Metformin Hydrochloride Quick inquiry Where to buy Suppliers range | Inhibits hepatic gluconeogenesis by activating AMP-activated protein kinase (AMPK). A widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. Anti-cancer activity of metformin has been attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation. Group: Biochemicals. Alternative Names: N, N-Di methyl imidodicarbonimidic Diamide Hydrochloride; Diabetosan; Diabex; Glucophage; Metiguanide; Glucoform; Glucomet; Glucomin; Glucomine; Orabet; Siamformet; Walaphage; Glumetza. Grades: Highly Purified. CAS No. 1115-70-4. Pack Sizes: 10g, 50g, 100g. Molecular Formula: C4H12ClN5, Molecular Weight: 165.62. US Biological Life Sciences. | Worldwide |
mTOR-IN-1 Quick inquiry Where to buy Suppliers range | Selective inhibitors of mammalian target of rapamycin (mTOR) kinase based upon saturated heterocycles fused to a pyrimidine core were designed and synthesized. Each series produced compounds with Ki < 10 nM for the mTOR kinase and>500-fold selectivity over closely related PI3 kinases. This potency translated into strong pathway inhibition, as measured by phosphorylation of mTOR substrate proteins and antiproliferative activity in cell lines with a constitutively active PI3K pathway. Two compounds exhibiting suitable mouse PK were profiled in in vivo tumor models and were shown to suppress mTORC1 and mTORC2 signaling for over 12 h when dosed orally. Both compounds were additionally shown to suppress tumor growth in vivo in a PC3 prostate cancer model over a 14 day study. Synonyms: mTOR-IN-1; mTOR IN 1. Grades: >98%. CAS No. 1207358-59-5. Molecular formula: C25H30N8O2. Mole weight: 474.56. | |
mTOR Inhibitor, Ku-0063794 (rel-5- [2- [ (2R, 6S) -2, 6-Dimethyl-4-morpholinyl] -4- (4-morpholinyl) pyrido [2, 3-d] pyrimidin-7-yl] -2-methoxy Benzene methanol) Quick inquiry Where to buy Suppliers range | A potent mTOR (mammalian target of rapamycin) inhibitor (IC?? =~10nM for mTORC1 and mTORC2, respectively). Displays no activity against PI 3-kinase or 76 other kinases tested. Group: Biochemicals. Grades: Highly Purified. CAS No. 938440-64-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |