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| Product | Description | |
|---|---|---|
| Reactive Red 106 | Reactive Red 106. Uses: For warm exhaust and pad dying with excellent wet fastness. Group: Dyes (technical grade). Alternative Names: Diamira Brilliant Red GG; Remazol Brilliant Red GG. CAS No. 105635-66-3. Catalog: AP105635663. |  |
| Reactive Red 11 | 1g Pack Size. Group: Analytical Reagents, Stains & Indicators. Formula: C20H9Cl2N6Na3O9S2. CAS No. 12226-08-3. Prepack ID 90026961-1g. Molecular Weight 681.33. See USA prepack pricing. |  |
| Reactive Red 11 | Reactive Red 11. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Procion Red MX-8B. Appearance: Dark purple powder. CAS No. 12226-08-3. Molecular formula: C20H9Cl2N6Na3O9S2. Mole weight: 681.33. Product ID: ACM12226083. Alfa Chemistry ISO 9001:2015 Certified. Categories: C.I. Reactive Red 11. |  |
| REACTIVE RED 120 | REACTIVE RED 120. Uses: Designed for use in research and industrial production. Additional or Alternative Names: C.I.Reactivered120;ReactivebrilliantredKE-3B;reactivered120dye;PROCION RED H-E3B;REACTIVE RED 120;ProcionRedHEB;4,4'-[1,4-phenylenebis[imino(6-chloro-1,3,5-triazine-4,2-diyl)imino]]bis[5-hydroxy-6-[(2-sulphophenyl)azo]naphthalene-2,7-disulphonic acid;REA. Product Category: Reactive Dyes. CAS No. 61951-82-4. Molecular formula: C44H24Cl2N14Na6O20S6. Mole weight: 1469.96. Density: 2.01 g/cm³. Product ID: ACM61951824. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red 120, C.I. | Reactive Red 120, C.I. Group: Biochemicals. Grades: Highly Purified. CAS No. 61951-82-4. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C44H24O20N14S6Cl2Na6. US Biological Life Sciences. |  Worldwide |
| Reactive Red 15 | Reactive Red 15. Uses: Designed for use in research and industrial production. Additional or Alternative Names: C.I. Reactive red 15;C.I.Reactive Red 15;Cibacron Brilliant 2G-P;Dycosactive Brilliant Red K-2G;Youhaoreactive Brilliant Red K-2G. Product Category: Reactive Dyes. CAS No. 12238-01-6. Molecular formula: C25H14ClN7O13S4.4Na. Product ID: ACM12238016. Alfa Chemistry ISO 9001:2015 Certified. Categories: guanosine-2'-monophosphate. | |
| Reactive red 180 | Reactive red 180. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Brilliant Red F 3B-SF; Reactive Red 180; C.I. Reactive Red 180; Brilliant Red F 3B; 2,7-Naphthalenedisulfonic acid, 5-(benzoylamino)-4-hydroxy-3-[[1-sulfo-6-[[2-(sulfooxy)ethyl]sulfonyl]-2-naphthalenyl]azo]-, tetrasodium salt; C.I. 181055. CAS No. 98114-32-0. Molecular formula: C29H19N3Na4O17S5. Mole weight: 933.76. IUPACName: methyl(2R)-5-methyl-2-[(2,2,2-triphenylacetyl)amino]hex-4-enoate. Canonical SMILES: CC(=CCC(C(=O)OC)NC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C. Product ID: ACM98114320. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red 180, Technical grade Dye content, C.I. | Reactive Red 180, Technical grade Dye content, C.I. Group: Biochemicals. Grades: Purified. CAS No. 72828-03-6. Pack Sizes: 2g, 5g. US Biological Life Sciences. | Worldwide |
| Reactive Red 195 | Reactive Red 195. Group: Biochemicals. Alternative Names: CINO.RED.195; C.I. Reactive red 195; Red F3B; Reactive Brilliant Red M-3BE. Grades: Highly Purified. CAS No. 93050-79-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Reactive Red 198 | 5g Pack Size. Group: Analytical Reagents, Stains & Indicators. Formula: C27H18ClN7Na4O15S5. CAS No. 145017-98-7. Prepack ID 90026962-5g. Molecular Weight 968.21. See USA prepack pricing. | |
| Reactive Red 239 | Reactive Red 239. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Reactive Red 239;Reactive Red 241;1,5-Naphthalenedisulfonic acid, 2-8-4-chloro-6-4-2-(sulfooxy)ethylsulfonylphenylamino-1,3,5-triazin-2-ylamino-1-hydroxy-3,6-disulfo-2-naphthalenylazo-, pentasodium salt;Reactive red 241 (C.I. 18220);Brilliant Red 2BF;R. Product Category: Heterocyclic Organic Compound. CAS No. 89157-03-9. Product ID: ACM89157039. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red 24 | Reactive Red 24. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Reactive Brilliant Red K-2BP (C.I. Reactive Red 24);Reactive Red 24. Product Category: Reactive Dyes. CAS No. 70210-20-7. Molecular formula: C26H20ClN7O10S3?3Na. Mole weight: 788.08. Product ID: ACM70210207. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red 261 | Reactive Red 261. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Reactive Red 261;5-((4-Chloro-6-((4-((2-sulfooxy)-ethyl)-sulfonyl)-phenyl)-amino)-1,3,5-tria;Red 3BF;2,7-Naphthalenedisulfonic acid, 5-((4-chloro-6-((4-((2-(sulfooxy)ethyl)sulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)-4-hydroxy-3-(2-phenyldiazenyl)-. Product Category: Heterocyclic Organic Compound. CAS No. 80156-96-3. Product ID: ACM80156963. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red 45 (technical grade) | Reactive Red 45 (technical grade). Uses: Designed for use in research and industrial production. Additional or Alternative Names: C.I.18209. Product Category: Promotional Products. CAS No. 12226-22-1. Purity: Tech. Product ID: ACM12226221-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red 88 | Reactive Red 88. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Reactive Red 88;C.I. Reactive red 88;C.I.Reactive Red 88(18205);Helatyn Red-4BAN;Brilliant Red X-7B;5-(4,6-Dichloro-1,3,5-triazin-2-ylamino)-4-hydroxy-3-(4-methyl-2-sulfophenylazo)-2,7-naphthalenedisulfonic acid trisodium salt;5-[(4,6-Dichloro-1,3,5-tr. Product Category: Heterocyclic Organic Compound. CAS No. 61109-27-1. Product ID: ACM61109271. Alfa Chemistry ISO 9001:2015 Certified. | |
| Reactive Red Brown K-B3r | Reactive Red Brown K-B3r. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Reactive Brown 9;Reactive Red Brown K-B3r;C.I. Reactive Brown 9;Reactive red brown KM-B3R;Brown K-B3R;Adiactive Brown H-4R;Ambifix Brown H5BR;Begative Brown P-4R. Product Category: Reactive Dyes. CAS No. 12225-66-0. Molecular formula: C29H20IN7Na2O12S3. Mole weight: 927.58. Product ID: ACM12225660. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid | 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1 β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 6501-72-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H11NO3, Molecular Weight: 205.21. US Biological Life Sciences. | Worldwide |
| 2',7'-Dichlorofluorescein | 2',7'-Dichlorofluorescein. CAS No. 76-54-0. Product ID: CDC10-0131. Molecular formula: C20H10O5Cl2. Category: Cosmetic Color Additives. Product Keywords: Cosmetic Ingredients; Cosmetic Color Additives; 2',7'-Dichlorofluorescein; CDC10-0131; 76-54-0; C20H10O5Cl2; 200-968-6; MFCD00005047; 76-54-0. Purity: ~90% (TLC). Color: Orange to red-brown, Powder. EC Number: 200-968-6. Physical State: Crystalline. Solubility: ethanol: 25 mg/mL. Quality Level: 200. Storage: room temp. Application: 2',7'-Dichlorofluorescein has been used as an oxidation-sensitive fluorescent probe to measure ROS (reactive oxygen species) formation in cells. Boiling Point: 514.77°C (rough estimate). Melting Point: 280 °C (dec.) (lit.). Density: 0.79 g/cm3. Product Description: 2',7'-Dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2'7'-dichlorofluorescein diacetate is oxidized to 2'7'-dichlorofluorescein in the presence of ROS (reactive oxygen species).citation. |  |
| (2S)-2-amino-5-(((2R)-1-((carboxymethyl)amino)-1-oxo-3-sulfinopropan-2-yl)amino)-5-oxopentanoic acid | One of the impurities of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Synonyms: Glutathione Impurity 06. CAS No. 17297-99-3. Molecular formula: C10H17N3O8S. Mole weight: 339.32. |  |
| 5-TAMRA-SE | 5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester. CAS No. 150810-68-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0048. |  |
| 8-Nitroguanosine | A highly reactive redox-active nucleic acid derivative that is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis. Synonyms: 8-Nitro-D-guanosine; 2-imino-8-nitro-9-(beta-D-ribofuranosyl)-3,9-dihydro-2H-purin-6-ol; 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-nitro-1H-purin-6(9H)-one. Grades: ≥95%. CAS No. 337536-53-5. Molecular formula: C10H12N6O7. Mole weight: 328.24. | |
| 8-Nitroguanosine | A highly reactive redox-active nucleic acid derivative that is is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 337536-53-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| A 438079 | A potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5nM and 6.9nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10uM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300nM at rat and human P2X7 receptors, respectively. Developed by Abbott. Group: Biochemicals. Alternative Names: 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine Hydrochloride; P2X7 Purinergic Receptor Antagonist; A 438079; A438079; A-438079. Grades: Highly Purified. CAS No. 899507-36-9. Pack Sizes: 10mg. Molecular Formula: C??H?Cl?N? HCl, Molecular Weight: DMSO. US Biological Life Sciences. | Worldwide |
| AICAR phosphate | AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell. Synonyms: Acadesine phosphate; AICA Riboside phosphate. Grades: >98%. CAS No. 681006-28-0. Molecular formula: C9H17N4O9P. Mole weight: 356.23. | |
| α-Lipoic Acid | α-Lipoic Acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury. The exogenous compound is reduced intracellularly by enzymes. Its reduced form is involved in radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and regulating transcription factor activity, specifically NFkappaB. It also acts as a conenzyme that is required for the activity of pyruvate dehydrogenase and glycine decarboxylase, among other enzyme complexes. Studies show that it can prevent a decrease in the renal antioxidant defense system and prevent the increase of lipid peroxidation, platinum content and plasma creatinine concentrations. In other studies, lipoic acid decreased the phagocytosis of myelin by macrophages, acting as a non-specific scavenger of reactive oxygen species (ROS). Applications: A metabolic antioxidant that regulates nf-κb signal transduction. Group: Coenzymes. Synonyms: DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid. CAS No. 1077-28-7. Purity: ≥95%. Mole weight: 206.32. Form: Solid. DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid; α-Lipoic Acid; 1077-28-7. Cat No: COEC-041. |  |
| Amustaline dihydrochloride | Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-303 dihydrochloride. CAS No. 210584-54-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106991A. | |
| β-Carotene | β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS) , with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis , with anticancer activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Provitamin A; beta-Carotene. CAS No. 7235-40-7. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N0411. | |
| β-Nicotinamide adenine dinucleotide phosphate | β-Nicotinamide adenine dinucleotide 2?-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2?-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Applications: A common form of nadp. Group: Coenzymes. Synonyms: β-NADP; Coenzyme II; TPN; Codehydrogenase II; NADP; Triphosphopyridine nucleotide; Nicotinamide adenine dinucleotide phosphate hydrate. Enzyme Commission Number: 200-178-1. CAS No. 53-59-8. Purity: > 95%. β-NADP. Mole weight: 743.41. Appearance: Powder. Storage: Store at -20°C. β-NADP; Coenzyme II; TPN; Codehydrogenase II; NADP; Triphosphopyridine nucleotide; Nicotinamide adenine dinucleotide phosphate hydrate. Cat No: NATE-1077. | |
| β-Nicotinamide-Adenine Dinucleotide Phosphate, Oxidized Form (β-NADP-K) | β-Nicotinamide adenine dinucleotide 2?-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2?-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Group: Coenzymes. Synonyms: β-Nicotinamide-Adenine Dinucleotide Phosphate, Oxidized Form (β-NADP-K); β-Nicotinamide-Adenine Dinucleotide Phosphate;. CAS No. 698999-85-8. Purity: Determined by increase in absorbance at 340nm on enzymatic reduction with G6PDH* at pH 10 (More than 95%) *G6PDH = Glucose-6-phosphate dehydrogenase (yeast) (EC 1.1.1.49.). β-NADP-K. Mole weight: 781.5. Storage: Keep tightly stoppered in the dark below 5°C. Moisture will reduce the purity. For prolonged storage, keep below-20°C. β-Nicotinamide-Adenine Dinucleotide Phosphate, Oxidized Form (β-NADP-K); β-Nicotinamide-Adenine Dinucleotide Phosphate; β-NADP-K. Cat No: NATE-0788. | |
| β-Nicotinamide adenine dinucleotide phosphate, reduced tetra(cyclohexylammonium) salt | β-Nicotinamide adenine dinucleotide 2'-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2'-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) that work together in a wide range of enzyme catalyzed oxidation reduction reactions. One of the pairs actions is that it facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is also used in a variety of antioxidation mechanisms where it protects against reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Applications: An electron donor and a cofactor for nitric oxide synthetase. Group: Coenzymes. Synonyms: β-NADPH; NADPH; TPNH. CAS No. 100929-71-3. Purity: ≥95%. Mole weight: 1142.12. Appearance: Powder. Form: Solid. β-NADPH; NADPH; TPNH; β-Nicotinamide adenine dinucleotide phosphate, reduced tetra(cyclohexylammonium) salt; 100929-71-3. Cat No: COEC-079. | |
| Biotin hydrazide | Biotin hydrazide is a biotinyl derivative that can be used as a probe for the determination of protein carbonylation, which is a component of several diseases. Protein carbonylation, an irreversible post translational modification (PTM), is caused by attack of reactive oxygen species (ROS), numerous lipid oxidation products (such as α,β-unsaturated γ-hydroxyalkenals), or nonemzymatic glycation resulting in the loss of protein function. Biotin hydrazide is a preferred carbonyl-reactive probe for its direct reaction and chemistry and no requirement of additional catalysts or reducing agents. Biotin hydrazide exclusively and readily derivatizes carbonyl groups at pH 5.5, which facilitates its use to measure carbonylated proteins in biological samples. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (+)-Biotin Hydrazide; Biotin-Hz; Hydrazide Biotin; Biotine Hydrazide. Product Category: Heterocyclic Organic Compound. Appearance: white or slightly yellow powder. CAS No. 66640-86-6. Molecular formula: C10H18N4O2S. Mole weight: 258.3 g/mol. Purity: 0.98. IUPACName: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide. Canonical SMILES: C1C2C(C(S1)CCCCC(=O)NN)NC(=O)N2. Density: 1.243 g/cm³. ECNumber: 613-970-0. Product ID: ACM66640866. Alfa Chemistry ISO 9001:2015 Certified. | |
| BODIPY FL hydrazide | BODIPY FL Hydrazide is a green-fluorescent dye, BODIPY FL Hydrazide is reactive with aldehyde/ketone on polysaccharides and glycoproteins, yielding a reversible Schiff base product that can be transformed to a stable linkage using a reducing agent like sodium borohydride or sodium cyanoborohydride. (λ ex =495 nm, λ em =516 nm) [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 178388-71-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-114351. | |
| Cy5-NHS ester | Cy5-NHS ester is a red-fluorescent probe that is reactive with primary amines on biomolecules such as proteins and nucleic acids. Synonyms: Sulfo-Cyanine5, SE (ethyl);Cyanine 5, SE; 2-[5-[1-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, Inner Salt. Grades: 98%. CAS No. 146368-14-1. Molecular formula: C37H43N3O10S2. Mole weight: 753.882. | |
| Cyanine3 carboxylic acid chloride | Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1032678-01-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1623. | |
| cypemycin cysteine dehydrogenase (decarboxylating) | Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide. Group: Enzymes. Synonyms: cypemycin decarboxylase; CypD. Enzyme Commission Number: EC 1.3.99.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1436; cypemycin cysteine dehydrogenase (decarboxylating); EC 1.3.99.36; cypemycin decarboxylase; CypD. Cat No: EXWM-1436. | |
| Cys-glutathione-[13C3,15N] | Cys-glutathione-[13C3,15N] is the labelled analogue of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione can be used not only as medicine, but also as a base material for functional foods. It is widely used in functional foods such as delaying aging, enhancing immunity, and anti-tumor. Synonyms: [13C3,15N]-Cys-glutathione; [1,2,3-13C3,15N]-Cys-glutathione; γ-glutamyl[13C3,15N]cysteinylglycine. CAS No. 1028814-07-4. Molecular formula: C7[13C]3H17N2[15N]O6S. Mole weight: 311.29. | |
| Danshensu | Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species ( ROS ) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC 50 of 0.97?μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Dan shen suan A; Salvianic acid A. CAS No. 76822-21-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1913. | |
| Danshensu sodium | Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species ( ROS ) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC 50 of 0.97?μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Dan shen suan A sodium; Salvianic acid A sodium. CAS No. 81075-52-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1913A. | |
| Desmosterol | Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species ( ROS ) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 313-04-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113224. | |
| Diethyl succinate | Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species ( ROS ), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Diethyl Butanedioate. CAS No. 123-25-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-Y0836. | |
| Dihydroethidium | Dihydroethidium is a cell-permeable blue fluorescent dye, which intercalates with nucleic acids and emits a red fluorescence detectable qualitatively by fluorescent microscopy or quantitatively by HPLC. It is a superoxide indicator. It exhibits blue fluorescence in the cytosol until oxidizedto ethidium, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red. It is neuroprotective by reducing superoxide in mice after stroke. It has been used to detect reactive oxygen species during the phagocytic respiratory burst and for the detection of intracellular superoxide in cultured cells. Synonyms: Hydroethidine; PD-MY 003; 5-ethyl-5,6-dihydro-6-phenyl-3,8-phenanthridinediamine; 5-Ethyl-6-phenyl-6H-phenanthridine-3,8-diamine. Grades: ≥98%. CAS No. 104821-25-2. Molecular formula: C21H21N3. Mole weight: 315.4. | |
| Dihydrofluorescein diacetate | Dihydrofluorescein diacetate is a chemical used for intracellular staining. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as 2', 7'-dichlorodi hydrofluorescein and Dihydrorhodamine 123. Dihydrofluorescein diacetate is first hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by hydrogen peroxide. Group: Biochemicals. Grades: Highly Purified. CAS No. 35340-49-9. Pack Sizes: 500mg, 1000mg. Molecular Formula: C24H18O7, Molecular Weight: 418.4. US Biological Life Sciences. | Worldwide |
| Ebselen | Ebselen, also known as SPI-1005, is an organoselenium compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation. Synonyms: SPI-1005; SPI1005; SPI 1005; Ebselen; PZ 51; PZ51; PZ-51; DR3305; DR 3305; DR-3305. Grades: >98%. CAS No. 60940-34-3. Molecular formula: C13H9NOSe. Mole weight: 274.192. | |
| Edaravone Trimer | Edaravone Trimer is an impurity of Edaravone. Edaravone is a novel potent free radical scavenger that reduces reactive oxygen species, inhibits apoptosis, and blocks nonenzymatic peroxidation and lipoxygenase activity. Synonyms: 5,?5',?5''-trimethyl-2,?2',?2''-triphenyl-[4,?4':4',?4''-Ter-4H-pyrazole]?-3,?3',?3''(2H,?2'H,?2''H)?-trione; 4,4-bis(3-methyl-5-oxo-1-phenyl(2-pyrazolin-4-yl))-3-methyl-1-phenyl-2-pyrazol in-5-one; 2-Phenyl-5-methyl-4,4-bis(2-phenyl-3-oxo-5-methyl-3,4-dihydro-2H-pyrazole-4-yl)-3,4-dihydro-2H-pyrazole-3-one. CAS No. 68195-63-1. Molecular formula: C30H26N6O3. Mole weight: 518.577. | |
| ERO1 Inhibitor II, EN460 | A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1alpha and inhibits its activity (IC50 = 1.9uM). Also prevents ERO1 re-oxidation both in vitro and in mouse embryonic fibroblasts. Activates the unfolded protein response and protects ER-stressed 293T cells. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. EN460 binding to ERO1alpha is shown to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme. Its inhibitory action appears to be irreversible, however addition of FAD and tris (hydroxypropyl) phosphine can restore some enzyme activity. Group: Biochemicals. Alternative Names: (Z)-2-Chloro-5-(4,5-dihydro-5-oxo-4-((5-phenyl-2-furanyl)methylene)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic Acid, (Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic Acid. Grades: Highly Purified. CAS No. 496807-64-8. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 460.8. US Biological Life Sciences. | Worldwide |
| ES 936 | ES 936 is a potent and specific NQO1 inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). NQO1 is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192820-78-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100367. | |
| EUK-118 ((acetato- kO)[[2, 2'- [1, 2- ethanediylbis[(nitrilo- κ N)methylidyne]]bis[3, 5- dimethoxyphenolato- κO]](2- )]- manganese) | A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC50 value of 2.0um. Group: Biochemicals. Grades: Highly Purified. CAS No. 186299-34-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| EUK-124 (chloro[[2, 2- [1, 2- ethanediylbis[(nitrilo- κN)methylidyne) | A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. EUK 124 inhibits superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with an IC?? value of 5.0um. Group: Biochemicals. Grades: Highly Purified. CAS No. 186299-35-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Feprazone | Feprazone (DA2370; Prenazone), an analogue of Phenylbutazone (HY-B0230), is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX)-2. Feprazone ameliorates free fatty acid (FFA)-induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA2370; Prenazone; Zepelin. CAS No. 30748-29-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-114911. | |
| Fluorescein-PEG6-Amine | Fluorescein-PEG6-Amine is a fluorescein dye with excitation/emmission maximum 494/517 nm containing a free amine group, which can be reactive with cabroxylic acid, activated NHS ester, carbonyl (ketone, aldehyde) etc. The hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Uses: For industrial and laboratory use. Product Category: Fluorescein-PEG. Molecular formula: C35H43N3O11S. Mole weight: 713.8 g/mol. Purity: 0.98. Product ID: DYE-FLU-0072. Alfa Chemistry ISO 9001:2015 Certified. | |
| FY26 (complex) | This active moleculr is a Os(II) anticancer drug candidate. It can generate reactive oxygen species and disrupt the redox balance in cancer cells. Using FY26 and nontoxic doses of L-BSO together allows the potentiation of its anticancer activity and inpartantly, it improves the selectivity for cancer cells versus normal fibroblasts. FY26 can shut down a cancer cell by exploiting weaknesses inherent in their energy generation. Uses: Anti-cancer. Synonyms: FY26; FY-26; FY 26. Osmium(1+)?, [N, ?N-dimethyl-4-[2-(2-pyridinyl-κN)?diazenyl-κN1]?benzenamine]?iodo[(1, ?2, ?3, ?4, ?5, ?6-η)?-1-methyl-4-(1-methylethyl)?benzene]?-, hexafluorophosphate(?1-) (1:1). Grades: 98%. CAS No. 1255143-82-8. Molecular formula: C23H28F6IN4OsP. Mole weight: 822.60. | |
| Gamma-L-glutamyl-L-cysteine (γ-Glu-Cys) | γ-L-Glutamyl-L-cysteine (γ-Glu-Cys) is a substrate used for the biosynthesis of L-glutathione by glutathione synthetase(s). γ-Glu-Cys is generated by the cleavage of the Cys-Gly peptide bond of glutathione. It is also essential for the formation of phytochelatins, which are cysteine-rich thiol-reactive peptides. Group: Biochemicals. Alternative Names: γ-Glu-Cys; γ-L-Glutamyl-L-cysteine, des-Gly-glutathione reduced. Grades: Purified. CAS No. 636-58-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C8H14N2O5S, Molecular Weight: 250.27. US Biological Life Sciences. | Worldwide |
| Ginsenoside Rk1 | Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures [1]. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB [2]. Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis [1]. Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species ( ROS ) generation and blocking PI3K/Akt pathway [3]. Uses: Scientific research. Group: Natural products. CAS No. 494753-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N2515. | |
| Glucopiericidin A | Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts. Synonyms: 10'-O-beta-D-Glucopyranosylpiercidin A1; Antibiotic MT 1882-II; 2-[(2E,5E,7E)-10-[(2R,3R,4S,5S,6R,9R,10R)-2-[(E)-but-2-en-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]oxy-3-methyldeca-2,5,7-trienyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one. Grades: ≥95%. CAS No. 108073-65-0. Molecular formula: C31H47NO9. Mole weight: 577.71. | |
| Glutathione | Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione can be used not only as medicine, but also as a base material for functional foods. It is widely used in functional foods such as delaying aging, enhancing immunity, and anti-tumor. Uses: Ingredient of health care products. Synonyms: L-γ-Glutamyl-L-cysteinyl-glycine; Agifutol S; Bakezyme RX; Copren; Deltathione; GSH; Glutathion; Glutathione-SH; Glutide; Glutinal; Isethion; L-Glutathione; Neuthion; Reduced glutathione; Tathion; Tathione; Triptide; N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine. Grades: >98%. CAS No. 70-18-8. Molecular formula: C10H17N3O6S. Mole weight: 307.32. | |
| Glutathione EP Impurity A | One of the impurities of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Synonyms: Cysteinylglycine; L-Cysteinylglycine; Cys-Gly; L-Cysteinyl-glycine; N-L-cysteinylglycine. Grades: 95%. CAS No. 19246-18-5. Molecular formula: C5H10N2O3S. Mole weight: 178.21. | |
| Glutathione EP Impurity C | Oxiglutatione is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, Oxiglutatione acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis. S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by an oxiglutatione-induced increase in GGT activity. Oxiglutatione may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo. Synonyms: L-Glutathione Oxidised; Oxiglutatione; glutathione disulfide; GSSG; NOV-002; NOV 002; NOV002. Grades: >98%. CAS No. 27025-41-8. Molecular formula: C20H32N6O12S2. Mole weight: 612.63. | |
| Glutathione-glycine-[13C2,15N] | Glutathione-glycine-[13C2,15N] is the labelled analogue of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione can be used not only as medicine, but also as a base material for functional foods. It is widely used in functional foods such as delaying aging, enhancing immunity, and anti-tumor. Synonyms: L-gamma-Glutamyl-L-cysteinyl-13C2,15N-glycine. CAS No. 815610-65-2. Molecular formula: C8[13C]2H17N2[15N]O6S. Mole weight: 310.30. | |
| Glycine, N-(N-L-gamma-glutamyl-D-cysteinyl)- | One of the impurities of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Synonyms: (S)-2-amino-5-(((S)-1-((carboxymethyl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-5-oxopentanoic acid; Glutathione Impurity 09; γ-Glu-D-Cys-Glu. CAS No. 128960-77-0. Molecular formula: C10H17N3O6S. Mole weight: 307.33. | |
| Histamine dihydrochloride | Histamine dihydrochloride is a reactive oxygen species ( ROS ) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 56-92-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B0722. | |
| hydrogen:quinone oxidoreductase | Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen). Group: Enzymes. Synonyms: hydrogen-ubiquinone oxidoreductase; hydrogen:menaquinone oxidoreductase; membrane-bound hydrogenase; quinone-reactive Ni/Fe-hydrogenase. Enzyme Commission Number: EC 1.12.5.1. CAS No. 151616-65-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0522; hydrogen:quinone oxidoreductase; EC 1.12.5.1; 151616-65-8; hydrogen-ubiquinone oxidoreductase; hydrogen:menaquinone oxidoreductase; membrane-bound hydrogenase; quinone-reactive Ni/Fe-hydrogenase. Cat No: EXWM-0522. | |
| Imeglimin hydrochloride | Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species ( ROS ) production, increases mitochondrial DNA and improves mitochondrial function [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD 387008 hydrochloride. CAS No. 775351-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14771A. | |
| Indole-3-propionamide | Indole-3-propionamide is a novel endogenous indole derivative which has a similar structure to melatonin. It acts as a stabilizer of energy metabolism, thereby reducing reactive oxygen species (ROS) production. Group: Biochemicals. Grades: Highly Purified. CAS No. 5814-93-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H12N2O, Molecular Weight: 188.23. US Biological Life Sciences. | Worldwide |
| IPAM (Indole 3-propionamide) | A cell-permeable indole derivative that acts as an antioxidant and mitochondrial metabolism modifier. IPAM binds to the rate-limiting component of oxidative phosphorylation in complex I of the respiratory chain and acts as a stabilizer of energy metabolism, thereby reducing the production of reactive oxygen species (ROS). Group: Biochemicals. Alternative Names: Indole 3-propionamide. Grades: Highly Purified. CAS No. 5814-93-7. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) | A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences. | Worldwide |
| Lactate Dehydrogenase A Inhibitor, FX11 (LDHA Inhibitor I, LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I) | A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8uM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866. Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-34-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Leteprinim potassium | Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AIT-082. CAS No. 192564-13-9. Pack Sizes: 5 mg. Product ID: HY-120251A. | |
| Letosteine | Letosteine is an orally active, potent and safe expectorant. Letosteine has the effect of scavenging reactive oxygen species (ROS). Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53943-88-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107355. | |
| monodehydroascorbate reductase (NADH) | This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. This enzyme participates in ascorbate and aldarate metabolism. In plants, the monodehydroascorbate reductase (MDAR) is an enzymatic component of the glutathione-ascorbate cycle that is one of the major antioxidant systems of plant cells for the protection against the damages produced by reactive oxygen species (ROS). The MDAR activity has been described in several cell compartments, such as chloroplasts, cytosol, mitochondria, glyoxysomes, and leaf peroxisomes. Group: Enzymes. Synonyms: NADH:semidehydroascorbic acid oxidoreductase; MDHA; s. Enzyme Commission Number: EC 1.6.5.4. CAS No. 9029-26-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1593; monodehydroascorbate reductase (NADH); EC 1.6.5.4; 9029-26-9; NADH:semidehydroascorbic acid oxidoreductase; MDHA; semidehydroascorbate reductase; AFR; AFR-reductase; ascorbic free radical reductase; ascorbate free radical reductase; SOR; MDAsA reductase (NADPH) SDA reductase; NADH:ascorbate radical oxidoreductase; NADH-semidehydroascorbate oxidoreductase; ascorbate free-radical reductase NADH:AFR oxidoreductase; monodehydroascorbate reductase (NADH2). Cat No: EXWM-1593. | |
| NADP-retinol dehydrogenase | Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary β-carotene by EC 1.13.11.63 (β-carotene 15,15'-dioxygenase). Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH. Group: Enzymes. Synonyms: all-trans retinal reductase (ambiguous); all-trans-retinol dehydrogenase; NADP(H)-dependent retinol dehydrogenase/reductase; RDH11; RDH12; RDH13; RDH14; retinol dehydrogenase 12; retinol dehydrogenase 14; retinol dehydrogenase [NADP+]; RalR1; PSDR1. Enzyme Commission Number: EC 1.1.1.300. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0211; NADP-retinol dehydrogenase; EC 1.1.1.300; all-trans retinal reductase (ambiguous); all-trans-retinol dehydrogenase; NADP(H)-dependent retinol dehydrogenase/reductase; RDH11; RDH12; RDH13; RDH14; retinol dehydrogenase 12; retinol dehydrogenase 14; retinol dehydrogenase [NADP+]; RalR1; PSDR1. Cat No: EXWM-0211. | |
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