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RGD peptide is an inhibitor of integrin-ligand interactions. Synonyms: H-Gly-Arg-Gly-Asp-Asn-Pro-OH; RGD peptide (GRGDNP); glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-asparagyl-L-proline; (S)-1-((6S,12S,15S)-1-amino-15-(2-amino-2-oxoethyl)-6-(2-aminoacetamido)-12-(carboxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecane)pyrrolidine-2-carboxylic acid. Grades: 98%. CAS No. 114681-65-1. Molecular formula: C23H38N10O10. Mole weight: 614.61.
RGD peptide (GRGDNP)
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 114681-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1740.
RGD-targeted Proapoptotic Peptide
RGD-targeted Proapoptotic Peptide is RGD-4C conjugated to a full D proapoptotic peptide. Synonyms: RGD-4C-GG-(klaklak)2-NH2; H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-OH (Disulfide bridge: Cys2-Cys10, Cys4-Cys8); D-Lysine, L-alanyl-L-cysteinyl-L-α-aspartyl-L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-cysteinylglycylglycyl-D-lysyl-D-leucyl-L-alanyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-, cyclic(2?10),(4?8)-bis(disulfide). Grades: ≥95%. CAS No. 2243207-09-0. Molecular formula: C116H199N35O31S4. Mole weight: 2708.34.
(1R, 3S) -3-Aminocyclopentane carboxylic Acid
(1R, 3S) -3-Aminocyclopentane carboxylic Acid is used in the synthesis of aminocyclopentane carboxylic acid-containing cyclic RGD peptides. It is also used to prepare BMS-457, a potent and selective CCR1 antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 71830-08-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H11NO2, Molecular Weight: 129.16. US Biological Life Sciences.
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Arg-Gly-Asp
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. Synonyms: Arginyl-Glycyl-Aspartic acid; RGD peptide. Grades: Min 98%. CAS No. 99896-85-2. Molecular formula: C12H22N6O6. Mole weight: 346.34.
Arg-Gly-Asp-Cys acetate
Arg-Gly-Asp-Cys, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; RGDC peptide. Molecular formula: C17H31N7O9S. Mole weight: 509.54.
Arg-Gly-Asp-Ser
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42.
Arg-Gly-Glu-Ser
Arg-Gly-Glu-Ser, a RGD-related peptide, is a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets. Synonyms: H-Arg-Gly-Glu-Ser-OH; L-arginyl-glycyl-L-alpha-glutamyl-L-serine; (4S) -4-[[2-[[ (2S) -2-amino-5- (diaminomethylideneamino) pentanoyl]amino]acetyl]amino]-5-[[ (1S) -1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid; RGES. Molecular formula: C16H29N7O8. Mole weight: 447.45.
CGGRGD acetate
CGGRGD acetate is a RGD derivative with cysteine as the n-terminal. CGGRGD was synthesized by solid phase peptide synthesis technology, and amino2-cyanobenzothiazole (2-cyanobenzothiazole) (2-cyanobenzothiazole (CBT) was added on the surface of PCL fiber for ammoniation. Molecular formula: C21H37N9O11S. Mole weight: 623.65.
(-)-cis-3-Aminocyclopentanecarboxylic acid
(-)-(1R,3S)-3-Aminocyclopentanecarboxylic acid is used in the synthesis of aminocyclopentanecarboxylic acid-containing cyclic RGD peptides. It is also used to prepare BMS-457, a potent and selective CCR1 antagonist. Synonyms: (-)-(1R,3S)-3-Aminocyclopentanecarboxylic acid; Cyclopentanecarboxylic acid, 3-amino-, (1R,3S)-; (1R,3S)-3-Aminocyclopentanecarboxylic acid; Cyclopentanecarboxylic acid, 3-amino-, (1R-cis)-; (1R,3S)-3-Aminocyclopentanecarboxylic acid. Grades: ≥95%. CAS No. 71830-08-5. Molecular formula: C6H11NO2. Mole weight: 129.16.
Cyclo(-Arg-Ala-Asp-D-Phe-Cys)
Cyclo(-Arg-Ala-Asp-D-Phe-Cys) is a control peptide for the αvβ3 integrin binding cyclic RGD peptide c(RGDfC). Synonyms: c(RADfC); Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl-L-arginyl). Grades: ≥95%. CAS No. 1055991-02-0. Molecular formula: C25H36N8O7S. Mole weight: 592.68.
Cyclo(-Arg-Ala-Asp-D-Tyr-Lys)
Cyclo(-Arg-Ala-Asp-D-Tyr-Lys) is a control peptide for c(RGDyK). Synonyms: c(RADyK); cyclo[L-alanyl-L-alpha-aspartyl-D-tyrosyl-L-lysyl-L-arginyl]; Cyclo(L-alanyl-L-α-aspartyl-D-tyrosyl-L-lysyl-L-arginyl). Grades: ≥95%. CAS No. 1193347-53-3. Molecular formula: C28H43N9O8. Mole weight: 633.71.
Cyclo(-Arg-Gly-Asp-D-Phe-Glu)
Cyclo(-Arg-Gly-Asp-D-Phe-Glu), a cyclic RGD peptide, has been used as an integrin ligand for radiologic labeling, on gold nanoparticles and for the delivery of nanomedicine. Its negative control c(RADfE) is also available. Synonyms: cyclo[L-arginyl-glycyl-L-alpha-aspartyl-D-phenylalanyl-L-alpha-glutamyl]; c(RGDfE); Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-α-glutamyl). Grades: ≥95%. CAS No. 756500-22-8. Molecular formula: C26H36N8O9. Mole weight: 604.62.
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Cyclo(RGDfV) TFA; C(RGDfV) TFA. CAS No. 199807-33-5. Pack Sizes: 5 mg. Product ID: HY-P1613A.
Cyclo(-Arg-Gly-Asp-D-Tyr-Lys(Tide FluorTM 7WS))
Cyclo(-Arg-Gly-Asp-D-Tyr-Lys(Tide FluorTM 7WS)) is a cyclic RGD peptide labeled with a fluorophore absorbing at 749 nm and emitting at 775 nm. Synonyms: c[RGDyK(Tide FluorTM 7WS)]. Grades: ≥90%. Molecular formula: C27H41N9O8 + dye. Mole weight: 1378.
Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro)
Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro), a cyclic RGD peptide, stimulates the contraction of rat afferent arterioles and is used for targeted delivery of cisplatin. It inhibits the adhesion of mouse B16 melanoma cells to fibronectin coated wells. Synonyms: cyclo[L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycyl]; c(GRGDSP). Grades: ≥90%. CAS No. 135432-37-0. Molecular formula: C22H35N9O9. Mole weight: 569.58.
Cyclo(RADfK)
Cyclo(RADfK) is a selective α(V)β(3) integrin ligand. It has been used for research, therapy, and diagnosis of neoangiogenesis. It is also used as a negative control for the cyclo (-RGDfK-), the RGD peptide, which are modulators of cell adhesion and are recognized by several members of the integrin family. It has low affinity binding to integrin peptides. Uses: Cyclo(radfk) has been used for research, therapy, and diagnosis of neoangiogenesis. it is also used as a negative control for the cyclo (-rgdfk-), the rgd peptide. Synonyms: c(RADfK); cyclo[L-alanyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl]. Grades: ≥95%. CAS No. 756500-23-9. Molecular formula: C28H43N9O7. Mole weight: 617.70.
cyclo[RGD(DMNPB)fK]
cyclo[RGD(DMNPB)fK], a photosensitive caged RGD peptide, is used for efficient phototriggering of cell attachment. Synonyms: Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl), 2-(4,5-dimethoxy-2-nitrophenyl)-1-methylpropyl ester. CAS No. 1035105-00-0. Molecular formula: C39H56N10O11. Mole weight: 840.94.
Cyclo(RGDyC)
Cyclo(RGDyC) is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1206475-79-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5840.
Fluciclatide F-18
Fluciclatide-F18 is a radiopharmaceutical compound of a small synthetic cyclic peptide containing an RGD-sequence (Arg-Gly-Asp) labeled with the positron-emitting isotope fluorine F 18 that may be used to selectively image tumor cells and tumor vasculature by PET imaging. The RGD motif of fluciclatide F 18 selectively binds to the alphaVbeta3 integrin receptor, commonly upregulated on the surfaces of tumor cells and endothelial cells of tumor vasculature. This agent may be of use in visualizing and quantifying the development of tumor vascularity in response to antiangiogenic agents. Synonyms: [18F]AH111585; 18F-Fluciclatide; Fluciclatide (f-18). CAS No. 879894-01-6. Molecular formula: C75H115FN18O27S3. Mole weight: 1815.02.
GRGDSP
GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor which can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Synonyms: H-Gly-Arg-Gly-Asp-D-Ser-Pro-OH; glycyl-L-arginyl-glycyl-L-alpha-aspartyl-D-seryl-L-proline. Grades: ≥95%. CAS No. 91037-75-1. Molecular formula: C22H37N9O10. Mole weight: 587.58.
GRGDSP acetate
GRGDSP acetate, a synthetic linear RGD peptide, is an integrin inhibitor that can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Synonyms: H-Gly-Arg-Gly-Asp-Ser-Pro-OH.CH3CO2H; Glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-proline acetic acid; L-Proline, 1-[N-[N-[N-(N2-glycyl-L-arginyl)glycyl]-L-α-aspartyl]-L-seryl]-, acetate. Grades: ≥95%. Molecular formula: C24H41N9O12. Mole weight: 647.64.
GRGDSPK
GRGDSPK is a competitive and reversible inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules. Synonyms: EMD 56574; H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH; glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-lysine; N2-(1-(N-(N-(N-(N2-Glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-L-seryl)-L-prolyl)-L-lysine. Grades: 95%. CAS No. 111119-28-9. Molecular formula: C28H49N11O11. Mole weight: 715.76.
H-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH
H-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH, an RGD peptide, inhibits the adhesion of fibronectin to fibroblasts. Synonyms: R-G-D-S-P-A-S-S-K-P; L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-lysyl-L-proline; N5-(Diaminomethylene)-L-ornithylglycyl-L-α-aspartyl-L-seryl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-lysyl-L-proline. Grades: 95%. CAS No. 91575-25-6. Molecular formula: C40H68N14O16. Mole weight: 1001.05.
H-Arg-Gly-Asp-Ser-Pro-OH
H-Arg-Gly-Asp-Ser-Pro-OH is an RGD peptide used to improve the biocompatibility of titanium dental implant model surfaces. It modified to enhance the cell viability in PEG-based hydrogels. Synonyms: H-RGDSP-OH; L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-proline. Grades: ≥95%. CAS No. 110697-44-4. Molecular formula: C20H34N8O9. Mole weight: 530.53.
H-Arg-Gly-Glu-Ser-OH
H-Arg-Gly-Glu-Ser-OH is a RGD-related peptide, which is a control of RGDS to inhibit the binding activity of fibrinogen and activated platelet. Synonyms: RGES; H-RGES-OH; L-arginyl-glycyl-L-alpha-glutamyl-L-serine; L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-glutamyl)-; rgespeptide. Grades: 95%. CAS No. 93674-97-6. Molecular formula: C16H29N7O8. Mole weight: 447.44.
H-Arg-Gly-Glu-Ser-OH.TFA
H-Arg-Gly-Glu-Ser-OH.TFA is a RGD-related peptide, which is a control of RGDS to inhibit the binding activity of fibrinogen and activated platelet. Synonyms: RGES.TFA; H-RGES-OH.TFA; L-arginyl-glycyl-L-alpha-glutamyl-L-serine trifluoroacetic acid. Grades: >98%. Molecular formula: C16H29N7O8.C2HF3O2. Mole weight: 561.47.
Integrin Binding Peptide
Integrin Binding Peptide is a peptide containing the cell adhesion sequence RGDSP, which is easily conjugated to carriers via Npys or maleimide chemistry. Synonyms: Ac-Gly-Cys-Gly-Tyr-Gly-Arg-Gly-Asp-Ser-Pro-Gly-NH2; N-acetyl-glycyl-L-cysteinyl-glycyl-L-tyrosyl-glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycinamide; Glycinamide, N-acetylglycyl-L-cysteinylglycyl-L-tyrosylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-. Grades: ≥95%. CAS No. 278792-07-7. Molecular formula: C42H63N15O16S. Mole weight: 1066.12.
NODAGA-RGD
NODAGA-RGD is a peptide that can be radiolabeled and used as a radiotracer for positron emission tomography (PET) diagnosis [1]. Uses: Scientific research. Group: Peptides. CAS No. 1321510-77-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10734.
RGD
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins. Uses: Scientific research. Group: Peptides. CAS No. 99896-85-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0278.
RGD Trifluoroacetate
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins. Uses: Scientific research. Group: Peptides. CAS No. 2378808-45-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0278A.
SF1126
SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. Integrins are transmembrane cell adhesion proteins expressed on the surfaces of endothelial and tumor cells. Synonyms: SF 1126, SF-1126. CAS No. 936487-67-1. Molecular formula: C39H48N8O14. Mole weight: 852.84.
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