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| Product | Description | |
|---|---|---|
| Sphingomyelin | Sphingomyelin. Group: Biochemicals. Alternative Names: N-Hexadecanoyl-D-sphingosine-1-phosphocholine. Grades: Highly Purified. CAS No. 85187-10-6,383907-87-7,13053-57-1. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C39H79N2O6P. US Biological Life Sciences. |  Worldwide |
| Sphingomyelin | Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann - Pick disease [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 85187-10-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113498. |  |
| sphingomyelin deacylase | The enzyme is involved in the sphingolipid metabolism in the epidermis. Group: Enzymes. Synonyms: SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase. Enzyme Commission Number: EC 3.5.1.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4388; sphingomyelin deacylase; EC 3.5.1.109; SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase. Cat No: EXWM-4388. |  |
| sphingomyelin phosphodiesterase | Has very little activity on phosphatidylcholine. Group: Enzymes. Synonyms: neutral sphingomyelinase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3712; sphingomyelin phosphodiesterase; EC 3.1.4.12; 9031-54-3; neutral sphingomyelinase. Cat No: EXWM-3712. | |
| sphingomyelin phosphodiesterase D | Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate. Group: Enzymes. Synonyms: sphingomyelinase D. Enzyme Commission Number: EC 3.1.4.41. CAS No. 54992-31-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3725; sphingomyelin phosphodiesterase D; EC 3.1.4.41; 54992-31-3; sphingomyelinase D. Cat No: EXWM-3725. | |
| Sphingomyelins, milk | Sphingomyelins, milk (SMs (buttermilk)) are compounds studied in sphingolipids, which play important roles in various biological processes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SMs (buttermilk). CAS No. 475662-40-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-165136. | |
| sphingomyelin synthase | The reaction can occur in both directions. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin. Group: Enzymes. Synonyms: SM synthase; SMS1; SMS2. Enzyme Commission Number: EC 2.7.8.27. CAS No. 58703-97-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3326; sphingomyelin synthase; EC 2.7.8.27; 58703-97-2; SM synthase; SMS1; SMS2. Cat No: EXWM-3326. | |
| C20 Sphingomyelin (d18:1/20:0) | Sphingolipids. Alternative Names: 4-hydroxy-7(S)-[(1(R),2E)-1-hydroxy-2-hexadecen-1-yl]-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-aza-4-phosphaoctacosan-1-aminium, 4-oxide, inner salt, N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine, SM(d18:1/20:0). CAS No. 121999-68-6. Molecular formula: C43H87N2O6P. Mole weight: 759.2. Purity: 98%+. Catalog: ACM121999686. |  |
| C6 NBD Sphingomyelin | C6 NBD Sphingomyelin is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). Chlamydia trachomatis acquires C6 NBD Sphingomyelin endogenously synthesizes from C6-NBD-ceramide and transportes to the chlamydial inclusion. C6 NBD Sphingomyelin can incorporate into the plasma membrane [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 94885-04-8. Pack Sizes: 100 μg; 500 μg. Product ID: HY-D1574. | |
| Native Bacillus cereus Sphingomyelinase | Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. Applications: Sphingomyelinase has been used in a study to assess the interaction of actin with the hiv-1 accessory protein nef. sphingomyelinase has also been used in a study to investigate x-ray scattering as a quality-control tool for liposomal drug-delivery systems. Group: Enzymes. Synonyms: Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Activity: > 100 units/mg protein. Storage: 2-8°C. Form: Type I, buffered aqueous glycerol solution, Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5; Type II, Lyophilized powder containing potassium phosphate buffer salts and stabilizer. Source: Bacillus cereus. Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Cat No: NATE-0672. | |
| Native Sphingomyelinase from Streptomyces sp. | Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. Applications: This enzyme is useful for enzymatic determination of sphingomyelin when coupled with alkaline phosphatase and choline oxidase. Group: Enzymes. Synonyms: Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; Smase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Mole weight: 37.5 kDa (SDS-PAGE). Activity: > 500 U/mg. Stability: At least one year at ?20°C. Appearance: White to brownish amorphous powder?lyophilized. Storage: Storage at ?20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Streptomyces sp. Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; Smase. Cat No: NATE-1160. | |
| Native Staphylococcus aureus Sphingomyelinase | Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. Group: Enzymes. Synonyms: Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Activity: 100-300 units/mg protein (Lowry). Storage: 2-8°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 0.25 M phosphate buffer, pH 7.5. Source: Staphylococcus aureus. Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Cat No: NATE-0673. | |
| N-Docosahexaenoic sphingomyelin | N-Docosahexaenoic sphingomyelin. Group: Biochemicals. Alternative Names: N- (all-Z-docosahexaenoyl ) sphingosyl phosphoryl choline; (7S, 12Z, 15Z, 18Z, 21Z, 24Z, 27Z)-4-Hydroxy-7-[(1R, 2E)-1-hydroxy-2-hexadecenyl]-N, N, N-trimethyl-9-oxo-3, 5-dioxa-8-aza-4-phosphatriaconta-12, 15, 18, 21, 24, 27-hexaen-1-aminium 4-oxide. Grades: Highly Purified. CAS No. 218608-41-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C45H79N2O6P. US Biological Life Sciences. | Worldwide |
| N-Oleoyl-D-sphingomyelin semisynthetic from bovine brain sphingomyelin,N-(cis-9-Octadecenoyl)-D-sphingosine-1-phosphocholine | Heterocyclic Organic Compound. CAS No. 108392-10-5. Molecular formula: NULL. Mole weight: 729.07. Catalog: ACM108392105. | |
| N-Palmitoyl-D-sphingomyelin | N-Palmitoyl-D-sphingomyelin. Group: Biochemicals. Alternative Names: N-Hexadecanoyl-D-sphingosine-1-phosphocholine. Grades: Highly Purified. CAS No. 6254-89-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C39H79N2O6P. US Biological Life Sciences. | Worldwide |
| Tnpal-sphingomyelin | Heterocyclic Organic Compound. Alternative Names: TNPAL-Sphingomyelin, tri nitrophenyl aminolauroyl sphingomyelin, 117985-56-5. CAS No. 117985-56-5. Molecular formula: C41H73N6O12P. Mole weight: 873.03. Purity: 0.96. IUPACName: [ (E) -3-hydroxy-2-[12- (2, 4, 6-trinitroanilino) dodecanoylamino]octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate. Canonical SMILES: CCCCCCCCCCCCCC=CC (C (COP (=O) ([O-])OCC[N+] (C) (C)C)NC (=O)CCCCCCCCCCCNC1=C (C=C (C=C1[N+] (=O)[O-])[N+] (=O)[O-])[N+] (=O)[O-])O. Catalog: ACM117985565. | |
| 1-Aminodecylidene bis-phosphonic acid sodium salt | 1-Aminodecylidene bis-phosphonic acid is a potent inhibitor of acid sphingomyelinase (IC50 = 20 nM). Synonyms: 1-Amindecane-1,1-Diphosphonic acid; ARC 39. Grades: ≥95%. Molecular formula: C10H25NO6P2·Na. Mole weight: 340.2. |  |
| 4-Ethylphosphonic Acid | 4-Ethylphosphonic Acid is a compound which shows the motif for metallophosphatase inhibition. Also used in the inhibition of acid sphingomyelinase through the synthesis of bisphosphonates for application towards antiinflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 6779-9-5. Pack Sizes: 1g, 5g. Molecular Formula: C2H7O3P, Molecular Weight: 110.05. US Biological Life Sciences. | Worldwide |
| 5-Aminovaleric acid | 5-Aminovaleric acid is used in the study of metabolic changes in male germ cells (toxins) after 24 hours of extinguishing cigarette smokes. Also used in the comprehensive characterization of the human saliva metabolome and in identification of different metabolites like sphingomyelins, phosphatidyl cholines, vitamins and trace elements in human saliva which showed diurnal variation. Synonyms: 5-Ava-OH; 5-Amino-n-pentanoic acid; 5-Aminopentanoic acid; H-5-Ava-OH; delta-Aminovaleric acid; Homopiperidinic acid; 5-amino-pentanoic acid; Pentanoic acid, 5-amino-; Valeric acid, 5-amino-; delta-Amino-n-valeric acid; 5-aminopentanoate; 5-aminovalerate; 5-ammoniopentanoate; H 5 Ava OH. Grades: ≥ 98% (HPLC). CAS No. 660-88-8. Molecular formula: C5H11NO2. Mole weight: 117.15. | |
| 6-Hexadecanoylamino-4-methylumbelliferyl Phosphorylcholine | 6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine is a phosphorylcholine derivative and was shown to be a specific substrate for the determination of acid (lysosomal) sphingomyelinase. Group: Biochemicals. Alternative Names: 2-[[Hydroxy[[4-methyl-2-oxo-6-[(1-oxohexadecyl)amino]-2H-1-benzopyran-7-yl]oxy]phosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt. Grades: Highly Purified. CAS No. 904315-61-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Altenusin | Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27. | |
| Altenusin, Penicillium sp. | Sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Also exhibits anti-HIV-1 integrase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 31186-12-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. | |
| C10 Bisphosphonate | C10 Bisphosphonate is an inhibitor for acid sphingomyelinase. C10 Bisphosphonate is promising for research of inflammatory lung diseases, cystic fibrosis and atherosclerosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15049-93-1. Pack Sizes: 1 mg. Product ID: HY-48917. | |
| C12-Ceramide | C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease [1] [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine. CAS No. 74713-60-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100353. | |
| C24:1 Ceramide (Nervonic Ceramide) | Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Group: Biochemicals. Alternative Names: Nervonic Ceramide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| C24 Ceramide (Lignoceric Ceramide) | Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Group: Biochemicals. Alternative Names: Lignoceric Ceramide. Grades: Highly Purified. CAS No. 34435-05-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| C2 Ceramide-1-phosphate (N-Acetylsphingosine-1-phosphate) | Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. Group: Biochemicals. Alternative Names: N-Acetylsphingosine-1-phosphate. Grades: Highly Purified. CAS No. 151729-55-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| C4 Ceramide-1-phosphate | Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. Group: Biochemicals. Alternative Names: N- [ (1S, 2R, 3E) -2-Hydroxy-1- [ (phosphonooxy) methyl] -3-heptadecenyl] butanamide; N-Butyl-D-sphingosine-1-phosphate; Butyl Ceramide-1-phosphate; N-Butanoyl-D-erythro-sphingosine-1-phosphate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| C6 NBD Ceramide | C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Nbd-ceramide. CAS No. 94885-02-6. Pack Sizes: 1 mg. Product ID: HY-W356116. | |
| Cambinol | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Group: Inhibitors. Alternative Names: cambinol, NSC112546, NSC-112546, SIRT1/2 Inhibitor IV, Cambinol, 14513-15-6, 5-(2-Hydroxy-naphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, AC1MMYEF, NCIStruc1_001428, NCIStruc2_001159, SureCN3332758, CHEMBL491960, CTK8G3107, HMS3261K21, CCG-37240, DNC009417, NCGC00014121, NCI112546, AKOS002364304, AG-D-88787, CCG-221684. CAS No. 14513-15-6. Molecular formula: C21H16N2O2S. Mole weight: 360.43. Purity: 0.96. IUPACName: 5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one. Density: 1.41g/cm³. Catalog: ACM14513156. | |
| CUN43389 | CUN43389, also known as SMS1-IN-1 and SAPA1j, is a SAPA inhibitor (sphingomyelin synthase 1 inhibitor). SAPA 1j was found to be the most potent SMS1 inhibitor with an IC50 value of 2.1 μM in in vitro assay. Group: Inhibitors. Alternative Names: SMS1-IN-1; SAPA1j; Compound 1j; CUN43389; CUN-43389; CUN 43389. CAS No. 1807943-38-9. Molecular formula: C23H23BrN2O4. Mole weight: 503.41. Appearance: Solid powder. Purity: >98%. IUPACName: N-(4-Bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide. Canonical SMILES: O=C (NCC1=CC=C (Br)C=C1)COC2=CC=C (S (=O) (NCCC3=CC=CC=C3)=O)C=C2. Catalog: ACM1807943389. | |
| Dofequidar | Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors. Dofequidar was found to sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Uses: Antineoplastic agents. Synonyms: Dofequidar. CAS No. 129716-58-1. Molecular formula: C30H31N3O3. Mole weight: 481.596. | |
| DPTIP | DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). DPTIP is metabolically stable and brain penetrant, regulating astrocyte-peripheral immune communication following brain inflammation. Synonyms: 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol. Grades: ≥98% by HPLC. CAS No. 351353-48-5. Molecular formula: C21H18N2O3S. Mole weight: 378.45. | |
| GW4869 | GW4869 is a cell-permeable, specific and non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). Synonyms: (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride; GW 4869; GW-4869. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.5. | |
| GW4869 | GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC 50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6823-69-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19363. | |
| Lansoprazole | Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-1749. CAS No. 103577-45-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-13662. | |
| Lipase-polyethylene glycol | A lipase is an enzyme that catalyzes the hydrolysis of fats (lipids). Lipases are a subclass of the esterases. Lipases perform essential roles in the digestion, transport and processing of dietary lipids (e.g. triglycerides, fats, oils) in most, if not all, living organisms. Genes encoding lipases are even present in certain viruses. Most lipases act at a specific position on the glycerol backbone of lipid substrate (A1, A2 or A3) (small intestine). Several other types of lipase activities exist in nature, such as phospholipases and sphingomyelinases, however these are usually treated separately from "conventional" lipases. Some lipases are expressed and secreted by pathogenic organisms during the infection. Group: Enzymes. Synonyms: PEG-Lipase; Lipase-polyethylene glycol. Lipase. Activity: ~75,000 units/mg protein (using olive oil). Storage: -20°C. Form: Lyophilized powder containing PEG. PEG-Lipase; Lipase-polyethylene glycol. Pack: Package size based on protein content. Cat No: NATE-0539. | |
| Malabaricone C | Malabaricone C is an orally active and noncompetitive sphingomyelin synthase ( SMS ) inhibitor with IC 50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 63335-25-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N8518. | |
| Manumycin A | Antibiotic. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50= 30nM). Does not affect geranyl geranyl transferase (IC50=180uM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 52665-74-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Myriocin | Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids. Group: Biochemicals. Alternative Names: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Native Arachis hypogaea (peanut) Phospholipase D | Phospholipase D is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Phospholipase D is involved in conferring drought susceptibility in peanuts, which increases the risk of aflatoxin contamination. Phospholipase d is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Applications: Research has shown adp-ribosylation factor regulation of phospholipase d is important in the release of nascent secretory vesicles from the trans-golgi network. it has also been used in a study to investigate stimulation of na+-ca2+ exchange activity in canine cardiac sarcolemmal vesicals. Group: Enzymes. Synonyms: Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 60 units/mg protein. Storage: -20°C. Form: Partially purified, lyophilized powder containing buffer salts. Source: Arachis hypogaea (peanut). Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Cat No: NATE-0594. | |
| Native Bacillus cereus Phospholipase C | Phospholipase C is an enzyme with system name phosphatidylcholine cholinephosphohydrolase. This enzyme catalyses the following chemical reaction: a phosphatidylcholine + H2O<-> 1, 2-diacyl-sn-glycerol + phosphocholine. The bacterial enzyme is a zinc protein. It also acts on sphingomyelin and phosphatidylinositol. Native phospholipase c (ec 3.1.4.3) was purified from bacillus cereus. Applications: Useful for enzymatic determination of lecithin. Group: Enzymes. Synonyms: Phospholipase C; EC 3.1.4.3; lipophosphodiesterase I; Clostridium welchii alpha-toxin; Clostridium oedematiens beta-and gamma-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; alpha-toxin. Enzyme Commission Number: EC 3.1.4.3. CAS No. 9001-86-9. Phospholipase C. Activity: > 30 U/mg. Appearance: White to brownish powder. Storage: Store in tightly closed containers, desiccated, protected from light, at-20°C. Form: Freeze dried powder. Source: Bacillus cereus. Phospholipase C; EC 3.1.4.3; lipophosphodiesterase I; Clostridium welchii alpha-toxin; Clostridium oedematiens beta-and gamma-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; alpha-toxin. Cat No: DIA-163. | |
| Native Cabbage Phospholipase D | Phospholipase D is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Phospholipase D is involved in conferring drought susceptibility in peanuts, which increases the risk of aflatoxin contamination. Applications: Phospholipase d (pld) is used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld is used in purification and kinetic studies. the enzyme has been used for the preparation of bodipy-phosphatidylcholine during the preparation of fluorescently labelled lipids. Group: Enzymes. Synonyms: Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 100 units/mg solid. Storage: -20°C. Form: lyophilized powder. Source: Cabbage. Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Cat No: NATE-0595. | |
| Native Clostridium perfringens (C. welchII) Phospholipase C | Phospholipase C is induced by thrombin and platelet-activating factor, forming 1,2-diacylglycerol and phosphatidic acid. PLC hydrolyzes the phosphate bond on phosphatidylcholine and other glycerophospholipids yielding diacylglycerol; this enzyme will also hydrolyze the phosphate bonds of sphingomyelin, cardiolipin, choline plasmalogen and ceramide phospholipids. Group: Enzymes. Synonyms: Phospholipase C; PLC; 9001-86-9; lipophosphodiesterase I; lecithinase C; Clostridium welchii α-toxin; Clostridium oede. Enzyme Commission Number: EC 3.1.4.3. CAS No. 9001-86-9. Phospholipase C. Activity: Type I, > 150 units/mg protein; Type II, 10-50 units/mg protein; Type III, Type IV, > 1,000 units/mg protein (Lowry). Storage: -20°C. Form: Type I, Lyophilized powder in buffered salts; Type II, lyophilized powder; Type III, buffered aqueous glycerol solution; Solution in 60% (v/v) glycerol containing 10 mM Tris-HCl, pH 8.0 and 10 mM EDTA; Type IV, lyophilized powder, Contains phosphate buffer salts, EDTA and stabilizer. Source: Clostridium perfringens (C. welchII). Phospholipase C; PLC; 9001-86-9; lipophosphodiesterase I; lecithinase C; Clostridium welchii α-toxin; Clostridium oedematiens β-and γ-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; α-toxin; EC 3.1.4.3. Cat No: NATE-0593. | |
| Native Pseudomonas sp. Sphingolipid ceramide N-deacylase | Sphingolipid ceramide N-deacylase (SCDase) is derived from Pseudomonas and hydrolyzes the N-acyl linkage between fatty acids and sphingosine bases in ceramides of various sphingolipids. The enzyme also catalyzes the reverse reaction and possesses transacylation activity. SCDase acts on various acidic and neutral glycosphingolipids and sphingomyelin; however, it exhibits low activity with ceramides. Applications: Hydrolysis of n-acyl linkages between fatty acids and sphingosine bases sphingolipid hydrolysis. Group: Enzymes. Synonyms: SCDase; Sphingolipid ceramide N-deacylase. SCDase. Storage: Store at -20°C until use. Store reconstituted solution in aliquots at -20°C. Avoid freeze-thaw. Form: Solution in 50 mM sodium acetate (pH 6.0) containing 0.1% Lubrol PX. Source: Pseudomonas sp. Species: Pseudomonas sp. SCDase; Sphingolipid ceramide N-deacylase. Cat No: NATE-0896. | |
| Native Streptomyces chromofuscus Phospholipase D | Phospholipase D is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Phospholipase D is involved in conferring drought susceptibility in peanuts, which increases the risk of aflatoxin contamination. Group: Enzymes. Synonyms: Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Mole weight: mol wt ~60 kDa. Activity: Type I, > 50,000 units/mL; Type II, > 150 units/mg solid. Storage: -20°C. Form: Type I, buffered aqueous glycerol solution; Solution in 100 mM Tris/HCl, pH 8.0, 10% glycerol (v/v), and 0.1% Triton X-100 (w/v); Type II, lyophilized powder. Source: Streptomyces chromofuscus. Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Cat No: NATE-0596. | |
| Native Streptomyces sp. Cholesterol Oxidase | Cholesterol oxidase (CHOD) is a monomeric flavoprotein containing FAD that catalyzes the first step in cholesterol catabolism. This bifunctional enzyme oxidizes cholesterol to cholest-5-en-3-one in an FAD-requiring step, which is then isomerized to cholest-4-en-3-one with the release of H2O2. Applications: Cholesterol oxidase from streptomyces has been used in a study to assess the relationship between the micellar structure of model bile and the activity of esterase. cholesterol oxidase from streptomyces has also been used in a study to investigate the effects of sphingomyelin degradation on cell cholesterol oxidizability and steady-state distribution between the cell ...ton boll weevil. chod has also been used as a molecular probe to elucidate cellular membrane structures. Group: Enzymes. Synonyms: EC 1.1.3.6, cholesterol-O2 oxidoreductase; 3β-hydroxy steroid oxidoreductase; 3β-hydroxysteroid:oxygen oxidoreductase; 9028-76-6. Enzyme Commission Number: EC 1.1.3.6. CAS No. 9028-76-6. CHOD. Mole weight: mol wt ~34 kDa. Activity: > 20 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing bovine serum albumin and sugars as stabilizers. Source: Streptomyces sp. EC 1.1.3.6, cholesterol-O2 oxidoreductase; 3β-hydroxy steroid oxidoreductase; 3β-hydroxysteroid:oxygen oxidoreductase; 9028-76-6. Cat No: NATE-0128. | |
| Native Streptomyces sp. Phospholipase D | Phospholipase D (PLD) is glycerophospholipid-specific. It is markedly less active on sphingomyelins and lysophospholipids. Phospholipase D hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Applications: Phospholipase d (pld) has been used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to yield the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld has been used in purification and kinetic studies. the enzyme has been used in the translocation of sphingosine kinase 1 (sk1) to membrane fractions under in vitro conditions. it has also been used to produce phosphatidic acid (pa) from phosphatidylcholine (pc) in hl60 permeabilized cells. Group: Enzymes. Synonyms: phospholipase D; lipophosphodiesterase II; lecithinase D;. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 150 units/mg solid. Storage: -20°C. Form: Type VII, lyophilized powder. Source: Streptomyces sp. phospholipase D; lipophosphodiesterase II; lecithinase D; choline phosphatase; phosphatidylcholine phosphatidohydrolase; EC 3.1.4.4; 9001-87-0; PLD. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0597. | |
| Nitrilotris (methylene) triphosphonic Acid | A powerful complexing agent. A potent acid sphingomyelinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 6419-19-8. Pack Sizes: 1g, 10g, 50g. Molecular Formula: C?H??NO?P?. US Biological Life Sciences. | Worldwide |
| Omeprazole | Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K i of 2 to 6 μM [1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria [2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: H 16868. CAS No. 73590-58-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0113. | |
| Omeprazole | Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Group: Inhibitors. Alternative Names: 2-Chloromethyl-3,5-dinmethyl-4-methoxypyridine. CAS No. 73590-58-6. Molecular formula: C17H19N3O3S. Mole weight: 345.42. Appearance: White solid. Purity: 99%+. IUPACName: 6-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole. Canonical SMILES: CC1=CN=C (C (=C1OC)C)CS (=O)C2=NC3=C (N2)C=C (C=C3)OC. Density: 1.332 g/cm³. Catalog: ACM73590586. | |
| Omeprazole sodium | Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a K i of 2 to 6 μM [1]. Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria [2]. Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: H 16868 sodium. CAS No. 95510-70-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0113A. | |
| Omeprazole (Standard) | Omeprazole (Standard) is the analytical standard of Omeprazole. This product is intended for research and analytical applications. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K i of 2 to 6 μM [1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria [2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 73590-58-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0113R. | |
| phospholipase C | The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol. Group: Enzymes. Synonyms: lipophosphodiesterase I; lecithinase C; Clostridium welchii α-toxin; Clostridium oedematiens β- and γ-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; α-toxin. Enzyme Commission Number: EC 3.1.4.3. CAS No. 9001-86-9. Phospholipase C. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3718; phospholipase C; EC 3.1.4.3; 9001-86-9; lipophosphodiesterase I; lecithinase C; Clostridium welchii α-toxin; Clostridium oedematiens β- and γ-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; α-toxin. Cat No: EXWM-3718. | |
| Phospholipids | Phospholipids occur as white powders. They are sometimes supplied as clear, nearly colorless chloroform or methylene chloride solutions. Synonyms: Coatsome; glycerol phosphatides; Lipoid; phosphatides; phosphatidic acid; phosphatidylcholine; phosphatidylethanolamine; phosphatidylglycerol; phosphatidylinositol; phosphatidylserine; phosphoglycerides; PhosphoLipid; purified egg yolk PC; sphingomyelin. Product ID: PE-0632. Category: Anionic Surfactant; Cationic Surfactant; Dispersing Agents; Emulsifying Agents; Emulsion Stabilizer; Nonionic Surfactant; Solubilizing Agents; Suspending Agents; Wetting Agents. Product Keywords: Excipients for Liquid Dosage Form; Surfactant Excipients; PE-0632; Phospholipids; Anionic Surfactant; Cationic Surfactant; Dispersing Agents; Emulsifying Agents; Emulsion Stabilizer; Nonionic Surfactant; Solubilizing Agents; Suspending Agents; Wetting Agents. UNII: NA. Grade: Pharmceutical Excipients. Administration route: Oral, otic, buccal, vaginal, topical, epidural, intravenous, intramuscular, and inhalation aerosol. Dosage Form: oral, otic, buccal, vaginal, topical, epidural, intravenous, intramuscular, and inhalation aerosol. Stability and Storage Conditions: Phospholipids are stable in the solid state if protected from oxygen, heat, and light. Chloroform or dichloromethane solutions are also stable. Both the solid-state and solution forms should be stored at -20°C. Liposomal phospholipids are k |  |
| Phosphorylethanolamine | Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane. Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer?s and Huntington?s disease. Group: Biochemicals. Alternative Names: 2-Aminoethanol 1-(Dihydrogen Phosphate); 2-Aminoethanol Dihydrogen Phosphate Ester; 2-Aminoethanol Phosphate; Phosphoric Acid 2-Aminoethyl Ester; 2-Aminoethanol O-Phosphate; 2-Aminoethyl Dihydrogen Phosphate; Colamine phosphate; Ethanolamine O-Phosphate; Mono(2-aminoethyl) phosphate; Monoaminoethyl Phosphate; NSC 254167; O-Phosphoethanolamine; O-Phosphoryl ethanolamine; Phosphoethanolamine; Phosphonoethanolamine. Grades: Highly Purified. CAS No. 1071-23-4. Pack Sizes: 10g, 25g. Molecular Formula: C2H8NO4P, Molecular Weight: 141.06. US Biological Life Sciences. | Worldwide |
| Phosphorylethanolamine-d4 | Labeled analogue of Phosphoryl ethanolamine. Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane. Group: Biochemicals. Alternative Names: 2-Aminoethanol-d4 1-(Dihydrogen Phosphate); 2-Aminoethanol-d4 Dihydrogen Phosphate Ester; 2-Aminoethanol-d4 Phosphate; Phosphoric Acid 2-Aminoethy-d4 Ester; 2-Aminoethanol-d4 O-Phosphate2-Aminoethyl-d4 Dihydrogen Phosphate; Colamine phosphate; Ethanolamine-d4 O-Phosphate; Mono(2-aminoethyl-d4) phosphate; Monoaminoethyl-d4 Phosphate; NSC 254167-d4; O-Phosphoethanolamine-d4; O-Phosphorylethanolamine-d4; Phosphoethanolamine-d4; Phosphonoethanolamine-d4. Grades: Highly Purified. CAS No. 1169692-38-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (S)-Lansoprazole | (S)-Lansoprazole (Levolansoprazole) is an isoform of Lansoprazole (HY-13662), which is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Levolansoprazole. CAS No. 138530-95-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13662C. | |
| Sphingosine-1-phosphate | Sphingosine-1-phosphate (S1P) is an agonist of S1P 1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca 2+ as an extracellular ligand for G protein-coupled receptors [1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids [2]. Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration [4]. Uses: Scientific research. Group: Natural products. Alternative Names: S1P. CAS No. 26993-30-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108496. | |
| Sphingosine-1-phosphate-d7 | Sphingosine-1-phosphate-d 7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: S1P-d7. CAS No. 2260670-15-1. Pack Sizes: 1 mg; 5 mg; 500 μg. Product ID: HY-108496S. | |
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