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| Product | Description | |
|---|---|---|
| Stem Cell Differentiation Compound Library | A unique collection of 1213 stem cell differentiation signaling targeted compounds for high throughput and high content screening; - Effective tool for research in regenerative medicine, stem cell differentiation signaling, and drug screening based on stem cells; - Targets include Wnt, GSK-2, Hedgehog, JAK, ROCK, γ-secretase, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L8000. Categories: Stem Cell Differentiation Compounds Libraries. |  |
| Bonemarrow-Derived Mesenchymal Stem Cells Affinity Peptide | Bonemarrow-Derived Mesenchymal Stem Cells Affinity Peptide is highly specific when binding to graphene, and has a high affinity for bone marrow stromal cells. Synonyms: BMSCs Specific Affinity Peptide; H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH; L-α-Glutamyl-L-prolyl-L-leucyl-L-glutaminyl-L-leucyl-L-lysyl-L-methionine. Grades: ≥95%. CAS No. 683750-83-6. Molecular formula: C38H67N9O11S. Mole weight: 858.06. |  |
| iPSC Induction Enhancer II, OAC1 N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1) | A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1uM OAC1 treatment starts 48h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294, Tranylcypromine, VPA, and Vitamin C, in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 300586-90-7. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 237.3. US Biological Life Sciences. |  Worldwide |
| iPSC Induction Enhancer, Thiazovivin (N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, Induced Pluripotent Stem Cells Induction Enhancer, Rho Kinase Inhibitor XII) | A cell-permeable aminothiazolo-carboxamide compound that is reported to augment SB431542 and PD0325901 in enhancing human iPSCs (induced Pluripotent Stem Cells) generation from fibroblast cultures virally transfected with 4-TF (Oct44, Klf4, Sox2, and c-Myc). Simultaneous blockage of TGFb and MEK-ERK pathways by SB431542 (2uM) and PD0325901 (0.5uM) in addition to 4-TF-induction is shown to result in >50-fold improvement of iPSCs generation, while the inclusion of Thiazovivin (0.5uM) on top of SB431542 and PD0325901 is demonstrated to further improve the efficiency to an over-all of >200-fold improvement from 4-TF-induction alone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Mesenchymal Stem Cells (mMSC), Mouse, Normal, Cryopreserved | Mesenchymal Stem Cells (mMSC), Mouse, Normal, Cryopreserved. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 500K Cells. US Biological Life Sciences. | Worldwide |
| ML243 (Cancer Stem Cell Inhibitor, ML243, (E) -N- (4, 5-Dihydrothiazol-2-yl) -3- (4-ethylphenyl) acrylamide, (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)prop-2-enamide) | A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2uM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64uM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5uM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10uM), but does not affect 68 other targets studied. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 1, 11-Bis (4- ( (1, 4, 8, 11-tetra azacyclotetra decan-1-yl ) methyl ) benzyl ) -1, 4, 8, 11-tetra azacyclotetra decane | 1, 11-Bis (4- ( (1, 4, 8, 11-tetra azacyclotetra decan-1-yl ) methyl ) benzyl ) -1, 4, 8, 11-tetra azacyclotetra decane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Group: Biochemicals. Grades: Highly Purified. CAS No. 771464-86-9. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C46H84N12, Molecular Weight: 805.24. US Biological Life Sciences. | Worldwide |
| 1-((2S,3S,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1-((2S,3S,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione is a powerful tool in the biomedical industry, indicated for cancer, HIV and hepatitis B treatment. Its multifunctional activity includes antiviral, antitumor, and anti-inflammatory effects, with early evidence supporting a potentially revolutionary capacity as a cancer stem cell targeting therapeutic agent. Molecular formula: C10H13FN2O5. Mole weight: 260.22. | |
| 16,16-Dimethyl prostaglandin E2 | 16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 16,16-dimethyl PGE2. CAS No. 39746-25-3. Pack Sizes: 5 mg (26.28 mM * 500 μL in Methyl acetate); 10 mg (26.28 mM * 1 mL in Methyl acetate); 25 mg (26.28 mM * 2.5 mL in Methyl acetate); 50 mg (26.28 mM * 5 mL in Methyl acetate); 100 mg (26.28 mM * 10 mL in Methyl acetate). Product ID: HY-106420. |  |
| 16,16-Dimethyl Prostaglandin E2 | 16,16-Dimethyl Prostaglandin E2, a prostaglandin E2 derivative, could induce an increase in hematopoietic stem cell (HSC) numbers in mouse model. Uses: Anti-ulcer agents. Synonyms: 16,16-Dimethyl-pge2; 16,16-dimethylprostaglandin E2; 16,16-Dimethyl-prostaglandin E2; dmpge2; (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Grades: >98%. CAS No. 39746-25-3. Molecular formula: C22H36O5. Mole weight: 380.52. | |
| 16,16-Dimethyl Prostaglandin E2 | Synthetic derivative of prostaglandin E2. Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos. Group: Biochemicals. Grades: Highly Purified. CAS No. 39746-25-3. Pack Sizes: 1mg. Molecular Formula: C22H36O5. US Biological Life Sciences. | Worldwide |
| 17-AAG | 17-AAG is an antibiotic with antineoplastic activity that inhibits heat shock protein 90 (HSP90). It was shown to induce apoptosis of mouse lymphoma cancer stem cells (CSCs) and human acute myeloid leukemia (AML) CSCs. Synonyms: Tanespimycin; 17-Allylaminogeldanamycin; BAY 579352; 17-(Allylamino) Geldanamycin; 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; CP 127374; NSC 330507; Tanespimycin; 17AAG. Grades: >98%. CAS No. 75747-14-7. Molecular formula: C31H43N3O8. Mole weight: 585.69. | |
| 1, 8-Bis (4- ( (1, 4, 8, 11-tetra azacyclotetra decan-1-yl ) methyl ) benzyl ) -1, 4, 8, 11-tetra azacyclotetra decane | 1, 8-Bis (4- ( (1, 4, 8, 11-tetra azacyclotetra decan-1-yl ) methyl ) benzyl ) -1, 4, 8, 11-tetra azacyclotetra decane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Group: Biochemicals. Grades: Highly Purified. CAS No. 414858-02-9. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C46H84N12, Molecular Weight: 805.24. US Biological Life Sciences. | Worldwide |
| 1-(β-D-2-Deoxyribofuranosyl)-4-methylindole | 1-(β-D-2-Deoxyribofuranosyl)-4-methylindole, a highly efficacious antineoplastic compound, is extensively utilized in the field of biomedicine. The renowned prowess of this product lies in its remarkable capacity to impede the proliferation of malignant cells, rendering it an indispensable weapon against a myriad of malignancies such as leukemia, melanoma, and gastrointestinal tumors. Its profound therapeutic efficacy stems from its ability to perturb DNA replication and encumber cellular division processes, thus conferring it immense utility in the realms of oncological investigation and pharmaceutical advancement. Grades: ≥ 97%. CAS No. 180420-84-2. Molecular formula: C14H17NO3. Mole weight: 247.29. | |
| 1-Deoxy-1-nitro-L-iditol | 1-Deoxy-1-nitro-L-iditol, a nitro sugar utilized in the field of pharmacology, has been researched extensively for its potential anticancer properties that stem from its glycosylation inhibiting effects. Its utility as an antitumor agent is considered a promising avenue given its ability to impede cell growth and proliferation. Synonyms: 1-Deoxy-1-nitro-L-iditol hemihydrate;(2S,3R,4R,5S)-6-nitrohexane-1,2,3,4,5-pentol; hydrate; (2S,3R,4R,5S)-6-Nitrohexane-1,2,3,4,5-pentaol hydrate. CAS No. 105499-37-4. Molecular formula: C6H13NO7.1/2 H2O. Mole weight: 220.18. | |
| 1-EBIO | Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 10045-45-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C9H10N2O. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl lysophosphatidic acid sodium salt | 1-Oleoyl lysophosphatidic acid sodium salt is lysophospholipid receptor (LPA1 and LPA2) agonist. It can inhibit differentiation of neural stem cells into neurons. Synonyms: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacid sodium salt; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/0:0) (sodium salt); 1-Oleoyl lysophosphatidic acid sodium salt. Grades: >99%. CAS No. 325465-93-8. Molecular formula: C21H40NaO7P. Mole weight: 458.50. | |
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.CAS Number:325465-93-8. Group: Biochemicals. Grades: Purified. CAS No. 325465-93-8. Pack Sizes: 1mg. Molecular Formula: C21H40NaO7P. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl Lysophosphatidic Acid (Sodium Salt) | 1-Oleoyl Lysophosphatidic Acid is a lysophophatidic acid (LSA) with oleic acid in the sn-1 position that is an endogenous agonist for LPA1 and LPA2 receptors. It is reported to inhibit the differentiation of neural stem cells into neurons and is involved in multiple biological activities such as smooth muscle contraction, platelet aggregation, cell proliferation, cell migration, and calcium mobilization. 1-Oleoyl Lysophosphatidic Acid is commonly used for growth stimulation in a variety of cell lines. Group: Biochemicals. Alternative Names: 9-Octadecenoicacid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 1-oleoyl sodium salt, LPA sodium salt. Grades: Highly Purified. CAS No. 22556-62-3. Pack Sizes: 10mg. Molecular Formula: C21H40O7, Molecular Weight 458.5. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-7-nitroquinazoline | 2,4-Dichloro-7-nitroquinazoline is an intermediate used in the synthesis of 4-phenoxy-2- (1-piperazinyl) quinazolines as potent anticonvulsive and antihypoxic agents. It is also used to prepare quinazoline-based stem cell mobilizers targeting chemokine receptor CXCR4. Group: Biochemicals. Grades: Highly Purified. CAS No. 129112-65-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H3Cl2N3O2, Molecular Weight: 244.03. US Biological Life Sciences. | Worldwide |
| 2'-Amino-2'-deoxyuridine | 2'-Amino-2'-deoxyuridine, a nucleoside analogue, finds its use in chemotherapy as an anti-cancer agent. Its ability to cause DNA damage and trigger apoptosis in cancer cells stem from its selective integration in cancer cell DNA. Additionally, it offers immense potential in the field of oncology research, studying tumor cell differentiation and proliferation. Synonyms: 2'-Amino-2'-deoxy-D-uridine; 2'-deoxy-2'-amino-uridine; 2,4(1H,3H)-pyrimidinedione, 1-(2-amino-2-deoxy-b-D-ribofuranosyl)-; 1-[(2R,3R,4S,5R)-3-amino-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 26889-39-4. Molecular formula: C9H13N3O5. Mole weight: 243.22. | |
| 2'-Deoxy-5-formyl-cytidine | 2'-Deoxy-5-formyl-cytidine is a nucleotide derivative found in embryonic stem cell DNA. Group: Biochemicals. Grades: Highly Purified. CAS No. 137017-45-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H13N3O5, Molecular Weight: 255.23. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy-5-formyl-cytidine-1,3-15N2,2-13C | 2'-Deoxy-5-formyl-cytidine-1,3-15N2,2-13C is the labelled form of 2'-Deoxy-5-formyl-cytidine (D239810). 2'-Deoxy-5-formyl-cytidine is a nucleotide derivative found in embryonic stem cell DNA. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C913CH13N15N2O5, Molecular Weight: 258.209999999999. US Biological Life Sciences. | Worldwide |
| 2-Fluoropalmitic acid | 2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16518-94-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117651. | |
| 2- (N- (5-Chloro-2-methylphenyl) methylsulfonamido) -N- (2, 6-difluorophenyl) acetamide | 2- (N- (5-Chloro-2-methylphenyl) methylsulfonamido) -N- (2, 6-difluorophenyl) acetamide is a small molecule that enhances hepatocyte functions and promotes the differentiation if induced pluripotent stem cell-derived hepatocytes towards a more mature phenotype than what was previously obtainable. Group: Biochemicals. Grades: Highly Purified. CAS No. 708219-39-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H15ClF2N2O3S, Molecular Weight: 388.82. US Biological Life Sciences. | Worldwide |
| 2-Nitrophenyl-6-O-dimethoxytrityl-β-D-galactopyranoside | 2-Nitrophenyl-6-O-dimethoxytrityl-β-D-galactopyranoside, a highly significant compound in the realm of biomedicine, assumes a pivotal role as a substrate for the meticulous detection and analysis of β-galactosidase enzymes. By virtue of its presence, this invaluable tool enriches the scientific exploration of gene expression, cell signaling pathways, and multifarious biological processes. Furthermore, its indispensable contribution permeates the domain of drug research and development, particularly in relation to maladies stemming from aberrant β-galactosidase activity, inclusive of lysosomal storage disorders and select cancers. Molecular formula: C33H33NO10. Mole weight: 603.62. | |
| 3,3,5-Triiodo-L-thyronine | 3,3,5-Triiodo-L-thyronine is a metabolite of thyroxine that binds to both thyroid hormone receptors TRα and TRβ so that might help maintain the metabolic homeostasis. It promotes chondrogenesis of human mesenchymal stem cells. Uses: 3,3,5-triiodo-l-thyronine(t3) is an active metabolite of thyroxine and could be effective in agonizing both thyroid hormone receptors trα and tr&beta. Synonyms: Liothyronine; Triiodothyronine; T3; (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid. Grades: >98%. CAS No. 6893-2-3. Molecular formula: C15H12I3NO4. Mole weight: 650.97. | |
| 3,3'-Diindolylmethane (3,3-Methylenediindole, DIM) | Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic properties in animal and in in vitro models of cancer. Also acts a selective and potent inhibitor of cancer stem cells, and HDAC activity in prostate cancer cells. Recently, it has been shown that DIM induces apoptosis in ovarian cancer cells by inhibiting JAK2/STAT3. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
| 3',4'-Dimethoxyflavone | 3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 4143-62-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N8572. | |
| 3',4'-Dimethoxyflavone | 3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,4-DIMETHOXYFLAVONE; 2-(3,4-Dimethoxyphenyl)chromen-4-one; 2-(3,4-dimethoxyphenyl)chromen-4-one. Product Category: Inhibitors. Appearance: Powder. CAS No. 4143-62-8. Molecular formula: C17H14O4. Mole weight: 282.3. Purity: 0.98. IUPACName: 2-(3,4-dimethoxyphenyl)chromen-4-one. Canonical SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2)OC. Density: 1.242g/cm³. Product ID: ACM4143628. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 3-Deazaneplanocin A | 3-Deazaneplanocin A is an inhibitor of S-adenosylmethionine-dependent methyltransferase. In combination with sodium butyrate, 3-Deazaneplanocin A can induce epigenetically reprogramming of human embryonic stem cells (hESC). Synonyms: DZNep; (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol. Grades: >98%. CAS No. 102052-95-9. Molecular formula: C12H14N4O3. Mole weight: 262.26. | |
| (3R,4S,5S,6S)-6-formyltetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate | (3R,4S,5S,6S)-6-formyltetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate is an intriguing and multifaceted compound that has gained traction in the biomedicine industry for its prodigious therapeutic potential in combating cancer. Its efficacy stems from the inhibition of key enzymes that facilitate the proliferation and metastasis of malignant cells. Though its benefits are salient, the extent of its capacity as a cancer treatment has yet to be fully elucidated through further studies. Grades: 98%. CAS No. 67968-62-1. Molecular formula: C14H18O10. Mole weight: 346.29. | |
| (4,8-Bis(4-chloro-5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) | (4,8-Bis(4-chloro-5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) is an organic compound conventionally employed in the manufacture of photovoltaic devices due to its ability to enhance solar cell efficiency. Remarkably, it constitutes a critical component within the active layer of the cell. Apart from its photovoltaic application, this compound shows promise as a prospective anticancer agent. Its potency stems from the compound's inhibitory effect on tumor growth, indicating that it may be useful in the development of novel therapeutic modalities for cancer patients. Synonyms: 1,1'-[4,8-Bis[4-chloro-5-(2-ethylhexyl)-2-thienyl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]bis[1,1,1-trimethylstannane]. Grades: ≥98%. CAS No. 2239295-69-1. Molecular formula: C40H56Cl2S4Sn2. Mole weight: 973.46. | |
| 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (CAS# 641569-94-0) is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia. Synonyms: 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid; 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoic acid. Grades: 98 %. CAS No. 641569-94-0. Molecular formula: C17H14N4O2. Mole weight: 306.32. | |
| 5-Carboxy-2'-deoxycytidine-5'-Triphosphate | 5-Carboxy-2'-deoxycytidine-5'-Triphosphate, a significant biomedical reagent, has multifaceted applications in DNA synthesis, repair and drug resistance in cancer cells. Its wide-ranging utility stems from its utilization as a DNA polymerase substrate and DNA oligonucleotide synthesis reagent. Additionally, it exhibits promising inhibition activity against DNA polymerase and reverse transcriptase, rendering it a potential therapeutic candidate. Synonyms: 5-Carboxy-dCTP; 5-cadCTP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H16N3O15P3. Mole weight: 511.17. | |
| 5-Hydroxymethylcytidine | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 5-Methoxy-4'-thiouridine | 5-Methoxy-4'-thiouridine, a modified nucleoside that has been widely investigated for its viable therapeutic applications in tackling viral infections and cancer, has shown great promise in blocking viral replication and instigating apoptosis in malignant cells. This anti-tumor activity might stem from the influential impact it has on RNA transcription and translation by interfering in DNA synthesis. Grades: ≥95%. Molecular formula: C10H14N2O6S. Mole weight: 290.29. | |
| 5-methoxycarbonylmethyl-2-thiouridine | 5-(Methoxycarbonylmethyl)-2-thiouridine can be used as analyte in biological study for attomole quantification and global profile of RNA modifications in study of epitranscriptome of human neural stem cells. It can also be used to biological computational studies to provide insights into effects of modified ribonucleotides and Mg2+ on structures and stabilities of tRNAs. A trace nucleoside, isolated from yeast transfer RNA. A nucleoside in the anticodon at the wobble position of some Saccharomyces cerevisiae bacteria. Synonyms: 5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-4-oxo-1-β-D-ribofuranosyl-2-thioxo-, methyl ester; 5-(Methoxycarbonylmethyl)-2-thiouridine; 5-(2-methoxy-2-oxoethyl)-1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; 5-(2-methoxy-2-oxoethyl)2-thiouridine. Grades: ≥95%. CAS No. 20299-15-4. Molecular formula: C7H8N2O3S. Mole weight: 332.33. | |
| 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - ATTO-700 | ATTO-700, a fluorescent dye widely utilized in biomedical research for protein and cell labeling, boasts exceptional spectral properties. This feature alone renders it invaluable for imaging inquiries, though it offers much more. Employing ATTO-700, researchers have probed into cancer cell glucose uptake, stem cell geographical activity, and the release plus distribution of therapeutic agents. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with ATTO 700, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H29N7O10P2- ATTO 700 (free acid). Mole weight: 1088.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GMP - 6-ROX | 8-[(6-Amino)hexyl]-amino-GMP - 6-ROX is a remarkable fluorescent dye. Its versatility and widespread adoption stem from its prominent attributes in terms of labeling and detection, particularly within nucleic acid investigations. This indispensable compound facilitates the visualization of intricate cellular mechanisms, encompassing vital phenomena like DNA enhancement, replication and gene expression. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, labeled with 6-ROX. Grades: ≥ 95% by HPLC. Molecular formula: C49H56N9O12P (free acid). Mole weight: 994.01 (free acid). | |
| 8-Methoxycarbonyloctyl-3-O-benzyl-2,2-dideoxy-2,2-diphthalimido-3,4,6-tri-O-acetyl-b-cellobiose | 8-Methoxycarbonyloctyl-3-O-benzyl-2,2-dideoxy-2,2-diphthalimido-3,4,6-tri-O-acetyl-b-cellobiose is a compound prominently utilized in the biomedical domain, exhibiting potential in studying afflictions stemming from resilient compound-resistant variants. The intricacy of its distinct configuration renders it proficient in selectively targeting and suppressing the proliferation of pernicious pathogens. Synonyms: 8-Methoxycarbonyloctyl 4-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-2-deoxy-3-O-benzyl-2-phthalimido-b-D-glucopyranoside. CAS No. 106445-30-1. Molecular formula: C51H58N2O18. Mole weight: 987.01. | |
| A 419259 trihydrochloride | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo. Synonyms: A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride. Grades: >98%. CAS No. 1435934-25-0. Molecular formula: C29H37Cl3N6O. Mole weight: 592.0. | |
| abieta-7,13-dien-18-al dehydrogenase | Abietic acid is the principle component of conifer resin. This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis (grand fir). The activity has been demonstrated in cell-free stem extracts of A. grandis, was present in the cytoplasm, and required NAD+ as cofactor. The enzyme is expressed constitutively at a high level, and is not inducible by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadienal dehydrogenase (ambiguous). Enzyme Commission Number: EC 1.2.1.74. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1176; abieta-7,13-dien-18-al dehydrogenase; EC 1.2.1.74; abietadienal dehydrogenase (ambiguous). Cat No: EXWM-1176. |  |
| abieta-7,13-dien-18-ol hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine), and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine). The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene. Group: Enzymes. Synonyms: CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0708; abieta-7,13-dien-18-ol hydroxylase; EC 1.14.13.109; CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Cat No: EXWM-0708. | |
| abieta-7,13-diene hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase. Activity is induced by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadiene hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0707; abieta-7,13-diene hydroxylase; EC 1.14.13.108; abietadiene hydroxylase (ambiguous). Cat No: EXWM-0707. | |
| AD 01 | FKBPL (FK506-binding protein like)-based peptide. Binds to and upregulates expression of CD44. Inhibits breast cancer stem cell (BCSC) growth. Decreases pluripotency markers and promotes differentiation of BCSCs. Also inhibits endothelial cell migration as well as tubule and microvessel formation in vitro and in vivo. Blocks tumor growth in xenograft models. Synonyms: AD 01; 959961-23-0; EX-A7468; H-Gln-Ile-Arg-Gln-Gln-Pro-Arg-Asp-Pro-Pro-Thr-Glu-Thr-Leu-Glu-Leu-Glu-Val-Ser-Pro-Asp-Pro-Ala-Ser-OH. Grades: ≥95%. CAS No. 959961-23-0. Molecular formula: C115H187N33O42. Mole weight: 2703.94. | |
| Adenosine-5'-O-diphosphoribose phosphate | Adenosine-5'-O-diphosphoribose phosphate (ADRP) is a highly significant biomolecule that participates in a myriad of intricate cellular processes. Its paramount importance stems from being an essential substrate for a class of enzymes known as poly(ADP-ribose) polymerases (PARPs), which undertake the arduous tasks of DNA repair and modification. Remarkably, ADRP assumes a pivotal role in combating diseases associated with DNA damage, most notably cancer. Furthermore, it assumes an indispensable function in orchestrating the intricate mechanisms governing cellular metabolism and the highly intricate machinery of mitochondrial function. Synonyms: ADPRP. Grades: 95%. CAS No. 53595-18-9. Molecular formula: C15H24N5O17P3. Mole weight: 639.30. | |
| Adenosine (9- β-D-ribofuranosyladenine, Adenine riboside, Adenine-9- β-D-ribofuranoside) | In the extracellular space, ecto-5?-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation. Adenosine has been used: as a supplement in embryonic type culture medium for in vitro osteogenic differentiation for evaluation of its effect on cell survival by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT assay) and cell proliferation by 3H-thymidine incorporation assay in multi drug resistant glioblastoma stem-like cells (GSCs), and as a standard in high performance liquid chromatography (HPLC). as a constituent in collagenase solution for the collagenase digestion of mice fat tissue. Group: Biochemicals. Alternative Names: 9- β-D-Ribofuranosyl-9H-purin-6-amine; 9- β-D-Ribofuranosyladenine; Adenine Riboside; Adenocard; Adenocor; Adenogesic; Adenoscan; Adrekar; Boniton; D-Adenosine; 1-(6-Amino-9H-purin-9-yl)-1-deoxy- β-D-ribofuranose; Myocol; NSC 7652. Grades: Molecular Biology Grade. CAS No. 58-61-7. Pack Sizes: 100g, 500g. Molecular Formula: C10H13N5O4, Molecular Weight: 267.25. US Biological Life Sciences. | Worldwide |
| AKN-028 | AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Synonyms: AKN 028; AKN028; N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine; 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)-; N3-(1H-Indol-5-yl)-5-(4-pyridinyl)-2,3-pyrazinediamine. Grades: ≥95%. CAS No. 1175017-90-9. Molecular formula: C17H14N6. Mole weight: 302.33. | |
| ALK5 Inhibitor II hydrochloride | ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Synonyms: E 616452; RepSox; SJN 2511. Grades: ≥98%. CAS No. 446859-33-2. Molecular formula: C17H13N5·HCl. Mole weight: 323.8. | |
| AM580 | AM580 is a selective RARα agonist. It was shown to induce differentiation of human induced pluripotent stem cells into intermediate mesoderm. Synonyms: AM-580; 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid. Grades: >98%. CAS No. 102121-60-8. Molecular formula: C22H25NO3. Mole weight: 351.44. | |
| AMD3465 hexahydrobromide | AMD 3465 is a potent and selective antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. MD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5. AMD3465 has the potential to mobilize hematopoietic stem cells. Synonyms: AMD3465; GENZ-644494 hexahydrobromide. Grades: ≥95%. CAS No. 185991-07-5. Molecular formula: C24H38N6·6HBr. Mole weight: 896.07. | |
| Anti-Aging Compound Library | A unique collection of 3324 anti-aging compounds for high throughput screening (HTS) and high content screening (HCS); - Targets cover various aging-related processes, such as cell protective, DNA damage repair, and stem cell induction, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. Uses: Scientific use. Product Category: L8200. Categories: Anti-Aging Compounds Libraries. | |
| Apocynin | Apocynin is a selective NADPH-oxidase inhibitor with an IC 50 of 10 μM [1] [2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model [3]. Apocynin can also be used for cancer research [4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Acetovanillone. CAS No. 498-02-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-N0088. | |
| Astaxanthin | Potent antioxidant carotenoid. Free radical scavenger. Reduces oxidative stress. Anticancer compound. Anti-inflammatory. Blocks NF-kappaB activatin. Anti-hypertensive. Cardiovascular protective. Improves neuronal stem cell potential. Neuroprotective. Inhibits tumor invasion. Apoptosis inducer. Increases insulin sensitivity. Attenuates diabetes associated coagulatory, oxidative and inflammatory stress PPAR-alpha agonist and PPAR-gamma antagonist. Shows positive effects on obesity and insulin resistance. Hepatoprotective. Group: Biochemicals. Alternative Names: 3,3'-Dihydroxy-b,b-carotene-4,4'-dione; 3,3'-Dhydroxy-4,4'-diketo-b-carotene; Ovoester; NSC635689; CCRIS 7118, HSDB 7468. Grades: Highly Purified. CAS No. 472-61-7. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C??H??O?, Molecular Weight: 596.84. US Biological Life Sciences. | Worldwide |
| AV023 | AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1107710-62-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145686. | |
| AZD2858 | AZD2858 is a potent and selective GSK3β inhibitor with Ki value of 4.9 nM. It was shown to promote osteoblast differentiation in human adipose-derived stem cells (hADSC) in vitro. Synonyms: AZD-2858; 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide. Grades: >98%. CAS No. 486424-20-8. Molecular formula: C21H23N7O3S. Mole weight: 453.52. | |
| Benztropine mesylate | Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D 2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate. CAS No. 132-17-2. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B0520A. | |
| Benzyl butyl phthalate | Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 85-68-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W011338. | |
| Benzyl butyl phthalate-d4 | Benzyl butyl phthalate-d 4 is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 93951-88-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W011338S. | |
| BIO | BIO is a potent and reversible inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/&beta. BIO enhances reprogramming of mouse fibroblasts, neural stem cells, and thymocytes to induced pluripotent stem (iPS) cells. It also promotes differentiation of cardiomyocytes from human ES and iPS cells. Synonyms: GSK-3 Inhibitor IX; 6-bromoindirubin-3-oxime; 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. Grades: >98%. CAS No. 667463-62-9. Molecular formula: C16H10BrN3O2. Mole weight: 356.17. | |
| BIO (2Z, 3E)-6-Bromo-3-(hydroxyimino)-[2,3-biindolinylidene]-2-one | A potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/ β (IC50 = 5nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferented state. Group: Biochemicals. Alternative Names: (2Z,3E)-6-Bromo-3-(hydroxyimino)-[2,3-biindolinylidene]-2-one. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide X hydrochloride | Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor with IC50 of 15 nM for rat brain PKC. It has also been identified as an inhibitor of Cdk2 with IC50 of 200. It has been used to activate mesenchymal stem cells, which increases the surface expression of homing ligands that bind to intercellular adhesion molecule and target delivery of these cells to sites of inflammation. Uses: Enzyme inhibitors. Synonyms: BIM X; Ro 31-8425. Grades: ≥98%. CAS No. 145317-11-9. Molecular formula: C26H24N4O2·HCl. Mole weight: 461. | |
| BIX 01294 | Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Pluripotent stem cell inducer. Group: Biochemicals. Alternative Names: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-4-quinazolinamine. Grades: Highly Purified. CAS No. 935693-62-2. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C28H38N6O2. US Biological Life Sciences. | Worldwide |
| BIX-01294 | BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. It does not compete with cofactor S-adenosyl-methionine. It enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. It may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS). Synonyms: BIX-01294; BIX 01294; BIX01294. Grades: >98%. CAS No. 935693-62-2. Molecular formula: C28H38N6O2. Mole weight: 490.64. | |
| BIX 01294 trihydrochloride | BIX 01294 is a G9a histone methyltransferase inhibitor. It enhances the induction of pluripotent stem cells from somatic cells in vitro. BIX-01294 trihydrochloride induces necroptosis and autophagy. Synonyms: BIX 01294 trihydrochloride; BIX-01294; N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride. Grades: >98%. CAS No. 1392399-03-9. Molecular formula: C28H41Cl3N6O2. Mole weight: 600.02. | |
| BIX 01294 Trihydrochloride | G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor that H3K9me2 chromatin levels modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro. Group: Biochemicals. Alternative Names: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| BKT140 | BKT140 is a CXCR4 inhibitor with antineoplastic activity. Studies demonstrated that BKT140 showed a robust mobilization of white blood cells (WBC) and hematopoietic stem cells (HSC). Synonyms: BL-8040; Motixafortide; 4F-benzoyl-TN14003. Grades: 98%. CAS No. 664334-36-5. Molecular formula: C97H144FN33O19S2. Mole weight: 2159.55. | |
| BMS-214662 mesylate | BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C&beta. Uses: A potent and selective inhibitor of farnesyltransferase. Synonyms: BMS-214662 mesylate; BMS 214662 mesylate; BMS214662 mesylate; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine mesylate. Grades: ≥98%. CAS No. 474010-58-7. Molecular formula: C25H25N5O6S3. Mole weight: 585.72. | |
| BOP sodium | BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with K d values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1947348-42-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129453. | |
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