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| Product | Description | |
|---|---|---|
| Tacrine | Tacrine is an effective oral acetylcholine (AChE) inhibitor ( IC 50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 321-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-111338. |  |
| Tacrine hydrochloride | Tacrine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1684-40-8. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| Tacrine hydrochloride | Tacrine hydrochloride is a potent inhibitor of both AChE and BChE , with IC 50 s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC 50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimers disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1684-40-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1488. | |
| Tacrine hydrochloride (hydrate) | Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl ( AChE ) and butyryl-cholinestrase ( BChE ) with IC 50 s of 31 nM and 25.6 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 206658-92-6. Pack Sizes: 100 mg. Product ID: HY-B2244. | |
| 1-Hydroxy Tacrine | One of the impurities of Tacrine, which is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease. Uses: Cholinesterase inhibitors. Synonyms: 1-Hydroxy Tacrine. Grade: > 95%. CAS No. 124027-47-0. Molecular formula: C13H14N2O. Mole weight: 214.27. |  |
| 1-Hydroxy Tacrine-d4 HCl | One of the isotopic labelled impurities of Tacrine, which is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease. Synonyms: 1-Hydroxy Tacrine-d4 HCl. Grade: > 95%. CAS No. 1246816-08-9. Molecular formula: C13H10N2OD4·HCl. Mole weight: 254.75. | |
| 1-Hydroxy Tacrine Maleate | One of the impurities of Tacrine, which is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease. Uses: Cholinesterase inhibitors. Synonyms: 1-Hydroxy Tacrine Maleate; 9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate; 9-Amino-1,2,3,4-tetrahydro-1-acridinol (2Z)-2-Butenedioate; HP 029; Mentane; P 83-6029A; Velnacrine Hydrogen Maleate; Velnacrine Maleate. Grade: > 95%. CAS No. 118909-22-1. Molecular formula: C13H14N2O. C4H4O4. Mole weight: 330.33. | |
| bis(7)-Tacrine | Acetylcholinesterase (AChE) is the primary cholinesterase in the body. It is an enzyme catalyzing the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), which has been proposed as a clinical treatment for Alzheimer's disease. Bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine. It is thought to have multiple mechanisms of action including inhibition of AChE, and inihbititon of the amyloid precursor protein/beta-amyloid cascade. It has been shown to inhibit the formation of Aβ1-42 oligomers and reduce the amount of pre-formed Aβ1-42 oligomers. Synonyms: 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine. Grade: ≥98%. CAS No. 224445-12-9. Molecular formula: C33H40N4·2HCl. Mole weight: 565.6. | |
| 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-[d3] Maleate | 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-[d3] Maleate is the labelled analogue of 9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate, which is an impurity of Tacrine. Tacrine is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease. Synonyms: 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate; 9-Amino-1,2,3,4-tetrahydro-1-acridinol-d3 Maleate; HP 029-d3 Maleate; Mentane-d3 Maleate; Velnacrine-d3 Maleate; 1-hydroxy tacrine-d3 Maleate; 9-Amino-1,2,3,4-tetrahydroacridin-1,2,2-d3-1-ol maleate; (±)-Velnacrine-1,2,2-d3 Maleate. Grade: 95% by HPLC; 98% atom D. CAS No. 1219806-48-0. Molecular formula: C17H15D3N2O5. Mole weight: 333.36. | |
| Coluracetam | MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding. Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested. Synonyms: Coluracetam; BCI-540; MKC-231; BCI 540; MKC 231; BCI540; MKC231. Grade: >98%. CAS No. 135463-81-9. Molecular formula: C19H23N3O3. Mole weight: 341.4. | |
| Ipidacrine | Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC 50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K + and Na + -channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimers disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NIK-247 free base. CAS No. 62732-44-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-W027553. | |
| Octahydroaminoacridine succinate | Octahydroaminoacridine succinate, a Tacrine analogue, is an acetylcholinesterse (AChE) and butyrylcholinesterase (BChE) inhibitor. Octahydroaminoacridine succinate can be used for Alzheimer's disease (AD) research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 866245-79-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135006. | |
| Onitin | Onitin isolated from the herbs of Onychium japonicum. It shows super-oxide and DPPH free radical scavenging effects, and exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Uses: Hepatoprotective activity. Synonyms: 2,3-Dihydro-4-hydroxy-6-(2-hydroxyethyl)-2,2,5,7-tetramethyl-1H-inden-1-one; 1H-Inden-1-one,2,3-dihydro-4-hydroxy-6-(2-hydroxyethyl)-2,2,5,7-tetraMethyl-; 4-hydroxy-6-(2-hydroxyethyl)-2,2,5,7-tetramethyl-3H-inden-1-one. Grade: 0.985. CAS No. 53823-02-2. Molecular formula: C15H20O3. Mole weight: 248.3. | |
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