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A cell-permeable aminothiazolo-carboxamide compound that is reported to augment SB431542 and PD0325901 in enhancing human iPSCs (induced Pluripotent Stem Cells) generation from fibroblast cultures virally transfected with 4-TF (Oct44, Klf4, Sox2, and c-Myc). Simultaneous blockage of TGFb and MEK-ERK pathways by SB431542 (2uM) and PD0325901 (0.5uM) in addition to 4-TF-induction is shown to result in >50-fold improvement of iPSCs generation, while the inclusion of Thiazovivin (0.5uM) on top of SB431542 and PD0325901 is demonstrated to further improve the efficiency to an over-all of >200-fold improvement from 4-TF-induction alone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Cell-permeable. Helps in promoting human embryonic stem cell (hESC) survival by > 30-fold. In combination with ALK5 inhibitor SB-431542 (Cat. No. 1674-1) and MEK inhibitor PD- 0325901 (Cat. No. 1643-2), Thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Acotiamide
Acotiamide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide. CAS No. 185106-16-5. Molecular formula: C21H30N4O5S. Mole weight: 450.55. Catalog: APB185106165.
Acotiamide hydrochloride trihydrate
Acotiamide, also known as YM-443 and Z-338, is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. Uses: Cholinesterase inhibitors. Synonyms: N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride trihydrate; YM443; YM-443; YM 443; Z338; Z-338; Z 338; Acotiamide; Acotiamide hydrochloride trihydrate; Brand name: Acofide. Grade: 98%. CAS No. 773092-05-0. Molecular formula: C21H37ClN4O8S. Mole weight: 541.06.
Acotiamide Impurity 5
An impurity of Acotiamide, a drug for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. Synonyms: 2-Amino-4-[(2-diisopropylaminoethyl)aminocarbonyl]-1,3-thiazole; 2-amino-N-(2-(diisopropylamino)ethyl)thiazole-4-carboxamide. CAS No. 206882-15-7. Molecular formula: C12H22N4OS. Mole weight: 270.395.
Acotiamide Impurity 9
An impurity of Acotiamide, a drug for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. Synonyms: 4-Thiazolecarboxamide, 2-amino-N-(2-aminoethyl); 2-amino-N-(2-aminoethyl)-1,3-thiazole-4-carboxamide. CAS No. 948053-83-6. Molecular formula: C6H10N4OS. Mole weight: 186.24.
CP-547632 hydrochloride
CP-547632 hydrochloride is a potent, orally active and ATP-competitive inhibitor of VEGFR-2 and FGF kinases with IC50s of 11 and 9 nM, respectively. It is selective for VEGFR2 and bFGF over EGFR, PDGFRβ and related tyrosine kinases (TKs). It has antitumor effect. Synonyms: 3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-Isothiazolecarboxamide hydrochloride; PF-01371182 hydrochloride; 3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-({[4-(1-pyrrolidinyl)butyl]carbamoyl}amino)-1,2-thiazole-4-carboxamide hydrochloride (1:1); 4-Isothiazolecarboxamide, 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-, hydrochloride (1:1). Grade: ≥98%. CAS No. 252003-71-7. Molecular formula: C20H25BrClF2N5O3S. Mole weight: 568.86.
GDC-0339
GDC-0339, also called as SCHEMBL14801965, is a selective inhibitor of BaF3 PIM1 that has the potential for treatment of cancer. BaF3 PIM1: IC50= 43.6 nM; PIM1 LC-3K: IC50= 0.04 nM. Synonyms: 5-amino-N-[5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideGDC-0339; GDC 0339; GDC0339; SCHEMBL14801965BDBM110706CS-4775; HY-16976; CS 4775; HY 16976; CS4775; HY16976; US8614206, 139. CAS No. 1428569-85-0. Molecular formula: C20H22F3N7OS. Mole weight: 465.50.
2-(2,4-Difluorophenyl)-N'-hydroxy-1,3-thiazole-4-carboximidamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-(2,4-DIFLUOROPHENYL)-N'-HYDROXY-1,3-THIAZOLE-4-CARBOXIMIDAMIDE;2-(2,4-DIFLUOROPHENYL)THIAZOLE-4-CARBOXAMIDOXIME. Product Category: Heterocyclic Organic Compound. CAS No. 263160-25-4. Molecular formula: C10H7F2N3OS. Mole weight: 255.24. Product ID: ACM263160254. Alfa Chemistry ISO 9001:2015 Certified.
Anguibactin
It is produced by the strain of Vibrio angullarum. It is an antibiotic that acts as a Siderophore and has a very strong affinity with Fe+3. Synonyms: (2Z)-N-hydroxy-2-(5-hydroxy-6-oxo-1-cyclohexa-2,4-dienylidene)-N-[2-(3H-imidazol-4-yl)ethyl]thiazolidine-4-carboxamide; ACMC-20m71m; (2Z)-N-hydroxy-2-(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)-N-[2-(1H-imidazol-5-yl)ethyl]-1,3-thiazolidine-4-carboxamide. CAS No. 104245-09-2. Molecular formula: C15H16N4O4S. Mole weight: 348.38.
Tubulysin IM-1
Tubulysin IM-1 is an ADC Cytotoxin and it is also a tubulin binder used as anti-microtubule toxin. Synonyms: ethyl (2S,4R)-4-(2-((1R,3R)-1-acetoxy-3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate. Grade: 95%. Molecular formula: C32H47N3O6S. Mole weight: 601.80.
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