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| Product | Description | |
|---|---|---|
| Thromboxane A2 | Thromboxane A2 is the predominant cyclooxygenase product formed from arachidonic acid (AA) in human platelets. Thromboxane A2 is neither stored in platelets, nor formed in the absence of activation. However, it is synthesized in response to platelet activation by a wide variety of receptor-dependent and -independent platelet agonists. Synonyms: thromboxane A2; TXA2; 57576-52-0; TXA-2; Rabbit aorta contracting substance; 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid; 4C2A5G825S; Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Benz(a)anthracene-1,7,12(2H)-trione, 3,4-dihydro-3,6,8-trihydroxy-3-methyl-, (-)-; (Z)-7-[(1S,3R,4S,5S)-3-[(E,3S)-3-hydroxyoct-1-enyl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid. Grades: > 95%. CAS No. 57576-52-0. Molecular formula: C20H32O5. Mole weight: 352.48. |  |
| thromboxane-A synthase | A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2. Group: Enzymes. Synonyms: thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase. Enzyme Commission Number: EC 5.3.99.5. CAS No. 61276-89-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5513; thromboxane-A synthase; EC 5.3.99.5; 61276-89-9; thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase. Cat No: EXWM-5513. |  |
| Thromboxane B1 | Thromboxane B1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: THROMBOXANE B1;9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID;(13E,15S)-9α,11,15-Trihydroxythrombox-13-en-1-oic acid;TXB1. Product Category: Heterocyclic Organic Compound. CAS No. 64626-32-0. Molecular formula: C20H36O6. Mole weight: 372.49. Product ID: ACM64626320. Alfa Chemistry ISO 9001:2015 Certified. Categories: Thromboxane B2. |  |
| Thromboxane B2 | Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Uses: Scientific research. Group: Signaling pathways. CAS No. 54397-85-2. Pack Sizes: 1 mg. Product ID: HY-113331. |  |
| Thromboxane B2 | Thromboxane B2 is a stable metabolite of Thromboxane A2 and is important in the platelet-release reaction. Synonyms: 9α,11,15S-trihydroxythromba-5Z,13E-dien-1-oic acid; TXB2. Grades: > 95%. CAS No. 54397-85-2. Molecular formula: C20H34O6. Mole weight: 370.49. | |
| Thromboxane b3 | Thromboxane b3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9ALPHA, 11, 15S-TRIHYDROXY-THROMBA-5Z, 13E, 17Z-TRIEN-1-OIC ACID;DELTA17-TXB2;THROMBOXANE B3;(E)-7-[4,6-dihydroxy-2-[(1E,5E)-3-hydroxyocta-1,5-dienyl]oxan-3-yl]hept-5-enoic acid;(5Z,13E,15S,17Z)-9α,11,15-Trihydroxythromboxa-5,13,17-trien-1-oic acid;TXB3. Product Category: Heterocyclic Organic Compound. Appearance: A solution in methyl acetate. CAS No. 71953-80-5. Molecular formula: C20H32O6. Mole weight: 368.46. Density: 1.189 g/cm³. Product ID: ACM71953805. Alfa Chemistry ISO 9001:2015 Certified. | |
| 11-Dehydro thromboxane B2 | 11-Dehydro thromboxane B2. Group: Biochemicals. Alternative Names: (5Z)-7-[(2R,3S,4S)-Tetrahydro-4-hydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-6-oxo-2H-pyran-3-yl]-5-heptenoic acid; 11-Dehydro-TXB2; 11-keto-thromboxane B2. Grades: Highly Purified. CAS No. 67910-12-7. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C20H32O6. US Biological Life Sciences. |  Worldwide |
| 11-Dehydro-thromboxane B2 | 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 67910-12-7. Pack Sizes: 50 μg (1.36 mM * 100 μL in Methyl acetate); 1 mg; 100 μg; 250 μg. Product ID: HY-113420. | |
| 11-Dehydro Thromboxane B2-d4 | Isotope labelled 11-Dehydro Thromboxane B2, a metabolite of Thromboxane that is an in vivo markers of oxidative stress and platelet activation. It is associated with adverse cardiovascular events in Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT). Group: Biochemicals. Grades: Highly Purified. CAS No. 1240398-15-5. Pack Sizes: 250ug, 2.5mg. Molecular Formula: C20H28D4O6, Molecular Weight: 372.49. US Biological Life Sciences. | Worldwide |
| 2, 3-Dinor Thromboxane B2-d9 | 2, 3-Dinor Thromboxane B2-d9 serves as an internal standard for the quantification of 2,3-Dinor TXB2. 2, 3-Dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker in vivo TXA2 synthesis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25ug, 50ug. Molecular Formula: C18H21D9O6, Molecular Weight: 351.48. US Biological Life Sciences. | Worldwide |
| Pinane Thromboxane A2 | Pinane Thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TXA2R antagonist and a TXA synthase inhibitor. It inhibits coronary artery constriction and platelet aggregation. Synonyms: 15(S)-Pinane Thromboxane A2; Pinane TXA2; PTA2; 7-[3-(3-hydroxyoct-1-enyl)-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 71111-01-8. Molecular formula: C24H40O3. Mole weight: 376.6. | |
| Pta2(pinane thromboxane a2) | Pta2(pinane thromboxane a2). Uses: Designed for use in research and industrial production. Additional or Alternative Names: PTA2;PINANE THROMBOXANE A2;9ALPHA,11ALPHA-(DIMETHYL)METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID;pinane thromboxane A2 ethanol solution;Pinane-thromboxanea2synthetic;(5Z)-7-[(1S,1β,5β)-3β-[(3S,1E)-3-Hydroxy-1-octene-1-yl]-. Product Category: Heterocyclic Organic Compound. Appearance: A solution in ethanol. CAS No. 71111-01-8. Molecular formula: C24H40O3. Mole weight: 376.57. Product ID: ACM71111018. Alfa Chemistry ISO 9001:2015 Certified. Categories: 15(R)-PTA2. | |
| 12(S)-HHTrE | 12(S)-HHTrE is a metabolite of arachidonic acid (A3303), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Grades: Highly Purified. CAS No. 54397-84-1. Pack Sizes: 500ug, 5mg. Molecular Formula: C17H28O3, Molecular Weight: 280.399999999999. US Biological Life Sciences. | Worldwide |
| 12(S)-HHTrE | 12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets. It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. Synonyms: 12(S)-HHT; 12-hydroxyheptadecatrienoic acid. Grades: ≥95%. CAS No. 54397-84-1. Molecular formula: C17H28O3. Mole weight: 280.4. | |
| 13-APA | 13-APA is a specific thromboxane A2 receptor (TP) antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 71629-07-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C19H37NO2, Molecular Weight: 311.5. US Biological Life Sciences. | Worldwide |
| 1,3-bis(4-((E)-2-carboxyvinyl)benzyl)-1H-imidazol-3-ium bromide | 1,3-bis(4-((E)-2-carboxyvinyl)benzyl)-1H-imidazol-3-ium bromide is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: (E)-3-(4-((1-(4-((E)-2-Carboxyvinyl)benzyl)-1H-imidazol-3-ium-3-yl)methyl)phenyl)acrylate; 883942-98-1. CAS No. 883942-98-1. Molecular formula: C23H21BrN2O4. Mole weight: 469.34. | |
| 14,15-Epoxyeicosatrienoic Acid (±14,15-EET) | Epoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,?N'-?dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore. Also, it is derived from Arachidonic Acid, which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Alternative Names: (5Z,8Z,11Z)-13-(3-Pentyl-2-oxiranyl)-5,8,11-tridecatrienoic Acid; 14(15)-EET; 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; (±)14,15-EET; (±)14,15-EpETrE; (all-Z)-13-(3-Pentyloxiranyl)-5,8,11-tridecatrienoic Acid. Grades: Highly Purified. CAS No. 197508-62-6. Pack Sizes: 50ug, 100ug, 500ug. Molecular Formula: C??H??O?, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
| 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside | 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside. CAS No. 82373-94-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0652. | |
| 2-Hydroxymethyl-2,3-dihydrobenzofuran | 2-Hydroxymethyl-2,3-dihydrobenzofuran is a reactant used in the preparation of thromboxane A2 agonist indane derivatives. Group: Biochemicals. Alternative Names: 2-Hydroxymethyl-2,3-dihydrobenzofuran; 2,3-Dihydro-2-benzofuranmethanol. Grades: Highly Purified. CAS No. 66158-96-1. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| (2R,4R)-trans-Ketoconazole | (2R,4R)-trans-Ketoconazole is an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 142128-58-3. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H28Cl2N4O4, Molecular Weight: 531.429999999999. US Biological Life Sciences. | Worldwide |
| (2R,4R)-trans-Ketoconazole-d8 | (2R,4R)-trans-Ketoconazole-d8 is the isotope labelled analog of (2R,4R)-trans-Ketoconazole (K186015); an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H20D8Cl2N4O4, Molecular Weight: 539.48. US Biological Life Sciences. | Worldwide |
| 2-(Tosyloxy)methyl-2,3-dihydrobenzofuran | Protected 2-Hydroxymethyl-2,3-dihydrobenzofuran , a reactant in the preparation of thromboxane A2 agonist indane derivatives. Group: Biochemicals. Alternative Names: 2,3-Dihydro-2-benzofuranmethanol 4-Methyl Benzene sulfonate; 2,3-Dihydro-2-benzofuranmethanol p-Toluenesulfonate. Grades: Highly Purified. CAS No. 94709-25-8. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 3-Bromo-5-iodobenzoic Acid | 3-Bromo-5-iodobenzoic Acid can be used as a starting material in the synthesis of 3- {3- [2- (4-Chloro Benzene sulfonamido) ethyl] -5- (4-fluorobenzyl) phenyl} propionic Acid, a potent thromboxane receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 188815-32-9. Pack Sizes: 1g, 5g. Molecular Formula: C7H4BrIO2, Molecular Weight: 326.91. US Biological Life Sciences. | Worldwide |
| 8-Isoprostaglandin E2 | 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A 2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: iPE2-III. CAS No. 27415-25-4. Pack Sizes: 1 mg. Product ID: HY-130304. | |
| ACA - CAS 110683-10-8 | A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 110683-10-8. Pack Sizes: 25MG. Mole Weight: 337.41. Catalog: AP110683108. Assay: ≥99% (HPLC). |  |
| Arachidonic acid | Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of thromboxanes, prostaglandins and leukotrienes. It is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. It is an important cellular signaling mediator in a variety of biological processes, including smooth chemotaxis, muscle contraction, apoptosis, cell proliferation and differentiation. It exits in liver, brain, glandular organs, and depot fats of animals and a constituent of animal phosphatides. It could bind to the subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). It stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules. Synonyms: Arachidonate. Grades: 98 %. CAS No. 506-32-1. Molecular formula: C20H32O2. Mole weight: 304.47. | |
| Arachidonic acid-[13C20] | Labelled Arachidonic acid. Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of thromboxanes, prostaglandins and leukotrienes. It is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. It is an important cellular signaling mediator in a variety of biological processes, including smooth chemotaxis, muscle contraction, apoptosis, cell proliferation and differentiation. It exits in liver, brain, glandular organs, and depot fats of animals and a constituent of animal phosphatides. It could bind to the subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). It stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules. Grades: > 98%. Molecular formula: [13C]20H32O2. Mole weight: 324.32. | |
| Arachidonic Acid Alkyne | Arachidonic Acid Alkyne is a metabolite of Arachidonic Acid (A3303). Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Grades: Highly Purified. CAS No. 1219038-32-0. Pack Sizes: 100ug, 500ug. Molecular Formula: C20H28O2, Molecular Weight: 300.44. US Biological Life Sciences. | Worldwide |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| BM 567 | Thromboxane A2 (TXA2) is a potent thrombogenic and vasoconstrictor eicosanoid. It has been reported as a causal factor in the onset of stroke and myocardial infarction. BM 567 is a dual acting antithrombogenic agent, which is acting as an inhibitor of thromboxane A2 (TXA2) synthase and an antagonist of the TP receptor. It also antagonizes the vascular smooth muscle TP receptor with an IC50 value of 1.1 nM. Synonyms: BM567; BM-567. Grades: ≥98%. CAS No. 284464-77-3. Molecular formula: C18H28N4O5S. Mole weight: 412.5. | |
| CAY10535 | TPα and TPβ are two isoforms of the human TP receptor, which is the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ with IC50 of 99 nM than TPα with IC50 of 1970 nM in the inhibition of U46619-mediated Ca2+ mobilization. Synonyms: CAY 10535; CAY-10535. Grades: ≥98%. CAS No. 945716-28-9. Molecular formula: C18H21N3O7S. Mole weight: 423.4. | |
| Chlorobutanol | Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria , and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57-15-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1263. | |
| cis-5,8,11,14,17-Eicosapentaenoic acid | reduces thromboxane A2 production and platelet aggregation, inhibits 5-lipoxygenase and prevents arteriosclerosis. CAS No. 73167-03-0. Product ID: 1-01079. Molecular formula: C20H30O2. Mole weight: 302.46. Reference: Lancet., 15, 117, 1978; New Engl. J. Med., 314, 937, 1986. |  |
| Cyclooxygenase 1 from Human, Recombinant | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. COX-1. Mole weight: ~70 kDa. Activity: >20,000 units/mg. Stability: > 6 months. Storage: -80°C (as supplied); avoid freeze/thaw cycles by aliquoting protein. Form: 80 mM Tris, pH 8.0, containing 0.1% polysorbate 20, 300 uM DDC, and 10% glycerol. Source: Sf21 cells. Species: Human. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-1237. | |
| Cyclooxygenase 2 from Human, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. COX-2. Mole weight: 70 kDa. Activity: >8,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Human. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1238. | |
| Cyclooxygenase 2 from Ovine, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Purity: >80% estimated by SDS-PAGE. COX-2. Mole weight: ~70 kDa. Activity: >20,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Ovine. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1239. | |
| Dazoxiben hydrochloride | Dazoxiben hydrochloride is a potent and orally active thromboxane (TX) synthase inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK 37248. CAS No. 74226-22-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106067A. | |
| Diclofenac amide | Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2 , that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15362-40-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-134521. | |
| Dimethyl (3-phenoxy-2-oxoproyl)phosphonate | Dimethyl (3-phenoxy-2-oxoproyl)phosphonate Travopropst (T715600), a selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma. Used in the synthesis ofnovel prostanoid thromboxane A2 agonists. Group: Biochemicals. Alternative Names: P- (2-oxo-3-Phenoxypropyl) phosphonic Acid Dimethyl Ester; (2-oxo-3-Phenoxypropyl) phosphonic Acid Dimethyl Ester; (2-Oxo-3-phenoxypropyl) phosphonic Acid Dimethyl Ester; Dimethyl (2-oxo-3-phenoxypropyl) phosphonate; Dimethyl (3-Phenoxyacetonyl) phosphonate; Dimethyl 3-{Phenoxy-2-oxopropylphosphonate. Grades: Highly Purified. CAS No. 40665-68-7. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)-1-(1H-imidazol-1-yl)prop-2-en-1-one | (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)-1-(1H-imidazol-1-yl)prop-2-en-1-one is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)-1-(1H-imidazol-1-yl)prop-2-en-1-one; 2452215-05-1. CAS No. 2452215-05-1. Molecular formula: C16H14N4O. Mole weight: 278.32. | |
| Eicosapentaenoic acid | Important polyunsaturated fatty acid of the marine food chain that serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid (the eicosatetraenoic acid that is a precursor for the prostaglandin and thromboxane-2 families) by the extra double bond between the third and fourth carbons from the methyl end of the molecule. Antilipemic. Group: Biochemicals. Alternative Names: (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic Acid; (all-Z)-5,8,11,14,17-Eicosapentaenoic Acid; EPA; EPA 45G; Icosapent; Icosapentaenoic Acid; Incromega E 7010SR; Ropufa 70; Timnodonic Acid. Grades: Highly Purified. CAS No. 10417-94-4. Pack Sizes: 10g. Molecular Formula: C20H30O2, Molecular Weight: 302.45. US Biological Life Sciences. | Worldwide |
| Eicosapentaenoic Acid | Eicosapentaenoic acid (EPA) is an omega-3 fatty acid found in fish oil. It acts as a precursor to prostaglandin-3 and thromboxane-3 families. EPA decreases serum lipid concentration, reduces the risk of cardiovascular disorders and suppresses platelet aggregation. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Timnodonic acid; Icosapent; Icosapentaenoic acid; EPA; (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic Acid; (all-Z)-5,8,11,14,17-Eicosapentaenoic Acid; Incromega E 7010SR; Ropufa 70; cis-5,8,11,14,17-Eicosapentaenoic acid; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid; all-cis-5,8,11,14,17-icosapentaenoic acid. Grades: 98%. CAS No. 10417-94-4. Molecular formula: C20H30O2. Mole weight: 302.46. | |
| (E)-Ozagrel hydrochloride | Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. Uses: Enzyme inhibitors. Synonyms: ozagrel hydrochloride; OKY-046 hydrochloride. Grades: >98%. CAS No. 78712-43-3. Molecular formula: C13H13ClN2O2. Mole weight: 264.71. | |
| Epoprostenol Sodium | Epoprostenol Sodium is the sodium salt form of epoprostenol, which is a synthetic prostacyclin. It has vasodilatory and anticoagulant activity. It is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It prevents the formation of platelet plugs and is an effective vasodilator. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. It directly simulates prostaglandin receptors in arterial vascular smooth muscle, thereby causing vasodilatation. lt is also used for the treatment of pulmonary hypertension. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. It is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract. It was developed by GlaxoSmithKline and has been listed. Uses: Epoprostenol sodium has vasodilatory and anticoagulant activity. it prevents the formation of platelet plugs and is an effective vasodilator. lt is also used for the treatment of pulmonary hypertension. Synonyms: Prostacyclin Sodium Salt; (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-Dihydroxy-prosta-5,13-dien-1-oic Acid Sodium Salt; Flolan. Grades: >99 %. CAS No. 61849-14-7. Molecular formula: C20H31O5Na. Mole weight: 374.45. | |
| Furegrelate sodium | Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC 50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U-63557A. CAS No. 85666-17-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-106080A. | |
| Furegrelate sodium salt | Furegrelate is a selective and potent inhibitor of thromboxane synthase with an IC50 value of 15 nM for human platelet microsomal thromboxane synthase. Synonyms: U-63557A; 5-(3-pyridinylmethyl)-2-benzofurancarboxylic acid, sodium salt. Grades: ≥99%. CAS No. 85666-17-7. Molecular formula: C15H10NO3·Na. Mole weight: 275.2. | |
| ICI 185,282 | ICI 185,282 is a potent thromboxane receptor antagonist. Synonyms: ICI-185282; ICI 185282; ICI185282; 5-(Z)-7-(4-o-Hydroxyphenyl-2-trifluoromethyl-1,3 dioxan-cis-5-yl)heptenoic acid. CAS No. 106393-80-0. Molecular formula: C18H21F3O5. Mole weight: 374.36. | |
| ICI 192,605 | ICI 192,605 is a potent thromboxane A2 receptor antagonist. It can reverse vasoconstriction induced by inhibition of NO production and inhibits platelet aggregation, which leads to an increase in TXA2 release. It also inhibits contractile responses to U 46619. Synonyms: ICI 192605 ; ICI192605; ICI-192605. (4Z)-rel-, 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-Hexenoic acid, 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid; rel-(4Z)-6-[(2R,4R,5S)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic Acid. Grades: ≥98% by HPLC. CAS No. 117621-64-4. Molecular formula: C22H23ClO5. Mole weight: 402.87. | |
| Ifetroban | Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291. CAS No. 143443-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218. | |
| Ifetroban | Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials for the treatment of Asthma, Hepatorenal syndrome, Portal hypertension and Systemic scleroderma is on-going. Uses: Asthma; hepatorenal syndrome; portal hypertension; systemic scleroderma. Synonyms: Ifetroban; BMS 180291-02; BMS-180291; BMS180291; CHEMBL283100; BMS-180291;SCHEMBL9589119;3-[2-[[3-[4-(pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]propanoic acid. Grades: 98%. CAS No. 143443-90-7. Molecular formula: C25H32N2O5. Mole weight: 440.54. | |
| Ifetroban sodium | Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291 sodium. CAS No. 156715-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218A. | |
| Imidazole | Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG 2 and PGH 2 ) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimers disease, gout, COVID-19 and thrombo-embolic disease [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene. CAS No. 288-32-4. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-D0837. | |
| Indobufen | Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase ( Cox ) activity inhibitor. Indobufen suppresses thromboxane A 2 (TxA 2 ) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ibustrin. CAS No. 63610-08-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18763. | |
| I-SAP | I-SAP is a high affinity TP receptor antagonist. I-SAP binds to and induces platelet shape change, but not aggregation, with EC50 value of 9.7 nM. Synonyms: Iodophenyl sulfonyl amino pinane Thromboxane A2; Iodophenyl sulfonyl amino pinane TXA2; (Z)-7-[(1S,2S,3S,5R)-3-[(4-iodophenyl)sulfonylamino]-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 133538-58-6. Molecular formula: C22H30INO4S. Mole weight: 531.4. | |
| Ketoconazole (cis-1-Acetyl-4- [4- [ [2- (2, 4-dichlorophenyl) -2- (1H-imidazol-1-ylmethyl) -1, 3-dioxolan-4-yl] methoxy] phenyl] piperazine) | Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Alternative Names: cis-1-Acetyl-4- [4- [ [2- (2, 4-dichlorophenyl) -2- (1H-imidazol-1-ylmethyl) -1, 3-dioxolan-4-yl] methoxy] phenyl] piperazine. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Ketoconazole-d8 (cis-1-Acetyl-4- [4- [ [2- (2, 4-dichlorophenyl) -2- (1H-imidazol-1-ylmethyl) -1, 3-dioxolan-4-yl] methoxy] phenyl] piperazine-d8) | Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Alternative Names: cis-1-Acetyl-4- [4- [ [2- (2, 4-dichlorophenyl) -2- (1H-imidazol-1-ylmethyl) -1, 3-dioxolan-4-yl] methoxy] phenyl] piperazine-d8. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| KF 13218 | KF 13218, a novel pyridobenzazepinone derivative, inhibited human and bovine platelet thromboxane synthase with IC50 values of 27 +/- 5.8 nmol/l (mean +/- S.E.M.) and 36 +/- 6.9 nmol/l, respectively. Synonyms: (6Z)-6-(6-methyl-5-oxopyrido[4,3-c][1]benzazepin-11-ylidene)hexanoic acid; 11-(5-carboxypentylidene)-6-methyl-5,11-dihydropyrido(4,3-c)(1)benzazepin-5(6H)-one; KF 13218; KF-13218; KF13218. CAS No. 127654-03-9. Molecular formula: C20H20N2O3. Mole weight: 336.38. | |
| L-655,240 | L-655,240 is a potent and selective antagonist of thromboxane and prostaglandin endoperoxide receptor. It also blocks TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Synonyms: 3-(1-(4-Chlorobenzyl)-5-fluoro-3-methylindol-2-yl)-2,2-dimethylpropanoic acid. Grades: ≥98%. CAS No. 103253-15-2. Molecular formula: C21H21ClFNO2. Mole weight: 373.9. | |
| L-670,596 | L-670,596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist with IC50 value of 5.5 nM. It displays ALDH1A1 specific inhibitory activity. It inhibits human platelet aggregation and U-44069-induced contractions of guinea pig trachea in vitro. It also inhibits thromboxane-mediated endothelial cell death. It is orally active in vivo. Synonyms: L-670596; L 670596; L670596; (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid; 2-[6,8-Difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid. Grades: ≥98% by HPLC. CAS No. 121083-05-4. Molecular formula: C22H21F2NO4S. Mole weight: 433.47. | |
| Linoleoyl coenzyme A | Linoleoyl coenzyme A acts as a vital molecular precursor in the polyunsaturated fatty acid biosynthesis process. These fatty acids are necessary in various biological frameworks. It's a driving force in the biosynthesis of crucial mediating factors like prostaglandins, leukotrienes, and thromboxanes which have a central role in managing inflammation and pain. Moreover, linoleoyl coenzyme A is a pivotal agent in the metabolism of drugs and toxins, making it a fundamental area of interest when researching toxicology, and drug discovery. Synonyms: cis,cis-9,12-Octadecadienoyl coenzyme A; (9Z,12Z)-Octadecadienoyl-CoA; Linoleoyl coenzyme A lithium salt. Grades: ≥ 92% (HPLC). CAS No. 6709-57-5. Molecular formula: C39H66N7O17P3S. Mole weight: 1029.97. | |
| methyl (E)-3-(4-(methoxymethyl)phenyl)acrylate | methyl (E)-3-(4-(methoxymethyl)phenyl)acrylate is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: methyl (E)-3-(4-(methoxymethyl)phenyl)acrylate; AKOS020185360; 121379-29-1. CAS No. 121379-29-1. Molecular formula: C12H14O3. Mole weight: 206.24. | |
| Native Sheep Cyclooxygenase 1 | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Enzyme Commission Number: EC 1.14.99.1. CAS No. 9055-65-6. Purity: > 95% (SDS-PAGE). COX-1. Mole weight: dimer subunit mol wt 70 kDa. Activity: > 40,000 units/mg protein. Storage: -70°C. Form: aqueous solution. Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN 20 and 300 μM diethyldithiocarbamate. Source: Sheep. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-0149. | |
| N,N-Diethylaminoethyl 2,2-diphenylvalerate hydrochloride (SKF-525A HCl) | Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis. Group: Biochemicals. Alternative Names: α-Phenyl-α-Propylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(Diethylamino)ethyl 2,2-Diphenylvalerate Hydrochloride; Proadifen Hydrochloride; RP 5171; SKF 525; U 5446. Grades: Highly Purified. CAS No. 62-68-0. Pack Sizes: 250mg, 500mg, 1g, 5g. Molecular Formula: C??H??ClNO?, Molecular Weight: 389.96. US Biological Life Sciences. | Worldwide |
| ONO3708 | ONO3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo. It could play an important role in the pathogenesis of thrombosis and may be of therapeutic use in preventing cerebral vasospasm. It has therapeutic advantages in preventing thrombosis. Uses: Ono3708 may be of therapeutic use in preventing cerebral vasospasm. it has therapeutic advantages in preventing thrombosis. Synonyms: Ono3708; Ono-3708; Ono 3708;5-Heptenoic acid, 7-((1S,2S,3S,5R)-3-(((2R)-cyclopentylhydroxyacetyl)amino)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)-, (5Z)-;(Z)-7-[(1R,3S,4S,5S)-3-[[(2R)-2-cyclopentyl-2-hydroxyacetyl]amino]-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: >98 %. CAS No. 102191-05-9. Molecular formula: C23H37NO4. Mole weight: 391.55. | |
| Ozagrel | Ozagrel is an antiplatelet agent working as a thromboxane A2 (TXA2) synthesis inhibitor. It has been a clinical objective for many years. lt is a 1-alkyl imidazole derivative that acts as a selective inhibitor of TXA2 with an IC50 of 11 nM. lt was selected as the best compound of highly selective inhibitors of TXA2 synthase. lt increased 6-keto-PGF1 alpha in various isolated cells and tissues. It blunted and delayed the decrease in cardiac output and maintained end-systolic pressure-diameter relation, +dp/dt, and lung lymph flow at baseline values. Uses: Ozagrel was selected as the best compound of highly selective inhibitors of txa2 synthase. lt increased 6-keto-pgf1 alpha in various isolated cells and tissues. Synonyms: OKY046; OKY 046; OKY-046; 2-Propenoic acid,3-[4-(1H-imidazol-1- ylmethyl)phenyl]-,(2E)-;(E)-p-(Imidazol-1-ylmethyl)cinnamic acid;(E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid;(E)-3-[P-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid. Grades: >98%. CAS No. 82571-53-7. Molecular formula: C13H12N2O2. Mole weight: 228.25. | |
| Ozagrel hydrochloride | Ozagrel hydrochloride is a thromboxane synthetase inhibitor with IC50 value of 4 nM. Uses: Enzyme inhibitors. Synonyms: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 74003-18-2. Molecular formula: C13H12N2O2.HCl. Mole weight: 264.71. | |
| Ozagrel Methyl Ester | Ozagrel Methyl Ester is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: methyl (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylate; (2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-methyl Ester 2-Propenoic Acid. CAS No. 956932-46-0. Molecular formula: C14H14N2O2. Mole weight: 242.27. | |
| Ozagrel sodium | Ozagrel is a thromboxane A2 synthase inhibitor used as an antiplatelet agent. It reduces the risk of neurological impairment and the volume of brain damage. Synonyms: KCT-0809; Cataclot; Xanbo; (E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoate sodium. CAS No. 189224-26-8. Molecular formula: C13H11N2O2·Na. Mole weight: 250.23. | |
| Parthenolide ((1aR-[1aR*, 4E, 7aS*, -10aS*, -10bR*])-2, 3-6, 7, 7a, 8, 10a, 10b-octahydro-1a, 5-dimethyl-8-methyleneoxireno[9, 10]cyclo deca[1,2-b]furan-9(1aH)-one) | An anti-inflammatory agent. Specifically inhibits activation of NF-kB by preventing the degradation of IkBa and IkBb. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs. Group: Biochemicals. Grades: Highly Purified. CAS No. 20554-84-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| p-Hydroxycinnamic acid | p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC 50 s of 371 μM, 126 μM for thromboxane B 2 production and lipopolysaccharide-induced prostaglandin E 2 generation, respectively. Uses: Scientific research. Group: Natural products. CAS No. 7400-08-0. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-N2391. | |
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