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| Product | Description | |
|---|---|---|
| thymidylate synthase | Thymidylate synthetase (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage. Group: Enzymes. Synonyms: dTMP synthase; thymidylate synthetase; methylenetetrahydrofolate:dUMP C-methyltransferase; TMP synthetase. Enzyme Commission Number: EC 2.1.1.45. CAS No. 9031-61-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1949; thymidylate synthase; EC 2.1.1.45; 9031-61-2; dTMP synthase; thymidylate synthetase; methylenetetrahydrofolate:dUMP C-methyltransferase; TMP synthetase. Cat No: EXWM-1949. |  |
| thymidylate synthase (FAD) | Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH. Group: Enzymes. Synonyms: Thy1; ThyX. Enzyme Commission Number: EC 2.1.1.148. CAS No. 850167-13-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1744; thymidylate synthase (FAD); EC 2.1.1.148; 850167-13-4; Thy1; ThyX. Cat No: EXWM-1744. | |
| 10-Formyl-5,8-dideazafolic acid | 10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor. Synonyms: 10-Fddf; N-(4-{[(2-Amino-4-hydroxyquinazolin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid; NSC 278167; (S)-2-(4-(N-((2-Amino-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)formamido)benzamido)pentanedioic acid; N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)formylamino)benzoyl)-L-glutamic acid. Grade: ≥95%. CAS No. 61038-31-1. Molecular formula: C22H21N5O7. Mole weight: 467.43. |  |
| 1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil | 1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil is a nucleoside analogue useful in cancer treatment research. This nucleoside analogue selectively interacts with a thymidylate synthase, inhibiting DNA synthesis thereby disrupting tumor cell growth. Synonyms: 1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-; 3,5-di-O-benzoyl-1,2-dideoxy-2-fluoro-1-uracil-1-yl-beta-L-arabino-pentofuranose. CAS No. 1312300-53-0. Molecular formula: C23H19FN2O7. Mole weight: 454.40. | |
| 1-(2-Deoxy-b-D-threo-pentofuranosyl)-5-fluorouracil | 1-(2-Deoxy-b-D-threo-pentofuranosyl)-5-fluorouracil, an effective antineoplastic agent employed in the management of diverse malignancies such as colorectal, breast, and pancreatic cancer, showcases its mechanistic action by suppressing the vital enzyme, thymidylate synthase, thereby impeding DNA synthesis. Undoubtedly, this compound's profound pharmacological features render it an indispensable asset within the biomedicine realm, proficiently combating a myriad of malignant conditions. Synonyms: 5-Fluoro-1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione. CAS No. 955-24-8. Molecular formula: C9H11FN2O5. Mole weight: 246.19. | |
| 2'-Deoxyuridine 5'-monophosphate disodium | 2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: dUMP disodium. CAS No. 42155-08-8. Pack Sizes: 10 mM * 1 mL; 250 mg. Product ID: HY-W011142. |  |
| 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester | 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Benzoic acid, 4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester; Pemetrexed Impurity 63; Methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate; Methyl 4-(2-(2-imino-4,6-dioxo-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate. Grade: ≥95%. CAS No. 1320346-43-7. Molecular formula: C16H16N4O4. Mole weight: 328.32. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid | An impurity of Pemetrexed which binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid. Grade: > 95%. CAS No. 137281-39-1. Molecular formula: C15H14N4O3. Mole weight: 298.3. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid methyl ester | 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester; 2-Amino-4,7-dihydro-5-[2-[4-(methoxycarbonyl)phenyl]ethyl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine; Pemetrexed Impurity 9. Grade: ≥95%. CAS No. 155405-80-4. Molecular formula: C16H16N4O3. Mole weight: 312.32. | |
| 5-(3-Amino-1-propen-1-yl)-2'-deoxyuridine | 5-(3-Amino-1-propen-1-yl)-2'-deoxyuridine, a potent chemotherapeutic agent against multiple types of cancer, works by inducing apoptosis and inhibiting DNA synthesis in malignant cells. Its active ingredient thwarts thymidylate synthase, blocking thymidine production and ultimately halting replication, stopping cancer in its tracks. This widely-used nucleoside treatment targets advanced cases of colon, ovarian, and breast cancer with remarkable success. Synonyms: 5-(3-Amino-1-propenyl)-2'-deoxyuridine; 5-[(E)-3-Amino-1-propenyl]-2'-deoxyuridine; Uridine, 5-(3-amino-1-propenyl)-2'-deoxy-; 5-[(1E)-3-Amino-1-propen-1-yl]-2'-deoxyuridine. Grade: ≥97% by HPLC. CAS No. 143908-73-0. Molecular formula: C12H17N3O5. Mole weight: 283.28. | |
| 5-Bromo-dUMP | 5-Bromo-dUMP is a highly active inhibitor of thymidylate synthase, serving as a pivotal component in hindering the catalytic ability of this vital enzyme involved in the research and development of DNA. Its efficacious employment as an antitumor compound against diverse malignancies proficiently impedes the generation of DNA, thus efficaciously curbing the proliferation of malignant cells inherent to cancerous growths. Synonyms: (5Br-dUMP); 5-Bromo-2'-deoxyuridine-5'-monophosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 6666-38-2. Molecular formula: C9H12N2O8PBr (free acid). Mole weight: 387.08 (free acid). | |
| 5'-Deoxy-5'-fluorothymidine | 5'-Deoxy-5'-fluorothymidine, a compound of utmost significance in the biomedical field, manifests its indispensability in countering a diverse range of malignant neoplasms. Its profound therapeutic efficacy arises from its ability to impede the crucial enzymatic function of thymidylate synthase, pivotal for the replication and mending of DNA. Commencing with colorectal malignancies, this extraordinary product finds extensive utilization in chemotherapy protocols tailored for breast and pancreatic cancers as well. Synonyms: 2',5'-Dideoxy-5'-fluorothymidine. CAS No. 17199-43-8. Molecular formula: C10H13FN2O4. Mole weight: 244.22. | |
| 5-Fluoro-2'-deoxycytidine | 5-Fluoro-2'-deoxycytidine (FdCyd), a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase ( DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of thymidylate synthase inhibitor 5-fluoro-2-dUMP. 5-Fluoro-2'-deoxycytidine can induce cell cycle arrest in tumor cells through the DNA damage response, and it has anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FdCyd; NSC-48006. CAS No. 10356-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116217. | |
| 5-Fluoro-2?-deoxyuridine | thymidylate synthase inhibitor. Group: Fluorescence/luminescence spectroscopy. |  |
| 5-Fluorouracil | Fluorouracil (5-Fluoracil, 5-FU) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS). Synonyms: 5-FU; Fluorouracil; Adrucil. Grade: >98%. CAS No. 51-21-8. Molecular formula: C4H3FN2O2. Mole weight: 130.08. | |
| 5-Fluorouracil-2-[13C,15N2] | 5-Fluorouracil-2-[13C,15N2] is an isotope analogue of 5-Fluorouracil (5-FU). 5-Fluorouracil (5-FU) is a pyrimadine analogue that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV. Synonyms: 5-Fluorouracil-13C,15N2; 5-Fluoro-2,4(1H,3H)pyrimidinedione-13C,15N2; Fluorouracil-13C,15N2; 5-FU-13C,15N2; Fluoroplex-13C,15N2; Efudex-13C,15N2; Adrucil-13C,15N2; Carac-13C,15N2. Grade: 99% by CP; 99% atom 13C. CAS No. 1189423-58-2. Molecular formula: [13C]C3H3F[15N]2O2. Mole weight: 133.06. | |
| 5-Fluoro-UTP | 5-Fluoro-UTP is an DNA/RNA synthesis inhibitor that terminate synthesis of nucleotide through inhibiting thymidylate synthase. It is used as an anticancer drug. Uses: 5-fluoro-utp is an dna/rna synthesis inhibitor. Synonyms: (5F-UTP); 5-Fluoro-uridine-5'-triphosphate; 5-F-UTP; 5-Fluorouridine 5'-(tetrahydrogen triphosphate); Uridine, 5-fluoro-, 5'-(tetrahydrogen triphosphate); Uridine, 5-fluoro-, 5'-triphosphate; 5-Fluorouridine 5'-triphosphate; 5-Fluorouridine triphosphate; Fluorouridine triphosphate. Grade: ≥95% by HPLC. CAS No. 3828-96-4. Molecular formula: C9H14FN2O15P3. Mole weight: 502.13. | |
| 5-Fluoro-UTP trisodium | 5-Fluoro-UTP is an DNA/RNA synthesis inhibitor that terminate synthesis of nucleotide through inhibiting thymidylate synthase. It is used as an anticancer drug. Synonyms: 5-Fluoro-uridine-5'-triphosphate trisodium; 5-F-UTP trisodium; 5-Fluorouridine 5'-(tetrahydrogen triphosphate) trisodium. Molecular formula: C9H14FN2Na3O15P3. Mole weight: 571.10. | |
| 5-Trifluorothymidine | Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency. Group: Biochemicals. Alternative Names: Trifluridine; Trifluorothymine Deoxyriboside; α, α, α-Trifluorothymidine; 2-Deoxy-5- (trifluoromethyl) uridine; 5-(Trifluoromethyl)-2-deoxyuridine; Viroptic. Grades: Highly Purified. CAS No. 70-00-8. Pack Sizes: 100mg, 250mg, 1g. Molecular Formula: C??H??F?N?O?, Molecular Weight: 296.2. US Biological Life Sciences. |  Worldwide |
| (6S)-Tetrahydrofolic acid | (6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (6S)-5,6,7,8-Tetrahydrofolic acid. CAS No. 71963-69-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14520A. | |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| BGC-638 | BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. Synonyms: BGC 638; BGC638; CB300638; CB-300638; D-Glutamic acid, N-(4-(2-propyn-1-yl((6S)-4,6,7,8-tetrahydro-2-methyl-4-oxo-3H-cyclopenta(g)quinazolin-6-yl)amino)benzoyl)-L-gamma-glutamyl-. CAS No. 416852-27-2. Molecular formula: C32H33N5O9. Mole weight: 631.64. | |
| BGC-945 | BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. BGC 945 has low affinity for the widely expressed reduced-folate carrier (RFC). BGC 945 selectively inhibits thymidylate synthase in α-FR-overexpressing tumors and should cause minimal toxicity to humans at therapeutic doses. Synonyms: Idetrexed; ONX-0801; N-[4-[2-Propynyl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; (R)-2-((S)-4-carboxy-4-(4-(((S)-2-(hydroxymethyl)-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)(prop-2-yn-1-yl)amino)benzamido)butanamido)pentanedioic acid. Grade: ≥95%. CAS No. 501332-69-0. Molecular formula: C32H33N5O10. Mole weight: 647.63. | |
| CB30865 | CB30865 is a highly potent cytotoxic agent. The compound inhibits isolated mammalian thymidylate synthase (TS), but this inhibition is insufficient to account for its cellular toxicity. Thymidylate synthase (TS) is a critical enzyme in the de novo synthesis of thymidylate (dTTP) and has long been recognized as a target for chemotherapeutic intervention. Synonyms: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421. Grade: >98%. CAS No. 206275-15-2. Molecular formula: C26H22BrN5O2. Mole weight: 516.39. | |
| CB30900 | CB30900 has been found to be a thymidylate synthase inhibitor that could have some extent of activity in models with low or defective folylpolyglutamate synthetase. Synonyms: CB 30900; CB30900; CB-30900; N-(N-(4-(N-((3,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl)-N-prop-2-ynylamino)-2-fluorobenzoyl)-L-gamma-glutamyl)-D-glutamic acid. Grade: 98%. CAS No. 145788-82-5. Molecular formula: C31H32FN5O9. Mole weight: 637.61. | |
| CB 3731 | CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase. Synonyms: CB 3731; CB-3731; CB3731. N-(4-((N-(2-Amino-4-hydroxy-6-quinazolinyl)methyl)-N-(fluoroethyl)amino)benzoyl)glutamic acid. Grade: 98%. CAS No. 80015-07-2. Molecular formula: C23H24FN5O6. Mole weight: 458.47. | |
| dihydrofolate reductase | The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. Group: Enzymes. Synonyms: tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Enzyme Commission Number: EC 1.5.1.3. CAS No. 9002-3-3. Dihydrofolate Reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1511; dihydrofolate reductase; EC 1.5.1.3; 9002-03-3; tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Cat No: EXWM-1511. | |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| D-Pemetrexed Dimethyl Diester | D-Pemetrexed dimethyl diester is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Diester. Grade: 98%. CAS No. 1391068-12-4. Molecular formula: C22H25N5O6. Mole weight: 455.46. | |
| D-Pemetrexed Hydrate | D-Pemetrexed Hydrate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic Acid Hydrate. Molecular formula: C20H23N5O7. Mole weight: 445.42. | |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| FdUTP | FdUTP, a remarkable nucleoside triphosphate, puts the brakes on thymidylate synthase, striking a fatal blow to DNA precursor synthesis and culminating in cellular collapse. This versatile substance has proven tadpole in tackling a gamut of solid tumors, from the grisly colorectal specter to the dauntingly defiant breast cancer. Synonyms: 5-Fluoro-2'-deoxyuridine-5'-triphosphate. Grade: ≥ 95 % (HPLC). Molecular formula: C9H14N2O14P3F (free acid). Mole weight: 486.1 (free acid). | |
| Hydroxyethyl disulfide | Hydroxyethyl disulfide blocks the inhibitory effect of showdomycin on methotrexate-resistant thymidylate synthase and is also protected by its substrate deoxyuridylic acid, preventing inactivation of the antibiotic [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1892-29-1. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-W076898A. | |
| (-)-LY-338979 | (-)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5R)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5R)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| (+)-LY-338979 | (+)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5S)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5S)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| N-Methyl Pemetrexed | N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed, an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; Pemetrexed EP Impurity A. Grades: Highly Purified. CAS No. 869791-42-4. Pack Sizes: 2.5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 441.44. US Biological Life Sciences. | Worldwide |
| Nolatrexed-[d4] Dihydrochloride | Nolatrexed-[d4] Dihydrochloride is the Antifolate labelled thymidylate synthase inhibitor. Used for Antineoplastic. Synonyms: Nolatrexed-d4 Dihydrochloride; 2-Amino-6-methyl-5-(4-pyridinylthio-d4)-4(1H)-quinazolinone Hydrochloride. CAS No. 1246815-52-0. Molecular formula: C14H10D4Cl2N4OS. Mole weight: 361.28. | |
| Nolatrexed dihydrochloride | Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nolatrexed dihydrochloride. Product Category: Inhibitors. Appearance: Tan Solid. CAS No. 152946-68-4. Molecular formula: C14H12N4OS?2(HCl). Mole weight: 357.26. Purity: ≥98%. Canonical SMILES: [H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl. Density: g/cm³. Product ID: ACM152946684. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Nolatrexed dihydrochloride | Nolatrexed dihydrochloride (AG 337) is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a K i of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases. Nolatrexed dihydrochloride induces cell cycle arrest in S phase of cancer cells. Nolatrexed dihydrochloride exhibits anticancer activity against cervical cancer. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG 337. CAS No. 152946-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108474. | |
| Nolatrexed Dihydrochloride | Antifolate thymidylate synthase inhibitor. Antineoplastic. Group: Biochemicals. Alternative Names: 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; AG 337; Thymitaq. Grades: Highly Purified. CAS No. 152946-68-4. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed | Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: LY231514; Alimta; LY 231514; LY-231514. Grade: >98%. CAS No. 137281-23-3. Molecular formula: C20H21N5O6. Mole weight: 427.41. | |
| Pemetrexed | Pemetrexed (LY231514) is an antifolate , the K i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820. | |
| Pemetrexed-d5 Diethyl Ester | Isotope labelled Pemetrexed-d5 Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: Diethyl 2- (4- (2- (2-Amino-4-oxo-4, 7-dihydro-3H-pyrrolo[2, 3-d]pyrimidin-5-yl) ethyl) benzamido) pentanedioate-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed-d5, Disodium Salt (N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d5 Disodium Salt) | Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Antineoplastic. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d5 Disodium Salt. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Pemetrexed Diethyl Ester | Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: Diethyl 2- (4- (2- (2-Amino-4-oxo-4, 7-dihydro-3H-pyrrolo[2, 3-d]pyrimidin-5-yl) ethyl) benzamido) pentanedioate. Grades: Highly Purified. CAS No. 146943-43-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed disodium | Pemetrexed disodium (LY231514 disodium) is an antifolate, the K i s of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium. CAS No. 150399-23-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10820A. | |
| Pemetrexed disodium heptahydrate | Pemetrexed disodium heptahydrate is a novel antifolate , the K i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium heptahydrate. CAS No. 357166-29-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820B. | |
| Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium, LY-231514, Alimta) | Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 357166-29-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| (Rac)-Plevitrexed | (Rac)-Plevitrexed is a racemate of Plevitrexed, which is a potent and orally active thymidylate synthase (TS) inhibitor. Synonyms: (Rac)-ZD 9331; (Rac)-BGC9331; 2H-Tetrazole-5-butanoic acid, α-[[4-[[(3,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]-2-fluorobenzoyl]amino]-; (±)-Plevitrexed; 2-[(4-{[(2,7-Dimethyl-4-oxo-1,4-dihydro-6-quinazolinyl)methyl](2-propyn-1-yl)amino}-2-fluorobenzoyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid. Grade: ≥95%. CAS No. 153538-08-0. Molecular formula: C26H25FN8O4. Mole weight: 532.53. | |
| Raltitrexed | Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZD1694; D1694; ICI-D1694. CAS No. 112887-68-0. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10821. | |
| Raltitrexed (N-[[5-[[ (1, 4-Dihydro-2-methyl-4-oxo-6-quinazolinyl) methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid, Tomudex, ICI-D-1694, ZD-1694) | Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic. Group: Biochemicals. Alternative Names: N-[[5-[[ (1, 4-Dihydro-2-methyl-4-oxo-6-quinazolinyl) methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid; Tomudex; ICI-D-1694; ZD-1694. Grades: Highly Purified. CAS No. 112887-68-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (S)-dimethyl 2-(4-(4-oxobutyl)benzamido)pentanedioate | (S)-dimethyl 2-(4-(4-oxobutyl)benzamido)pentanedioate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed Impurity 10. CAS No. 1081974-98-2. Molecular formula: C18H23NO6. Mole weight: 349.38. | |
| Tegafur-Uracil | Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UFT; BMS-200604. CAS No. 74578-38-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16110. | |
| Trifluridine | Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV , rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trifluorothymidine; 5-Trifluorothymidine; TFT. CAS No. 70-00-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-A0061. | |
| Trifluridine-[13C,15N2] | Labelled Trifluridine. Trifluorothymidine (TFT) is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA. Synonyms: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione-13C,15N2. Grade: >98%. CAS No. 2086328-10-9. Molecular formula: C9[13C]H11F3[15N]2O5. Mole weight: 299.18. | |
| Trifluridine/tipiracil hydrochloride mixture | Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAS-102; FTD/TPI. CAS No. 733030-01-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16478. | |
| Vanoxonin | Vanoxonin is produced by the strain of Saccharopolyspora hirsuta. It can inhibit thymidylate synthase (IC50 = 0.7μg/mL). And the MIC of the complex against L-1210 and Ehrlich ascites cancer cells was 25 μg/mL. Synonyms: Antibiotic MG 245CF2A; N(sup 5)-Acetyl-N(sup 2)-(N-(2,3-dihydroxybenzoyl)-L-threonyl)-N(sup 5)-hydroxy-L-ornithine; (S)-2-((2S,3R)-2-(2,3-dihydroxybenzamido)-3-hydroxybutanamido)-5-(N-hydroxyacetamido)pentanoic acid. CAS No. 86933-99-5. Molecular formula: C18H25N3O9. Mole weight: 427.40. | |
| glucose-1-phosphate thymidylyltransferase | Involved in the biosynthesis of L-rhamnose in bacteria. Group: Enzymes. Synonyms: glucose 1-phosphate thymidylyltransferase; dTDP-glucose synthase; dTDP-glucose pyrophosphorylase; thymidine diphosphoglucose pyrophosphorylase; thymidine diphosphate glucose pyrophosphorylase; TDP-glucose pyrophosphorylase. Enzyme Commission Number: EC 2.7.7.24. CAS No. 9026-3-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3237; glucose-1-phosphate thymidylyltransferase; EC 2.7.7.24; 9026-03-3; glucose 1-phosphate thymidylyltransferase; dTDP-glucose synthase; dTDP-glucose pyrophosphorylase; thymidine diphosphoglucose pyrophosphorylase; thymidine diphosphate glucose pyrophosphorylase; TDP-glucose pyrophosphorylase. Cat No: EXWM-3237. | |
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