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TOFA is a cell-permeable, potent, reversible, and competitive allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). It inhibits the fatty acid biosynthesis by blocking the synthesis of malonyl-CoA. Uses: Hypolipidemic agents. Synonyms: 5-tetradecoxyfuran-2-carboxylic acid; 5-(tetradecyloxy)-2-furancarboxylic acid; 5-(tetradecyloxy)-2-furoic acid; RMI 14514; RMI-14514. CAS No. 54857-86-2. Molecular formula: C19H32O4. Mole weight: 324.45.
TOFA
TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α ( ACCA ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMI14514; MDL14514. CAS No. 54857-86-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101068.
TOFA - CAS 54857-86-2
A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Group: Fluorescence/luminescence spectroscopy.
Tofacitinib
Tofacitinib is an orally available JAK3/2/1 inhibitor with IC 50 s of 1, 20, and 112 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tasocitinib; CP-690550. CAS No. 477600-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-40354.
Tofacitinib
Tofacitinib is an orally available JAK3 inhibitor (IC50 = 1 nM), exhibiting 20- and 100-fold less potency against JAK2 and JAK1. Tofacitinib induces G1 cell cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. It is approved for the treatment of rheumatoid arthritis (RA). Synonyms: Tasocitinib; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550. Grades: >98%. CAS No. 477600-75-2. Molecular formula: C16H20N6O. Mole weight: 312.37.
Tofacitinib
Tofacitinib is a novel Janus kinase 3 (JAK3) inhibitor. JAK3 is a critical cytoplasmic tyrosine kinase in the signaling pathways of multiple cytokines (interleukin (IL)-2, -7, -15 and -21) that are associated with various T cell functions. Group: Biochemicals. Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)- β -oxo-1-piperidinepropane nitrile; 1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine; CP 690550; Tofacitinib. Grades: Highly Purified. CAS No. 936487-63-7. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences.
Worldwide
Tofacitinib citrate
Tofacitinib citrate. Group: Biochemicals. Alternative Names: 3-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 200mg. Molecular Formula: C16H20N6O·C6H8O7. US Biological Life Sciences.
Worldwide
Tofacitinib citrate
Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile; 2-Hydroxy-1,2,3-propanetricarboxylate. Product Category: Inhibitors. CAS No. 540737-29-9. Molecular formula: C22H28N6O8. Mole weight: 504.4986. Purity: 0.96. Product ID: ACM540737299. Alfa Chemistry ISO 9001:2015 Certified.
Tofacitinib citrate
Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC 50 s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tasocitinib citrate; CP-690550 citrate. CAS No. 540737-29-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-40354A.
Tofacitinib Citrate (TOF) is a JAK3 inhibitor that achieves efficacy in treating rheumatoid arthritis by inhibiting the intracellular target Janus kinases (JAKs). This product is a pre-formulated liposome encapsulating Tofacitinib Citrate. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
Tofacitinib Impurity 5
Tofacitinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride. CAS No. 1062580-52-2. Molecular formula: C14H22N2·2HCl. Mole weight: 291.26. Catalog: APB1062580522.
Tofacitinib Impurity C (Racimic Mixture)
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Molecular formula: C16H20N6O. Mole weight: 312.38.
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H22N2. 2HCl. Mole weight: 291.26.
Tofacitinib Impurity J
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H22N2. 2HCl. Mole weight: 291.26.
Tofacitinib Impurity K
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H22N5O3. Mole weight: 332.39.
Tofacitinib Impurity L
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide; 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanamide; Tofacitinib Impurity 25; Tofacitinib impurity L; SCHEMBL17718764; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl) amino)piperidin-1-yl)-3-oxopropanamide; CS-M2251; AKOS037650370; CS-14706; C12680. Molecular formula: C16H22N6O2. Mole weight: 330.39.
Tofacitinib Impurity N
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-methyl-N-((3s,4s)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 1260614-73-0. Molecular formula: C13H19N5. Mole weight: 245.33.
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-Des-(2-Cyanide-acetyl)-(3R,4S). Molecular formula: C13H19N5. Mole weight: 245.33.
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-Des-(2-Cyanide-acetyl)-(3S,4R). Molecular formula: C13H19N5. Mole weight: 245.33.
Tofacitinib Impurity O
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine. Molecular formula: C20H25N5. Mole weight: 335.46.
Tofacitinib Impurity P
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-((3S,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 1252883-90-1. Molecular formula: C20H25N5. Mole weight: 335.46.
Tofacitinib Impurity R
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 4-Chloro-7-tosyl-7h-pyrrolo[2,3-d]pyrimidine. CAS No. 479633-63-1. Molecular formula: C13H10ClN3O2S. Mole weight: 307.76.
Tofacitinib Impurity S
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C27H31N5O2S. Mole weight: 489.64.
Tofacitinib Impurity T
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H18N6O. Mole weight: 310.36.
Tofacitinib Impurity U
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H18ClN5. Mole weight: 297.77.
Tofacitinib Impurity V
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H19ClN6O. Mole weight: 346.82.
Tofacitinib Impurity W
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H18ClN5. Mole weight: 279.77.
Tofacitinib Impurity X
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5. Mole weight: 245.33.
Tofacitinib Impurity Y
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H21N5. Mole weight: 259.36.
Tofacitinib Impurity Z
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)-. CAS No. 477600-76-3. Molecular formula: C15H21N5O. Mole weight: 287.37.
Tofacitinib N-hydroxy impurity
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5O. Mole weight: 261.33.
Tofacitinib N-Oxide
Tofacitinib N-Oxide is an impurity of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: Tofacitib related impuritie 8; 1-Piperidinepropanenitrile, 4-methyl-3-(methyloxido-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, (3R,4R)-. Grades: ≥95%. CAS No. 2028267-73-2. Molecular formula: C16H20N6O2. Mole weight: 328.37.
Tofacitinib related compound 1
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H22N6O2. Mole weight: 330.39.
Tofacitinib Related Compound 10
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5. Mole weight: 245.33.
Tofacitinib Related Compound 11
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H20N6O. Mole weight: 288.36.
Tofacitinib Related Compound 12
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C20H25N5. Mole weight: 335.46.
Tofacitinib Related Compound 13
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C20H25N5. Mole weight: 335.46.
Tofacitinib Related Compound 14
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H19N5O. Mole weight: 273.34.
Tofacitinib Related Compound 15
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C15H21N5O. Mole weight: 287.37.
Tofacitinib Related Compound 16
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C15H23N5. Mole weight: 273.38.
Tofacitinib related compound 2
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C10H17N3O. Mole weight: 195.27.
Tofacitinib related compound 3
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H18N4O2. Mole weight: 262.31.
Tofacitinib related compound 4
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H20N6O. Mole weight: 312.38.
Tofacitinib related compound 5
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5. Mole weight: 245.33.
Tofacitinib Related Compound 6
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C19H21N7O2. Mole weight: 379.42.
Tofacitinib Related Compound 7
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H22N6O2. Mole weight: 330.39.
Tofacitinib Related Compound 8
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C29H38N10O2. Mole weight: 558.69.
Tofacitinib Related Compound 9
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C34H45N7. Mole weight: 551.78.
Tofacitinib Related Impurity (PF-05579970)
One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: PF-05579970. Molecular formula: C15H21N5O. Mole weight: 287.37.
Tofatinib Impurity 20
Tofatinib Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092578-44-3. Molecular formula: C27H31N5O2S. Mole weight: 489.64. Catalog: APB1092578443.
Tofatinib Impurity 22
Tofatinib Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092578-45-4. Molecular formula: C20H25N5. Mole weight: 335.45. Catalog: APB1092578454.
Tofatinib Impurity 30
Tofatinib Impurity 30. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1675248-18-6. Molecular formula: C18H25N5O3. Mole weight: 359.43. Catalog: APB1675248186.
Tofatinib Impurity 31
Tofatinib Impurity 31. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1243290-37-0. Molecular formula: C15H21N5O2. Mole weight: 303.37. Catalog: APB1243290370.
Tofatinib Impurity 33
Tofatinib Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1527525-58-1. Molecular formula: C15H18N6O. Mole weight: 298.34. Catalog: APB1527525581.
Tofatinib Impurity A
Tofatinib Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092578-46-5. Molecular formula: C16H20N6O. Mole weight: 312.38. Catalog: APB1092578465.
Tofatinib Impurity D
Tofatinib Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1252883-90-1. Molecular formula: C20H25N5. Mole weight: 335.45. Catalog: APB1252883901.
Tofatinib Impurity Q
Tofatinib Impurity Q. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1675248-19-7. Molecular formula: C16H22N6O2. Mole weight: 330.39. Catalog: APB1675248197.
Tofatinib Impurity T
Tofatinib Impurity T. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092578-43-2. Molecular formula: C16H20N6O. Mole weight: 312.38. Catalog: APB1092578432.
(3R,4S)-Tofacitinib
(3R,4S)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity A; 3-((3R,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-46-5. Molecular formula: C16H20N6O. Mole weight: 312.27.
(3R,4S)-Tofacitinib
(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC 50 of 1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092578-46-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-40354D.
(3S,4R)-Tofacitinib
(3S,4R)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity B; 3-((3S,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-48-7. Molecular formula: C16H20N6O. Mole weight: 312.27.
(3S,4S)-Tofacitinib
(3S,4S)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity C; 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-47-6. Molecular formula: C16H20N6O. Mole weight: 312.27.
Potent JAK inhibitor (IC50 values are 1, 20, and 112nm for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models. Group: Biochemicals. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CP-690550 Citrate (Tofacitinib Citrate)
CP-690550 is a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis. Group: Biochemicals. Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)- β -oxo-1-piperidinepropane nitrile; 2-Hydroxy-1,2,3-propanetricarboxylate; (3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine 2-Hydroxy-1,2,3-propanetricarboxylate; CP 690500-10; CP 690550-10; Tofacitinib Citrate. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Dihydro Tofacitinib Citrate
An impurity of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: Tofacitinib Impurity; 5,6-Dihydro CP-690550 citrate; 5,6-Dihydro Tofacitinib citrate. Molecular formula: C22H30N6O8. Mole weight: 506.51.
A dihydrochloride salt form of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine;dihydrochloride; 1-benzyl-N,4-dimethylpiperidin-3-amine;dihydrochloride. Grades: 99 %. CAS No. 1228879-37-5. Molecular formula: C14H24Cl2N2. Mole weight: 291.26.
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