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| Product | Description | |
|---|---|---|
| TPA | TPA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,10-Bis[phenyl(m-tolyl)-amino]anthracene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 189263-81-8. Molecular formula: C40H32N2. Mole weight: 540.70 g/mol. Purity: 95%+. IUPACName: 9-N,10-N-bis(3-methylphenyl)-9-N,10-N-diphenylanthracene-9,10-diamine. Canonical SMILES: CC1=CC(=CC=C1)N(C2=CC=CC=C2)C3=C4C=CC=CC4=C(C5=CC=CC=C53)N(C6=CC=CC=C6)C7=CC=CC(=C7)C. Density: 1.194 ± 0.06 g/ml. Product ID: ACM189263818. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TPA023 | TPA023, also called as MK-0777, is a subtype-selective, mixed agonist-antagonist at GABAA receptor with anxiolytic and anticonvulsant effects. Synonyms: 7-tert-butyl-6-[(2-ethyl-1,2,4-triazol-3-yl)methoxy]-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine; TPA023; TPA-023; TPA 023; MK0777; MK 0777; MK-0777; L830982; L-830982; L 830982. Grades: >98%. CAS No. 252977-51-8. Molecular formula: C20H22FN7O. Mole weight: 395.44. |  |
| TPA-696 | TPA-696. Group: Polymersacrylic resins. |  |
| TPA-DCPP | TPA-DCPP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7,10-Bis(4-(diphenylamino)phenyl)-2,3-dicyanopyrazino-phenanthrene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1803287-94-6. Molecular formula: C54H34N6. Mole weight: 766.89 g/mol. Product ID: ACM1803287946. Alfa Chemistry ISO 9001:2015 Certified. | |
| TPA_exp: DEFB103-like protein | TPA_exp: DEFB103-like protein is an antimicrobial peptide isolated from Papio anubis. It has anti-gram-positive bacteria, gram-negative bacteria, anti-fungal and anti-viral activities. Synonyms: Gln-Lys-Tyr-Tyr-Cys-Arg-Val-Arg-Gly-Gly-Arg-Cys-Ala-Val-Leu-Ser-Cys-Leu-Pro-Lys-Glu-Glu-Gln-Ile-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg. | |
| TPA_exp: DEFB4-like protein | TPA_exp: DEFB4-like protein is an antimicrobial peptide isolated from Papio anubis. It has anti-gram-positive bacteria, gram-negative bacteria, anti-fungal and anti-viral activities. Synonyms: Ile-Arg-Asn-Pro-Val-Thr-Cys-Ile-Arg-Ser-Gly-Ala-Ile-Cys-Tyr-Pro-Arg-Ser-Cys-Pro-Gly-Ser-Tyr-Lys-Gln-Ile-Gly-Val-Cys-Gly-Val-Ser-Val-Ile-Lys-Cys-Cys-Lys-Lys-Pro. | |
| TPA_exp: EP2E protein | TPA_exp: EP2E protein is an antimicrobial peptide isolated from Sus scrofa. Synonyms: Arg-Asp-Val-Ile-Cys-Leu-Met-Gln-His-Gly-Thr-Cys-Arg-Leu-Phe-Phe-Cys-His-Ser-Gly-Glu-Lys-Lys-Ser-Glu-Ile-Cys-Ser-Asp-Pro-Trp-Asn-Arg-Cys-Cys. | |
| TPA: ovochymase precursor (314-332) | | |
| TPA-SBFF | TPA-SBFF. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N5,N5,N9,N9-Tetraphenylspiro[benzo[c]fluorene-7,9'-fluorene]-5,9-diamine. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1262333-45-8. Molecular formula: C53H36N2. Mole weight: 700.87 g/mol. Product ID: ACM1262333458. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2- (Tripentylammonium) ethyl Methanethiosulfonate Bromide (MTS-TPAE) | Water soluble. Group: Biochemicals. Alternative Names: MTS-TPAE. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CN-TPB-TPA | CN-TPB-TPA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4'''-(Diphenylamino)-2',5'-diphenyl-[1,1':4',1'':4'',1'''-quaterphenyl]-4-carbonitrile. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2408719-17-3. Molecular formula: C49H34N2. Mole weight: 650.81 g/mol. Product ID: ACM2408719173. Alfa Chemistry ISO 9001:2015 Certified. | |
| Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. | Worldwide |
| TBN-TPA | TBN-TPA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,12-Di-tert-butyl-5,9-bis(4-(tert-butyl)phenyl)-7(3,6-di-tert-butyl-9H-carbazol-9-yl)-5,9-dihydro-5,9-iaza-13b-boranaphtho[3,2,1-de]anthracene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2376745-32-1. Molecular formula: C66H76BN3. Mole weight: 922.14 g/mol. Product ID: ACM2376745321. Alfa Chemistry ISO 9001:2015 Certified. Categories: Tent Partnership for Refugees. | |
| TXO-TPA | TXO-TPA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-[4-(diphenylamino) phenyl]-10, 10-dioxide-9H-thioxanthen-9-one. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1623010-63-8. Molecular formula: C31H21NO3S. Mole weight: 487.57 g/mol. Purity: 95%+. IUPACName: 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one. Canonical SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC5=C(C=C4)S(=O)(=O)C6=CC=CC=C6C5=O. Density: 1.333 ± 0.06 g/ml. Product ID: ACM1623010638. Alfa Chemistry ISO 9001:2015 Certified. Categories: Totpavit. | |
| Z-TPAV-AMC | Synonyms: Cbz-Thr-Pro-Ala-Val-AMC. Molecular formula: C35H43N5O9. Mole weight: 677.76. | |
| 4'-Demethylepipodophyllotoxin | 4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.IC50 Value: 0.31uM(EC5 0in HL60 cell, MTT assay, 48h); 0.37uM(EC50 in HepG2 cell, MTT assay, 48h) Target: microtubulein vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP.in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Domethylpodophyllotoxin, 4'-demethyl-epi-podophyllotoxin. Product Category: Inhibitors. Appearance: Powder. CAS No. 6559-91-7. Molecular formula: C21H20O8. Mole weight: 400.38. Purity: 0.98. IUPACName: (5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one. Canonical SMILES: COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O. Density: 1.446±0.06 g/ml. Product ID: ACM6559917. Alfa Chemistry | |
| 5,10,15,20-Tetrakis(4-aminophenyl)porphyrin | 5,10,15,20-Tetrakis(4-aminophenyl)porphyrin. Group: Ligands for functional metal complexesphthalocyanine dyes, porphyrin dyes. Alternative Names: C44H34N8; tetra-(4-aminophenyl)porphyrin; TPAPP; I14-59390; AK102897; 5,10,15,20-Tetrakis(4-aminophenyl)porphyrin; CHEMBL376444; TR-032161; ANW-24725; 5,10,15,20-Tetrakis(4-aminophenyl)-21H,23H-porphine. CAS No. 22112-84-1. Product ID: 4-[10,15,20-tris(4-aminophenyl)-21,23-dihydroporphyrin-5-yl]aniline. Molecular formula: 674.812g/mol. Mole weight: C44H34N8. C1=CC (=CC=C1C2=C3C=CC (=C (C4=NC (=C (C5=CC=C (N5)C (=C6C=CC2=N6)C7=CC=C (C=C7)N)C8=CC=C (C=C8)N)C=C4)C9=CC=C (C=C9)N)N3)N. InChI=1S/C44H34N8/c45-29-9-1-25 (2-10-29)41-33-17-19-35 (49-33)42 (26-3-11-30 (46)12-4-26)37-21-23-39 (51-37)44 (28-7-15-32 (48)16-8-28)40-24-22-38 (52-40)43 (36-20-18-34 (41)50-36)27-5-13-31 (47)14-6-27/h1-24, 49, 52H, 45-48H2. REPFNYFEIOZRLM-UHFFFAOYSA-N. | |
| 5-Chloro-6-[(2-Oxo-1-Pyrrolidinyl)Methyl]-2,4(1H,3H)-Pyrimidinedione | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Synonyms: Tipiracil Impurity C. Grades: ≥95%. CAS No. 2101241-71-6. Molecular formula: C9H12ClN3O3. Mole weight: 245.66. | |
| 5'-O-Tritylinosine | KIN59 is a purine riboside derivative that suppresses thymidine phosphorylase (TPase). TPase is an enzyme catalyzing the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases. KIN59 noncompetitively inhibits TPase-induced angiogenesis in the chorioallantoic membrane assay. Synonyms: 5'-Trt-rI; (2R,3R,4S,5R)-9-(3,4-Dihydroxy-5-trityloxymethyl-tetrahydrofuran-2-yl)-1,9-dihydropurin-6-one; KIN-59; Inosine, 5'-O-(triphenylmethyl)-; 5'-O-(triphenylmethyl)-inosine. Grades: ≥98% by HPLC. CAS No. 4152-77-6. Molecular formula: C29H26N4O5. Mole weight: 510.55. | |
| 6-[(2-Imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Synonyms: Tipiracil Impurity des Cl. Grades: ≥95%. CAS No. 2069937-25-1. Molecular formula: C9H12N4O2. Mole weight: 208.22. | |
| 7-Deazaxanthine | 7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase ( TPase ). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC 50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7DX. CAS No. 39929-79-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-77537. |  |
| ADT-OH | ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. ADT is a putative neuroprotectant and antioxidant that increases glutathione levels in cultured astroglial cells. ADT-OH was shown to reduce tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Synonyms: 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione; Desmethylanethol trithione; 3H-1,2-Dithiole-3-thione, 5-(4-hydroxyphenyl)-. CAS No. 18274-81-2. Molecular formula: C9H6OS3. Mole weight: 226.326. | |
| Angelicin | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target:In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways.In vivo: Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 523-50-2. Molecular formula: C11H6O3. Mole weight: 186.16. Purity: 0.9986. Canonical SMILES: O=C1C=CC2=CC=C(OC=C3)C3=C2O1. Product ID: ACM523502. Alfa Chemistry ISO 9001:2015 Certified. | |
| Benzamidine hydrochloride | Benzamidine hydrochloride is a trypsin-like serine proteases with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1670-14-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W018781. | |
| Benzamidine hydrochloride hydrate | Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Benzenecarboximidamide hydrochloride hydrate. CAS No. 206752-36-5. Pack Sizes: 5 g; 10 g. Product ID: HY-W087937. | |
| CAY10502 | Phospholipases A2 (PLA2s) are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule. It catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively. Synonyms: CAY10502; CAY-10502. Grades: ≥98% (mixture of isomers). CAS No. 888320-29-4. Molecular formula: C30H37NO7. Mole weight: 523.6. | |
| Clethramycin | It is produced by the strain of Streptomyces hygroscopicus TPA0623. Clethramycin has activities against candida, cryptococcus neoforme and aspergillus fumigatus with MIC of 0.5-8 μg/mL. And it also inhibits the growth of Pollen tubes. Synonyms: CHEBI:65643. Molecular formula: C63H99N3O18S. Mole weight: 1218.53. | |
| Cycloepoxydon | It is produced by the strain of Duteromycete 45-93. It can inhibit TPA induced expression of k gene binding nuclear factor (NF-KB) and activator protein-1 (APT-1) mediated secreted alkaline phosphatase (SEAP), with IC50 of 4.2-9.4 mol/L and 4.2-9.4 mol/L, respectively. Molecular formula: C12H16O5. Mole weight: 240.25. | |
| D-Ile-Pro-Arg p-nitroanilide dihydrochloride | D-Ile-Pro-Arg p-nitroanilide dihydrochloride is a chromogenic peptide substrate of tissue plasminogen activator (tPA) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 96323-41-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-137837. | |
| Drospirenone | Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dihydrospirorenone. CAS No. 67392-87-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0111. | |
| (±)-Equol | (R,S)-Equol is a flavonoid. Racemic mixture. This is a metabolite that is produced in vivo from soy phytoestrogen daidzein from gut microflora. (R,S)-Equol inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. (R,S)-Equol shows positive effects on the incidence of prostate cancer. Functions as a DHT blocker. Preferentially activates estrogen receptor β (ERβ). Uses: Phytoestrogens. Synonyms: 3-(4-hydroxyphenyl)chroman-7-ol. Grades: ≥98%. CAS No. 94105-90-5. Molecular formula: C15H14O3. Mole weight: 242.3. | |
| Heptaminol hydrochloride | Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP-2831 hydrochloride. CAS No. 543-15-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1231. | |
| Immobilized human plasmin | We have immobilized human Lys plasmin on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tPA and uPA to the two-chain form. It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3. 4. 21. 7; 9001-90-5; PLG. Enzyme Commission Number: EC 3. 4. 21. 7. Purity: >95% by SDS-PAGE analysis. Mole weight: 85000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Human plasma. Species: Human. fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3. 4. 21. 7; 9001-90-5; PLG; Immobilized plasmin. Cat No: NATE-1757. |  |
| Immobilized human tissue plasminogen activator, single chain | Useful for controlled plasminogen activation studies. May be used to immuno purify monoclonal and polyclonal antibodies directed against human tPA. May be used repeatedly. Group: Enzymes. Synonyms: Tissue-type plasminogen activator; EC 3. 4. 21. 68; tPA; t-PA; t-plasminogen activator; TPA; T-PA. Enzyme Commission Number: EC 3. 4. 21. 68. Purity: >95% by SDS-PAGE analysis. Mole weight: 70000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: CHO cells. Species: Human. Tissue-type plasminogen activator; EC 3. 4. 21. 68; tPA; t-PA; t-plasminogen activator; TPA; T-PA; Immobilized tissue plasminogen activator; Immobilized tPA. Cat No: NATE-1758. | |
| Immobilized porcine pancreatic elastase | Cleaves PAI-1 between the P3 and P4 residues to create a loop-inserted species that is non-inhibitory towards the target enzymes uPA and tPA. Group: Enzymes. Synonyms: EC 3. 4. 21. 36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1. Enzyme Commission Number: EC 3. 4. 21. 36. Purity: >95% by SDS-PAGE analysis. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Porcine pancreas. Species: Porcine. EC 3. 4. 21. 36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1; Immobilized elastase; Immobilized pancreatic elastase; Immobilized ELA1. Cat No: NATE-1760. | |
| Irsogladine | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Uses: Anti-ulcer agents. Synonyms: Irsogladine; 57381-26-7; dicloguamine; 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine; Irsogladine [INN]; 1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-; QBX79NZC1D; 2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine;[4-amino-6-(2,5-dichlorophenyl)-s-triazin-2-yl]amine; maleic acid; (Z)-2-butenedioic acid; 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine; 6-[2,5-bis(chloranyl)phenyl]-1,3,5-triazine-2,4-diamine; (Z)-but-2-enedioic acid. Grades:>98%. CAS No. 57381-26-7. Molecular formula: C9H7Cl2N5. Mole weight: 256.09. | |
| Irsogladine Maleate | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. It inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice. It up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. It also produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions. Synonyms: Dicloguamine maleate; MN1695; MN 1695; MN-1695. Grades: >98%. CAS No. 84504-69-8. Molecular formula: C13H11Cl2N5O4. Mole weight: 372.16. | |
| LCKLSL | LCKLSL is a competitive inhibitor of annexin A2 (AnxA2). It can effectively inhibit the binding of tissue plasminogen activator (tPA) and AnxA2. It can also inhibit the production of plasmin and has an anti-angiogenic effect. Synonyms: LCKLSL; HY-P2333; AKOS040758181; 533902-29-3; CS-0130051. CAS No. 533902-29-3. Molecular formula: C30H57N7O8S. Mole weight: 675.88. | |
| Multiflorenol | Multiflorenol is a triterpenoid found in the geranium family and other flowering plants. It inhibits histamine release induced by antigen-antibody reaction and inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate (TPA) in a concentration-dependent manner. Synonyms: 26-Norolean-7-en-3-ol, 13-methyl-, (3β,13α,14β)-; (3β)-D:C-Friedoolean-7-en-3-ol; (14β)-13α-methyl-26-norolean-7-en-3β-ol; 26-Norolean-7-en-3-ol, 13-methyl-, (3beta,13alpha,14beta)-; (3S,4aR,6aS,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,7,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-ol. Grades: ≥95% by HPLC. CAS No. 2270-62-4. Molecular formula: C30H50O. Mole weight: 426.72. | |
| Nidulal | Nidulal is originally isolated from Nidula candida 87220. Nidulal induces differentiation of human promyelocytic leukemia cells. In COS-7 cells it selectively activates AP-1 dependent signal transduction in a manner which is similar to TPA/PMA. Synonyms: 4-(8-Methyl-4,7-dioxo-1,6-dioxaspiro[4.4]nona-2,8-dien-3-yl)cyclohexanecarbaldehyde. Grades: 95%. CAS No. 185853-14-9. Molecular formula: C15H16O5. Mole weight: 276.28. | |
| Phorbol-12,13-didecanoate | Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 24928-17-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-160070. | |
| Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator [1] [2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells [3] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: PMA; TPA; Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18739. | |
| Phthalic acid | Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers [1]. Uses: Scientific research. Group: Natural products. CAS No. 88-99-3. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-I0508. | |
| Plasminogen, Human plasma | Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-91-6. Pack Sizes: 1 mg. Product ID: HY-P2821. | |
| Steffimycin B (Antibiotic U 40615) | Steffimycin B is a anthracycline metabolite isolated from a Streptomyces sp. displaying antibacterial and antineoplastic properties. Binding to DNA, crystallographic studies suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells. Group: Biochemicals. Alternative Names: Antibiotic U 40615. Grades: Highly Purified. CAS No. 54526-94-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Sulodexide | Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III ( AT III ) and heparin cofactor II ( HC II ), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57821-29-1. Pack Sizes: 250 LSU. Product ID: HY-100897. | |
| taurine-pyruvate aminotransferase | The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. β-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine-2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group. Group: Enzymes. Synonyms: Tpa. Enzyme Commission Number: EC 2.6.1.77. CAS No. 51901-18-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2917; taurine-pyruvate aminotransferase; EC 2.6.1.77; 51901-18-9; Tpa. Cat No: EXWM-2917. | |
| Tenecteplase | Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNK-tPA. CAS No. 191588-94-0. Pack Sizes: 100 μg. Product ID: HY-108845. | |
| Terephthalic Acid | Terephthalic acid (a portmanteau of the turpentine producing tree terebinthus, and phthalic acid) is the organic compound with formula C6H4(CO2H)2. This White solid is a commodity chemical, used principally as a precursor to the polyester PET, used to make clothing and plastic bottles. Several million tonnes are produced annually. Uses: Terephthalic acid (tpa) can be synthesized from bio-based materials for a variety of s, which include the production of polyester fiber, non-fiber field, pet bottles, synthetic perfumes and medicines. terephthalic acid is used as a linker molecule in the preparation of metal organic frameworks (mofs). Group: Hydrogen storage materials metal organic frameworks (mofs)monomers. Alternative Names: TEREPHTHALIC ACID FOR SYNTHESIS; Terephthalic acid; Terephthalicacid; TEREPHTHALIC ACID/BENZENE-1,4-DICARBOXYLIC ACID; p-Phthalic acid. CAS No. 100-21-0. Pack Sizes: Packaging 5, 100, 500 g in poly bottle. Product ID: terephthalic acid. Molecular formula: 166.13. Mole weight: C8H6O4. OC(=O)c1ccc(cc1)C(O)=O. 1S/C8H6O4/c9-7 (10)5-1-2-6 (4-3-5)8 (11)12/h1-4H, (H, 9, 10) (H, 11, 12). KKEYFWRCBNTPAC-UHFFFAOYSA-N. 99%. | |
| Terephthalic Acid | Terephthalic acid is a benzenepolycarboxylic acid with potential anti-hemorrhagic properties. Group: Biochemicals. Alternative Names: 1,4-Benzenedicarboxylic Acid; 1,4-Dicarboxybenzene; 4-Carboxybenzoic Acid; Amoco TA 33; NSC 36973; QTA; S-LOP; TA 33LP; TPA; WR 16262; p-Benzenedicarboxylic Acid; p-Carboxybenzoic Acid; p-Dicarboxybenzene; p-Phthalic Acid. Grades: Highly Purified. CAS No. 100-21-0. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| Terephthalic-d4 Acid | Isotope labelled Terephthalic acid is a benzenepolycarboxylic acid with potential anti-hemorrhagic properties. Group: Biochemicals. Alternative Names: 1,4-Benzenedicarboxylic-d4 Acid; 1,4-Dicarboxybenzene-d4; 4-Carboxybenzoic-d4 Acid; Amoco TA 33-d4; NSC 36973-d4; QTA-d4; S-LOP-d4; TA 33LP-d4; TPA-d4; WR 16262-d4; p-Benzenedicarboxylic-d4 Acid; p-Carboxybenzoic-d4 Acid; p-Dicarboxybenzene-d4; p-Phthalic-d4 Acid. Grades: Highly Purified. CAS No. 60088-54-2. Pack Sizes: 500mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Tetradecylphosphonic acid | 98%. Uses: Tdpa can be used to cap copper nanoparticles to protect them from oxidation. it may also be used in the synthesis of cadmium sulfate (cds) core, which can be used in the fabrication of cadmium selenium (cdse)/cds core quantum dots (qds). it may also be coated on caesium lead bromide (cspbbr3) perovskite quantum dots for the development of white light emitting diodes (wled). Group: Self-assembly materials self assembly and contact printing materials. Alternative Names: TPA, TDPA. CAS No. 4671-75-4. Pack Sizes: 1 g/5 g/100 g. Product ID: tetradecylphosphonic acid. Molecular formula: 278.37 g/mol. Mole weight: C14H31O3P. CCCCCCCCCCCCCCP(=O)(O)O. InChI=1S / C14H31O3P / c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18 (15, 16) 17 / h2-14H2, 1H3, (H2, 15, 16, 17). BVQJQTMSTANITJ-UHFFFAOYSA-N. | |
| Tetrapropylammonium perruthenate | Tetrapropylammonium perruthenate (TPAP) is an organic compound commonly used as a catalyst and oxidizing agent. It can play an oxidation role in some organic synthesis reactions, and can catalyze the oxidation reactions of olefins and aromatic compounds. In addition, the compound is widely used in some industrial production areas, such as in the application of plastics, rubber and textile manufacturing processes. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: TPAP. CAS No. 114615-82-6. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-W007801. | |
| Tetrapropylammonium Perruthenate | Tetrapropylammonium Perruthenate. Group: Biochemicals. Alternative Names: TPAP. Grades: Highly Purified. CAS No. 114615-82-6. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Tipiracil | Tipiracil, a thymidine phosphorylase (TPase) inhibitor, has been found to be a potential drug candidate for metastatic colorectal cancer. Synonyms: TAS-102; TAS102. CAS No. 183204-74-2. Molecular formula: C9H11ClN4O2. Mole weight: 242.67. | |
| Tipiracil | Tipiracil is a thymidine phosphorylase ( TPase ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 183204-74-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-A0063A. | |
| Tipiracil Impurity 1 | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Molecular formula: C9H10ClN3O3. Mole weight: 243.65. | |
| Tipiracil Impurity 2 | One of the impurities of Tipiracil, which is a thymidine phosphorylase (TPase) inhibitor and has been found to be a potential drug candidate for metastatic colorectal cancer. Molecular formula: C6H7ClN2O3. Mole weight: 190.59. | |
| Tissue plasminogen activator from Human, Recombinant | Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism. Tissue plasminogen activator human recombinant produced in cho cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a mol...0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. tPA. Mole weight: 59008.71 Da. Activity: 580,000 IU/mg. Stability: Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution tPA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. Appearance: Sterile Filtered White lyophilized (freeze-dried) powder. Source: CHO. Species: Human. Tissue-type plasminogen activator; EC 3.4.21.68; tPA; t-PA; t-plasminogen activator; TPA; T-PA. Cat No: NATE-0920. | |
| t-plasminogen activator | A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26. Group: Enzymes. Synonyms: tissue plasminogen activator; plasminogen activator, tissue-type; tissue-type plasminogen activator; tPA; t-PA. Enzyme Commission Number: EC 3.4.21.68. CAS No. 139639-23-9. tPA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4159; t-plasminogen activator; EC 3.4.21.68; 139639-23-9; tissue plasminogen activator; plasminogen activator, tissue-type; tissue-type plasminogen activator; tPA; t-PA. Cat No: EXWM-4159. | |
| Triclopyr | Triclopyr. Group: Biochemicals. Alternative Names: 2-[(3,5,6-Trichloro-2-pyridinyl)oxy]acetic acid; [(3,5,6-tTichloro-2-pyridyl)oxy]acetic acid; 3,5,6-TPA. Grades: Highly Purified. CAS No. 55335-06-3. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C7H4Cl3NO3. US Biological Life Sciences. | Worldwide |
| Tris[4-(5-dicyanomethylidenemethyl-2-thienyl)phenyl]amine | Tris[4-(5-dicyanomethylidenemethyl-2-thienyl)phenyl]amine. Uses: Isotropic organic semiconductor for opv's and oled's. tdcv-tpa is soluble in a large variety of organic solvents and can be used for the fabrication of heterojunction solar cells with high open-circuit voltage (1.15v), efficiency close to 2% and longer ambient condition lifetimes than cells based on poly(alkylthiophenes). the compound absorbs at 509nm (in ch2cl2 solution) and 538nm as thin film. it can be used as high spectral purity luminophore in led's, emitting red light at 658nm. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. Alternative Names: TDCV-TPA. CAS No. 883236-54-2. Pack Sizes: 100 mg in glass insert. Product ID: 2-[[5-[4-[4-[5-(2,2-dicyanoethenyl)thiophen-2-yl]-N-[4-[5-(2,2-dicyanoethenyl)thiophen-2-yl]phenyl]anilino]phenyl]thiophen-2-yl]methylidene]propanedinitrile. Molecular formula: 719.86. Mole weight: C42H21N7S3. N#C\C (=C/c1ccc (s1)-c2ccc (cc2)N (c3ccc (cc3)-c4ccc (\C=C (/C#N)C#N)s4)c5ccc (cc5)-c6ccc (\C=C (/C#N)C#N)s6)C#N. 1S/C42H21N7S3/c43-22-28 (23-44)19-37-13-16-40 (50-37)31-1-7-34 (8-2-31)49 (35-9-3-32 (4-10-35)41-17-14-38 (51-41)20-29 (24-45)25-46)36-11-5-33 (6-12-36)42-18-15-39 (52-42)21-30 (26-47)27-48/h1-21H, KJHGHQMIPHPKIY-UHFFFAOYSA-N. KJHGHQMIPHPKIY-UHFFFAOYSA-N. | |
| UK122 | UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC 50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC 50 >100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 940290-58-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111056. | |
| UK-371804 | UK-371804 is a novel and selective inhibitors of urokinase plasminogen activator (uPA). UK-371804 exhibits excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Synonyms: 2- ( (4-chloro-1- ( (diaminomethylene) amino) isoquinoline) -7-sulfonamido) -2-methylpropanoic acid; UK-371804; UK371804; UK 371804; UK-371,804; UK 371,804; UK371,804. Grades: >98%. CAS No. 256477-09-5. Molecular formula: C14H16ClN5O4S. Mole weight: 385.82. | |
| Valrubicin | Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC 50 s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AD-32. CAS No. 56124-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13772. | |
| YM 26734 | YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) with a broad inhibitory profile to several sPLA2s (IC50 = 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE, respectively). YM 26734 displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. YM 26734 is used to ameliorates local inflammatory responses in TPA-induced mouse ear edema. Synonyms: YM 26734; YM26734; YM-26734; 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone; 1-[3-dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]phenyl]dodecan-1-one. Grades: ≥95% by HPLC. CAS No. 144337-18-8. Molecular formula: C45H62O8. Mole weight: 730.97. | |
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