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(1R,2S,5R)-Menthol-5R-hydroxy-[1,3]-oxathiolane-2R-carboxylate is an intermediate of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (2S,5R)-5-Hydroxy[1,3]oxathiolane-2-carboxylic Acid L-Menthol Ester; (1R,2S,5R)-Menthol-5R-hydroxy Acid 2-Isopropyl-5-methyl-cyclohexyl Ester; HME; Lamivudine Impurity 8; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5R)-. Grades: 98%. CAS No. 147126-62-3. Molecular formula: C14H24O4S. Mole weight: 288.40.
It is the uracil impurity of the parent compound Emtricitabine, a reverse transcriptase inhibitor. Synonyms: 5-Fluoro-1-(2'-L-menthyloxycarbonyl-1'-3'-oxathiolan-5'-yl)-cytosine; (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate. Grades: ≥95%. CAS No. 1422361-25-8. Molecular formula: C18H25FN2O5S. Mole weight: 400.46.
(2R,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-((3-Fluoro-6-hydroxypyridin-2-yl)amino)-1,3-oxathiolane-2-carboxylate is an impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H27FN2O4S, Molecular Weight: 398.49. US Biological Life Sciences.
(2R,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-((3-Fluoro-6-hydroxypyridin-2-yl)amino)-1,3-oxathiolane-2-carboxylate is an impurity of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Molecular formula: C19H27FN2O4S. Mole weight: 398.49.
(2S,5S)-(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl 5-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1,3-Oxathiolane-2-carboxylate is an intermediate and impurity of Lamivudine, which is a potent nucleoside reverse transcriptase inhibitor and antiviral agent used to treat chronic hepatitis B. Synonyms: (2S,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; Lamivudine Impurity 3; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S,5S)-. Molecular formula: C18H27N3O4S. Mole weight: 381.49.
Intermediate for the preparation of Glimepiride. Group: Biochemicals. Alternative Names: Des[ (trans-4-methylcyclohexyl) amino]carbonyl Glimepiride; N-[2-[4- (Aminosulfonyl) phenyl]ethyl]-3-ethyl-2, 5-dihydro-4-methyl-2-oxo-1H-pyrrole-1-carboxamide. Grades: Highly Purified. CAS No. 119018-29-0. Pack Sizes: 25mg. US Biological Life Sciences.
Intermediate for the preparation of Glimepiride. Group: Biochemicals. Alternative Names: Des[ (trans-4-methylcyclohexyl) amino]carbonyl Glimepiride-d5; N-[2-[4- (Aminosulfonyl) phenyl]ethyl]-3-ethyl-d5-2, 5-dihydro-4-methyl-2-oxo-1H-pyrrole-1-carboxamide. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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5-Fluoro ent-Lamivudine Acid D-Menthol Ester
5-Fluoro ent-Lamivudine Acid D-Menthol Ester is an intermediate in the synthesis of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: (2S,5R)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid (1S,2R,5S)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester; (1S,2R,5S)-2-Isopropyl-5-methylcyclohexyl (2S,5R)-5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-, (1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S,5R)-. Grades: 98%. CAS No. 764659-79-2. Molecular formula: C18H26FN3O4S. Mole weight: 399.48.
D-3263
D-3263 is a TRPM8 agonist ( transient receptor potential melastatin member 8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer. Synonyms: 3-(2-Aminoethyl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbonyl)-5-methoxy-1H-benzo[d]imidazol-2(3H)-one; 2H-Benzimidazol-2-one, 3-(2-aminoethyl)-1,3-dihydro-5-methoxy-1-(((1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl)carbonyl)-; 3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]carbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥95%. CAS No. 947257-66-1. Molecular formula: C21H31N3O3. Mole weight: 373.49.
Glimepiride-d5
A sulfonylurea hypoglycemic agent. Used as an antidiabetic. Group: Biochemicals. Alternative Names: 3-Ethyl-2, 5-dihydro-4-methyl-N- [2- [4- [ [ [ [trans-4-methylcyclohexyl) amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2-oxo-1H-pyrrole-1-carboxyamide-d5; Amaryl-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Glimepiride Impurity 7
Glimepiride Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: trans-4-Methylcyclohexyl Isocyanate; (1r,4r)-1-isocyanato-4-methylcyclohexane. CAS No. 32175-00-1. Molecular Formula: C8H13NO. Mole Weight: 139.19. Catalog: APB32175001.
An impurity of Glimepiride, an antidiabetic medication used to treat type 2 diabetes. Synonyms: ortho-Glimepiride Impurity; 3-Ethyl-2, 5-dihydro-4-methyl-N- [2- [2- [ [ [ [ (trans-4-methylcyclohexyl) amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2-oxo-1H-pyrrole-1-carboxamide; Glimepride 2-Isomer; Glimepiride ortho isomer. Grades: ≥95%. CAS No. 878480-70-7. Molecular formula: C24H34N4O5S. Mole weight: 490.63.
Isomer-II of EMTRI-111
Isomer-II of EMTRI-111 is an intermediate of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (2R,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; Emtricitabine Impurity; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5R)-. Molecular formula: C18H26FN3O4S. Mole weight: 399.48.
Lamivudine Impurity 10
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2S)-5-hydroxy-1,3-oxathiolane-2-carboxylate is an impurity of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Molecular formula: C14H24O4S. Mole weight: 288.40.
Lamivudine Impurity 11
[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 5-hydroxy-1,3-oxathiolane-2-carboxylate is an impurity of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl-5-hydroxy-1,3-oxathiolane-2-carboxylate; [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 5-hydroxy-1,3-oxathiolane-2-carboxylate; (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester; AKOS024463325; CS-0449401; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl5-hydroxy-1,3-oxathiolane-2-carboxylate. Grades: 95%. CAS No. 200396-19-6. Molecular formula: C14H24O4S. Mole weight: 288.40.
Lamivudine Impurity 1 (Mixture of Diastereomers)
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate is an impurity of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Molecular formula: C18H27N3O4S. Mole weight: 381.49.
Lamivudine Impurity 2
Lamivudine Impurity 2 is an intermediate in the preparation of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl (2S,5R)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, [1R-[1α(2S*, 5R*), 2β, 5α]]-. Grades: ≥95%. CAS No. 200396-21-0. Molecular formula: C18H27N3O4S. Mole weight: 381.49.
Lamivudine Impurity 6
Lamivudine Impurity 6 is an impurity of Lamivudine, which is a potent nucleoside reverse transcriptase inhibitor and antiviral agent used to treat chronic hepatitis B. Synonyms: [1R-[1α(2S*, 5R*), 2β, 5α]]-5-Hydroxy-5-methyl-2-(1-methylethyl)cyclohexyl ester 1,3-Oxathiolane-2-carboxylic Acid; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S,5R)-. Grades: ≥95%. CAS No. 147126-64-5. Molecular formula: C14H24O4S. Mole weight: 288.40.
Lamivudine Impurity 7
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2S,5S)-5-hydroxy-1,3-oxathiolane-2-carboxylate is an impurity of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: 147126-63-41; 3-Oxathiolane-2-carboxylic acid, 5-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, [1R-[1alpha(2S*,5S*),2beta,5alpha]]-(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester; ZINC65743182; AKOS030568271. CAS No. 147126-63-4. Molecular formula: C14H24O4S. Mole weight: 288.40.
Lamivudine Impurity 9
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R)-5-hydroxy-1,3-oxathiolane-2-carboxylate is an impurity of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. CAS No. 130949-32-2. Molecular formula: C14H24O4S. Mole weight: 288.40.
Lomibuvir
Lomibuvir is an nonnucleoside NS5B polymerase inhibitor. It inhibits the 1b/Con1 HCV subgenomic replicon. It binds to the HCV polymerase with dissociation constants of 17 nM. It demonstrated effective antiviral efficacy and may be used for the treatment of HCV. It was developed by ViroChem Pharma, which was acquired by Vertex Pharmaceuticals in 2009. It is in clinical phase 2 with no progress. Uses: Lomibuvir demonstrated effective antiviral efficacy and may be used for the treatment of hcv. Synonyms: 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-; 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid; 5- (3, 3-Dimethyl-1-butynyl) -3-[ (trans-4-hydroxycyclohexyl) [ (trans-4-methylcyclohexyl) carbonyl]amino]thiophene-2-carboxylic acid; VCH 222; VX 222. Grades: >98 %. CAS No. 1026785-55-6. Molecular formula: C25H35NO4S. Mole weight: 445.62.
meta-Glimepiride Impurity
3-Isomeric impurity of the antidiabetic Glimepride. Glimepiride EP Impurity D. Group: Biochemicals. Alternative Names: 3-Ethyl-2, 5-dihydro-4-methyl-N- [2- [3- [ [ [ [ (trans-4-methylcyclohexyl) amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2-oxo-1H-pyrrole-1-carboxamide; Glimepride 3-Isomer; USP Glimepiride Related Compound D; Glimepiride EP Impurity D. Grades: Highly Purified. CAS No. 791104-62-6. Pack Sizes: 500ug. Molecular Formula: C??H??N?O?S, Molecular Weight: 490.62. US Biological Life Sciences.
Worldwide
rac-cis-Lamivudine Acid (1R,2S,5R)-5-Methyl-2-isopropylcyclohexyl Ester (Mixture of 2 Diastereomers)
rac-cis-Lamivudine Acid (1R,2S,5R)-5-Methyl-2-isopropylcyclohexyl Ester (Mixture of 2 Diastereomers) is a protected impurity of Lamivudine, which is a potent nucleoside reverse transcriptase inhibitor and antiviral agent used to treat chronic hepatitis B. Synonyms: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate. CAS No. 1322623-20-0. Molecular formula: C18H27N3O4S. Mole weight: 381.49.
trans 4-Aminocyclohexane methanol
Metabolites of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (Me CCNU). Group: Biochemicals. Alternative Names: (trans-4-Aminocyclohexyl) methanol. Grades: Highly Purified. CAS No. 1467-84-1. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
VX-222 (VCH-222, Lomibuvir)
VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2. Synonyms: 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-; 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid; Lomibuvir; VCH 222; VX 222; VX222. Grades: >98%. CAS No. 1026785-59-0. Molecular formula: C25H35NO4S. Mole weight: 445.61.
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