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2-[(1S)-1-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-2-oxoethoxy]acetic Acid Methyl Ester is an intermediate in the preparation of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: Intermediate in the preparation of aprepitant metabolites. Synonyms: Methyl [(1S)-1-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-2-(4-fluorophenyl)-2-oxoethoxy]acetate; [(1S)-1-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-2-oxoethoxy]acetic Acid Methyl Ester; Acetic acid, 2-[(1S)-1-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-2-oxoethoxy]-, methyl ester. Grades: ≥95%. CAS No. 419574-29-1. Molecular formula: C21H17F7O5. Mole weight: 482.34.
2-Bromo-4-(trifluoromethyl)phenylacetic acid. Uses: Designed for use in research and industrial production. Product Category: Bromine Series. CAS No. 518070-15-0. Purity: 0.98. Product ID: ACM518070150. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2-[2-bromo-4-(trifluoromethyl)phenyl]acetic Acid.
2-Chloro-5-(trifluoromethyl)phenylacetic acid
2-Chloro-5-(trifluoromethyl)phenylacetic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JRD-1187, ST5408432, 2-Chloro-5-(trifluoromethyl)phenylacetic acid, 22893-39-6. Product Category: Heterocyclic Organic Compound. CAS No. 22893-39-6. Molecular formula: C9H6ClF3O2. Mole weight: 238.59. Purity: 0.96. IUPACName: 2-[2-chloro-5-(trifluoromethyl)phenyl]acetic acid. Canonical SMILES: C1=CC(=C(C=C1C(F)(F)F)CC(=O)O)Cl. Density: 1.469g/cm³. Product ID: ACM22893396. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2-(2-Chloro-5-(trifluoromethyl)phenyl)acetic acid.
2-Oxo-2-[[4- (trifluoromethyl) phenyl]amino]acetic Acid Ethyl Ester. Group: Biochemicals. Grades: Highly Purified. CAS No. 69066-00-8. Pack Sizes: 1g. Molecular Formula: C11H10F3NO3, Molecular Weight: 261.2. US Biological Life Sciences.
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4-(Trifluoromethoxy)phenylacetic acid
4-(Trifluoromethoxy)phenylacetic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,3,3-trichloro-1,1,2-trifluoro-propene; 1-Propene,3,3,3-trichloro-1,1,2-trifluoro; 3,3,3-Trichlor-1,1,2-trifluor-propen. Product Category: Heterocyclic Organic Compound. CAS No. 431-57-5. Molecular formula: C9H7F3O3. Mole weight: 220.15. Purity: 0.96. IUPACName: 3,3,3-trichloro-1,1,2-trifluoroprop-1-ene. Product ID: ACM431575. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2-[4-(trifluoromethoxy)phenyl]acetic acid.
A small molecule agonist of the human Peroxisome Proliferator-Activated Recept d (PPAR d). It shows an EC50 of 1.1 nM against PPAR d with 100-fold selectivity over the other human subtypes. Group: Biochemicals. Alternative Names: 4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] Acetic Acid. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
[3-(Trifluoromethyl)phenyl]2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: IF-1, m-Trifluoromethylphenyl-1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, 1H-Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-, (alpha,alpha,alpha-trifluoro-m-tolyl) ester, AC1L2MEQ, LS-82152, [3-(trifluoromethyl)phenyl] 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate, 67369-98-6. Product Category: Heterocyclic Organic Compound. CAS No. 67369-98-6. Molecular formula: C26H19ClF3NO4. Mole weight: 501.882 g/mol. Purity: 0.96. IUPACName: [3-(trifluoromethyl)phenyl] 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate. Canonical SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OC4=CC=CC(=C4)C(F)(F)F. Product ID: ACM67369986. Alfa Chemistry ISO 9001:2015 Certified.
Ac2-26 TFA
Ac2-26 TFA is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. It reduces neutrophil adhesion and emigration. It has anti-inflammatory effect. Synonyms: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys.TFA; Annexin A1 (1-25) (dephosphorylated) (human).TFA; L-Lysine, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-, trifluoroacetic acid. Grades: ≥95%. Molecular formula: C143H211F3N32O46S. Mole weight: 3203.45.
AMG-747
AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2. Uses: Amg-747 was used as an antipsychotic drug. Synonyms: 1-Piperazineacetic acid, 4- ( (R) -phenyl (3- (trifluoromethyl) phenyl) methyl) -; 2-[4-[ (R) -phenyl-[3- (trifluoromethyl) phenyl]methyl]piperazin-1-yl]acetic acid; Tilapertin; AMG747; AMG-747; AMG 747. Grades: >98 %. CAS No. 1000690-85-6. Molecular formula: C20H21F3N2O2. Mole weight: 378.39.
APD334
This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grades: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49.
Benzeneacetic acid, a-amino-4-(trifluoromethyl)-, (aS)-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ZINC04202370, 144789-75-3. Product Category: Heterocyclic Organic Compound. CAS No. 144789-75-3. Molecular formula: C9H8 F3 N O2. Mole weight: 219.1605. Purity: 0.96. IUPACName: (2S)-2-azaniumyl-2-[4-(trifluoromethyl)phenyl]acetate. Canonical SMILES: C1=CC(=CC=C1C(C(=O)O)N)C(F)(F)F. Density: 1.415 g/cm³. Product ID: ACM144789753. Alfa Chemistry ISO 9001:2015 Certified.
BI671800
BI671800 is a CRTH2 antagonist. It is used to treat patients with asthma. It is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on inhaled corticosteroid (ICS) therapy. Uses: Bi671800 is used to treat patients with asthma. Synonyms: AP-761; AP 761; AP761; 5-Pyrimidineacetic acid, 4, 6-bis (dimethylamino) -2-[[4-[[4- (trifluoromethyl) benzoyl]amino]phenyl]methyl]-; 2- (4, 6-Bis (dimethylamino) -2- (4- (4- (trifluoromethyl) benzamido) benzyl) pyrimidin-5-yl) acetic acid; BI-671800; BI 671800; BI671800. Grades: >98%. CAS No. 1093108-50-9. Molecular formula: C25H26F3N5O3. Mole weight: 501.51.
D-Cys(4)-Terlipressin Trifluoroacetic Acid Salt
D-Cys(4)-Terlipressin Trifluoroacetic Acid Salt is an impurity of Terlipressin, which is a partial agonist of the vasopressin V1A receptor used as a vasoactive drug in the management of low blood pressure. Synonyms: (2S) -1-[ (4R, 7S, 10S, 13S, 16S, 19S) -19-[[2-[[2-[ (2-aminoacetyl) amino]acetyl]amino]acetyl]amino]-7- (2-amino-2-oxoethyl) -10- (3-amino-3-oxopropyl) -13-benzyl-16-[ (4-hydroxyphenyl) methyl]-6, 9, 12, 15, 18-pentaoxo-1, 2-dithia-5, 8, 11, 14, 17-pentazacycloicosane-4-carbonyl]-N-[ (2S) -6-amino-1-[ (2-amino-2-oxoethyl) amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide Trifluoroacetic Acid Salt; H-Gly-Gly-Gly-D-Cys(1)-Tyr-Phe-Gln-Asn-Cys(1)-Pro-Lys-Gly-NH2.TFA; glycyl-glycyl-glycyl-D-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-lysyl-glycinamide (4->9)-disulfide TFA. Grades: >98%. Molecular formula: C52H74N16O15S2.xC2HF3O2. Mole weight: 1227.37 (free base).
D-Gln(7)-Terlipressin Trifluoroacetic Acid Salt
D-Gln(7)-Terlipressin Trifluoroacetic Acid Salt is an impurity of Terlipressin, which is a partial agonist of the vasopressin V1A receptor used as a vasoactive drug in the management of low blood pressure. Synonyms: (2S) -1-[ (4R, 7S, 10R, 13S, 16S, 19R) -19-[[2-[[2-[ (2-aminoacetyl) amino]acetyl]amino]acetyl]amino]-7- (2-amino-2-oxoethyl) -10- (3-amino-3-oxopropyl) -13-benzyl-16-[ (4-hydroxyphenyl) methyl]-6, 9, 12, 15, 18-pentaoxo-1, 2-dithia-5, 8, 11, 14, 17-pentazacycloicosane-4-carbonyl]-N-[ (2S) -6-amino-1-[ (2-amino-2-oxoethyl) amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide Trifluoroacetic Acid Salt; H-Gly-Gly-Gly-Cys(1)-Tyr-Phe-D-Gln-Asn-Cys(1)-Pro-Lys-Gly-NH2.TFA; glycyl-glycyl-glycyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-D-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-lysyl-glycinamide (4->9)-disulfide TFA. Molecular formula: C52H74N16O15S2.xC2HF3O2. Mole weight: 1227.37 (free base).
GPR120-IN-1
GPR120-IN-1, a cell-permeable azaspiroundecanyl acetic acid compound, is an orally available, selective agonist of GPR120 (EC50 = ~0.35 μM) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). Synonyms: 2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid; GPR120 Compound A; MDK77754; MDK-77754; MDK 77754; GPR120 cpdA. CAS No. 1599477-75-4. Molecular formula: C19H23ClF3NO3. Mole weight: 405.84.
GW0742
GW0742. Group: Biochemicals. Alternative Names: 4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] acetic acid. Grades: Highly Purified. CAS No. 317318-84-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C21H17F4NO3S2. US Biological Life Sciences.
Worldwide
GW3965
GW3965 is a potent, selective LXR agonist for hLXRα and hLXR&beta. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay; Potent antagonistic activity against hLXRα and hLXRβ in cell-based assays with EC50 of 190 nM and 30 nM, respectively; In human islets, GW3965 (1 μM) reduces expression of selected pro-inflammatory cytokines including IL-8, monocyte chemotactic protein-1 and tissue factor In Vivo: At a dose of 10 mg/kg upregulates ABCA1 expression 8-fold and raises circulating levels of HDL by 30% with Cmax of 12.7 μg/mL and t1/2 of 2 hours. Uses: A liver x receptor agonist; represses the production of pro-inflammatory cytokines by murine mast cells; in vitro: reduces tissue factor production and inflammatory responses in human islets. Synonyms: GW3965; GW 3965; GW-3965; 2- (3- (3- ( (2-chloro-3- (trifluoromethyl) benzyl) (2, 2-diphenylethyl) amino) propoxy) phenyl) acetic acid hydrochloride. Grades: ≥ 98.0%. CAS No. 405911-09-3. Molecular formula: C33H31ClF3NO3. Mole weight: 582.05.
GW 501516
An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol. Grades: Highly Purified. CAS No. 317318-70-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??F?NO?S?, Molecular Weight: 453.5. US Biological Life Sciences.
Worldwide
GW 501516 Methyl Ester
Precursor to GW 501516. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid. Grades: Highly Purified. CAS No. 317318-69-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
J 147
J 147, under the IUPAC name N- (2, 4-dimethylphenyl) -2, 2, 2-trifluoro-N-[ (E) - (3-methoxyphenyl) methylideneamino]acetamide, is a phenyl hydrazide compound that has been shown to prevent memory deficits in an Alzheimer's disease mouse model. in vitro: A potent neuroprotective and neurotrophic compound (EC50 = 25 - 200 nM) in vivo: Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus. Uses: Implicated in alzheimer's disease. Synonyms: J147; J 147; J-147. N- (2, 4-dimethylphenyl) -2, 2, 2-trifluoro-N-[ (E) - (3-methoxyphenyl) methylideneamino]acetamide; J-147; 1146963-51-0; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; CHEMBL2387144; SCHEMBL12995834; 3752AH; AKOS024458485; CS-3688; AK279964; BC600735; HY-13779; 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide; J 147|2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide. CAS No. 1146963-51-0. Molecular formula: C18H17F3N2O2. Mole weight: 350.33.
Letermovir Impurity 7
Letermovir Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid. CAS No. 917389-37-8. Molecular Formula: C29H28F4N4O4. Mole Weight: 572.20. Catalog: APB917389378.
[Leu5]-Enkephalin TFA
[Leu5]-Enkephalin TFA is an endogenous opioid agonist peptide with morphine-like activity. It inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Synonyms: L-Leucine, L-tyrosylglycylglycyl-L-phenylalanyl-, mono(trifluoroacetate) (salt); L-Leucine, N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-, mono(trifluoroacetate) (salt); Acetic acid, trifluoro-, compd. with N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-leucine (1:1); Leucine-enkephalin trifluoroacetate; H-Tyr-Gly-Gly-Phe-Leu-OH.TFA; YGGFL.TFA; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine trifluoroacetic acid. Grades: ≥95%. CAS No. 73563-78-7. Molecular formula: C28H37N5O7.C2HF3O2. Mole weight: 669.65.
Pentafluorophenyl Trifluoroacetate
Pentafluorophenyl Trifluoroacetate is a reagent in the synthesis of multivalent carbohydrate-centered glycoclusters which are used as nanomolar ligands of bacterial lectin LecA from Pseudomonas aeruginosa. Pentafluorophenyl Trifluoroacetate is also used in the preparation of photocrosslinkable dextran hydrogel films as substrates for osteoblast and endothelial cell growth. Synonyms: 2,2,2-Trifluoroacetic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Trifluoroacetic Acid Pentafluorophenyl Ester; Perfluorophenyl 2,2,2-trifluoroacetate; PFP-O-TFA; PENTAFLUOROPHENYL TRIFLUOROACETATE; TRIFLUORO ACETIC ACID PENTAFLUORO PHENYL ESTER; TFA-OPFP. Grades: > 95% (GC). CAS No. 14533-84-7. Molecular formula: C8F8O2. Mole weight: 280.07.
RGX-104 hydrochloride
RGX-104 is an orally bioavailable liver X receptor agonist displaying immunomodulating and antineoplastic activity. Synonyms: RGX-104; 2-[3-[ (3R) -3-[[2-Chloro-3- (trifluoromethyl) phenyl]methyl- (2, 2-diphenylethyl) amino]butoxy]phenyl]acetic acid hydrochloride. CAS No. 610318-03-1. Molecular formula: C34H34Cl2F3NO3. Mole weight: 632.54.
Ro 26-4550 trifluoroacetate
Ro 26-4550 trifluoroacetate is a competitive inhibitor of IL-2/ IL-2Rα receptor interaction. Synonyms: methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate; 2,2,2-trifluoroacetic acid; Ro26-4550; Ro-26-4550 trifluoroacetate; Ro 26-4550 trifluoroacetate; Ro264550 trifluoroacetate. CAS No. 1217448-66-2. Molecular formula: C26H30N4O3.CF3CO2H. Mole weight: 560.57.
Semaglutide-[Val-d8] Tetratrifluoroacetate
Semaglutide-[Val-d8] Tetratrifluoroacetate is the labelled salt of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Semaglutide-d8 Tetratrifluoroacetate; L-histidyl-2-methylalanyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-valyl-d8-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-a-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-a-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-a-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-Glycine, trifluoroacetic acid (1:4); H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val(D8)-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH.4TFA. Molecular formula: C187H283D8N45O59.4C2HF3O2. Mole weight: 4577.78.
1-(2,2,2-Trifluoro-N-phenylethanimidate)-2,3,4-tri-O-acetyl-D-glucopyranuronic acid methyl ester is a profoundly efficacious and multifaceted biomedical compound. With an intricate mode of action, it selectively interacts with targeted receptors and enzymes, effectively ameliorating the symptoms associated with inflammation, pain, and allergic responses. Synonyms: 2,3,4-Tri-O-acetyl-D-glucopyranuronic acid methyl ester, 1-(2,2,2-trifluoro-N-phenylethanimidate). CAS No. 869996-05-4. Molecular formula: C21H22F3NO10. Mole weight: 505.40.
13-{[ (3-tert-Butyloxycarbonyl) -2, 2-dimethyl-4S-phenyl-1, 3-oxazolidin-5R-yl]formyl}-7-O- ( (trifluoromethyl) sulfonyl]oxy) Baccatin III
Intermediate in the synthesis of taxol analogs. Group: Biochemicals. Alternative Names: (4S, 5R) -2, 2-Di methyl -4-phenyl -3, 5-oxazolidinedicarboxyl ic Acid 5-[ (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS) -6, 12b-Bis (acetyloxy) -12- (benzoyloxy) -2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-11-hydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-4-[[ (trifluoromethyl) sulfonyl]oxy]-7, 11-methano-1H-cyclodeca[3, 4]benz[1, 2-b]oxet-9-yl] 3-(1,1-dimethylethyl) Ester. Grades: Highly Purified. CAS No. 168120-69-2. Pack Sizes: 10mg. US Biological Life Sciences.
A reactant used in the preparation of the immunosuppressive agent FTY720 (F805000). Group: Biochemicals. Alternative Names: 1,1,1-Trifluoro-methanesulfonic Acid 4-[2- (Acetyloxy) ethyl]phenyl Ester. Grades: Highly Purified. CAS No. 712223-57-9. Pack Sizes: 50mg. US Biological Life Sciences.
5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50 = 83 nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R, 3R, 4S, 5S, 6S)-2- ( (4-Chloro-3- (trifluoromethyl)phenyl) (chlorocarbonyl)amino)-6- (methoxycarbonyl)tetrahydro-2H-pyran-3, 4, 5-triyl Triacetate. Molecular formula: C21H20Cl2F3NO10. Mole weight: 574.29.
5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R,3R,4S,5S,6S)-2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C20H21ClF3NO9. Mole weight: 511.83.
Casopitant Mesylate
Casopitant Mesylate is a potent, selective and orally active neurokinin 1 (NK1) receptor antagonist binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. Uses: Active tachykinin nk1 receptor antagonist. Synonyms: (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide;methanesulfonic acid. Grades: ≥98%. CAS No. 414910-30-8. Molecular formula: C31H39F7N4O5S. Mole weight: 712.72.
CATPB
CATPB is a human FFA2 inverse agonist (pKi = 7.87). It increases forskolin-induced cAMP production, and inhibits acetate-induced MAPK signaling in cells expressing human FFA2. Synonyms: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid. Grades: ≥98% by HPLC. CAS No. 1322598-09-3. Molecular formula: C19H17ClF3NO3. Mole weight: 399.79.
Granotapide
Granotapide is used as an antihyperlipidaemic drug candidate. Uses: Granotapide is used as an antihyperlipidaemic drug candidate. Synonyms: JTT130; JTT 130; JTT-130; 2- [ [3- (Dimethylcarbamoyl) -4- [ [4'- (trifluoromethyl) biphenyl-2-yl] carbonylamino] phenyl] acetoxymethyl] -2-phenylmalonic acid diethyl ester. Grades: 98%. CAS No. 594842-13-4. Molecular formula: C39H37F3N2O8. Mole weight: 718.73.
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