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1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid is a marine derived natural products found in Cinachyrella sp. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Carboxy-1,3,5-trimethyl-1H-pyrazole. Product Category: Heterocyclic Organic Compound. CAS No. 1125-29-7. Molecular formula: C7H10N2O2. Mole weight: 154.17. Purity: 95%+. IUPACName: 1,3,5-Trimethylpyrazole-4-carboxylic acid. Canonical SMILES: CC1=C(C(=NN1C)C)C(=O)O. Density: 1.24±0.1 g/cm³. Product ID: ACM1125297. Alfa Chemistry ISO 9001:2015 Certified.
1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride
1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 59340-27-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C6H9ClN2O2S. US Biological Life Sciences.
3-(Bromomethyl)-2,6,7-trimethyl-1H,5H-pyrazolo[1,2-a]pyrazole-1,5-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MBBR;BROMOBIMANE;THIOLYTE(R) MONOBROMOBIMANE REAGENT, FLUORESCENT LABELING COMPOUND;THIOLYTE(R) MONOBROMOBIMANE REAGENT;THIOLYTE(R) MB REAGENT;THIOLYTE(R) MB;THIOLYTE MONOBROMOBIMANE REAGENT;MMB. Product Category: Heterocyclic Organic Compound. CAS No. 74235-78-2. Molecular formula: C10H11BrN2O2. Mole weight: 271.11. Density: 1.66. Product ID: ACM74235782. Alfa Chemistry ISO 9001:2015 Certified.
4-(Bromomethyl)-1,3,5-trimethyl-1H-pyrazole
4-(Bromomethyl)-1,3,5-trimethyl-1H-pyrazole. Uses: Designed for use in research and industrial production. Product Category: Bromine Series. CAS No. 1341324-54-6. Product ID: ACM1341324546. Alfa Chemistry ISO 9001:2015 Certified.
4-Iodo-1,3,5-trimethyl-1H-pyrazole
4-Iodo-1,3,5-trimethyl-1H-pyrazole. Group: Biochemicals. Grades: Highly Purified. CAS No. 51660-65-2. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C6H9IN2. US Biological Life Sciences.
Worldwide
4-Iodo-1,3,5-trimethyl-1H-pyrazole
4-Iodo-1,3,5-trimethyl-1H-pyrazole. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE;AKOS PAO-1279;BUTTPARK 154\11-07. Product Category: Other. CAS No. 51660-65-2. Molecular formula: C6H9IN2. Mole weight: 236.05. Purity: 0.96. IUPACName: 4-iodo-1,3,5-trimethylpyrazole. Canonical SMILES: CC1=C(C(=NN1C)C)I. Density: 1.8g/cm³. Product ID: ACM51660652. Alfa Chemistry ISO 9001:2015 Certified.
A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6nM and 400nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. US Biological Life Sciences.
DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. Synonyms: IMP-366; 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide. Grades: ≥98%. CAS No. 1215010-55-1. Molecular formula: C21H24Cl2N6O2S. Mole weight: 495.4.
Edaravone Trimer
Edaravone Trimer is an impurity of Edaravone. Edaravone is a novel potent free radical scavenger that reduces reactive oxygen species, inhibits apoptosis, and blocks nonenzymatic peroxidation and lipoxygenase activity. Synonyms: 5,?5',?5''-trimethyl-2,?2',?2''-triphenyl-[4,?4':4',?4''-Ter-4H-pyrazole]?-3,?3',?3''(2H,?2'H,?2''H)?-trione; 4,4-bis(3-methyl-5-oxo-1-phenyl(2-pyrazolin-4-yl))-3-methyl-1-phenyl-2-pyrazol in-5-one; 2-Phenyl-5-methyl-4,4-bis(2-phenyl-3-oxo-5-methyl-3,4-dihydro-2H-pyrazole-4-yl)-3,4-dihydro-2H-pyrazole-3-one. CAS No. 68195-63-1. Molecular formula: C30H26N6O3. Mole weight: 518.577.
mBBr
mBBr. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Monobromobimane. Product Category: Other Fluorophores. Appearance: Yellow powder. CAS No. 71418-44-5. Molecular formula: C10H11BrN2O2. Mole weight: 271.11. Purity: 95%+. IUPACName: 7-(bromomethyl)-1,2,6-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione. Canonical SMILES: CC1=C(N2C(=C(C(=O)N2C1=O)C)CBr)C. Density: 1.66 ± 0.1 g/ml. Product ID: ACM71418445-1. Alfa Chemistry ISO 9001:2015 Certified.
mBCl
mBCl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Monochlorobimane. Product Category: Other Fluorophores. CAS No. 76421-73-3. Molecular formula: C10H11ClN2O2. Mole weight: 226.66. Purity: 95%+. IUPACName: 7-(chloromethyl)-1,2,6-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione. Canonical SMILES: CC1=C(N2C(=C(C(=O)N2C1=O)C)CCl)C. Product ID: ACM76421733-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: BENOMYL, MB A-Class.
SR 144528
SR 144528. Group: Biochemicals. Alternative Names: (1S-endo)-5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-(1, 3, 3-trimethylbicyclo[2. 2. 1]hept-2-yl)-1H-Pyrazole-3-carboxamide. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. Molecular Formula: C29H34ClN3O, Molecular Weight: 476.05. US Biological Life Sciences.
Worldwide
SR 144528
SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with selectivity for CB2 over CB1 receptors. It antagonizes the inhibitory effects of the cannabinoid receptor agonist CP 55,940 on forskolin-stimulated adenylyl cyclase activity in cell lines permanently expressing the h CB2 receptor. It selectively blocks the mitogen-activated protein kinase activity induced by CP 55,940 in cell lines expressing h CB2. Synonyms: SR144528; SR-144528; 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide. Grades: ≥98%. CAS No. 192703-06-3. Molecular formula: C29H34ClN3O. Mole weight: 476.1.
1H-Pyrazolo[3,4-b]pyridine,6-hydrazinyl-1,3,4-trimethyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-HYDRAZINO-1,3,4-TRIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE;6-HYDRAZINYL-1,3,4-TRIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE;6H-Pyrazolo[3,4-b]pyridin-6-one,1,7-dihydro-1,3,4-trimethyl-,hydrazone(9CI);1,3,4-TRIMETHYL-1H-PYRAZOLO(3,4-B)PYRIDIN-6-HYDRAZINE. Product Category: Heterocyclic Organic Compound. CAS No. 175202-00-3. Molecular formula: C9H13 N5. Mole weight: 191.23. Product ID: ACM175202003. Alfa Chemistry ISO 9001:2015 Certified.
4- (1H-Pyrazol-4-yl)-7-[[2- (trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2, 3-d]pyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 941685-27-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-78248.
Baricitinib Impurity 17. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(1-(ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetamide. Molecular Formula: C22H33N7O4SSi. Mole Weight: 519.69. Catalog: APB03629.
Baricitinib Impurity 18
Baricitinib Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(1-(ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile. Molecular Formula: C22H31N7O3SSi. Mole Weight: 501.68. Catalog: APB03630.
Baricitinib impurity 43
Baricitinib impurity 43. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(1-(1-(ethylsulfonyl)-3-(prop-2-yn-1-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine. Molecular Formula: C23H32N6O3SSi. Mole Weight: 500.69. Catalog: APB03610.
CHEMBRDG-BB 4172534
CHEMBRDG-BB 4172534. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBRDG-BB 4172534;2-{[(1,3,5-Trimethyl-1H-pyrazol-4-yl)methyl]-amino}ethanol;2-{[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]amino}ethanol dihydrochloride;Albb-003680. Product Category: Heterocyclic Organic Compound. CAS No. 400877-08-9. Molecular formula: C9H17N3O. Product ID: ACM400877089. Alfa Chemistry ISO 9001:2015 Certified.
DDD85646
DDD85646 is a T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. DDD85646 has potent activity against the enzyme (IC(50) = 2 nM) and T. brucei (EC(50) = 2 nM) in culture. DDD85646 has good oral pharmacokinetics and cures rodent models of peripheral HAT infection. DDD85646 provides an excellent tool for validation of T. brucei NMT as a drug target for HAT as well as a valuable lead for further optimization. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DDD85646; DDD-85646; DDD 85646. Product Category: Others. Appearance: Solid powder. CAS No. 1215010-55-1. Molecular formula: C21H24Cl2N6O2S. Mole weight: 495.42. Purity: >98%. IUPACName: 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide. Canonical SMILES: O=S(C1=C(Cl)C=C(C2=CC(N3CCNCC3)=NC=C2)C=C1Cl)(NC4=C(C)N(C)N=C4C)=O. Product ID: ACM1215010551. Alfa Chemistry ISO 9001:2015 Certified.
HTH-01-015
HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH-01-015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound-healing assay to a similar extent as NUAK1-knockout. HTH-01-015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout and U2OS cells to the same extent as NUAK1 shRNA knockdown. HTH-01-015 impaired the invasive potential of U2OS cells in a 3D cell invasion assay to the same extent as NUAK1 knockdown. HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.57. Purity: >98%. IUPACName: 4,5,13-trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one. Canonical SMILES: CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1. Product ID: ACM1613724427. Alfa Chemistry ISO 9001:2015 Certified.
IMP-1088
IMP-1088 is an inhibitor of N-myristoyltransferase 1 (NMT1) and NMT2 (IC50 = <1 nM for both human enzymes). It prevents rhinoviral replication without inducing cytotoxicity, and inhibits co-translational myristoylation of a specific virus-encoded protein (VP0) to block viral capsid assembly. Synonyms: EX-A2075; 1-(5-{3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine. Grades: ≥98%. CAS No. 2059148-82-0. Molecular formula: C25H29F2N5O. Mole weight: 453.53.
(+)-ITD-1
(+)-ITD-1 is the (+)-enantiomer of ITD 1 that is more active. ITD-1 is a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (-)-ITD 1, respectively for TGF-β inhibition) that clears the type II TGFβ receptor from the cell surface. ITD 1 promotes the differentiation of cardiomyocytes and cardiogenesis in murine embryonic stem cell (mESCs). Synonyms: ITD-1; 1099644-42-4; ITD 1; ITD1; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate; (+)-ITD 1; 1409968-46-2; 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester; Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate; ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;6-{(1R)-1-[8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H) -one; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate. Grades: 99%. CAS No. 1409968-46-2. Molecular formula: C27H29NO3. Mole weight: 415.52.