A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
| Product | Description | |
|---|---|---|
| TLR4-IN-C34 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| TLR4 Inhibitor, TAK-242 (Ethyl- (6R) -6- (N- (2-chloro-4-fluorophenyl) sulfamoyl) cyclohex-1-ene-1-carboxylate) | A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences. |  Worldwide |
| TLR7/8/9-IN-1 | TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9). Uses: Scientific research. Group: Signaling pathways. CAS No. 2180127-82-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131952. |  |
| TLR7/8 agonist 1 | TLR7/8 agonist 1 is a toll-like receptor ( TLR7 )/ TLR8 dual-agonistic imidazoquinoline. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258457-59-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698. | |
| TLR7/8 agonist 1 | TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It exhibits prominent immunostimulatory activities. CAS No. 1258457-59-8. Molecular formula: C22H25N5. Mole weight: 359.5. |  |
| TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620278-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698A. | |
| TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It exhibits prominent immunostimulatory activities. Synonyms: TLR7/8 agonist 1 hydrochloride. CAS No. 1620278-72-9. Molecular formula: C22H27Cl2N5. Mole weight: 432.4. | |
| TLR7/8 agonist 4 | TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2388520-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139017. | |
| TLR7/8 agonist 8 | TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC 50 s of 27 and 12 nM for hTLR7 and hTLR8 , respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2649170-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153543. | |
| TLR7 agonist 1 | TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC 50 of 90 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2178156-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111358. | |
| TLR9-IN-1 | TLR9-IN-1 is a potent and selective TLR9 inhibitor with an IC50 value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226366-86-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148045. | |
| TM-1 | TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase ( PDHK1 ). TM-1 inhibits PDHK1 and PDHK2 with IC 50 s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 921099-13-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136882. | |
| TM-38837 | TM-38837 is a peripheral selective cannabinoid receptor 1 (CB1) receptor antagonist. Synonyms: TM38837; TM 38837; 1- (2, 4-Dichlorophenyl) -4-ethyl-N- (piperidin-1-yl) -5- (5- ( (4- (trifluoromethyl) phenyl) ethynyl) thiophen-2-yl) -1H-pyrazole-3-carboxamide; N-Piperidino-1-(2,4-dichlorophenyl)-4-ethyl-5-[5-[4-(trifluoromethyl)phenylethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide. Grades: ≥ 95 %. CAS No. 1253641-65-4. Molecular formula: C30H25Cl2F3N4OS. Mole weight: 617.51. | |
| Tm3PyP26PyB | Tm3PyP26PyB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,3,5-Tris(6-(3-(pyridin-3-yl)phenyl)pyridin-2-yl)benzene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1492917-78-8. Molecular formula: C54H36N6. Mole weight: 768.9 g/mol. Product ID: ACM1492917788. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TM5275 sodium | TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1103926-82-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100447. | |
| TM-5275 sodium salt | TM-5275 sodium salt is an orally bioavailable, potent and selective plasminogen activator inhibitor-1 (PAI-1). It delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Uses: Tm-5275 sodium salt delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Synonyms: TM5275 sodium salt; TM 5275 sodium salt; TM-5275 sodium salt; 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt; Sodium 2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate. Grades: >98%. CAS No. 1103926-82-4. Molecular formula: C28H27ClN3NaO5. Mole weight: 543.98. | |
| TM5275 sodium salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Tm5441 | TM5441 is a plasminogen activator inhibitor-1 (PAI-1) that inhibits some tumor cell lines (IC50 = 9.7 ~ 60.3 μM). Studies indicated that it could be used to treat high-fat diet-induced obesity and adipocyte injury in mice. Uses: Tm5441 is a plasminogen activator inhibitor-1 (pai-1). Synonyms: TM-5441; TM 5441; TM5441; BMS-790052; BMS-790052; BMS790052; EBP 883; EBP-883; EBP883. 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid. CAS No. 1190221-43-2. Molecular formula: C21H17ClN2O6. Mole weight: 428.825. | |
| TM5441 | TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 ?M and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates N?-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190221-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101761. | |
| TMAD | TMAD. Group: Biochemicals. Alternative Names: 1,1'-Azobis(N,N'-dimethylformamide); N, N, N', N'-Tetra methyl azodicarboxamide. Grades: Highly Purified. CAS No. 10465-78-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C6H12N4O2. US Biological Life Sciences. | Worldwide |
| TMA-DPH | TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 115534-33-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0986. | |
| TMAH | Tetramethylammonium hydroxide is a solid in the hydrated form or a colorless liquid with a strong ammonia-like odor. It is soluble in water. It is corrosive to metals and tissue.;Liquid. Group: Polymers. CAS No. 75-59-2. Product ID: tetramethylazanium; hydroxide. Molecular formula: 91.15g/mol. Mole weight: C4H13NO. C[N+](C)(C)C.[OH-]. InChI=1S/C4H12N.H2O/c1-5(2, 3)4;/h1-4H3;1H2/q+1;/p-1. WGTYBPLFGIVFAS-UHFFFAOYSA-M. |  |
| TMAH-22 (Tetramethylammonium hydroxide aq. solution) | TMAH-22 (Tetramethylammonium hydroxide aq. solution). Group: Acids and alkalis. CAS No. 75-59-2. | |
| TMAH-25 (Tetramethylammonium hydroxide aq. solution) | TMAH-25 (Tetramethylammonium hydroxide aq. solution). Group: Acids and alkalis. CAS No. 75-59-2. | |
| TMB | TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species ( ROS/RNS ), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue; Sure Blue TMB. CAS No. 54827-17-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930. | |
| TMB | TMB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,3',5,5'-Tetramethylbenzidine,BMblue,SureBlueTMB,TMBBlottingPlus,TMBsubstrate,TMBZ. Product Category: Other Fluorophores. Appearance: White to light yellow powder. CAS No. 54827-17-7. Molecular formula: C16H20N2. Mole weight: 240.34. Purity: 99%+. IUPACName: 4-(4-amino-3,5-dimethylphenyl)-2,6-dimethylaniline. Canonical SMILES: CC1=CC(=CC(=C1N)C)C2=CC(=C(C(=C2)C)N)C. Density: 1 g/ml. Product ID: ACM54827177-2. Alfa Chemistry ISO 9001:2015 Certified. | |
| TMB 8 hydrochloride | TMB 8 is a PKC inhibitor and intracellular calcium antagonist. It also acts as a noncompetitive, functional antagonist at diverse nicotinic acetylcholine receptor (nAChR) subtypes. Synonyms: 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride. Grades: ≥ 98 %. CAS No. 53464-72-5. Molecular formula: C22H38ClNO5. Mole weight: 431.99. | |
| TMB dihydrochloride | TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue dihydrochloride; Sure Blue TMB dihydrochloride. CAS No. 64285-73-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930A. | |
| TMC-135A | TMC-135A is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60 with IC50 values of 0.07, 0.88, 0.11, 0.20, 0.15 and 0.05 μmol/L, respectively. Synonyms: TMC-135 A. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-135B | TMC-135B is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60. Synonyms: TMC-135 B. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-154 | TMC-154 is an antibiotic produced by Gliocladium sp. TC 1282. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC 154. Molecular formula: C41H72O14. Mole weight: 789. | |
| TMC-169 | TMC-169 is an antibiotic of the aspochalasin group produced by Aspergillus flavipes TC 1446. It has cytotoxicity. Synonyms: TMC 169. Molecular formula: C24H35NO3. Mole weight: 385.5. | |
| TMC-171A | TMC-171A is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 A. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171B | TMC-171B is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 B. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171C | TMC-171C is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 C. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-1A | TMC-1A is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 A. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1B | TMC-1B is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 B. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1C | TMC-1C is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 C. Molecular formula: C30H38N2O7. Mole weight: 538.6. | |
| TMC-1D | TMC-1D is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 D. Molecular formula: C30H40N2O7. Mole weight: 540.6. | |
| TMC-205 | TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines, activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region. Uses: Transcriptional up-regulator. Synonyms: TMC-205; TMC 205; TMC205. 6-(3-methylbuta-1,3-dienyl)-1H-indole-3-carboxylic acid. Grades: ≥98%. CAS No. 403646-00-4. Molecular formula: C14H13NO2. Mole weight: 227.26. | |
| TMC-256A1 | TMC-256A1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 25 μmol/L. Synonyms: TMC-256 A1. CAS No. 3773-18-0. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-256C1 | TMC-256C1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 1.7 μmol/L. Synonyms: TMC-256 C1. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-260 | TMC-260 is an inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703. It inhibited the IL-4 driven luciferase activity with IC50 values of 9 μmol/L. Synonyms: TMC 260. Molecular formula: C17H27NO5. Mole weight: 325.4. | |
| TMC-264 | TMC-264 is a STAT6 activation inhibitor produced by Phoma sp. TC 1674. It suppressed expression of IL-4 driven luciferase and germline Cepsilon mRNA with IC50 values of 0.3 and 0.4 μmol/L, respectively, and inhibited tyrosine phosphorylation of STAT6 with an IC50 value of 1.6 μmol/L. Synonyms: TMC 264. Molecular formula: C16H13ClO7. Mole weight: 352.72. | |
| TMC-2A | TMC-2A is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 A. Molecular formula: C28H34N4O9. Mole weight: 570.6. | |
| TMC-2B | TMC-2B is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 B. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-2C | TMC-2C is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 C. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC310911 | TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC 50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASC-09. CAS No. 1000287-05-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107123. | |
| TMC-310911 | TMC-310911, also known as ASC-09, is an HIV protease inhibitor potentially for the treatment of HIV infection. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TMC-310911; ASC-09; TMC310911; ASC09; TMC 310911; ASC 09. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1000287-05-7. Molecular formula: C38H53N5O7S2. Mole weight: 755.99. Purity: >98%. IUPACName: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((2-((1-cyclopentylpiperidin-4-yl)amino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate. Canonical SMILES: O=C(O[C@H]1CO[C@@]2([H])OCC[C@]21[H])N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C5N=C(NC6CCN(C7CCCC7)CC6)SC5=C4)=O)CC(C)C. Product ID: ACM1000287057. Alfa Chemistry ISO 9001:2015 Certified. | |
| TMC-34 | TMC-34 is an macrolide antifungal antibiotic produced by Streptomyces sp. A-3030. Synonyms: TMC 34. Molecular formula: C54H93N3O17. Mole weight: 1056.3. | |
| TMC353121 | TMC353121 is a potent RSV fusion inhibitor. Its activity profile was found to be identical to the profile of JNJ-2408068. Synonyms: TMC-353121; TMC 353121; TMC353121. Grades: >98%. CAS No. 857066-90-1. Molecular formula: C32H42N6O3. Mole weight: 558.71. | |
| TMC-49A | TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Synonyms: TMC-49 A; 2-phenylethyl n-butyl carbamate. Molecular formula: C13H19NO2. Mole weight: 221.29. | |
| TMC-52A | TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM. Synonyms: TMC-52 A. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52B | TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 B. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52C | TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 C. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-52D | TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM. Synonyms: TMC-52 D. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-66 | TMC-66 is a selective endothelin conversion enzyme (ECE) inhibitor isolated from the culture broth of Streptomyces sp. A5008. Synonyms: TMC 66. Molecular formula: C29H21NO9. Mole weight: 527.5. | |
| TMC-69 | TMC-69 is an antitumor antibiotic isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. It exhibited moderate in vitro cytotoxic activity. Synonyms: TMC 69. Molecular formula: C26H31NO4. Mole weight: 421.5. | |
| TMC-86A | TMC-86A is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 5.1 and 3.7 μmol/L, respectively. Synonyms: TMC-86 A. Molecular formula: C16H26N2O6. Mole weight: 342.39. | |
| TMC-86B | TMC-86B is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 1.1 and 31 μmol/L, respectively. Synonyms: TMC-86 B. Molecular formula: C20H34N2O7. Mole weight: 414.5. | |
| TMC-89A | TMC-89A is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.39 and 7.2 μmol/L, respectively. Synonyms: TMC-89 A; N-[(2R)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-89B | TMC-89B is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.51 and 7.1 μmol/L, respectively. Synonyms: TMC-89 B; N-[(2S)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-95A | TMC-95A is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 values of 5.4nM, 200nM, and 60nM, respectively. Synonyms: TMC-95 A. CAS No. 220666-21-7. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95B | TMC-95B is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome to the same extent as TMC-95A. Synonyms: TMC-95 B. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95C | TMC-95C is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 C. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95D | TMC-95D is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 D. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-96 | TMC-96 is a proteasome inhibitor produced by Saccharothrix sp. TC 1094. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 2.9 and 3.5 μmol/L, respectively. Synonyms: TMC 96. Molecular formula: C18H32N2O6. Mole weight: 372.5. | |
| Tmcb | TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBL1233807, SureCN1759230, ABP000318, [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, 905105-89-7, K66. Product Category: Inhibitors. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: C11H9Br4N3O2. Purity: >98 %. IUPACName: 2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid. Canonical SMILES: CN(C)C1=NC2=C(N1CC(=O)O)C(=C(C(=C2Br)Br)Br)Br. Product ID: ACM905105897. Alfa Chemistry ISO 9001:2015 Certified. Categories: TMC Bulldogs. | |
| TMCB | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). TMCB exhibits selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki = 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2, respectively). Synonyms: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid. Grades: ≥98% by HPLC. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: 534.82. | |
| TMCB | TMCB. Group: Biochemicals. Grades: Purified. CAS No. 905105-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Our database is helping our users find suppliers everyday.
