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| Product | Description | |
|---|---|---|
| TLC neutral glycosphingolipid mixture | TLC neutral glycosphingolipid mixture. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Bovine and porcine. TLC neutral glycosphingolipid mixture; TLC; Neutral Glycosphingolipid Mixture (TLC)(qualmixture); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-122. |  |
| TLC non-polar lipid mixture-1 | TLC non-polar lipid mixture-1. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Plant, ovine. TLC non-polar lipid mixture-1; TLC; Non-Polar Lipid Mixture A (quantitative); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-103. | |
| TLC non-polar lipid mixture-2 | TLC non-polar lipid mixture-2. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Plant, ovine. TLC non-polar lipid mixture-2; TLC; Non-Polar Lipid Mixture B (quantitative); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-104. | |
| TLC polar lipid mixture | TLC polar lipid mixture. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Natural, egg, ovine. TLC polar lipid mixture; TLC; Polar Lipid Mixture (quantitative); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-101. | |
| TLC sphingolipid mixture | TLC sphingolipid mixture. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Bovine. TLC sphingolipid mixture; TLC; Sphingolipid Mixture (quantitative); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-102. | |
| TLN-232 | TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: TLN 232; TLN232; CAP-232; CAP 232; CAP232; H-D-Phe-Cys(1)-D-Trp-Lys-Cys(1)-Thr-NH2. CAS No. 158899-10-6. Molecular formula: C36H49N9O7S2. Mole weight: 783.96. |  |
| TLQP 21 | TLQP 21. Group: Biochemicals. Grades: Purified. CAS No. 869988-94-3. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| TLQP 21 | TLQP 21 is a VGF-derived peptide. TLQP 21 has been shown to protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. TLQP 21 has the potential for the prevention of early phase diet-induced diabetes. Synonyms: TLQP 21; TLQP21; TLQP-21. Grades: ≥95%. CAS No. 869988-94-3. Molecular formula: C107H170N40O26. Mole weight: 2432.7. | |
| TLQP-21 (human) | Synonyms: H-Thr-Leu-Gln-Pro-Pro-Ser-Ala-Leu-Arg-Arg-Arg-His-Tyr-His-His-Ala-Leu-Pro-Pro-Ser-Arg-OH; L-Threonyl-L-leucyl-L-glutaminyl-L-prolyl-L-prolyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-histidyl-L-tyrosyl-L-histidyl-L-histidyl-L-alanyl-L-leucyl-L-prolyl-L-prolyl-L-seryl-L-arginine. Grades: ≥95%. CAS No. 1259837-37-0. Molecular formula: C110H176N40O27. Mole weight: 2490.83. | |
| TLR1 | TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 566914-00-9. Pack Sizes: 500 μg (33 mM * 50 μL in Ethanol); 1 mg (33 mM * 100 μL in Ethanol). Product ID: HY-W011400. |  |
| TLR1/TLR2 Antagonist, CU-CPT22 (Hexyl-3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate) | A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| TLR2-IN-C29 | TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Group: Inhibitors. Alternative Names: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. CAS No. 363600-92-4. Molecular formula: C16H15NO4. Mole weight: 285.29. Appearance: Solid powder. Purity: >98%. IUPACName: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid. Canonical SMILES: O=C (O)C1=CC=CC (/N=C/C2=CC=CC (OC)=C2O)=C1C. Catalog: ACM363600924. |  |
| TLR3, Control Peptide (Toll Like Receptor 3) | TLR3, Control Peptide (Toll Like Receptor 3). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| TLR3/dsRNA Complex Inhibitor (CU CPT 4a; Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor; (R) -2- (3-Chloro-6-fluorobenzo [b]thiophene-2-carboxamido) -3-phenylpropanoic Acid) | A thiophene carboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Group: Biochemicals. Alternative Names: (R) -2- (3-Chloro-6-fluorobenzo [b]thiophene-2-carboxamido) -3-phenylpropanoic Acid; CU CPT 4a. Grades: Highly Purified. CAS No. 1279713-77-7. Pack Sizes: 10mg. Molecular Formula: C18H13ClFNO3S, Molecular Weight: 377.8. US Biological Life Sciences. | Worldwide |
| TLR4 Inhibitor, TAK-242 (Ethyl- (6R) -6- (N- (2-chloro-4-fluorophenyl) sulfamoyl) cyclohex-1-ene-1-carboxylate) | A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences. | Worldwide |
| TLR7/8 agonist 1 | TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It exhibits prominent immunostimulatory activities. CAS No. 1258457-59-8. Molecular formula: C22H25N5. Mole weight: 359.5. | |
| TLR7/8 agonist 1 | TLR7/8 agonist 1 is a toll-like receptor ( TLR7 )/ TLR8 dual-agonistic imidazoquinoline. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258457-59-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698. | |
| TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620278-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698A. | |
| TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It exhibits prominent immunostimulatory activities. Synonyms: TLR7/8 agonist 1 hydrochloride. CAS No. 1620278-72-9. Molecular formula: C22H27Cl2N5. Mole weight: 432.4. | |
| TLR7/8 agonist 4 | TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2388520-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139017. | |
| TLR7/8 agonist 8 | TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC 50 s of 27 and 12 nM for hTLR7 and hTLR8 , respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2649170-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153543. | |
| TLR7 agonist 1 | TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC 50 of 90 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2178156-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111358. | |
| TM-1 | TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase ( PDHK1 ). TM-1 inhibits PDHK1 and PDHK2 with IC 50 s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 921099-13-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136882. | |
| TM-38837 | TM-38837 is a peripheral selective cannabinoid receptor 1 (CB1) receptor antagonist. Synonyms: TM38837; TM 38837; 1- (2, 4-Dichlorophenyl) -4-ethyl-N- (piperidin-1-yl) -5- (5- ( (4- (trifluoromethyl) phenyl) ethynyl) thiophen-2-yl) -1H-pyrazole-3-carboxamide; N-Piperidino-1-(2,4-dichlorophenyl)-4-ethyl-5-[5-[4-(trifluoromethyl)phenylethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide. Grades: ≥ 95 %. CAS No. 1253641-65-4. Molecular formula: C30H25Cl2F3N4OS. Mole weight: 617.51. | |
| TM-5275 sodium salt | TM-5275 sodium salt is an orally bioavailable, potent and selective plasminogen activator inhibitor-1 (PAI-1). It delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Uses: Tm-5275 sodium salt delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Synonyms: TM5275 sodium salt; TM 5275 sodium salt; TM-5275 sodium salt; 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt; Sodium 2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate. Grades: >98%. CAS No. 1103926-82-4. Molecular formula: C28H27ClN3NaO5. Mole weight: 543.98. | |
| Tm5441 | TM5441 is a plasminogen activator inhibitor-1 (PAI-1) that inhibits some tumor cell lines (IC50 = 9.7 ~ 60.3 μM). Studies indicated that it could be used to treat high-fat diet-induced obesity and adipocyte injury in mice. Uses: Tm5441 is a plasminogen activator inhibitor-1 (pai-1). Synonyms: TM-5441; TM 5441; TM5441; BMS-790052; BMS-790052; BMS790052; EBP 883; EBP-883; EBP883. 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid. CAS No. 1190221-43-2. Molecular formula: C21H17ClN2O6. Mole weight: 428.825. | |
| TMAD | TMAD. Group: Biochemicals. Alternative Names: 1,1'-Azobis(N,N'-dimethylformamide); N, N, N', N'-Tetra methyl azodicarboxamide. Grades: Highly Purified. CAS No. 10465-78-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C6H12N4O2. US Biological Life Sciences. | Worldwide |
| Tma-dph | Heterocyclic Organic Compound. Alternative Names: Tma-dph, N,N,N-Trimethyl-4-(6-phenyl-1,3,5-hexatrien-1-yl)phenylammonium p-toluenesulfonate, 115534-33-3, 1-(4-Trimethylammoniophenyl)-6-phenyl-1,3,5-hexatriene p-toluenesulfonate, 4- (Trimethylammonio)diphenylhexatriene p-toluenesulfonate, 1,6-Diphenyl-1,3,5-hexatriene-4-trimethylammonium tosylate, AC1NWJJB, T0775_SIGMA, 43060_FLUKA, 43060_SIGMA, AKOS015903812, FT-0605780, I14-17904, 1,6-Diphenyl-1,3,5-hexatriene-4 inverted exclamation marka-trimethylammonium tosylate, 4 inverted exclamation marka- (Trimethylammonio)diphenylhexatriene p-toluenesulfonate, 4-methylbenzenesulfonate; trimethyl-[4-[(1E,3E,5E)-6-phenylhexa-1,3,5-trienyl]phenyl]azanium. CAS No. 115534-33-3. Molecular formula: C28H31NO3S. Mole weight: 461.62. Purity: 0.96. IUPACName: 4-methylbenzenesulfonate; trimethyl-[4-[(1E, 3E, 5E)-6-phenylhexa-1, 3, 5-trienyl]phenyl]azanium. Catalog: ACM115534333. | |
| TMA-DPH | TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 115534-33-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0986. | |
| TMAH | Tetramethylammonium hydroxide is a solid in the hydrated form or a colorless liquid with a strong ammonia-like odor. It is soluble in water. It is corrosive to metals and tissue.;Liquid. Group: Polymers. CAS No. 75-59-2. Product ID: tetramethylazanium; hydroxide. Molecular formula: 91.15g/mol. Mole weight: C4H13NO. C[N+](C)(C)C.[OH-]. InChI=1S/C4H12N.H2O/c1-5(2, 3)4;/h1-4H3;1H2/q+1;/p-1. WGTYBPLFGIVFAS-UHFFFAOYSA-M. |  |
| TMAH-22 (Tetramethylammonium hydroxide aq. solution) | TMAH-22 (Tetramethylammonium hydroxide aq. solution). Group: Acids and alkalis. CAS No. 75-59-2. | |
| TMAH-25 (Tetramethylammonium hydroxide aq. solution) | TMAH-25 (Tetramethylammonium hydroxide aq. solution). Group: Acids and alkalis. CAS No. 75-59-2. | |
| T-MAS | 4,4-dimethyl cholest-8(9),24-dien-3ß-ol (T-MAS). Group: Sterols. Alternative Names: 4,4-dimethylzymosterol 14-demethyl-lanosterol. CAS No. 7448-2-4. Molecular formula: C29H48O. Mole weight: 412.69. Purity: >99%. Catalog: ACM7448024. | |
| TMB | TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species ( ROS/RNS ), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue; Sure Blue TMB. CAS No. 54827-17-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930. | |
| TMB 8 hydrochloride | TMB 8 is a PKC inhibitor and intracellular calcium antagonist. It also acts as a noncompetitive, functional antagonist at diverse nicotinic acetylcholine receptor (nAChR) subtypes. Synonyms: 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride. Grades: ≥ 98 %. CAS No. 53464-72-5. Molecular formula: C22H38ClNO5. Mole weight: 431.99. | |
| TMB dihydrochloride | TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue dihydrochloride; Sure Blue TMB dihydrochloride. CAS No. 64285-73-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930A. | |
| TMC-135A | TMC-135A is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60 with IC50 values of 0.07, 0.88, 0.11, 0.20, 0.15 and 0.05 μmol/L, respectively. Synonyms: TMC-135 A. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-135B | TMC-135B is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60. Synonyms: TMC-135 B. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-154 | TMC-154 is an antibiotic produced by Gliocladium sp. TC 1282. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC 154. Molecular formula: C41H72O14. Mole weight: 789. | |
| TMC-169 | TMC-169 is an antibiotic of the aspochalasin group produced by Aspergillus flavipes TC 1446. It has cytotoxicity. Synonyms: TMC 169. Molecular formula: C24H35NO3. Mole weight: 385.5. | |
| TMC-171A | TMC-171A is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 A. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171B | TMC-171B is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 B. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171C | TMC-171C is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 C. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-1A | TMC-1A is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 A. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1B | TMC-1B is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 B. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1C | TMC-1C is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 C. Molecular formula: C30H38N2O7. Mole weight: 538.6. | |
| TMC-1D | TMC-1D is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 D. Molecular formula: C30H40N2O7. Mole weight: 540.6. | |
| TMC-205 | TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines, activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region. Uses: Transcriptional up-regulator. Synonyms: TMC-205; TMC 205; TMC205. 6-(3-methylbuta-1,3-dienyl)-1H-indole-3-carboxylic acid. Grades: ≥98%. CAS No. 403646-00-4. Molecular formula: C14H13NO2. Mole weight: 227.26. | |
| TMC-256A1 | TMC-256A1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 25 μmol/L. Synonyms: TMC-256 A1. CAS No. 3773-18-0. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-256C1 | TMC-256C1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 1.7 μmol/L. Synonyms: TMC-256 C1. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-260 | TMC-260 is an inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703. It inhibited the IL-4 driven luciferase activity with IC50 values of 9 μmol/L. Synonyms: TMC 260. Molecular formula: C17H27NO5. Mole weight: 325.4. | |
| TMC-264 | TMC-264 is a STAT6 activation inhibitor produced by Phoma sp. TC 1674. It suppressed expression of IL-4 driven luciferase and germline Cepsilon mRNA with IC50 values of 0.3 and 0.4 μmol/L, respectively, and inhibited tyrosine phosphorylation of STAT6 with an IC50 value of 1.6 μmol/L. Synonyms: TMC 264. Molecular formula: C16H13ClO7. Mole weight: 352.72. | |
| TMC-2A | TMC-2A is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 A. Molecular formula: C28H34N4O9. Mole weight: 570.6. | |
| TMC-2B | TMC-2B is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 B. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-2C | TMC-2C is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 C. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC310911 | TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC 50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASC-09. CAS No. 1000287-05-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107123. | |
| TMC-310911 | TMC-310911, also known as ASC-09, is an HIV protease inhibitor potentially for the treatment of HIV infection. Group: Inhibitors. Alternative Names: TMC-310911; ASC-09; TMC310911; ASC09; TMC 310911; ASC 09. CAS No. 1000287-05-7. Molecular formula: C38H53N5O7S2. Mole weight: 755.99. Appearance: Solid powder. Purity: >98%. IUPACName: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((2-((1-cyclopentylpiperidin-4-yl)amino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate. Canonical SMILES: O=C (O[C@H]1CO[C@@]2 ([H])OCC[C@]21[H])N[C@@H] (CC3=CC=CC=C3)[C@H] (O)CN (S (=O) (C4=CC=C5N=C (NC6CCN (C7CCCC7)CC6)SC5=C4)=O)CC (C)C. Catalog: ACM1000287057. | |
| TMC-34 | TMC-34 is an macrolide antifungal antibiotic produced by Streptomyces sp. A-3030. Synonyms: TMC 34. Molecular formula: C54H93N3O17. Mole weight: 1056.3. | |
| TMC353121 | TMC353121 is a potent RSV fusion inhibitor. Its activity profile was found to be identical to the profile of JNJ-2408068. Synonyms: TMC-353121; TMC 353121; TMC353121. Grades: >98%. CAS No. 857066-90-1. Molecular formula: C32H42N6O3. Mole weight: 558.71. | |
| TMC-49A | TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Synonyms: TMC-49 A; 2-phenylethyl n-butyl carbamate. Molecular formula: C13H19NO2. Mole weight: 221.29. | |
| TMC-52A | TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM. Synonyms: TMC-52 A. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52B | TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 B. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52C | TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 C. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-52D | TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM. Synonyms: TMC-52 D. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-66 | TMC-66 is a selective endothelin conversion enzyme (ECE) inhibitor isolated from the culture broth of Streptomyces sp. A5008. Synonyms: TMC 66. Molecular formula: C29H21NO9. Mole weight: 527.5. | |
| TMC-69 | TMC-69 is an antitumor antibiotic isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. It exhibited moderate in vitro cytotoxic activity. Synonyms: TMC 69. Molecular formula: C26H31NO4. Mole weight: 421.5. | |
| TMC-86A | TMC-86A is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 5.1 and 3.7 μmol/L, respectively. Synonyms: TMC-86 A. Molecular formula: C16H26N2O6. Mole weight: 342.39. | |
| TMC-86B | TMC-86B is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 1.1 and 31 μmol/L, respectively. Synonyms: TMC-86 B. Molecular formula: C20H34N2O7. Mole weight: 414.5. | |
| TMC-89A | TMC-89A is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.39 and 7.2 μmol/L, respectively. Synonyms: TMC-89 A; N-[(2R)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-89B | TMC-89B is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.51 and 7.1 μmol/L, respectively. Synonyms: TMC-89 B; N-[(2S)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
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