A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Titropium bromide EP impurity G Bromine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1508-46-9. Molecular Formula: C9H16BrNO2. Mole Weight: 250.14. Catalog: APB1508469.
Titropium bromide EP impurity H Bromine
Titropium bromide EP impurity H Bromine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 845870-40-8. Molecular Formula: C9H16BrNO2. Mole Weight: 250.14. Catalog: APB845870408.
TiVAlC (MAX) Phase Ceramic Material
TiVAlC (MAX) Phase Ceramic Material. Uses: High temperature coating, mxene precursor, conductive self-lubricating ceramic, lithiumionbattery, super capacitor, electrochemical catalysis. Group: Mxene materials. >90%.
TiVAlC MAX phase material
TiVAlC MAX phase material. Uses: Energy storage, catalysis, analytical chemistry, mechanics, adsorption, biology, microelectronics, sensors, etc. Group: Mxenes materials. 0.99.
TiVAlCrZr High-Entropy Alloy Spherical Powder
TiVAlCrZr High-Entropy Alloy Spherical Powder is composed of Ti, V, Al, Cr, Zr. Alfa Chemistry offers high-quality High-Entropy Alloy with competitive pricing. Uses: Tivalcrzr high-entropy alloy spherical powder is widely used in aerospace parts and auto parts, profile surface coating, powder metallurgy, nuclear energy, and industrial fields. Group: High entropy alloys. Pack Sizes: Our TiVAlCrZr High-Entropy Alloy Spherical Powder is carefully handled during storage and transportation to preserve the quality of our product in its original condition.
Tivantinib
Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. Synonyms: ARQ-197; ARQ 197; ARQ197; Tivantinib. CAS No. 905854-02-6. Molecular formula: C23H19N3O2. Mole weight: 369.424.
Tivantinib
Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a K i of 355 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARQ 197; (3R,4R)-ARQ 198. CAS No. 905854-02-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50686.
TiVC MXene
TiVC MXene. Uses: Energy storage, catalysis, analytical chemistry, mechanics, adsorption, biology, microelectronics, sensors, etc. Group: Mxenes materials. 0.99.
Tiviciclovir
Tiviciclovir (AM188) is an antiviral guanosine analog and a hepatitis B virus inhibitor. Group: Inhibitors. CAS No. 103024-93-7. Molecular formula: C9H13N5O3. Mole weight: 239.23. Canonical SMILES: O=C1N=C(NC2=C1N=CN2CC(CO)CO)N. Catalog: ACM103024937.
Tivozanib
Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor ( VEGFR )-1, 2 3, with IC 50 s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AV-951; KRN951. CAS No. 475108-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10977.
Tivozanib
Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. Check for active clinical trials or closed clinical trials using this agent. Synonyms: AV-951; AV951; AV 951; KRN951; KRN 951; KRN-951. Grades: 0.98. CAS No. 475108-18-0. Molecular formula: C22H19ClN4O5. Mole weight: 454.86306.
Tivozanib hydrate
Tivozanib hydrate (AV-951 hydrate; KRN951 hydrate) is the hydrate form of Tivozanib (HY-10977). Tivozanib hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor ( VEGFR )-1, 2 3, with IC 50 s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrate exhibits antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AV-951 hydrate; KRN951 hydrate. CAS No. 682745-40-0. Pack Sizes: 1 mg. Product ID: HY-112467.
Tivozanib hydrate
Tivozanib is an orally available VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. It has been improved for the treatment of renal cell carcinoma. It also displays activity against other cancers. Synonyms: VEGFR Tyrosine Kinase Inhibitor IV; AV-951; KRN 951; 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea hydrate. Grades: ≥95%. CAS No. 682745-40-0. Molecular formula: C22H19ClN4O5·H2O. Mole weight: 472.9.
Tivozanib hydrochloride hydrate
Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib (HY-10977). Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor ( VEGFR )-1, 2 3, with IC 50 s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate. CAS No. 682745-41-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10977A.
Tivumecirnon
Tivumecirnon (FLX475) is an orally active, selective CCR4 antagonist. Tivumecirnon blocks the binding of CCR4 to its ligands, CCL17 and CCL22 , thereby reducing Treg infiltration into the tumor microenvironment. Tivumecirnon has antitumor activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FLX475. CAS No. 2174938-78-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148494.
Tixagevimab
Tixagevimab (AZD8895) is a human monoclonal antibody that targets the SARS-CoV-2 receptor binding domain (RBD). It exhibits neutralizing activity against SARS-CoV-2 by binding to the RBD and the S-glycoprotein ectodomain and blocking S-glycoprotein-mediated binding to the receptor [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AZD8895. CAS No. 2420564-02-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99556.
Tixocortol Pivalate
Tixocortol Pivalate is a corticosteroid showing topical anti-inflammatory properties. It is marketed under the brand name Pivalone. Synonyms: Pivalone; Tixocortol 21-pivalate. Grades: >95%. CAS No. 55560-96-8. Molecular formula: C26H38O5S. Mole weight: 462.645.
Tixosil
Tixosil. Group: Polymers.
Tizanidine
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 51322-75-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194.
Tizanidine
Tizanidine, a short-acting drug, is an agonist at a2-adrenergic receptor reducing spasticity by increasing presynaptic inhibition of motor neurons. Uses: An agonist at a2-adrenergic receptor. Synonyms: 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-8-thia-7,9-diazabicyclo(4.3.0)nona-2,4,6,9-tetraen-5-amine; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine. Grades: ≥98%. CAS No. 51322-75-9. Molecular formula: C9H8ClN5S. Mole weight: 253.71.
Tizanidine
Tizanidine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 51322-75-9. Molecular Formula: C9H8ClN5S. Mole Weight: 253.71. Catalog: APB51322759.
Tizanidine-d4
Tizanidine-d 4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1188331-19-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0194S.
Tizanidine-d4
Labeled Tizanidine, a muscle relaxant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: N1,N2-bis(5-chlorobenzo[c][1,2,5]thiadiazol-4-yl)ethane-1,2-diamine. Molecular formula: C14H12ClN8S2. Mole weight: 427.34.
Tizanidine EP Impurity A
Tizanidine EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 51322-69-1. Molecular Formula: C9H9N5S. Mole Weight: 219.27. Catalog: APB51322691.
Tizanidine EP Impurity B
Tizanidine EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 51323-05-8. Molecular Formula: C7H5ClN4S2. Mole Weight: 244.72. Catalog: APB51323058.
Tizanidine EP Impurity D
Tizanidine EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 560120-68-5. Molecular Formula: C8H7ClN4S2. Mole Weight: 258.74. Catalog: APB560120685.
Tizanidine EP Impurity D Hydriodide Salt
Tizanidine EP Impurity D Hydriodide Salt. Uses: For analytical and research use. Group: Impurity standards. CAS No. 51323-03-6. Molecular Formula: C8H8ClIN4S2. Mole Weight: 386.65. Catalog: APB51323036.
Tizanidine EP Impurity E
Tizanidine EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 30536-19-7. Molecular Formula: C6H4ClN3S. Mole Weight: 185.63. Catalog: APB30536197.
Tizanidine EP Impurity G
Tizanidine EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 51322-80-6. Molecular Formula: C7H3ClN4S. Mole Weight: 210.64. Catalog: APB51322806.
Tizanidine hydrochloride
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Synonyms: Tizanidine HCl; Zanaflex; Sirdalud; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride. Grades: >98%. CAS No. 64461-82-1. Molecular formula: C9H8ClN5S·HCl. Mole weight: 290.17.
Tizanidine hydrochloride
Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 64461-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194A.
Tizanidine hydrochloride
Tizanidine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Tizanidine hydrochloride
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H8N5ClS ¢HCl. CAS No. 64461-82-1. Prepack ID 71395830-5g. Molecular Weight 290.17. See USA prepack pricing.
Tizanidine, Hydrochloride
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). Group: Biochemicals. Grades: Highly Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C?H?Cl?N?S. US Biological Life Sciences.
Worldwide
Tizanidine Impurity 1
Tizanidine Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 22308-12-9. Molecular Formula: C19H24O6S2. Mole Weight: 412.52. Catalog: APB22308129.
Tizanidine Impurity A
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: 4-Amino-5-chloro-2,1,3-benzothiadiazole; 5-Chloro-2,1,3-benzothiadiazol-4-amine; Tizanidine EP Impurity E. CAS No. 30536-19-7. Molecular formula: C6H4ClN3S. Mole weight: 185.64.
Tizanidine Impurity B
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: N-Acetyl Tizanidine; 1-[2-[(5-Chloro-2,1,3-benzothiadiazol-4-yl)amino]-4,5-dihydro-1H-imidazol-1-yl]-ethanone; Tizanidine USP Related Compound B. CAS No. 173532-15-5. Molecular formula: C11H10ClN5OS. Mole weight: 295.75.
Tizanidine Impurity C
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: 1-Acetylimidazolidinethione; 1-(2-Thioxo-1-imidazolidinyl)ethanone; 1-Acetyl-2-imidazolidinethione; Tizanidine USP Related Compound C. CAS No. 5391-52-6. Molecular formula: C5H8N2OS. Mole weight: 144.2.
Tizanidine Metabolite
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: N-(5-chloro-2,1,3-benzothiadiazol-4-yl)-guanidine; (5-Chloro-2,1,3-benzothiadiazol-4-yl)-guanidine; 2,1,3-Benzothiadiazole Guanidine Derivative. CAS No. 125292-37-7. Molecular formula: C7H6ClN5S. Mole weight: 227.68.
Tizanidine USP Related Compound B
Tizanidine USP Related Compound B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 173532-15-5. Molecular Formula: C11H10ClN5OS. Mole Weight: 295.75. Catalog: APB173532155.
Tizanidine USP Related Compound C
Tizanidine USP Related Compound C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 5391-52-6. Molecular Formula: C5H8N2OS. Mole Weight: 144.19. Catalog: APB5391526.
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells. Group: Inhibitors. CAS No. 173903-47-4. Molecular formula: C10H7N3O4S. Mole weight: 265.243. Appearance: Solid. Purity: 0.97. Canonical SMILES: O=C (NC1=NC=C ([N+] ([O-])=O)S1)C2=CC=CC=C2O. Catalog: ACM173903474.
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC 50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells [1] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TIZ. CAS No. 173903-47-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12687.
Tizoxanide
A metabolite of Nitazoxonide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Tizoxanide
Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM)3, and inhibits hepatitis B and hepatitis C virus replication (EC50s both=0.15 μM). Uses: Anti-infective agents. Synonyms: TIZ; NSC-697856; NSC697856; NSC697856; Tizoxanide; Desacetylnitazoxanide; Desacetyl-nitazoxanide. Grades: >98%. CAS No. 173903-47-4. Molecular formula: C10H7N3O4S. Mole weight: 265.25.
Tizoxanide D4
2H Labeled Compounds. Alternative Names: 2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide-3,4,5,6-d4. CAS No. 1246817-56-0. Mole weight: 269.27. Purity: >98%. Catalog: ACM1246817560.
Tizoxanide Glucuronide Sodium Salt
One of the metabolite impurities of Nitazoxanide, which is a hepatitis B as well as hepatitis C virus inhibitor and could exhibit potential effect in studies of tuberculosis. Synonyms: 2-[[(5-Nitro-2-thiazolyl)amino]carbonyl]phenyl β-D-Glucopyranosiduronic Acid Monosodium Salt. CAS No. 221287-83-8. Molecular formula: C16H14N3NaO10S. Mole weight: 463.35.
Tizoxanide sulfate
One of the metabolite impurities of Nitazoxanide, which is a hepatitis B as well as hepatitis C virus inhibitor and could exhibit potential effect in studies of tuberculosis. Synonyms: 2-Sulfooxy-N-(5-nitro-2-thiazolyl)benzamide. CAS No. 1391053-06-7. Molecular formula: C10H7N3O7S2. Mole weight: 345.31.
TiZrVTa High-Entropy Alloy
Unlike most current alloy materials, high-entropy alloys are alloy materials that contain equimolar or approximately equimolar elements. TiZrVTa High-Entropy Alloy is composed of Ti, Zr, V, and Ta. Uses: Military use, replace part of superalloy. Group: High entropy alloys. Pack Sizes: Our TiZrVTa High-Entropy Alloy is carefully handled during storage and transportation to preserve the quality of our product in its original condition.
TJN-331
TJN-331 is a TGF-β1 inhibitor, which can inhibit the expression of TGF-β1 and improve anti-glomerular basement membrane nephritis. Synonyms: TJN331; TJN 331. CAS No. 219964-53-1. Molecular formula: C19H22N2O3. Mole weight: 326.4.
TK05
TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1245734-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117143.
TKIM
TKIM is a TREK-1 channel inhibitor with an IC 50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326921-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-134559.
TL02-59
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC 50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC 50 s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1315330-17-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112852.
TL 102 hydrobromide
TL 102 hydrobromide is a dopamine receptor agonist. Synonyms: 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol hydrobromide; TL 102 HBr; TL102 HBr; TL-102 HBr. Grades: 98%. CAS No. 62421-54-9. Molecular formula: C16H25NO2.HBr. Mole weight: 344.29.
TL-119
TL-119 is an antibiotic isolated from Bacillus subtilis. It is effective against gram-positive bacteria and fungi. Synonyms: Antibiotic TL-119; TL 119. CAS No. 55599-68-3. Molecular formula: C42H57N7O9. Mole weight: 803.9.
TL 13-110
TL 13-110 is an ALK inhibitor with IC50 value of 0.34 nM. It acts as a negative control for TL 13-112. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -5-isopropoxy-2-methylphenyl) piperidin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229037-09-4. Molecular formula: C49H62ClN9O9S. Mole weight: 988.59.
TL 13-22
TL 13-22 is an ALK inhibitor with IC50 value of 0.54 nM. It acts as a negative control for TL 13-22. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -3-methoxyphenyl) piperazin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229036-65-9. Molecular formula: C45H55ClN10O9S. Mole weight: 947.5.
TL310 is a novel, oral taxane with potent pre-clinical activity in taxane-resistant model systems. This is the first study to evaluate the safety, tolerability and pharmacokinetics (PK) of TL310 in pts with advanced refractory solid tumors. Synonyms: TL310; TL 310. CAS No. 352697-38-2. Molecular formula: C45H55NO16. Mole weight: 865.91.
TL4-12
TL4-12 is a potent MAP4K2 (GCK) inhibitor with IC50 value of 37 nM, suppressing IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro. Synonyms: 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1620820-12-3. Molecular formula: C25H27F3N6O2. Mole weight: 500.53.
TL8-506
TL8-506 is a benzoazepine compound as an agonist of TLR8 agonist. Synonyms: Ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate; 3H-1-Benzazepine-4-carboxylic acid, 2-amino-8-(3-cyanophenyl)-, ethyl ester; TL 8-506; TLR 8-506. Grades: ≥95%. CAS No. 1268163-15-0. Molecular formula: C20H17N3O2. Mole weight: 331.37.
TL-895
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC 50 and a K i of 1.5 nM and 11.9 nM, respectively [1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415823-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139481.