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| Product | Description | |
|---|---|---|
| TFLLR-NH2 | TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: TFLLR amide; (Thr1)-TRAP-5 amide; (Thr1)-PAR-1 (1-5) amide (human); PAR-1-activating peptide; PAR-1-AP; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide. Grade: 98%. CAS No. 197794-83-5. Molecular formula: C31H53N9O6. Mole weight: 647.81. |  |
| TFLLR-NH2 2TFA | TFLLR-NH2 2TFA, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: H-Thr-Phe-Leu-Leu-Arg-NH2.2TFA; TFLLR-NH2.2TFA; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid; PAR-1-AP trifluoroacetate; Protease-activated receptor-1-activating peptide trifluoroacetate. Grade: ≥95%. Molecular formula: C31H53N9O6.2C2HF3O2. Mole weight: 875.87. | |
| TFLLR-NH2(TFA) | TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: TFLLR-NH2 trifluoroacetate salt; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid. Grade: 99%. CAS No. 1313730-19-6. Molecular formula: C33H54F3N9O8. Mole weight: 761.83. | |
| TFLLR-NH2 trifluoroacetate salt | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| TFM-4AS-1 | TFM-4AS-1 is a selective androgen receptor modulator (SARM) , and a potent androgen receptor (AR) ligand with an IC 50 of 38 nM. TFM-4AS-1 is a gene-selective agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 188589-61-9. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-103246. |  |
| TFM-4AS-1 | TFM-4AS-1. Group: Biochemicals. Grades: Purified. CAS No. 188589-61-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TFMB-(R)-2-HG | TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1445700-01-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129079. | |
| TFMB-(S)-2-HG | TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, ?-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1445703-64-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129079A. | |
| TFP-PEG12-biotinidase resistant biotin | TFP-PEG12-biotinidase resistant biotin. Synonyms: TFP-PEG12-biotinidase resistant biotin; GS-9358; TFP-dPEG(R)12-biotinidase resistant biotin. Molecular formula: C47H76F4N4O17S. Mole weight: 1077.2. | |
| TFP-PEG3-TFP | TFP-PEG3-TFP. Uses: Designed for use in research and industrial production. Product Category: Other PEG Linkers. CAS No. 1446282-34-3. Molecular formula: C22H18F8O7. Mole weight: 546.09. Purity: 95%+. Product ID: ACM1446282343. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TFP-PEG4-biotinidase resistant biotin | TFP-PEG4-biotinidase resistant biotin. Synonyms: TFP-PEG4-biotinidase resistant biotin; GS-9357; TFP-dPEG(R)4-biotinidase resistant biotin. Molecular formula: C31H44F4N4O9S. Mole weight: 724.8. | |
| TfR-T12 | TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide. CAS No. 344618-30-0. Molecular formula: C71H99N19O15S. Mole weight: 1490.73. | |
| TfR Targeting Peptide | The 12-mer peptide sequence is a transferrin receptor (TfR) targeting peptide. It binds to TfR and is internalized via endocytosis into TfR-expressing cells. TfR targeting peptide is a potential carrier for transportation of small molecules across the blood-brain barrier to the brain, or into malignant tissues. Synonyms: H-Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro-OH; L-threonyl-L-histidyl-L-arginyl-L-prolyl-L-prolyl-L-methionyl-L-tryptophyl-L-seryl-L-prolyl-L-valyl-L-tryptophyl-L-proline; TfR-T12. Grade: ≥95%. Molecular formula: C71H99N19O15S. Mole weight: 1490.75. | |
| TG003 | TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 719277-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15338. | |
| TG003 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TG 003 | TG 003. Group: Biochemicals. Grades: Purified. CAS No. 719277-26-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TG 100713 | TG 100713. Group: Biochemicals. Grades: Purified. CAS No. 925705-73-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TG 100801 | TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases ; has IC 50 s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1 , VEGFR2 , FGFR1 , FGFR2 , PDGFRβ , Fgr , Fyn , Hck , Lck , Lyn , Src , Yes , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 867331-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10186. | |
| TG101209 | TG101209 is a selective JAK2 inhibitor with IC 50 of 6 nM, less potent to Flt3 and RET with IC 50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. Uses: Scientific research. Group: Signaling pathways. CAS No. 936091-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10410. | |
| TG101209 | TG101209. Group: Biochemicals. Alternative Names: N- (1, 1-Dimethylethyl) -3- [ [5-methyl-2- [ [4- (4-methyl-1-piperazinyl) phenyl] amino] -4-pyrimidinyl] amino] benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-14-4. Pack Sizes: 2.5mg. Molecular Formula: C26H35N7O2S, Molecular Weight: 509.67. US Biological Life Sciences. | Worldwide |
| TG101348 (SAR302503) | TG101348 is a potent, and selective inhibitor of JAK2 (IC50 = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively. Group: Biochemicals. Alternative Names: N-tert-butyl-3- (5-methyl-2- (4- (2- (pyrrolidin-1-yl) ethoxy) phenylamino) pyrimidin-4-ylamino) benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-26-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TG 4-155 | TG 4-155. Group: Biochemicals. Grades: Purified. CAS No. 1164462-05-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TG4-155 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TG4-155 | TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K i of 9.9 nM [1] [2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 [1]. TG4-155 has an EP2 Schild K B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1164462-05-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18971. | |
| TG53 | TG53 is a novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 946369-04-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H22ClN5O2, Molecular Weight: 411.88. US Biological Life Sciences. | Worldwide |
| Tgf-alpha | Tgf-alpha. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HUMAN TRANSFORMING GROWTH FACTOR ALPHA;HUMAN TGF-A;HUMAN TGF-ALPHA;H-VAL-VAL-SER-HIS-PHE-ASN-LYS-CYS-PRO-ASP-SER-HIS-THR-GLN-TYR-CYS-PHE-HIS-GLY-THR-CYS-ARG-PHE-LEU-VAL-GLN-GLU-GLU-LYS-PRO-ALA-CYS-VAL-CYS-HIS-SER-GLY-TYR-VAL-GLY-VAL-ARG-CYS-GLU-HIS-ALA-A. Product Category: Heterocyclic Organic Compound. CAS No. 89899-53-6. Molecular formula: C244H367N71O71S6. Mole weight: 5623.35. Product ID: ACM89899536. Alfa Chemistry ISO 9001:2015 Certified. Categories: TGF alpha. | |
| TGF α (1-50) (rat) | TGF α (1-50) (rat) was originally identified as an agent that can reversibly confer a transformed phenotype on normal non-tumor cells, such as normal rat renal fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which enhances the effects of TGF-α through a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and a variety of tissues and tumors. (approx. ED50 = 0.2 ng/mL). Synonyms: H-Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala-OH (Disulfide bridge: Cys8-Cys21, Cys16-Cys32, Cys34-Cys43); Transforming Growth Factor-α (1-50) from rat. CAS No. 89899-53-6. Molecular formula: C244H361N71O71S6. Mole weight: 5617.38. | |
| TGF-beta 3-E. coli human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| TGFβ-IN-2 | TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC 50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387678-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146434. | |
| TGFβ-IN-5 | TGFβ-IN-5(Compd 12) is a TGFβ inhibitor useful for the study of fibroproliferative diseases associated with TGF-β signaling [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 259870-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128437. | |
| TGF-beta receptor type-2 (131-139) | TGF-beta receptor type-2 (131-139) is a truncated fragment of TGF-beta receptor type-2. TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. Synonyms: Transforming Growth Factor Beta Receptor 2 (131-139); TGF-Beta Type II Receptor (131-139). | |
| TGF-beta/Smad Compound Library | A unique collection of 180 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4100. Categories: TGF-beta/Smad Compounds Libraries. |  |
| TGFBR1-IN-2 | TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 733806-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164793. | |
| TGF?R1 (80-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| TGF?R1 (80-end), GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| TGF?R2 (190-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| TGN 020 | TGN 020. Group: Biochemicals. Grades: Purified. CAS No. 51987-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TGN-020 | TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 ?M[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51987-99-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W008574. | |
| TGN-020 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TGN-020 sodium | TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 ?M[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313731-99-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W008574A. | |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC 50 s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14229. | |
| TGR5 Receptor Agonist (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) | Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. Group: Biochemicals. Alternative Names: 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TGX-115, PI3K Inhibitor (8-(2-Methylphenoxy)-2-(4-morphonilyl)-4(1H)-quinolinone) | Cell-permeable. A potent and selective inhibitor of PI 3-K isoforms p110b/p110e (IC?? p110b=0.13uM, p110e=0.63uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 351071-62-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. | |
| TGX-221, PI3K Inhibitor (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one) | Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase b (IC?? = 5nM for p110b). Inhibits other PI3K isoforms at higher concentrations (IC?? = 0.1uM for p110e, 5uM for p110a, and 3.5uM for p110g). Group: Biochemicals. Grades: Highly Purified. CAS No. 663619-89-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| TH1020 | TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 ?M. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1841460-82-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116961. | |
| TH1020 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH10785 | TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates ?, ?-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1002801-51-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147313. | |
| TH1217 | TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZINC1775962367. CAS No. 1862212-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135909. | |
| TH1834 | TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108830-08-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604. | |
| TH257 | TH257 is a Potent and selective allosteric LIMK 1/2 inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TH257; TH-257; TH 257. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2244678-29-1. Molecular formula: C24H26N2O3S. Mole weight: 422.54. Purity: >98%. IUPACName: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide. Canonical SMILES: O=C(N(CCCC)CC1=CC=CC=C1)C2=CC=C(S(=O)(NC3=CC=CC=C3)=O)C=C2. Product ID: ACM2244678291. Alfa Chemistry ISO 9001:2015 Certified. Categories: TH 257 (MN). | |
| TH-257 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH-263 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH287 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH5427 | TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2253744-56-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125209. | |
| TH5487 | TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304947-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125276. | |
| TH588 | TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. TH588 a first-in-class nudix hydrolase family inhibitor that potently and selectively engages and inhibits the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitor binds in the active site of MTH1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TH588; TH-588; TH 588. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. Purity: >98%. IUPACName: N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine. Canonical SMILES: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1. Product ID: ACM1609960317. Alfa Chemistry ISO 9001:2015 Certified. Categories: TH 88 (MN). | |
| TH588 | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1609960-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12814. | |
| TH588 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH-6 | TH-6 is a potent HDAC inhibitor with IC 50 s of 0.115, 0.135, 0.242, 0.138, 2.120 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031349-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149029. | |
| TH9619 | TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2379556-22-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155950. | |
| Thailanstatin A | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker-less ADC[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1426953-21-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129589. | |
| Thailanstatin B | Thailanstatin B is a pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs. Synonyms: EX-A5053. CAS No. 1426953-23-2. Molecular formula: C28H42ClNO9. Mole weight: 572.1. | |
| Thailanstatin C | Thailanstatin C is an antiproliferative agent and pre-mRNA splicing inhibitor (IC50 = 6.84 μM) from Burkholderia thailandensis MSMB43. Synonyms: (1S,5R)-1,5-Anhydro-1-(carboxymethyl)-3-C-(chloromethyl)-2-deoxy-5-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(isobutyryloxy)-2-pentenoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl}-D-erythro-pentitol; D-arabino-Heptonic acid, 3,7-anhydro-5-C-(chloromethyl)-2,4-dideoxy-7-C-[(1E,3E)-3-methyl-5-[(2S,3S,5R,6R)-tetrahydro-3,6-dimethyl-5-[[(2Z,4S)-4-(2-methyl-1-oxopropoxy)-1-oxo-2-penten-1-yl]amino]-2H-pyran-2-yl]-1,3-pentadien-1-yl]-, (7R)-. Grade: ≥95%. CAS No. 1426953-24-3. Molecular formula: C30H46ClNO9. Mole weight: 600.14. | |
| Thailanstatin D | Thailanstatin D inhibits AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis. Synonyms: Spliceostatin C. CAS No. 1609105-89-6. Molecular formula: C28H41NO8. Mole weight: 519.63. | |
| thalianol synthase | This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. Group: Enzymes. Synonyms: (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Enzyme Commission Number: EC 5.4.99.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5572; thalianol synthase; EC 5.4.99.31; (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Cat No: EXWM-5572. |  |
| Thalidomide | Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K d of ?250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 50-35-1. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-14658. | |
| Thalidomide (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Thalidomide 4-fluoride | Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon ligand 4; E3 ligase Ligand 4. CAS No. 835616-60-9. Pack Sizes: 1 g; 5 g. Product ID: HY-41547. | |
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