A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE). It inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells. Grades: ≥95%. Molecular formula: C21H30N4O7·xCF3COOH. Mole weight: 450.49.
YW1128
YW1128 is an inhibitor of Wnt/β-catenin signaling. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. Synonyms: 5-Methyl-1-(2-methylphenyl)-N-quinolin-2-yltriazole-4-carboxamide. Grades: ≥98%. CAS No. 2131223-64-6. Molecular formula: C20H17N5O. Mole weight: 343.38.
YW1159
YW1159 is an inhibitor of Wnt signaling. Synonyms: Compound 3d; 1-(2-Fluorophenyl)-5-methyl-N-quinolin-2-yltriazole-4-carboxamide. Grades: ≥98%. CAS No. 2131223-69-1. Molecular formula: C19H14FN5O. Mole weight: 347.35.
YW3-56 hydrochloride
YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 with IC50 values of 0.5-1 and 1-5 μM, respectively. It inhibits the growth of U2OS osteosarcoma cells with IC50 value of 2.5 μM in a p53-dependent manner. Synonyms: N-[(2S)-5-[(1-Amino-2-chloroethylidene)amino]-1-(benzylamino)-1-oxopentan-2-yl]-6-(dimethylamino)naphthalene-2-carboxamide hydrochloride. Grades: ≥80%. Molecular formula: C27H32ClN5O2·HCl. Mole weight: 530.49.
YYA-021
YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA. Synonyms: YYA-021; YYA 021; YYA021. Grades: >98%. CAS No. 144217-65-2. Molecular formula: C18H27N3O2. Mole weight: 317.43.
YZ9
YZ9 is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). YZ9 also competitively inhibits F-6-P (Ki = 0.094 μM), and suppresses cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay. Synonyms: YZ9; YZ 9; YZ-9; Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate; 7-Hydroxycoumarin-3-carboxylic acid ethyl ester; 3-carbethoxy-7-hydroxycoumarin. Grades: ≥98% by HPLC. CAS No. 6093-71-6. Molecular formula: C12H10O5. Mole weight: 234.2.