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Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-578; A 179578. CAS No. 221877-54-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12424.
Zotarolimus
Zotarolimus, also known as ABT-578 and A-179578, is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Coronary stents reduce early complications and improve late clinical outcomes in patients needing interventional cardiology. Medtronic are using zotarolimus as the anti-proliferative agent in the polymer coating of their Endeavor and Resolute products. Uses: Designed for use in research and industrial production. Additional or Alternative Names: A-179578; A 179578; A179578; ABT578; ABT-578; ABT 578; Endeavor; Zotarolimus; Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 221877-54-9. Molecular formula: C52H79N5O12. Mole weight: 966.23. Purity: >95%. IUPACName: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-3-{(1R)-2-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-4,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-heptadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone. Canonical SMILES: O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)CC[C@@](O2)([H])C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H]3C)=O)=O)=O)O[C@H]([C@H](C)C[C@H]4C[C@@H](OC)[C@@H](N5N=NN=C5)CC4)CC3=O. Product ID: ACM221877549. Alfa Chemistry ISO
Zotarolimus
Zotarolimus (also known as ABT-578) is an analogue of rapamycin (sirolimus) that was designed to have a shorter in vivo half-life than rapamycin. Zotarolimus was found to be comparable in potency for inhibiting in vitro proliferation of both rat and human T cells and mechanistically similar to sirolimus in having high-affinity binding to the immunophilin FKBP12. Zotarolimus is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Group: Biochemicals. Alternative Names: 40-epi-(N1-Tetrazolyl)-rapamycin; ABT-578; KY 12420. Grades: Highly Purified. CAS No. 221877-54-9. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
Zotatifin
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs ( IC 50 =2 nM) and interferes with the assembly of the eIF4F initiation complex [1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis ( IC 90 =37 nM) [2]. Zotatifin induces cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: eFT226. CAS No. 2098191-53-6. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg. Product ID: HY-112163.
Zotepine
Zotepine. Group: Biochemicals. Grades: Highly Purified. CAS No. 26615-21-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Zotepine
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT 2A , 5-HT 2C , Histamine H 1 , α 1 -adrenergic and Dopamine D 2 receptors , with K d s of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 26615-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103093.
Zotepine impurity 3
Zotepine impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1514918-29-6. Molecular formula: C18H18ClNO3S. Mole weight: 363.86. Catalog: APB1514918296.
Zotepine impurity 9
Zotepine impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133884-20-5. Molecular formula: C16H18ClNOS. Mole weight: 307.84. Catalog: APB133884205.
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt. Group: Biochemicals. Alternative Names: Z-D-allo-Thr(tBu)-OH·DCHA. Grades: Highly Purified. CAS No. 100157-55-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt 99+% (GC)
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt 99+% (GC). Group: Biochemicals. Grades: GC. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences.
Z-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Zotizalkib
Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK ( IC 50 of 1.4 nM) and ALK-resistant mutation , e.g. G1202R ( IC 50 of 0.3 nM), L1196M ( IC 50 of 0.3 nM). Zotizalkib has strong antitumor activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TPX-0131. CAS No. 2648641-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139279.
Z-O-trityl-L-serine
Z-O-trityl-L-serine. Group: Biochemicals. Alternative Names: Z-L-Ser(Trt)-OH. Grades: Highly Purified. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences.
Centrally acting myorelaxant; formerly used as an antispasmodic and uricosuric. Used as a tool for assessing hepatic cytochrome P-450 activity in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 61-80-3. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Zoxazolamine
Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. Uses: Scientific research. Group: Signaling pathways. CAS No. 61-80-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B1307.
Z-Phe-Ala-diazomethylketone
ZPAD is a specific inhibitor of thiol proteinases. The diazomethyl ketones Z-FA-CHN2 and Z-LVG-CHN2 inhibited cathepsin L-like cysteine proteinase B from Leishmania mexicana. Synonyms: ZPAD; Z-FA-DMK; benzyl (S)-1-((S)-4-diazo-3-oxobutan-2-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate. CAS No. 71732-53-1. Molecular formula: C21H22N4O4. Mole weight: 394.42.
z-Phe-ala-nh2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Z-PHE-ALA-NH2. Product Category: Heterocyclic Organic Compound. CAS No. 65118-54-9. Molecular formula: C20H23N3O4. Mole weight: 369.41. Product ID: ACM65118549. Alfa Chemistry ISO 9001:2015 Certified.
Z-Phe-Ala-OH
Z-Phe-Ala-OH. Group: Biochemicals. Alternative Names: N-Benzyloxycarbonyl-L-phenylalanyl-L-alanine; Z-L-phenylalanyl-L-alanine. Grades: Highly Purified. CAS No. 21881-18-5. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Z-Phe-Ala-OH
Sensitive substrate for cathepsin A. Synonyms: N-Benzyloxycarbonyl-L-phenylalanyl-L-alanine; Z-L-phenylalanyl-L-alanine; Z Phe Ala OH. Grade: ≥ 99% (HPLC). CAS No. 21881-18-5. Molecular formula: C20H22N2O5. Mole weight: 370.41.
Z-Phe-Ala-OH 99+% (HPLC)
Z-Phe-Ala-OH 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.