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Zorubicin is a benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Synonyms: RP-22050; RP 22050; RP22050; Zorubicine; N'- (1-{ (2S, 4S) -4-[ (3-Amino-2, 3, 6-trideoxy-α -L-lyxo-hexopyranosyl) oxy]-2, 5, 12-trihydroxy-7-methoxy-6, 11-dioxo-1, 2, 3, 4, 6, 11-hexahydro-2-tetracenyl}ethylidene) benzohydrazide; Rubidazone; Benzoic acid hydrazide, 3-hydrazone with daunorubicin; Benzoic acid, (1-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide, (2S-cis)-; Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide; Daunomycin benzoylhydrazone; MCMC 4222; Rubidazon. Grades: ≥95%. CAS No. 54083-22-6. Molecular formula: C34H35N3O10. Mole weight: 645.66.
Zosuquidar
Zosuquidar, also called as LY335979, a cyclopropyldibenzosuberane, was developed as an inhibitor of P-glycoprotein (P-gp). It is undergoing testing in a phase I/II trial clinical study in acute myeloid leukaemia. Synonyms: (2R)-anti-5-(3-(4-(10,11-difluoromethanodibenzo-suber-5-yl)piperazin-1-yl)2-hydroxypropoxy)quinoline trihydrochlorideLY 335979; LY-335979LY335979RS 33295-198RS-33295-198zosuquidar trihydrochloride. CAS No. 167354-41-8. Molecular formula: C32H31F2N3O2. Mole weight: 527.60.
Zosuquidar
Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor ( K i =59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RS 33295-198; LY-335979. CAS No. 167354-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-15255.
Zosuquidar trihydrochloride
Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with a Ki value of 60 nM. Synonyms: LY 335979; LY-335979; D06387; RS-33295-198; Zosuquidar HCl. CAS No. 167465-36-3. Molecular formula: C32H34Cl3F2N3O2. Mole weight: 636.99.
Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB 2 FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abx MCP; RG6006. CAS No. 2379336-76-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147429.
Zotarolimus
Zotarolimus (also known as ABT-578) is an analogue of rapamycin (sirolimus) that was designed to have a shorter in vivo half-life than rapamycin. Zotarolimus was found to be comparable in potency for inhibiting in vitro proliferation of both rat and human T cells and mechanistically similar to sirolimus in having high-affinity binding to the immunophilin FKBP12. Zotarolimus is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Group: Biochemicals. Alternative Names: 40-epi-(N1-Tetrazolyl)-rapamycin; ABT-578; KY 12420. Grades: Highly Purified. CAS No. 221877-54-9. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
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Zotarolimus
Zotarolimus, also known as ABT-578 and A-179578, is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Coronary stents reduce early complications and improve late clinical outcomes in patients needing interventional cardiology. Medtronic are using zotarolimus as the anti-proliferative agent in the polymer coating of their Endeavor and Resolute products. Uses: Designed for use in research and industrial production. Additional or Alternative Names: A-179578; A 179578; A179578; ABT578; ABT-578; ABT 578; Endeavor; Zotarolimus; Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 221877-54-9. Molecular formula: C52H79N5O12. Mole weight: 966.23. Purity: >95%. IUPACName: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-3-{(1R)-2-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-4,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-heptadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone. Canonical SMILES: O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)CC[C@@](O2)([H])C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H]3C)=O)=O)=O)O[C@H]([C@H](C)C[C@H]4C[C@@H](OC)[C@@H](N5N=NN=C5)CC4)CC3=O. Product ID: ACM221877549. Alfa Chemistry ISO
Zotarolimus
Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-578; A 179578. CAS No. 221877-54-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12424.
Zotarolimus
Zotarolimus (INN, codenamed ABT-578) is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Coronary stents reduce early complications and improve late clinical outcomes in patients needing interventional cardiology. Synonyms: A-179578; A 179578; A179578; ABT-578; ABT578; ABT 578. Grades: >98%. CAS No. 221877-54-9. Molecular formula: C52H79N5O12. Mole weight: 966.21.
Zotatifin
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs ( IC 50 =2 nM) and interferes with the assembly of the eIF4F initiation complex [1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis ( IC 90 =37 nM) [2]. Zotatifin induces cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: eFT226. CAS No. 2098191-53-6. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg. Product ID: HY-112163.
Zotepine
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT 2A , 5-HT 2C , Histamine H 1 , α 1 -adrenergic and Dopamine D 2 receptors , with K d s of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 26615-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103093.
Zotepine. Group: Biochemicals. Grades: Highly Purified. CAS No. 26615-21-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Zotepine
Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki = 0.69 and 2.3 nM, respectively) used as an atypical antipsychotic for the treatment of schizophrenia. Zotepine also exhibits an antagonistic effect at histamine H1 receptor (IC50 = 8.0 nM). Uses: Antipsychotic agents. Synonyms: 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine; Nipolept; Lodopin; Zoleptil; Zotepina. Grades: ≥99% by HPLC. CAS No. 26615-21-4. Molecular formula: C18H18ClNOS. Mole weight: 331.86.
Zotepine Impurity1
Zotepine Impurity1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 63720-83-2. Molecular Formula: C18H18ClNO2S. Mole Weight: 347.86. Catalog: APB63720832.
Zotepine impurity 10
Zotepine impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 19905-07-8. Molecular Formula: C14H9ClS. Mole Weight: 244.74. Catalog: APB19905078.
Zotepine impurity 11
Zotepine impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4789-54-2. Molecular Formula: C22H24ClNO5S. Mole Weight: 449.95. Catalog: APB4789542.
Zotepine Impurity2
Zotepine Impurity2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 78105-23-4. Molecular Formula: C18H18ClNO2S. Mole Weight: 347.86. Catalog: APB78105234.
Zotepine impurity 3
Zotepine impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1514918-29-6. Molecular Formula: C18H18ClNO3S. Mole Weight: 363.86. Catalog: APB1514918296.
Zotepine impurity 4
Zotepine impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 47289-31-6. Molecular Formula: C19H20ClNOS. Mole Weight: 345.89. Catalog: APB47289316.
Zotepine impurity 5
Zotepine impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 93665-48-6. Molecular Formula: C21H25ClN2OS. Mole Weight: 388.95. Catalog: APB93665486.
Zotepine impurity 6
Zotepine impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6823-52-5. Molecular Formula: C22H24ClNO5S. Mole Weight: 449.95. Catalog: APB6823525.
Zotepine impurity 7
Zotepine impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 62456-48-8. Molecular Formula: C16H15ClO. Mole Weight: 258.75. Catalog: APB62456488.
Zotepine impurity 8
Zotepine impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 96722-16-6. Molecular Formula: C11H10OS. Mole Weight: 190.26. Catalog: APB96722166.
Zotepine impurity 9
Zotepine impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133884-20-5. Molecular Formula: C16H18ClNOS. Mole Weight: 307.84. Catalog: APB133884205.
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt. Group: Biochemicals. Alternative Names: Z-D-allo-Thr(tBu)-OH·DCHA. Grades: Highly Purified. CAS No. 100157-55-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt 99+% (GC)
Z-O-tert-butyl-D-allo-threonine cyclohexylammonium salt 99+% (GC). Group: Biochemicals. Grades: GC. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences.
Z-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Zotizalkib
Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK ( IC 50 of 1.4 nM) and ALK-resistant mutation , e.g. G1202R ( IC 50 of 0.3 nM), L1196M ( IC 50 of 0.3 nM). Zotizalkib has strong antitumor activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TPX-0131. CAS No. 2648641-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139279.