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| Product | Description | |
|---|---|---|
| Avrainvillamide | Avrainvillamide is a fungal metabolite and monomeric form of stephacidin B that has been found in A. ochraceus. It is active against S. aureus, S. pyogenes, and E. faecalis (MICs = 12.5, 12.5, and 25 μg/ml, respectively). Avrainvillamide inhibits the growth of LNCaP, BT-549, T47D, and MALME-3M cancer cells with GI50 values of 0.24, 0.62, 0.21, and 0.41 μM, respectively. Synonyms: CJ-17,665; CJ17,665; CJ 17,665; 3,11,12,13,13aS,14-hexahydro-3,3,14,14-tetramethyl-8H,10H-7aS,12aS-(iminomethano)indolizino[6,7-h]pyrano[3,2-a]carbazole-8,16-dione 15-oxide. Grades: >95% by HPLC. CAS No. 269741-97-1. Molecular formula: C26H27N3O4. Mole weight: 445.52. |  |
| Avridine | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Avridine | Avridine is a potent synthetic non-immunogenic adjuvant that used to induce arthritis in Lewis (LEW) and DA rats. Uses: A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Synonyms: CP 20961; CP20961; CP-20961;N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane. Grades: ≥98%. CAS No. 35607-20-6. Molecular formula: C43H90N2O2. Mole weight: 667.19. | |
| Avridine | A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Group: Biochemicals. Alternative Names: 2, 2'- [ [3- (Dioctadecylamino) propyl] imino] bisethanol; CP 20961; CP-20961; N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane; N, N-Dioctadecyl-N', N'-bis (2-hydroxyethyl) propanediamine. Grades: Highly Purified. CAS No. 35607-20-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Avutometinib | Avutometinib (Ro 5126766) is a first-in-class dual MEK / RAF inhibitor that allosterically inhibits BRAF V600E , CRAF , MEK , and BRAF (IC 50 : 8.2, 56, 160 nM, and 190 nM, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 5126766; CH5126766. CAS No. 946128-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18652. |  |
| AVX 13616 | AVX 13616 shows the potent in vivo antibacterial activity of Avexa's lead antibacterial candidate, particularly against drug-resistant Staphylococcus pathogens. It was as active as mupirocin in a nasal decolonization model but required only a single application. It showed broad spectrum antibacterial activity against a range of isolates with MICs of 2-4 micrograms per millilitre against S. aureus, coagulase negative staphylococci, enterococci, MRSA, VISA and VRSA. Synonyms: AVX-13616; AVX 13616; AVX13616. Grades: >98%. CAS No. 900814-48-4. Molecular formula: C50H73Cl2N7O7. Mole weight: 955.06. | |
| Avycaz | Avycaz is a fixed-dose combination medication composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor. Synonyms: ceftazidime & avibactam; ceftazidime + avibactam; Avibactam / Ceftazidime. CAS No. 1393723-27-7. Molecular formula: C29H33N9O13S3. Mole weight: 811.8. | |
| Awamycin | Awamycin is produced by the strain of Streptomyces sp. No. 80-217. It has anti-gram-positive bacteria and antitumor activity. Synonyms: Antibiotic Tan 528A; Protostreptovaricin I, 10,25-didemethyl-21-hydroxy-10-(methoxycarbonyl)-19-O-methyl-25-(methylthio)-; Protostreptovaricin-31-oic acid, 25-demethyl-21-hydroxy-19-O-methyl-2S-(methylthio)-, methyl ester. Molecular formula: C38H49NO12S. Mole weight: 743.86. | |
| AWD 12-281 | AWD 12-281 is a strong selective phosphodiesterase 4 (PDE4) inhibitor which has potent effects in models of lung inflammation using inhalative administration. Synonyms: N-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide; AWD 12-281; AWD12-281; AWD-12-281;UNII-550671J24D; GSK 842470; GSK 842470; GSK-842470. Grades: >98%. CAS No. 257892-33-4. Molecular formula: C22H14Cl2FN3O3. Mole weight: 458.27. | |
| AWD 131-138 | AWD 131-138 is a partial agonist of GABAA receptor with low affinity for the benzodiazepine binding site. AWD 131-138 exhibits potent anticonvulsant and anxiolytic properties in rodent models. It is used as an antiepileptic drug for the treatment of canine idiopathic epilepsy. Synonyms: AWD 131-138; AWD-131-138; AWD131-138; AWD 131138; Imepitoin; 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one. CAS No. 188116-07-6. Molecular formula: C13H14ClN3O2. Mole weight: 279.724. | |
| AX-024 hydrochloride | AX-024 hydrochloride is an inhibitor of T cell receptor (TCR) that selectively inhibits the TCR-Nck interaction. By modulating TCR signaling, AX-024 prevents the development of psoriasis and asthma and, furthermore, exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. Synonyms: 1-[[4-(4-Fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]pyrrolidine hydrochloride; Pyrrolidine, 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-, hydrochloride (1:1). Grades: 99%. CAS No. 1704801-24-0. Molecular formula: C21H22FNO2.HCl. Mole weight: 375.86. | |
| AX 048 | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grades: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
| AX-15836 | AX-15836 is a highly potent and selective ERK5 inhibitor (IC50 = 8 nM) with >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Synonyms: 2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methyl-11-methylsulfonylpyrimido[4,5-b][1,4]benzodiazepin-6-one; AKOS030210962; ZINC669678933; AX15836; AX 15836; AX-15836. CAS No. 2035509-96-5. Molecular formula: C32H40N8O5S. Mole weight: 648.78. | |
| Axatilimab | Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SNDX-6352. CAS No. 2155851-88-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99452. | |
| AXC-715 | AXC-715 is a dual agonist of TLR7/TLR8. Synonyms: 1H-Imidazo[4,5-c]quinoline-1-butanamine, 4-amino-2-butyl-; 4-Amino-2-butyl-1H-imidazo[4,5-c]quinoline-1-butanamine; 1-(4-Aminobutyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine; AXC 715; AXC715. Grades: ≥95%. CAS No. 313350-31-1. Molecular formula: C18H25N5. Mole weight: 311.43. | |
| Axenomycin B | Axenomycin B is produced by the strain of Streptomyces lisandri F. I. 2604. It has antifungal, nematode and trichomonas activities. Molecular formula: C29H38O10. Mole weight: 546.60. | |
| Axinysone A | Axinysone A is a natural compound used in the research of cancer. Derived from natural sources, this product acts as a valuable inhibitor of specific signaling pathways involved in tumor growth and progression. Synonyms: (-)-Axinysone A. Grades: 97.5%. CAS No. 1114491-57-4. Molecular formula: C15H22O2. Mole weight: 234.338. | |
| Axinysone B | Axinysone B is a metabolite of the mushroom Anthracophyllum sp. BCC18695. Synonyms: (-)-Axinysone B; 2H-Cyclopropa[a]naphthalen-2-one, 1,1a,4,5,6,7,7a,7b-octahydro-4-hydroxy-1,1,7,7a-tetramethyl-, (1aS,4R,7S,7aS,7bR)-. Grades: 98.0%. CAS No. 1114491-60-9. Molecular formula: C15H22O2. Mole weight: 234.33. | |
| Axitinib | Axitinib is a multi-targeted tyrosine kinase inhibitor with IC 50 s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1 , VEGFR2 , VEGFR3 and PDGFRβ , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-013736. CAS No. 319460-85-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10065. | |
| Axitinib | Axitinib. Group: Biochemicals. Alternative Names: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; AG 013736. Grades: Highly Purified. CAS No. 319460-85-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H18N4OS. US Biological Life Sciences. | Worldwide |
| Axitinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Axitinib-d3 | Labeled analogue of Axitinib, a tyrosine kinase inhibitor. Axitinib is used in cancer therapy. Group: Biochemicals. Alternative Names: N-(Methyl-d3)-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; AG 013736-d3. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Axitinib-D3 (Axitinib Impurity 36) | Axitinib-D3 (Axitinib Impurity 36). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1126623-89-9. Molecular formula: C22H15D3N4OS. Mole weight: 389.49. Catalog: APB1126623899. | |
| Axitinib Impurity 1 | Axitinib Impurity 1 is an impurity of Axitinib, a drug primarily used in the treatment of advanced renal cell carcinoma and metastatic thyroid cancer. Synonyms: Axitinib Impurity c. Grades: > 95%. CAS No. 885126-40-9. Molecular formula: C22H18N4OS. Mole weight: 386.48. | |
| Axitinib Impurity 2 | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide). Grades: > 95%. CAS No. 1428728-83-9. Molecular formula: C44H36N8O2S2. Mole weight: 772.96. | |
| Axitinib Impurity 4 | Cas No. 1443118-73-7. | |
| Axitinib Impurity 6 | Axitinib Impurity 6 is an impurity arising from the depths of Axitinib - an oral tyrosine kinase inhibitor profoundly employed in the therapy against advanced renal carcinoma. Synonyms: Axitinib Impurity d. Grades: > 95%. CAS No. 1443118-72-6. Molecular formula: C29H25N5OS. Mole weight: 491.62. | |
| Axitinib Impurity 8 | Axitinib Impurity 8 is an impurity of axitinib fortifying the therapy against the perilous adversity known as advanced renal carcinoma. Synonyms: 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide; BenzaMide, 2-(1H-indazol-6-ylthio)-N-Methyl-; Axitinib Impurity e. Grades: > 95%. CAS No. 944835-85-2. Molecular formula: C15H13N3OS. Mole weight: 283.35. | |
| Axitinib sulfone | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: Sulfonyl axitinib; (E)-N-methyl-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylsulfonyl)benzamide; N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide. Grades: ≥95%. CAS No. 1348536-59-3. Molecular formula: C22H18N4O3S. Mole weight: 418.47. | |
| Axitinib sulfoxide | A major metabolite of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide; Axitinib Impurity A. Grades: > 95%. CAS No. 1347304-18-0. Molecular formula: C22H18N4O2S. Mole weight: 402.48. | |
| AXL (473-end), active, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Axl active human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Axltide | Axltide is based on mouse insulin receptor substrate 1 (amino acids 979-989). It is also a substrate for the kinases AXL, DDR2, MST1 and JAK2. Synonyms: Axl/Insulin Receptor Substrate Peptide; H-Lys-Lys-Ser-Arg-Gly-Asp-Tyr-Met-Thr-Met-Gln-Ile-Gly-OH; L-lysyl-L-lysyl-L-seryl-L-arginyl-glycyl-L-alpha-aspartyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-glutaminyl-L-isoleucyl-glycine. Grades: ≥98%. CAS No. 143364-95-8. Molecular formula: C63H107N19O20S2. Mole weight: 1514.77. | |
| AY 9944 | Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol ?7-reductase and ?8,7-sterol isomerase. A sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: trans-N1, N4-Bis [ (2-chlorophenyl) methyl ] -1, 4-cyclohexane dimethanamine Hydrochloride; N, N'-Bis (o-chlorobenzyl)-trans-1, 4-cyclohexanebis (methylamine) Dihydrochloride. Grades: Highly Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. | |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY-NH2 | AY-NH2. Group: Biochemicals. Grades: Purified. CAS No. 352017-71-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AY-NH2 | AY-NH is a selective proteinase-activated receptor 4 (PAR4) receptor agonist peptide. It stimulates aggregation of rat and human platelets in vitro. It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. It induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips. It also inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. It increases paw thickness in a rat paw edema inflammation model in vivo. Synonyms: PAR-4 Agonist Peptide, amide; L-Alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide; PAR-4-AP; Proteinase-activated Receptor 4 Activating Peptide. Grades: 98%. CAS No. 352017-71-1. Molecular formula: C34H48N8O7. Mole weight: 680.79. | |
| AZ0108 | AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S) -4- ( (3- (3- (1, 1-difluoroethyl) -6-methyl-5, 6, 7, 8-tetrahydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7-carbonyl) phenyl) difluoromethyl) phthalazin-1 (2H) -one; AZ0108; AZ-0108; AZ 0108. Grades: >98%. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. | |
| AZ 10397767 | AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). It significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grades: ≥98% by HPLC. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88. | |
| AZ 10417808 | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grades: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
| AZ 10606120 dihydrochloride | AZ 10606120 dihydrochloride is the dihydrochloride salt of AZ 10606120, which is a potent and negative allosteric modulator of the human P2X7 receptor. Its KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively. It binds in a positive cooperative manner to sites and acts as a negative allosteric modulator. It is a key modulator of the PI3K/GSK3β/VEGF signaling network. It inhibits tumor growth and shows antiangiogenic effects in mice. Synonyms: AZ10606120; AZ 10606120; AZ-10606120; N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide Dihydrochloride; 2- (1-Adamantyl) -N-[2-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]quinolin-5-yl]acetamide Dihydrochloride. Grades: ≥98% by HPLC. CAS No. 607378-18-7. Molecular formula: C25H36N4O2Cl2. Mole weight: 495.48. | |
| AZ10606120 dihydrochloride | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC 50 of about 10?nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 607378-18-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108669. | |
| AZ11645373 | AZ11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Uses: Purinergic p2x receptor antagonists. Synonyms: 2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-; 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione; AZ 11645373; AZ-11645373; 3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione. Grades: >98%. CAS No. 227088-94-0. Molecular formula: C24H21N3O5S. Mole weight: 463.51. | |
| AZ11645373 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| AZ 11645373 | AZ 11645373. Group: Biochemicals. Alternative Names: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione. Grades: Highly Purified. CAS No. 227088-94-0. Pack Sizes: 5mg. Molecular Formula: C24H21N3O5S, Molecular Weight: 463.51. US Biological Life Sciences. | Worldwide |
| AZ11665362 | AZ11665362 is a potent CRTH2 antagonist. It blocks the migration of eosinophils and basophils, and the rapid mobilization of eosinophils from bone marrow. It might be useful for the treatment of allergic diseases. Uses: Az11665362 might be useful for the treatment of allergic diseases. Synonyms: AZ-11665362; AZ 11665362; AZ11665362; (2,5-Dimethyl-3-(8-methyl-4-quinolinyl)-1H-indol-1-yl)acetic acid. Grades: 98%. CAS No. 629645-40-5. Molecular formula: C22H20N2O2. Mole weight: 344.41. | |
| AZ 12080282 dihydrochloride | AZ 12080282 dihydrochloride is a potent Hh inhibitor with IC50 value <0.012 μM. It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency. Synonyms: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride. Grades: ≥98%. Molecular formula: C23H20N4O2·2HCl. Mole weight: 457.35. | |
| AZ12216052 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZ 12216052 | AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grades: ≥98% by HPLC. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35. | |
| AZ 12216052 | AZ 12216052. Group: Biochemicals. Grades: Purified. CAS No. 1290628-31-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AZ-1355 | AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I 2 /thromboxane A 2 ratio in vitro. Uses: Scientific research. Group: Signaling pathways. CAS No. 75451-07-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101692. | |
| AZ13705339 | AZ13705339 is a potent and selective PAK1 inhibitor (IC50 = 0.33 nM). PAK1 is commonly overexpressed in breast tumors. Synonyms: AZ13705339; AZ 13705339; AZ-13705339; 2-[[N-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile. Grades: 99%. CAS No. 2016806-57-6. Molecular formula: C33H36FN7O3S. Mole weight: 629.75. | |
| AZ191 | AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Synonyms: AZ191; AZ 191; AZ-191. Grades: >98%. CAS No. 1594092-37-1. Molecular formula: C24H27N7O. Mole weight: 429.52. | |
| AZ191 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZ20 | AZ20 is a potent and selective inhibitor of ATR with an IC 50 of 5 nM, and has 8-fold selectivity against mTOR (IC 50 =38 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1233339-22-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15557. | |
| AZ20 | In vitro, AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Synonyms: AZ20; AZ-20; AZ 20. Grades: >98%. CAS No. 1233339-22-4. Molecular formula: C21H24N4O3S. Mole weight: 412.51. | |
| AZ20 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZ-2088 | AZ-2088 is a powerful and discriminating inhibitor exhibiting its prowess by selectively antagonizing the Akt pathway. Synonyms: AZ 2088; AZ2088; Dimethylheptyl(1-hydroxy-p-menth-2-yl)ammonium bromide; N-Heptyl-2-hydroxy-N,N,2-trimethyl-5-(propan-2-yl)cyclohexan-1-aminium bromide. Grades: >98%. CAS No. 20091-61-6. Molecular formula: C19H40BrNO. Mole weight: 378.44. | |
| AZ 23 | AZ 23 is a potent and selective tyrosine kinase (Trk) inhibitor with the potential for therapeutic utility in neuroblastoma and multiple other cancer indications. Uses: Multiple cancer therapy. Synonyms: AZ-23; AZ 23; AZ23; UNII-009OMI967N; 5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine. Grades: 99%. CAS No. 915720-21-7. Molecular formula: C17H19ClFN7O. Mole weight: 391.83. | |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grades: ≥98%. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC 50 s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 ( IC 50 , 6 nM), CSF1R ( IC 50 , 35 nM). Anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942507-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117273. | |
| AZ31 | AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC 50 of <1.2 nM for ATM enzyme, and an IC 50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088113-98-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112198. | |
| AZ31 | AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grades: ≥98%. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. | |
| AZ3146 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grades: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grades: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZ32; AZ-32; AZ 32. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.38. Purity: >98%. IUPACName: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Canonical SMILES: O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32. Product ID: ACM2288709964. Alfa Chemistry ISO 9001:2015 Certified. Categories: AZD-2327. |  |
| Az-33 | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grades: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
| AZ 3451 | AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling. Synonyms: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide; AZ-3451; AZ3451. Grades: ≥98%. CAS No. 2100284-59-9. Molecular formula: C30H27BrN4O3. Mole weight: 571.46. | |
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