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| Product | Description | |
|---|---|---|
| BMS 182874 | BMS 182874 is an endothelin receptor antagonist used as an antihypertensive agent. Uses: Antihypertensive agents. Synonyms: 5-Ddins; BMS 182874; BMS-182874; BMS182874; CHEMBL267458; 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide. CAS No. 153042-42-3. Molecular formula: C17H19N3O3S. Mole weight: 345.417. |  |
| BMS 182874 | BMS 182874 is an orallyactive, highly selective endothelin receptor ( ET A receptor) antagonist, with IC 50 value of 0.150 μM, K i of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 153042-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118497. |  |
| BMS 182874 Hydrochloride | This active molecular is a selective non-peptide Endothelin ETA receptor antagonist. It displays more than 1000-fold selectivity over ETB receptors (Ki of 48 nM for ETA receptors and >50 μM for ETB). BMS 182874 displays ET-1 inhibitory efficacy in vivo and vitro and it also inhibits ET-1-induced longitudinal muscle contraction in vitro. In 2006, BMS 182874 for coronary disorders and hypertension were discontinued in USA. Uses: Coronary disorders and hypertension. Synonyms: BMS 182874; BMS-182874; BMS182874; BMS 182874 HCl; BMS 182874 hydrochloride; 5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulfonamide hydrochloride. Grades: 98%. CAS No. 1215703-04-0. Molecular formula: C17H20ClN3O3S. Mole weight: 381.88. | |
| BMS 183920 | BMS 183920, a quinoline derivative, has been found to be an angiotensin II receptor antagonist that could have potential usage in antihypertensive study. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: BMS 183920; BMS-183920; BMS183920; CHEMBL305365; 2-Cyclopropyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)oxy)-4-quinolinecarboxylic acid; 4-Quinolinecarboxylicacid, 2-cyclopropyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]oxy]-. Grades: 98%. CAS No. 153072-33-4. Molecular formula: C26H19N5O3. Mole weight: 449.47. | |
| BMS-186318 | BMS-186318 has been found to be a HIV protease inhibitor that was once studied against HIV by Bristol-Myers Squibb. Synonyms: BMS 186318; BMS-186318; BMS186318; 12-Oxa-2,6,10-triazatetradecanoic acid, 4,8-dihydroxy-13,13-dimethyl-3-((4-(2-(4-morpholinyl)-2-oxoethoxy)phenyl)methyl)-11-oxo-9-(phenylmethyl)-, 1,1-dimethylethyl ester, (3S,4R,8R,9S)-; BMS-186318 analog 19; 12-Oxa-2,6,10-triazat. Grades: 98%. CAS No. 161302-40-5. Molecular formula: C36H54N4O9. Mole weight: 686.85. | |
| BMS-186511 | BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. Synonyms: BMS186511; BMS 186511; ((5S,8S,11S)-8,11-diisopropyl-5-(methoxycarbonyl)-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-15-yl)((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)phosphinic acid. Grades: >98%. CAS No. 167467-53-0. Molecular formula: C26H27N5O5. Mole weight: 685.90. | |
| BMS-187071 | BMS-187071 has been found to be a HIV protease inhibitor that was once studied against HIV by Bristol-Myers Squibb. Synonyms: BMS 187071; BMS187071; BMS187071; (3-((3-((2,3,3-Trimethyl-2(S)-2-hydroxy-1-oxobutyl)amino)-2-hydroxy-4-phenylbutyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamic acid, 1,1-dimethylethyl ester; [3-[[3-[(2,3,3-Trimethyl-2(S)-2-hydroxy-1-oxobutyl)amino]-2-hydroxy-4. Grades: 98%. CAS No. 161302-39-2. Molecular formula: C32H49N3O6. Mole weight: 571.75. | |
| BMS-187308 | BMS-187308, a sulfonamide derivative, has been found to be an endothelin-A (ETA) antagonist that was once studied about its activity against pressor effect in rats. Synonyms: BMS-187308; BMS 187308; BMS187308; UNII-7K0YU35900; CHEMBL106684; 7K0YU35900; SCHEMBL6767698; BDBM50068674; 2-[2-amino-4-(2-methylpropyl)phenyl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide. Grades: 98%. CAS No. 153624-15-8. Molecular formula: C21H25N3O3S. Mole weight: 399.51. | |
| BMS-188494 | BMS-188494 is the prodrug of BMS-187745, a squalene synthase inhibitor used as an anticholesterol drug. Synonyms: 1-[bis (2, 2-dimethylpropanoyloxymethoxy) phosphoryl]-4- (3-phenoxyphenyl) butane-1-sulfonic acid; BMS-188494; BMS 188494; BMS188494; UNII-F4W2579G7P. Grades: >98%. CAS No. 191866-32-7. Molecular formula: C28H39O11PS. Mole weight: 614.645. | |
| BMS 188745 potassium salt | BMS 188745 potassium salt. Group: Biochemicals. Alternative Names: (a-S) -3-Phenoxy-a-phosphono Benzene butanesulfonic acid tripotassium salt. Grades: Highly Purified. CAS No. 157126-15-3. Pack Sizes: 10mg. Molecular Formula: C16H16K3O7PS. US Biological Life Sciences. |  Worldwide |
| BMS 191011 | BMS 191011 is a potent opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel. It is neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke). Synonyms: 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-one; BMS-191011; BMS 191011; BMS191011; UNII-LW7MXS978N; Bms-a. Grades: >99 %. CAS No. 202821-81-6. Molecular formula: C16H10ClF3N3O3. Mole weight: 370.71. | |
| BMS 191011 | BMS 191011. Group: Biochemicals. Grades: Purified. CAS No. 202821-81-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-191095 | BMS-191095 is an activators that has selective effects on mitochondrial ATP-sensitive potassium (mitoKATP) channels. in vitro: induces mitochondrial-depolarization and vasodilation. Synonyms: (3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrileBMS-191095; BMS 191095; BMS191095CHEMBL11594SCHEMBL8896325ZI NC3821976BDBM50409914. CAS No. 166095-21-2. Molecular formula: C22H21ClN4O2. Mole weight: 408.88. | |
| BMS-192364 | BMS-192364 is a prominent and discriminating inhibitor, finding profound application in the research of cancer. Specifically designed for efficacious cancer research, this remarkable compound effectively obstructs kinases that play a crucial role in the propagation and sustenance of malignant cells. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-192364; BMS 192364; BMS192364; UNII-1NC8D8P7QF. Grades: >98%. CAS No. 202822-21-7. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS-192548 | BMS-192548 is a neuropeptide Y (NPY) receptor binding inhibitor produced by Aspergillus niger WB2346. It also has weak cytotoxicity, with an IC50 of 240 μmol/L for murine tumor cells M-109. Synonyms: TAN-1612. CAS No. 156368-93-3. Molecular formula: C21H18O9. Mole weight: 414.36. | |
| BMS-193884 | BMS-193884, an oxazol derivative, has been found to be an endothelin A receptor antagonist and was once studied in the treatmen of heart failure. Uses: Endothelin receptor antagonists. Synonyms: BMS-193884; BMS 193884; BMS193884; 7ON53PV45J; SCHEMBL4204130; BDBM50091105; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide. Grades: 98%. CAS No. 176960-47-7. Molecular formula: C20H17N3O4S. Mole weight: 395.43. | |
| BMS 193885 | BMS 193885. Group: Biochemicals. Grades: Purified. CAS No. 679839-66-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-193885 | BMS-193885 is a potent and selective neuropeptide Y1 receptor antagonist with IC50=5.9nM, Ki=3.3 nM. BMS-193885 displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Synonyms: dimethyl 4-[3-[3-[4-(3-methoxyphenyl)piperidin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; BMS 193885; 679839-66-8BMS-193885; BMS193885; BMS 193885. Grades: >98%. CAS No. 186185-03-5. Molecular formula: C33H42N4O6. Mole weight: 590.71. | |
| BMS-193885 salt | BMS-193885 is a potent and selective neuropeptide Y1 receptor antagonist with IC50=5.9nM, Ki=3.3 nM. BMS-193885 displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Synonyms: BMS 193885; BMS193885; 1, 4-dihydro-4- [3- [ [ [ [3- [4- (3-methoxyphenyl) -1-piperidinyl] propyl] amino] carbonyl] amino] phenyl] -2, 6-dimethyl-3, 5-dimethyl ester-3,5-pyridinedicarboxylic acid. Grades: >98%. CAS No. 679839-66-8. Molecular formula: C36H48N4O9. Mole weight: 680.79. | |
| BMS-194449 | BMS-194449 was found to be a β-adrenergic receptor agonist that was once studied in antihyperglycaemics as well as obesity therapy. Synonyms: BMS-194449; BMS 194449; BMS194449; UNII-93ZDV2P17I; CHEMBL320915; 93ZDV2P17I; SCHEMBL7042103; BDBM50106794; (R) -N- (5- (2- ( (bis (4- (difluoromethoxy) phenyl) methyl) amino) -1-hydroxyethyl) -2-hydroxyphenyl) methanesulfonamide. Grades: 98%. CAS No. 170686-12-1. Molecular formula: C24H24F4N2O6S. Mole weight: 544.52. | |
| BMS-195270 | BMS-195270 is a robust and discriminating small molecule inhibitor, finding paramount application in the biomedical sector. Its remarkable efficacy against fibroblast growth factor receptor 4 (FGFR4) imparts exceptional potency, rendering it a formidable intervention modality for malignancies driven by FGFR4. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-195270; BMS 195270; BMS195270; UNII-20UM0T170J; CHEMBL13637; SCHEMBL5754043; 20UM0T170J. Grades: >98%. CAS No. 202822-23-9. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS 195614 | BMS 195614. Group: Biochemicals. Grades: Purified. CAS No. 253310-42-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS 195614 | BMS 195614 is a neutral RARα selective antagonist (Ki = 2.5 nM) and exhibits no significant effect on nuclear receptor corepressor (NCoR) binding. BMS 195614 moderately decreases SMRT binding to RAR and agonist-induced coactivator (CoA) recruitment. Synonyms: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid; 4-({[5,5-Dimethyl-8-(3-quinolinyl)-5,6-dihydro-2-naphthalenyl]carbonyl}amino)benzoic acid; Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-; BMS 614. Grades: ≥98% by HPLC. CAS No. 253310-42-8. Molecular formula: C29H24N2O3. Mole weight: 448.51. | |
| BMS-196085 | BMS-196085, a sulfanilamide derivative, has been found to be a β-adrenergic receptor agonist that was once studied in obesity as well as yype 2 diabetes mellitus. Synonyms: BMS-196085; BMS 196085; BMS196085; CHEMBL322862; FM0D5L3W03; SCHEMBL7042488; BDBM50106829; UNII-FM0D5L3W03; N-[5-[(1R)-2-[[(1R)-1-[4-(difluoromethoxy)phenyl]-2-phenylethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide. Grades: 98%. CAS No. 170686-10-9. Molecular formula: C24H26F2N2O5S. Mole weight: 492.54. | |
| BMS-202 | BMS-202 Inhibitor. Uses: Scientific use. Product Category: T3146. CAS No. 1675203-84-5. |  |
| BMS-202 | BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC 50 of 18 nM and a K D of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1675203-84-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19745. | |
| BMS-210285 | BMS-210285 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-210285; BMS210285; BMS 210285; UNII-WS7S13Q9RH; CHEMBL60116; WS7S13Q9RH; SCHEMBL13550990; BDBM50073046. N-[5-[(1R)-2-[[(1R)-2-(3-chlorophenyl)-1-[4-(difluoromethoxy)phenyl]ethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide. Grades: ≥98%. CAS No. 344607-69-8. Molecular formula: C24H25ClF2N2O5S. Mole weight: 526.98. | |
| BMS-212 | BMS-212 is a potent and selective stimulator of glucokinase (GK) (EC50 = 35 nM) that is promisingly used as an antidiabetic. BMS-212 has a preference for GK in liver over GK in pancreas, of which the activation may lead to non-glucose-dependent insulin secretion. Half-life of BMS-212 is 4.2h, and oral bioavailability is 15%. Uses: Potential antidiabetic. Synonyms: BMS212; BMS 212. CAS No. 2173153-38-1. Molecular formula: C25H30N3O9PS2. Mole weight: 611.62. | |
| BMS-212122 | BMS-212122 is a benzimidazole-based analogue of the potent MTP inhibitor BMS-201038. Synonyms: 9-[4-[2, 5-dimethyl-4-[[2-[4- (trifluoromethyl) phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N- (2, 2, 2-trifluoroethyl) fluorene-9-carboxamide; BMS-212122; BMS212122; BMS 212122; UNII-0Z473OO6GB. Grades: >98%. CAS No. 194213-64-4. Molecular formula: C43H36F6N4O2. Mole weight: 754.76. | |
| BMS 214428 | BMS 214428 has antineoplastic effect. Synonyms: dimethyl 4-[3-[[N-cyano-N'-[3- (4-phenylpiperidin-1-yl) propyl]carbamimidoyl]amino]phenyl]-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylate; UNII-6774Z74TWN; 6774Z74TWN; BMS 214428; BMS-214428; BMS214428. Grades: >98%. CAS No. 216508-01-9. Molecular formula: C33H40N6O4. Mole weight: 584.71. | |
| BMS-214662 | BMS-214662 is a Farnesyltransferase inhibitor and a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. Synonyms: BMS 214662; BMS214662; ARQ-171; ARQ 171; ARQ171; (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile. Grades: 98%. CAS No. 195987-41-8. Molecular formula: C25H23N5O2S2. Mole weight: 489.61. | |
| BMS-214662 hydrochloride | BMS-214662, a nonsedating benzodiazepine derivative, inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction. Treatment with BMS-214662 may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. BMS-214662 may be a useful drug for treating B-CLL and, in particular, an alternative for the therapy of purine analog-resistant or relapsed B-CLL. Synonyms: (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile; 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine; ARQ171; ARQ 171; ARQ-171; BMS214662; BMS214662; BMS-214662. Grades: >98%. CAS No. 195981-08-9. Molecular formula: C25H24ClN5O2S2. Mole weight: 526.1. | |
| BMS-214662 mesylate | BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C&beta. Uses: A potent and selective inhibitor of farnesyltransferase. Synonyms: BMS-214662 mesylate; BMS 214662 mesylate; BMS214662 mesylate; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine mesylate. Grades: ≥98%. CAS No. 474010-58-7. Molecular formula: C25H25N5O6S3. Mole weight: 585.72. | |
| BMS-229724 | BMS-229724 is a selective tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2) in that it did not inhibit secreted phospholipase A2 in vitro, nor phospholipase C and phospholipase D in cells. BMS-22972 acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. Synonyms: 4-[4-[2-[2-[bis (4-chlorophenyl) methoxy]ethylsulfonyl]ethoxy]phenyl]-1, 1, 1-trifluorobutan-2-one; 4- (4- (2- (2- (bis (4-chlorophenyl) methoxy) ethylsulfonyl) ethoxy) phenyl) -1, 1, 1-trifluoro-2-butanone; BMS-229724; BMS 229724; BMS229724; 42AD6D8ECA; SCHEMBL3304414; LS-46643; UNII-42AD6D8ECA. Grades: >98%. CAS No. 221914-85-8. Molecular formula: C27H25Cl2F3O5S. Mole weight: 589.45. | |
| BMS-243117 | BMS-243117 is a potent and selective Lck inhibitor with good cellular activity against T-cell proliferation. BMS-24311 has potential to treat diseases such as rheumatoid arthritis and asthma. Synonyms: BMS-243117; BMS 243117; BMS243117; UNII-MBE6KWV0QI; CHEMBL67237; MBE6KWV0QI; SCHEMBL6058200. 2-(tert-butylcarbamoylamino)-N-(2-chloro-6-methylphenyl)-1,3-benzothiazole-6-carboxamide; BMS-243117; UNII-MBE6KWV0QI. Grades: >98%. CAS No. 225521-80-2. Molecular formula: C20H21ClN4O2S. Mole weight: 416.92. | |
| BMS-247243 | BMS-247243 is a novel β-Lactamase inhibitor which is a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Uses: Beta-lactamase-inhibitor. Synonyms: BMS-247243; BMS 247243; BMS247243; UNII-KG8365V22L. (6R,7R)-7-[[2-[4-[(E)-3-(carboxylatomethylamino)-3-oxoprop-1-enyl]-2,5-dichlorophenyl]sulfanylacetyl]amino]-3-[[2,6-dimethyl-1-[3-(4-methylmorpholin-4-ium-4-yl)propyl]pyridin-1-ium-4-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Grades: ≥98%. CAS No. 307316-55-8. Molecular formula: C36H41Cl2N5O8S3. Mole weight: 838.83. | |
| BMS-248360 | BMS-248360 is a first orally active generation dual action receptor antagonist. BMS-248360 antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50=8.5, ETA IC50=8.9 nM). Synonyms: 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-[(3,3-dimethyl-2-oxopyrrolidin-1-yl)methyl]phenyl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide; BMS-248360; BMS 248360; BMS248360; UNII-EEP77N970Y; CHEMBL11706; EEP77N970Y; SCHEMBL4764273; BDBM50117910. Grades: >98%. CAS No. 254737-87-6. Molecular formula: C36H45N5O5S. Mole weight: 659.84. | |
| BMS 262084 | BMS 262084 is a potent and selective azetidinone-based beta-lactam tryptase inhibitor. Synonyms: (2S,3R)-1-[4-(tert-butylcarbamoyl)piperazine-1-carbonyl]-3-[3-(diaminomethylideneamino)propyl]-4-oxoazetidine-2-carboxylic acid; BMS-262084; BMS 262084; BMS262084; CHEMBL71037; UNII-I0IR71971G; I0IR71971G; BDBM50120368; DNC004491. Grades: >98%. CAS No. 253174-92-4. Molecular formula: C18H31N7O5. Mole weight: 425.48. | |
| BMS-265246 | BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD. Group: Biochemicals. Alternative Names: (4-Butoxy-1H-pyrazolo[3, 4-b]pyridin-5-yl) (2, 6-difluoro-4-methylphenyl) methanone. Grades: Highly Purified. CAS No. 582315-72-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| BMS-265246 | BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM. It is 25-fold more selective for CDK1/2 than CDK4. Synonyms: BMS265246; BMS-265246; BMS 265246. Grades: >98%. CAS No. 582315-72-8. Molecular formula: C18H17F2N3O2. Mole weight: 345.34. | |
| BMS 270394 | BMS 270394 is a nuclear retinoic acid receptor (RAR-γ) agonist. Synonyms: BMS270394; BMS-270394 ; BMS 270394; BMS 189961; BMS189961; BMS-189961; (R)-3-fluoro-4-(2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamido)benzoic acid; 3-fluoro-4-[[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetyl]amino]benzoic acid. Grades: 99%. CAS No. 262433-54-5. Molecular formula: C23H26FNO4. Mole weight: 399.46. | |
| BMS-275183 | BMS-275183 is an oral C-4 methyl carbonate analogue of paclitaxel that has the same mechanism of action, stabilization of tubulin polymerization. BMS-275183 given p.o. was active in a human, hormone-dependent, prostate tumor model, CWR-22, and just as effective as anti-androgen chemotherapy. BMS-275185 is lack of evidence of clinical benefit with the occurrence of two fatal events of neutropenic sepsis. Synonyms: BMS 275183; BMS275183. CAS No. 355113-98-3. Molecular formula: C43H59NO16. Mole weight: 845.94. | |
| BMS-279700 | BMS-279700, belonging to a family of novel anilino 5-azaimidazoquinoxaline analogues, is an orally active lead candidate that blocks the production of proinflammatory cytokines (IL-2 and TNFalpha) in vivo. Synonyms: (S)-N-(2-chloro-6-methylphenyl)-2-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine; BMS279700; BMS 279700; BMS-279700. Grades: >98%. CAS No. 240814-54-4. Molecular formula: C21H22ClN7. Mole weight: 407.899. | |
| BMS-284640 | BMS-284640 is a Na(+)/H(+) exchanger (NHE) inhibitor developed for the treatment of cardiovascular therapies. Synonyms: BMS 284640; BMS284640; N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidine. Grades: >98%. CAS No. 230640-88-7. Molecular formula: C15H19N3O2. Mole weight: 273.33. | |
| BMS 299897 | BMS 299897 is a known γ-secretase inhibitor that effectively reduces amyloid β-peptide (A β) in transgenic mice and guinea pigs. Studies have shown the possibility of using BMS 299897 in the treatments for Alzheimers patients. Group: Biochemicals. Alternative Names: 2-[ (1R) -1-[[ (4-Chlorophenyl) sulfonyl] (2, 5-difluorophenyl) amino]ethyl]-5-fluorobenzenebutanoic Acid. Grades: Highly Purified. CAS No. 290315-45-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BMS 299897 | BMS 299897, under the IUPAC name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid, synthesized by the radiosynthesis group at Bristol-Myers Squibb, is a β-secretase inhibitor that has the potential for treatment of Alzheimer's diseases (IC50 = 12 nM; gamma-secretase express: EC50 = 7 nM (CHO cells)). BMS 299897 blocks the formation of Aβ40 (IC50 = 7.9 nM) and Aβ42 (IC50 = 7.9 nM) in the brain, and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Synonyms: 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid; 4-(2-((1R)-1-(((4-chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic acid; BMS299897; BMS 299897; BMS-299897; 290315-45-6; 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid; C24H21ClF3NO4S; CHEMBL247471; SCHEMBL6394108; DTXSID50460039; 3496AH; ZINC28883606; AKOS024457319; CCG-222540; CS-1339; NCGC00346875-01; HY-50883; KB-75603; DB-017854; W-5550; BRD-K02950022-001-01-1; 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid; BMS 299897|2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid. CAS No. 290315-45-6. Molecular formula: C24H21ClF3NO4S. Mole weight: 511.94. | |
| BMS 299897, gamma-Secretase Inhibitor XXIV (4-(2-((1R)-1-(((4-Chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic Acid, BMS-299897, BMS 299897) | An orally bioavailable sulfonamide compound that acts as a potent, reversible and allosteric y-secretase activity inhibitor with ~15-fold greater selectivity over Notch-1 proteolysis processing (IC50=7.1 and 105.9nM in HEK293-wtAPP) and preferentially inhibits PS1 (presenillin 1)-comprised y-secretase (EC50=8, 108, 286 and 29nM for PS1, Triple PS1-L172M,T281P, L282I, PS2 and Triple PS2-M178L, P287T, I288L), respectively). Shown to reduce the levels of Ab38, Ab40 and Ab42 in Tg2576 mice, Ab40 brain and plasma in APP-YAC mice (ED50=30 and 16mg/kg, p.o.) and Abtotal brain, CSF and plasma in guinea pigs (ED50=30mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 290315-45-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| BMS-3 | BMS-3, a LIMK1 inhibitor, could be probably influence the migration and cycle progression of cells so that has patential value in studying its effect against cancer. Synonyms: N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)cyclopropanecarboxamide; BMS3; BMS 3; Cyclopropanecarboxamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-; N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}cyclopropanecarboxamide. Grades: 95%. CAS No. 1338247-30-5. Molecular formula: C17H12Cl2F2N4OS. Mole weight: 429.27. | |
| BMS303141 | BMS 303141 is a cell-permeable, 2-hydroxy-N-arylbenzenesulfonamide that inhibits ACL with an IC50 value of 0.13 μM. BMS 303141 has been reported to reduce weight gain and lower plasma cholesterol, triglycerides, and glucose in a mouse model of hyperlipidemia. Synonyms: BMS303141; BMS-303141; BMS 303141. CAS No. 943962-47-8. Molecular formula: C19H15Cl2NO4S. Mole weight: 424.30. | |
| BMS303141 | BMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model. Group: Inhibitors. Alternative Names: BMS303141; BMS-303141; BMS 303141. CAS No. 943962-47-8. Molecular formula: C19H15Cl2NO4S. Mole weight: 424.3. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 3,5-dichloro-2-hydroxy-N-(4-methoxy-[1,1'-biphenyl]-3-yl)benzenesulfonamide. Canonical SMILES: O=S (C1=CC (Cl)=CC (Cl)=C1O) (NC2=CC (C3=CC=CC=C3)=CC=C2OC)=O. Catalog: ACM943962478-1. |  |
| BMS 303141 | BMS 303141. Group: Biochemicals. Grades: Purified. CAS No. 943962-47-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS 303141 (ATP Citrate Lyase Inhibitor, Orally Bioavailable, 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide) | ATP citrate lyase (ACL) inhibitor (IC50 = 0.13um for human recombinant ACL); blocks lipid synthesis (IC50 = 8um in HepG2 cells). Displays no cytotoxicity up to a concentration of 50um. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 943962-47-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BMS 309403 | BMS 309403. Group: Biochemicals. Grades: Purified. CAS No. 300657-03-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS 309403 | BMS 309403 is a potent, selective and cell-permeable inhibitor of adipocyte fatty acid binding protein (FABP4) with a Ki of less than 2 nM, which exhibits Ki values of 250 nM for FABP3 and 350 nM for FABP5. BMS 309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS 309403 is a biphenyl azole inhibitor against fatty acid binding protein 4 (FABP4) and regarded as a lead compound for effective treatment of obesity related cardio-metabolic diseases. Synonyms: BMS-309403; BMS309403; Adipocyte FABP Inhibitor; A-FABP Inhibitor; ALBP Inhibitor; aP2 Inhibitor; FABP4 Inhibitor; Fatty Acid Binding Protein 4 Inhibitor. Grades: ≥98%. CAS No. 300657-03-8. Molecular formula: C31H26N2O3. Mole weight: 474.55. | |
| BMS-317180 | BMS-317180 is a potent, and orally effective growth hormone secretagogue (GHS) that shows an excellent safety profile in preclinical studies. Synonyms: BMS317180; BMS 317180; (S)-2-(5-(1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-1H-tetrazol-1-yl)ethyl (4-hydroxybutyl)carbamate. Grades: >98%. CAS No. 295337-71-2. Molecular formula: C26H30N5O2P. Mole weight: 463.54. | |
| BMS-337197 | BMS-337197 is a a potent inhibitor of IMPDH with potential anticancer activity. Synonyms: BMS 337197; BMS337197; N-(2-(2-((3-methoxy-4-(oxazol-5-yl)phenyl)amino)oxazol-5-yl)phenyl)-N-methyl-2-morpholinoacetamide. Grades: >98%. CAS No. 267645-83-0. Molecular formula: C24H34N5OP. Mole weight: 489.53. | |
| BMS-344577 | BMS-344577 is aroylguanidine-based lactam derivative, which is a potent FXa inhibitor (FXa IC(50)=4 nM, EC(2xPT)=7 microM). Uses: Aroylguanidine-based factor xa inhibitor. Synonyms: BMS-344577; BMS344577; BMS 344577; UNII-U259PQB19A; CHEMBL570867; U259PQB19A; BDBM35316; BDBM50328724; N5-[[[(3S)-Hexahydro-2-oxo-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-azepin-3-yl]imino][(2-methyl-5-benzofuranyl)amino]methyl]-N2,N2-dimethyl-2,5-pyridinedicarboxamide;(S,E)-N2,N2-dimethyl-N5-(N'-(2-methylbenzofuran-5-yl)-N-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)carbamimidoyl)pyridine-2,5-dicarboxamide. Grades: ≥95%. CAS No. 288079-93-6. Molecular formula: C31H37N7O5. Mole weight: 587.67. | |
| BMS 345541 | BMS 345541. Group: Biochemicals. Grades: Purified. CAS No. 547757-23-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-345541 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. Synonyms: BMS-345541 free base; BMS345541; UNII-26SU0NEF5F; BMS 345541; BMS-345541. Grades: >98%. CAS No. 445430-58-0. Molecular formula: C14H17N5. Mole weight: 255.32. | |
| BMS-345541 | BMS-345541 is a selective inhibitor of the catalytic subunits of IKK ( IKK-2 IC 50 =0.3 μM, IKK-1 IC 50 =4 μM). BMS-345541 binds at an allosteric site of IKK. Uses: Scientific research. Group: Signaling pathways. CAS No. 445430-58-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10519. | |
| BMS-345541 hydrochloride | BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK ( IKK-2 IC 50 =0.3 μM, IKK-1 IC 50 =4 μM). BMS-345541 binds at an allosteric site of IKK. Uses: Scientific research. Group: Signaling pathways. CAS No. 547757-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10518. | |
| BMS 345541 trifluoroacetate salt | BMS 345541 is a cell-permeable inhibitor of the IκB kinases IKKα with IC50s of 4 uM and IKKβ with IC50s of 0.3 μM, which binds at allosteric site of the enzyme and displays ~10-fold greater selectivity at IKK-2 over IKK-1. It exhibits no effect against a panel of 15 other kinases. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling. Synonyms: IKK Inhibitor III. Grades: ≥98%. CAS No. 547757-23-3. Molecular formula: C14H17N5·2CF3COOH. Mole weight: 483.4. | |
| BMS-347070 | BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer. Synonyms: (3Z) -3-[ (4-bromophenyl) - (4-methylsulfonylphenyl) methylidene]oxolan-2-one; BMS-347070; BMS 347070; BMS347070; UNII-0CKM4H090C; 0CKM4H090C; SCHEMBL6882900; SCHEMBL6882905. Grades: >98%. CAS No. 197438-73-6. Molecular formula: C18H15BrO4S. Mole weight: 407.28. | |
| BMS-351 | BMS-351 is a selective and nonsteroidal CYP17A1 lyase inhibitor with good selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 has become a preclinical candidate to treat Castration-resistant prostate cancer (CRPC) and is likely to minimize the side effects of current therapies because of its exceptional selectivity. Uses: Castration-resistant prostate cancer. Synonyms: BMS-351; BMS 351; BMS351; 4-(4-methylpyridin-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazole. Grades: 98%. CAS No. 1370001-71-0. Molecular formula: C15H12F3N3. Mole weight: 291.28. | |
| BMS-354326 | BMS-354326 is a tryptase inhibitor with IC50 value of 1.8 nM. It has excellent selectivity against trypsin and most other related serine proteases. Synonyms: BMS-354326; BMS 354326; BMS354326; CHEMBL306448; BDBM50144532.(2S,3R)-4-oxo-1-((4-(1-oxo-6-phenylhexyl)-1-piperazinyl)carbonyl)-3-(2-(3-piperidinyl)ethyl)- 2-Azetidinecarboxylic acid. Grades: 98%. CAS No. 708258-16-6. Molecular formula: C28H40N4O5. Mole weight: 512.65. | |
| BMS358233 | BMS358233 is a potent Lck inhibitor. It has excellent cellular activities against T-cell proliferation. Uses: Bms358233 has excellent cellular activities against t-cell proliferation. Synonyms: BMS-358233; BMS 358233; 6-Benzothiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-methyl-2-((((2R)-tetrahydro-2-furanyl)methyl)amino)-4-pyrimidinyl)amino)-. Grades: 98%. CAS No. 601519-75-9. Molecular formula: C25H25ClN6O2S. Mole weight: 509.02. | |
| BMS-36313 | BMS-363131 is very potent inhibitor of human tryptase with inhibitory activity against bovine trypsin. Uses: Tryptase inhibitor. Synonyms: BMS-363131; BMS 363131; BMS363131. (2S,3R)-3-[[(3R)-1-carbamimidoylpiperidin-3-yl]methyl]-4-oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]azetidine-2-carboxylic acid. Grades: ≥98%. CAS No. 384829-65-6. Molecular formula: C28H40N6O5. Mole weight: 540.66. | |
| BMS-378806 | BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. Synonyms: BMS-378806; BMS 378806; BMS378806; BMS-806; BMS806; Bms 806. Grades: >98%. CAS No. 357263-13-9. Molecular formula: C22H22N4O4. Mole weight: 406.43. | |
| BMS-394136 | BMS-394136 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-394136; BMS 394136; BMS394136;UNII-M694U7167K. [(7R)-7-(3,4-dichlorophenyl)-5-methyl-1,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanone. Grades: ≥98%. CAS No. 343246-73-1. Molecular formula: C24H21Cl2FN4O. Mole weight: 471.35. | |
| BMS-419437 | BMS-419437 is a synthetic organic bio-active chemical. Uses: A synthetic organic bio-active chemical. Synonyms: BMS-419437; BMS419437; BMS 419437; UNII-09RR39UU4V; CHEBI:34550; AC1NQZWA; BMS-387032 analog 2. N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-2-[4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenyl]acetamide. Grades: ≥98%. CAS No. 333389-24-5. Molecular formula: C23H30N4O4S2. Mole weight: 490.64. | |
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