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| Product | Description | |
|---|---|---|
| BMS 433771 | BMS 433771 is a potent inhibitor of RSV replication in vitro with an average EC of 20nM. Uses: Viral fusion protein inhibitor. Synonyms: BMS 433771; BMS433771; BMS-433771; BMS-433771 HCl hydrate; BMS-433771 HCl; BMS-433771 hydrochloride. 1-cyclopropyl-1,3-dihydro-3-((1-(3-hydroxypropyl)-1H-benzimidazol-2-yl)methyl)-2H-Imidazo(4,5-c)pyridin-2-one. Grades: ≥98%. CAS No. 380603-10-1. Molecular formula: C20H21N5O2. Mole weight: 363.41. |  |
| BMS-433796 | BMS-433796 is a γ-secretase inhibitor. Chronic dosing of BMS-433796 in Tg2576 mice suggested a narrow therapeutic window and Notch-mediated toxicity at higher doses. Uses: Gamma secretase inhibitors and modulators. Synonyms: BMS433796; BMS-433796; BMS 433796. (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(5S)-3-methyl-4-oxo-5H-2,3-benzodiazepin-5-yl]propanamide; BMS-433796; UNII-R1E8M783K2; 935525-13-6; CHEMBL247361; R1E8M783K2; ZINC28899741; (alphaS)-N-[(1S)-2-[[(5S)-4,5-Dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide; (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide; Benzeneacetamide, N-((1S)-2-(((5S)-4,5-dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl)amino)-1-methyl-2-oxoethyl)-3,5-difluoro-alpha-hydroxy-, (alphaS)-. CAS No. 935525-13-6. Molecular formula: C21H20F2N4O4. Mole weight: 430.15. | |
| BMS 453 | BMS 453 is a synthetic retinoid that acts as an RARβ agonist in vivo, and also an RARα and RARγ antagonist in vitro. It inhibits the proliferation of breast cells by inducing active transforming growth factor β (TGFβ) and causes G1 arrest. Synonyms: BMS453; BMS 453; BMS-453; BMS 189453; BMS-189453; BMS189453. 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid. Grades: ≥98% by HPLC. CAS No. 166977-43-1. Molecular formula: C27H24O2. Mole weight: 380.48. | |
| BMS 453 | BMS 453. Group: Biochemicals. Grades: Purified. CAS No. 166977-43-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| BMS 470539 dihydrochloride | BMS 470539 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 457893-92-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS 470539 dihydrochloride | BMS 470539 dihydrochloride is a potent and selective melanocortin MC1 receptor agonist (IC50 = 120 nM) with anti-inflammatory activity. It also inhibits leukocyte trafficking. Synonyms: BMS 470539 dihydrochloride; BMS470539 dihydrochloride; BMS-470539 dihydrochloride; 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C32H41N5O4.2HCl. Mole weight: 632.62. | |
| BMS480404 | BMS480404 is a potent small molecule inhibitor. It bounds to human keratinocyte fatty acid-binding protein. Synonyms: BMS-480404; BMS 480404; (S)-2-(2,3-bis(2-chlorobenzyloxy)phenyl)-2-hydroxyacetic acid. Grades: 98%. CAS No. 533889-36-0. Molecular formula: C22H18Cl2O5. Mole weight: 433.28. | |
| BMS-488043 | BMS-488043 is a small-molecule HIV fusion inhibitor. Uses: Hiv fusion inhibitor. Synonyms: BMS-488043; BMS488043; BMS 488043; UNII-MKS21EJ435; CHEMBL238103; BMS 043; 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione. Grades: ≥98%. CAS No. 452296-83-2. Molecular formula: C22H22N4O5. Mole weight: 422.44. | |
| BMS 493 | BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Synonyms: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic Acid; BMS-493; BMS493; (E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid; Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-. Grades: 97%. CAS No. 215030-90-3. Molecular formula: C29H24O2. Mole weight: 404.50. | |
| BMS 493 | BMS 493. Group: Biochemicals. Grades: Purified. CAS No. 215030-90-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-5 | BMS-5, a LIMK inhibitor, has been found to restrain the cofilin phosphorylation in MDA-MB-231 breast cancer cells. Synonyms: LIMKi 3; N-(5-(1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide; N-{5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}-2-methylpropanamide; BMS 5; BMS5. Grades: 98%. CAS No. 1338247-35-0. Molecular formula: C17H14Cl2F2N4OS. Mole weight: 431.29. | |
| BMS-505130 | BMS-505130 is a selective serotonin transport inhibitor with Ki of 0.18 nM. Ki value for binding to the norepinephrine is 4.6 mM and for dopamine transporters is 2.1 mM. Synonyms: BMS-505130; BMS 505130; BMS505130; UNII-E892TW82D9; E892TW82D9;1H-Indole-5-carbonitrile, 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-, (2Z)-2-butenedioate (1:1). Grades: 98%. CAS No. 859230-84-5. Molecular formula: C19H21N3O4. Mole weight: 355.39. | |
| BMS-505130 Free base | BMS-505130 is a potent and selective serotonin transport inhibitor with K(I) of 0.18 nM. Uses: A potent and selective serotonin transport inhibitor. Synonyms: BMS-505130; BMS 505130; BMS505130; 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-1H-Indole-5-carbonitrile. Grades: ≥98%. CAS No. 468715-83-5. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| BMS 509744 | BMS 509744. Group: Biochemicals. Grades: Purified. CAS No. 439575-02-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BMS-509744 | BMS-509744 is a selective Itk inhibitor. It is useful for treatment of inflammatory and autoimmune diseases. Synonyms: BMS-509744; BMS 509744; BMS509744; CHEMBL209148. Grades: >98%. CAS No. 439575-02-7. Molecular formula: C32H41N5O4S2. Mole weight: 623.83. | |
| BMS-512148 | BMS-512148 Inhibitor. Uses: Scientific use. Product Category: T2389. CAS No. 461432-26-8. |  |
| BMS-520 | This active molecular is a selective S1P1 receptor agonist that originated by Bristol-Myers Squibb. BMS-520 shows really good efficacy in animal models of arthritis as well as in a mouse EAE (experimental autoimmune encephalomyelitis) model of multiple sclerosis. Agonism of S1P1 has been known to play an important role in lymphocyte trafficking from the thymus and secondary lymphoid organs, resulting in immunosuppression. Uses: Haematological malignancies; solid tumours. Synonyms: BMS-520; BMS 520; BMS520. 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid. Grades: 98%. CAS No. 1236188-38-7. Molecular formula: C23H17F3N4O4. Mole weight: 470.41. | |
| BMS 536924 | BMS 536924. Group: Biochemicals. Grades: Purified. CAS No. 468740-43-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-536924 | BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC 50 s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 468740-43-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10262. |  |
| BMS-536924 | BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma. Synonyms: BMS536924; BMS-536924; BMS 536924. Grades: 0.98. CAS No. 468740-43-4. Molecular formula: C25H26ClN5O3. Mole weight: 479.965. | |
| BMS538158 | BMS538158 is a bio-active chemical compound developed by Bristol-Myers Squibb. Synonyms: BMS-538158; BMS 538158; Acetamide, 2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)-N-((4-fluorophenyl)methyl)-N-methoxy-. Grades: 98%. CAS No. 543730-36-5. Molecular formula: C15H16FNO5. Mole weight: 309.29. | |
| BMS-538203 | BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent. Synonyms: BMS-538203; BMS 538203; BMS538203. Grades: >98%. CAS No. 543730-41-2. Molecular formula: C12H12FNO5. Mole weight: 269.23. | |
| BMS-554417 | BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, with the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). Uses: A novel inhibitor of igf-ir. Synonyms: BMS-554417; BMS 554417; BMS554417; 3-[4-[(2Z)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperazin-1-yl]propanenitrile. Grades: ≥98%. CAS No. 468741-42-6. Molecular formula: C28H30ClN7O2. Mole weight: 532.04. | |
| BMS561392 | BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms561392 has the potential treatment of diseases characterized by overproduction of tnf alpha, such as rheumatoid arthritis (ra). Synonyms: BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,?3R)?-3-Amino-N-hydroxy-α-(2-methylpropyl)?-3-[4-[(2-methyl-4-quinolinyl)?methoxy]?phenyl]?-2-oxo-1-pyrrolidineacetamide?;BMS-561392;DPC-333;(2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd. Grades: 98%. CAS No. 611227-74-8. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| BMS-564929 | BMS-564929 is a novel androgen receptor (AR) modulator (Ki= 2.11 nM) which has been advanced to clinical trials for the treatment of age-related functional decline. Uses: Androgen receptor (ar) modulator. Synonyms: BMS-564929; BMS 564929; BMS564929. 4-[(7R,7aS)-7-hydroxy-1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-2-chloro-3-methylbenzonitrile. Grades: ≥98%. CAS No. 627530-84-1. Molecular formula: C14H12ClN3O3. Mole weight: 305.71. | |
| BMS-566419 | Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Synonyms: BMS 566419; BMS566419; N-(1-(6-(4-Ethyl-1-piperazinyl)-3-pyridinyl)-1-methylethyl)-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide. Grades: >98%. CAS No. 566161-24-8. Molecular formula: C28H30FN5O2. Mole weight: 487.57. | |
| BMS582949 | BMS582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 value of 13nM, which plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1&beta. It is used for the treatment of rheumatoid arthritis. It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms582949 is used for the treatment of rheumatoid arthritis. Synonyms: 4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;BMS-582949;PS-540446; BMS 582949; PS 540446; BMS582949; PS540446. Grades: 98%. CAS No. 623152-17-0. Molecular formula: C22H26N6O2. Mole weight: 406.49. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grades: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC 50 of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912806-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14305A. | |
| BMS585248 | BMS585248 is a highly potent and novel human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with 4-fluoro-6-azaindole core heterocycles. It targets the viral envelope protein gp120. It showed much improved in vitro potency and pharmacokinetic properties than the previous clinical candidate BMS488043. Uses: Bms585248 targets the viral envelope protein gp120. Synonyms: BMS-585248; BMS 585248; BMS585248; UNII-CIO2TZZ9H1; CIO2TZZ9H1; CHEMBL236995; SCHEMBL2628937;1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-(4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo(2,3-c)pyridin-3-yl)-;1-(4-Benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione. Grades: 98%. CAS No. 619331-12-3. Molecular formula: C22H18FN7O3. Mole weight: 447.43. | |
| BMS587101 | BMS-587101 is an LFA-1 small-molecule antagonist. It could reduce inflammation and joint destruction in murine models of arthritis. It inhibited LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production in vitro. It is developed by Bristol Myers Squibb research. It is used for the treatment of moderate to severe psoriasis. It was in phase II clinical trials, but has been terminated. Uses: Bms-587101 is used for the treatment of moderate to severe psoriasis. Synonyms: BMS-587101; BMS 587101; BMS587101; UNII-5V7E4UQL93. 5-[[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl]thiophene-3-carboxylic acid. Grades: 98%. CAS No. 509083-77-6. Molecular formula: C26H20Cl2N4O4S. Mole weight: 555.43. | |
| BMS-593214 | BMS-593214 is an active-site, direct FVIIa inhibitor. It displayed direct, competitive inhibition of human FVIIa in the hydrolysis of a tripeptide substrate with Ki of 5 nM. Synonyms: BMS593214; BMS 593214; 2'-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid. Grades: >98%. CAS No. 1004551-40-9. Molecular formula: C31H27N3O4. Mole weight: 505.56. | |
| BMS 599626 | BMS 599626. Group: Biochemicals. Alternative Names: N-[4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester. Grades: Highly Purified. CAS No. 714971-09-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C27H27FN8O3. US Biological Life Sciences. | Worldwide |
| BMS 599626 dihydrochloride | BMS 599626 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BMS 599626 dihydrochloride | BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC50 = 22 nM and 32 nM, respectively), and also inhibits HER4 (IC50 = 190 nM). BMS 599626 displays 100-fold selectivity for EGFR and ErbB2 over VEGFR2, c-Kit, Lck, MET etc MEK and Lck. It can be used as an antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Synonyms: BMS599626 dihydrochloride; BMS-599626 dihydrochloride; AC480 dihydrochloride; AC 480 dihydrochloride; AC-480 dihydrochloride; (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:2); (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1781932-33-9. Molecular formula: C27H27FN8O3.2HCl. Mole weight: 603.48. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC 50 s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC 50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AC480 Hydrochloride. CAS No. 873837-23-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12010. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride is a selective and efficacious orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases with potential antineoplastic activity. It inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: AC480 hydrochloride; AC 480 hydrochloride; AC-480 hydrochloride; BMS-599626 HCl; BMS-599626 monohydrochloride; BMS 599626 Hydrochloride; BMS599626 hydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:1); Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)imino)-5-methyl-1,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride. Grades: >98%. CAS No. 873837-23-1. Molecular formula: C27H28ClFN8O3. Mole weight: 567.01. | |
| BMS 605541 | BMS 605541 is a potent and ATP-competitive VEGFR-2 inhibitor (IC50 = 23 nM) displaying >10-fold selectivity for VEGFR-2 over VEGFR-1. It exhibits antitumor activity in human lung and colon tumor xenograft models. Synonyms: BMS-605541; BMS 605541; BMS605541. N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide. Grades: ≥98% by HPLC. CAS No. 639858-32-5. Molecular formula: C19H17F2N5OS. Mole weight: 401.43. | |
| BMS-626529 | BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. Research result suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound. Synonyms: BMS626529; BMS 626529; BMS-626529; Temsavir. Grades: 99.46%. CAS No. 701213-36-7. Molecular formula: C24H23N7O4. Mole weight: 473.493. | |
| BMS639623 | BMS639623 is a CCR3 antagonist with picomolar inhibition potency against eosinophil chemotaxis. It may be used for the treatment of asthma. Uses: Bms639623 may be used for the treatment of asthma. Synonyms: BMS-639623; BMS 639623; Urea, N-((1R,2S)-3-((3S)-3-((4-fluorophenyl)methyl)-1-piperidinyl)-2-hydroxy-1-methylpropyl)-N'-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)-. Grades: 98%. CAS No. 675122-44-8. Molecular formula: C25H32FN7O2. Mole weight: 481.57. | |
| BMS-641988 | BMS-641988 is a nonsteroidal androgen receptor (AR) antagonist with anti-androgenic and potential antineoplastic activities. BMS-641988 binds to ARs in target tissues and prevents AR activation, which may result in the inhibition of AR-mediated transcriptional activity and tumor cell death in susceptible tumor cell populations. Synonyms: BMS641988; BMS 641988; Ethanesulfonamide, N-((3aR,4R,5R,7R,7aS)-2-(4-cyano-3-(trifluoromethyl)phenyl)octahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-1H-isoindol-5-yl)-. CAS No. 573738-99-5. Molecular formula: C20H20F3N3O5S. Mole weight: 471.45. | |
| BMS-645737 | BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. Synonyms: BMS645737; BMS 645737; 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine. Grades: >98%. CAS No. 651744-16-0. Molecular formula: C20H20N8O. Mole weight: 388.43. | |
| BMS-663068 | BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Synonyms: Fostemsavir; BMS-663068; BMS 663068; BMS663068. Grades: >98%. CAS No. 864953-29-7. Molecular formula: C25H26N7O8P. Mole weight: 583.49. | |
| BMS-663068 Tris | BMS-663068 tris is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. Synonyms: Fostemsavir Tris; Fostemsavir tromethamine; BMS-663068 Tris; BMS 663068 Tris; BMS663068 Tris. Grades: >98%. CAS No. 864953-39-9. Molecular formula: C29H37N8O11P. Mole weight: 704.62. | |
| BMS-663749 | BMS-663749 is HIV-1 attachment inhibitor. Uses: Hiv. Synonyms: BMS-663749; BMS 663749; BMS663749; UNII-667A5745M0; SCHEMBL2688950; CHEMBL2219875;(3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl dihydrogen phosphate. Grades: 98%. CAS No. 864953-33-3. Molecular formula: C23H25N4O9P. Mole weight: 532.44. | |
| BMS-6690514 | BMS-690514 is a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3. BMS-690514 is currently under investigation as an oral agent for the treatment of solid tumors. The preclinical ADME properties of BMS-690514 suggest good oral bioavailability in humans and metabolism by multiple pathways including oxidation and glucuronidation. Synonyms: BMS-6690514; BMS 6690514; BMS6690514. Grades: 0.98. CAS No. 859853-30-8. Molecular formula: C19H24N6O2. Mole weight: 368.441. | |
| BMS-687453 | BMS-687453 is a potent and selective peroxisome proliferator activated receptor PPARα agonist. with an IC50 of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. Synonyms: BMS-687453; BMS 687453; BMS687453. Grades: 98%. CAS No. 1000998-59-3. Molecular formula: C22H21ClN2O6. Mole weight: 444.87. | |
| BMS 688521 | BMS 688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1). It has provided proof-of-concept for LFA-1 as an immunological target. BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively), which inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model. Synonyms: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid; BMS-688521; BMS688521; SCHEMBL5392413. Grades: ≥98%. CAS No. 893397-44-9. Molecular formula: C26H19Cl2N5O4. Mole weight: 536.37. | |
| BMS694153 | BMS694153 is a potent and selective calcitonin gene-related peptide(CGRP) receptor antagonist. It is related with the pathogenesis of migraine. Uses: Bms694153 is related with the pathogenesis of migraine. Synonyms: BMS-694153; BMS 694153; BMS694153; (R)-N-(1-([1,4'-bipiperidin]-1'-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide;(R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide;4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamide. Grades: >98 %. CAS No. 1050381-35-5. Molecular formula: C35H45FN8O3. Mole weight: 644.79. | |
| BMS695735 | BMS695735 is a benzimidazole inhibitor of the insulin-like growth factor-1 receptor. It was also found to have potent CYP3A4 inhibition. It has broad spectrum in vivo antitumor activity. Uses: Bms695735 has broad spectrum antitumor activity. Synonyms: BMS-695735; BMS 695735; BMS695735; CHEMBL459729; BDBM27888; DNC008930; 2(1H)-Pyridinone, 4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-3-(5-(1-(3-fluoropropyl)-4-piperidinyl)-7-methyl-1H-benzimidazol-2-yl)-;(3Z)-4-[2-(4-chloropyrazol-1-yl)ethylamino]-3-[6-[1-(3-fluoropropyl)piperidin-4-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one. Grades: 95%. CAS No. 1054315-48-8. Molecular formula: C26H31ClFN7O. Mole weight: 512.02. | |
| BMS-707035 | BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2. Group: Fluorinated apis. Alternative Names: HIV Integrase Inhibitor. CAS No. 729607-74-3. Molecular formula: C17H19FN4O5S. Mole weight: 410.42. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 2-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxopyrimidine-4-carboxamide. Catalog: OFC729607743. |  |
| BMS-707035 | BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Uses: Hiv integrase inhibitors. Synonyms: BMS-707035; BMS-707035; BMS-707035. Grades: >98%. CAS No. 729607-74-3. Molecular formula: C17H19FN4O5S. Mole weight: 410.42. | |
| BMS711939 | BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPAR&alpha. It is >1000-fold selectivity vs human PPARγ with EC50 value of 4.5 μM and PPARδ with EC50 value of > 100 μM in PPAR-GAL4 transactivation assays. It shows excellent in vivo efficacy and safety profiles in preclinical studies. It was chosen for further preclinical evaluation. Uses: Bms711939 was chosen for further preclinical evaluation. Synonyms: BMS-711939; BMS 711939; BMS711939. Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-; 2-[[5-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]-2-fluorophenyl]methyl-methoxycarbonylamino]acetic acid. Grades: >98 %. CAS No. 1000998-62-8. Molecular formula: C22H20ClFN2O6. Mole weight: 462.86. | |
| BMS-740808 | BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa with Ki of 0.03 nM. Synonyms: 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-[2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]phenyl]phenyl]-3-(trifluoromethyl)-4,5-dihydropyrazolo[3,4-c]pyridin-7-one; BMS 740808; BMS-740808; BMS740808; UNII-LDD74E663F. Grades: >99%. CAS No. 280118-23-2. Molecular formula: C31H27F3N6O3. Mole weight: 588.58. | |
| BMS 753 | BMS 753 is a RARα-selective agonist (Ki = 2 nM) that modulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1). Synonyms: BMS753; BMS 753; BMS-753. 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid. Grades: ≥99% by HPLC. CAS No. 215307-86-1. Molecular formula: C21H21NO4. Mole weight: 351.4. | |
| BMS 753 | BMS 753. Group: Biochemicals. Grades: Purified. CAS No. 215307-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-754807 | BMS-754807 is a potent and reversible IGF-1R / IR inhibitor ( IC 50 =1.8 and 1.7 nM, respectively; K i =<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC 50 values of 6, 44, 7, 4, 9, and 25 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1001350-96-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10200. | |
| BMS-754807 | BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways. Synonyms: BMS754807; BMS-754807; BMS 754807. Grades: 0.98. CAS No. 1001350-96-4. Molecular formula: C23H24FN9O. Mole weight: 461.505. | |
| BMS 777607 | BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met , Axl , Ron and Tyro3 with IC 50 s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS 817378. CAS No. 1025720-94-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12076. | |
| BMS-777607 | BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2. Group: Fluorinated apis. Alternative Names: N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide. CAS No. 1025720-94-8. Molecular formula: C25H19ClF2N4O4. Mole weight: 512.89. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide. Catalog: OFC1025720948. | |
| BMS-777607 | BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor. It shows antitumor activity, inducing apoptosis and decreasing proliferation and migration. Synonyms: BMS817378; BMS 817378; BMS-817378; BMS 777607; BMS777607; ASLAN 002; ASLAN-002; ASLAN002. CAS No. 1025720-94-8. Molecular formula: C25H19ClF2N4O4. Mole weight: 512.893. | |
| BMS779333 | BMS779333 is a novel AR pan-antagonist with significantly improved cardiovascular and metabolic profiles. It has anti- tumor effect. Uses: Bms779333 has anti- tumor effect. Synonyms: BMS-779333; BMS779333; BMS 779333; UNII-3MJN2P4998. Benzonitrile, 4-((3aR,4S,6R,6aS,8aS,8bR)-octahydro-4-hydroxy-6-methyl-7-oxo-3a,6-epoxy-3ah-pyrano(2,3,4-cd)isoindol-8(4H)-yl)-2-(trifluoromethyl)-. Grades: >98%. CAS No. 1095181-60-4. Molecular formula: C19H17F3N2O4. Mole weight: 394.35. | |
| BMS-779788 | BMS-779788 is a LXR partial agonist with IC50 values of 68 nM and 14 nM for LXRα and LXRβ respectively. BMS-779788 induces LXR target genes in blood in vivo with EC50 value of 610 nM, and significantly increases plasma triglyceride and LDL cholesterol. Synonyms: BMS-779788; BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652;; 2-[2-[2-(2-chlorophenyl)propan-2-yl]-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol. CAS No. 918348-67-1. Molecular formula: C28H29ClN2O3S. Mole weight: 509.061. | |
| Bms-790052 | Heterocyclic Organic Compound. Alternative Names: BMS790052. CAS No. 1214735-16-6. Molecular formula: C40H50N8O6. Mole weight: 738.88. Purity: >99%. IUPACName: methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate. Canonical SMILES: CC (C)C (C (=O)N1CCCC1C2=NC=C (N2)C3=CC=C (C=C3)C4=CC=C (C=C4)C5=CN=C (N5)C6CCCN6C (=O)C (C (C)C)NC (=O)OC)NC (=O)OC. Density: 1.25 g/cm³. Catalog: ACM1214735166. | |
| BMS-791325 HCl | BMS-791325 HCl is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50 < 28 nM). In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. BMS-791325 is currently under Phase III trials. Synonyms: Beclabuvir hydrochloride; BMS-791325 HCl; BMS 791325 HCl; BMS791325 HCl. Grades:> 98%. CAS No. 958002-36-3. Molecular formula: C36H46ClN5O5S. Mole weight: 696.304. | |
| BMS-794833 | BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM. Synonyms: BMS794833; BMS 794833. Grades: 0.98. CAS No. 1174046-72-0. Molecular formula: C23H15ClF2N4O3. Mole weight: 468.845. | |
| BMS 795311 | BMS 795311 is a potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay) that inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Synonyms: BMS 795311; BMS795311; BMS-795311; N-[(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide. Grades: ≥98% by HPLC. CAS No. 939390-99-5. Molecular formula: C33H23F10NO3. Mole weight: 671.52. | |
| BMS-813160 | BMS-813160 is an effective and selective CCR2/CCR5 antagonist with potential immunomodulatory and anti-tumor activities. It inhibits the activation of CCR2/CCR5 mediated signal transduction pathways, and may inhibit the inflammatory process, angiogenesis, tumor cell migration, tumor cell proliferation and invasion. Synonyms: BMS813160; BMS 813160; BMS 813160-Bio-X. CAS No. 1286279-29-5. Molecular formula: C25H40N8O2. Mole weight: 484.6. | |
| BMS-813160 | BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC 50 s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1286279-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109593. | |
| BMS-833923 | BMS-833923 is an orally bioavailable small-molecule Smo (Smoothened) inhibitor with potential antineoplastic activity. It inhibits the sonic hedgehog (shh) pathway protein Smo, which may result in suppression of shh signaling pathway. Synonyms: BMS 833923; XL139; N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide. Grades: >98%. CAS No. 1059734-66-5. Molecular formula: C30H27N5O. Mole weight: 473.57. | |
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