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| Product | Description | |
|---|---|---|
| BM635 | BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC 50 of 0.12 μM against M. tuberculosis H37Rv. Uses: Scientific research. Group: Signaling pathways. CAS No. 1493762-74-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109587. |  |
| BM635 hydrochloride | BM635 hydrochloride, is an MmpL3 inhibitor with great anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. Molecular formula: C25H30ClFN2O. Mole weight: 428.97. |  |
| BM635 mesylate | BM635 mesylate, is an MmpL3 inhibitor with great anti-mycobacterial activity. BM635 mesylate has an MIC50 of 0.6 μM against M. tuberculosis H37Rv. Molecular formula: C26H33FN2O4S. Mole weight: 488.61. | |
| BM 957 | BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM, respectively. Synonyms: BM-957; (R)-5-(4-Chlorophenyl)-1-ethyl-4-(3-(4-(4-((4-((4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl)piperazin-1-yl)phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid; 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-1-ethyl-4-[3-[4-[4-[[[4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-. Grade: ≥95%. CAS No. 1391107-54-2. Molecular formula: C52H56ClF3N6O7S3. Mole weight: 1065.68. | |
| BM-962 | BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC 50 value of 4 nM ( K i =0.8 nM) and Bcl-xL with an IC 50 value of 3.9 nM ( K i <1 nM). BM-962 inhibits the cell growth in H1417 and H146 cell lines with IC 50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1391107-57-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-169925. | |
| b-Maleimidopropionic acid hydrazide 99+% | b-Maleimidopropionic acid hydrazide 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| b-Maltosyl azide | b-Maltosyl azide is a useful compound in the biomedical industry commonly used as a reactive probe in click chemistry reactions for the labeling of biomolecules and bioconjugation studies. This azide derivative can facilitate specific and efficient modifications of various drugs, peptides and nucleic acids. Synonyms: 4-O-a-D-Glucopyranosyl-b-D-glucopyranosyl azide. CAS No. 51970-30-0. Molecular formula: C12H21N3O10. Mole weight: 367.3. | |
| b-Mangostin | b-Mangostin. Group: Biochemicals. Grades: Highly Purified. CAS No. 20931-37-7. Pack Sizes: 100mg. Molecular Formula: C25H28O6. US Biological Life Sciences. | Worldwide |
| Bme18 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. G↑GWCC CCWG↓G. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: Bacillus megaterium 18. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 100 μg/ml BSA; 50% glycerol. Cat No: ET-1035RE. |  |
| B melanoma antigen 1 (2-10) | B melanoma antigen 1 (2-10) is a peptide derived from B melanoma antigen 1. B melanoma antigen 1 is an antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Synonyms: Antigen MZ2-BA (2-10); Cancer/testis antigen 2.1 (2-10). | |
| BMeS-p-A | Alfa Chemistry offers BMeS-p-A products for various research purposes. Please contact us by email if you do not find the specification you are looking for on this page. Uses: Functional dyes for photonics and optics. Group: other materials. Alternative Names: 1,4-Diamino-2,5-bis(methylsulfonyl)benzene 2,5-Bis(methylsulfonyl)-1,4-phenylenediamine. CAS No. 1678513-97-7. Pack Sizes: 1G-Glass Bottle with Plastic Insert, 200MG-Glass Bottle with Plastic Insert. Product ID: 2,5-bis(methylsulfonyl)benzene-1,4-diamine. Molecular formula: 264.31. Mole weight: C8H12N2O4S2. CS (=O) (=O)C1=CC (=C (C=C1N)S (=O) (=O)C)N. InChI=1S/C8H12N2O4S2/c1-15(11, 12)7-3-6(10)8(4-5(7)9)16(2, 13)14/h3-4H, 9-10H2, 1-2H3. PBKAXANOUZYEDU-UHFFFAOYSA-N. >95.0%(HPLC). |  |
| b-Methylcrotonyl coenzyme A lithium salt | b-Methylcrotonyl coenzyme A lithium salt, a crucial compound in the biomedicine realm, boasts paramount importance. Its pivotal function lies in the treatment of diverse ailments, notably beta-ketothiolase deficiencya scarcely encountered metabolic anomaly. Operating as a coenzyme, this product facilitates the degradation of fatty acids, thereby ensuring optimal energy metabolism within the organism. Synonyms: (c5:1)Coenzyme a lithium salt; trans-3-Methyl-2-butenoyl Coenzyme A; lithium [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-4-[[3-[2-(3-methylbut-2-enoylsulfanyl)ethylamino]-3-oxopropyl]amino]-4-oxobutoxy]phosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-yl] hydrogen phosphate. Grade: ≥ 95%. CAS No. 108347-83-7. Molecular formula: C26H41LiN7O17P3S. Mole weight: 855.57. | |
| b-Methyldigoxin | Cardiotonic. Obtained by the O-methylation of Digoxin. Group: Biochemicals. Alternative Names: (3 β,5 β,12 β)-3-[(O-2,6-Dideoxy-4-O-methyl- β-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy- β-D-ribo-hexopyranosyl-(14)-2,6-dideoxy- β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide; 4-Methyldigoxin; 4-O-Methyldigoxin; Lanirapid; Lanitop; Medigoxin; Methyldigoxin; Metildigoxin. Grades: Highly Purified. CAS No. 30685-43-9. Pack Sizes: 1mg, 2.5mg, 5mg, 10mg. Molecular Formula: C42H66O14. US Biological Life Sciences. | Worldwide |
| BMF-219 | Menin-MLL inhibitor 21 (example 9) is a specific, irreversible inhibitor of Menin-MLL interaction, useful for the study of autoimmune diseases, heteroimmune diseases, cancer, and other diseases dependent on menin-MLL. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Menin-MLL inhibitor 21. CAS No. 2448172-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150105. | |
| BMf-BH3 | BMf-BH3 belongs to the family of Bcl-2 apoptosis mediator. BMf-BH3 is a key molecule in enhancing ionizing radiation-induced cell death mediated by histone deacetylase (HDAC) inhibitors. Synonyms: Leu-Gln-His-Arg-Ala-Glu-Val-Gln-Ile-Ala-Arg-Lys-Leu-Gln-Cys-Ile-Ala-Asp-Gln-Phe-His-Arg-Leu-His-Thr. Grade: ≥95%. Molecular formula: C131H214N45O35S. Mole weight: 3012.50. | |
| BMH 21 | BMH 21. Group: Biochemicals. Grades: Purified. CAS No. 896705-16-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMH-21 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| BMH-21 | BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I ( Pol I ) transcription. BMH-21 possesses anticancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 896705-16-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-12484. | |
| BMH-21 | BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. Uses: Enzyme inhibitors. Synonyms: BMH-21; BMH 21; BMH21. Grade: >98%. CAS No. 896705-16-1. Molecular formula: C21H22N4O2. Mole weight: 362.43. | |
| BMH-7 | BMH-7 is a p53 activator with potent antitumor activity. Synonyms: BMH 7; BMH7. CAS No. 379247-14-0. Molecular formula: C20H21N5O. Mole weight: 347.42. | |
| BMI-1026 | BMI-1026 is an exceedingly potent and remarkably selective inhibitor utilized in the biomedical sector, specifically zeroes in on the intricate signalling pathway of interleukin-1 receptor-associated kinase 4 (IRAK-4). Synonyms: BMI 1026; BMI1026; 4-(2-Aminopyrimidin-4-yl)-6-(2-aminopyrimidin-4(3H)-ylidene)cyclohexa-2,4-dien-1-one. Grade: >98%. CAS No. 477726-77-5. Molecular formula: C34H60N3O7PS. Mole weight: 280.29. | |
| Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) | A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2alpha ubiquitination at 25 and 50uM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50uM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33uM, respectively) by preventing Top2alpha degradation following VM26 treatment (100% inhibition at 50uM in HeLa cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 31083-55-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| BmKb1 | BmKb1 is produced by Mesobuthus martensii. BmKb1 has antibacterial activity against Gram-positive bacteria S.aureus, M.luteus, B.subtilis, and Gram-negative bacteria E.coli, and P.aeruginosa. Grade: >97% by HPLC. Molecular formula: C94H147N19O23. Mole weight: 1911.28. | |
| BmKn1 | BmKn1 has antibacterial activity. BmKn1 was found in Mesobuthus martensii. | |
| BmKn2 | BmKn2 was found in Mesobuthus martensii. BmKn2 has strong antibacterial activity against Gram-positive bacteria S.aureus, M.luteus, B.subtilis, and Gram-negative bacteria E.coli, P.aeruginosa and N.gonorrhoeae. BmKn2 also shows low activity against HIV-1 PV. | |
| BML 111 | BML 111 is a FPR2 (lipoxin A4 receptor) agonist. It inhibits tumor-related angiogenesis and reduces tumor growth in hepatoma H22 cell bearing mice. BML 111 also protects against hemorrhagic shock-induced acute lung injury in rats and attenuates renal ischemia/reperfusion injury. Synonyms: BML-111; BML 111; BML111. (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate; methyl (5S,6R)-5,6,7-trihydroxyheptanoate. CAS No. 78606-80-1. Molecular formula: C8H16O5. Mole weight: 192.21. | |
| BML-190 | BML-190. Group: Biochemicals. Grades: Purified. CAS No. 2854-32-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BML-210 | BML-210, also known as CAY10433, is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells, what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.44. Purity: >98%. IUPACName: N-(2-aminophenyl)-N'-phenyl-octanediamide. Canonical SMILES: O=C(NC1=CC=CC=C1N)CCCCCCC(NC2=CC=CC=C2)=O. Product ID: ACM537034176. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BML-210 | BML-210 is a Histone deacetylase (HDAC) inhibitor (IC50 = 87 μM), inducingchanges in gene expression profile. Uses: A histone deacetylase (hdac) inhibitor. Synonyms: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433N1-(2-aminophenyl)-N8-phenyloctanediamide; N-(2-aminophenyl)-N'-phenyl-octanediamide. Grade: ≥98%. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| BML-210 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| BML-210, HDAC Inhibitor (N1-(2-aminophenyl)-N8-. phenyloctanediamide) | A novel non-hydroxamic acid HDAC inhibitor. IC50=5-10uM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines. Group: Biochemicals. Alternative Names: N1-(2-aminophenyl)-N8-phenyloctanediamide. Grades: Highly Purified. CAS No. 537034-17-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| BML-244 | BML-244 is a potent cathespin K inhibitor. Synonyms: BML 244; BML244; (1-formyl-pentyl)-carbamic acid tert-butyl ester; 2-[(tert-Butyloxycarbonyl)amino]hexanal. Grade: 98%. CAS No. 104062-70-6. Molecular formula: C11H21NO3. Mole weight: 215.29. | |
| Bml-259 | BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 267654-00-2. Molecular formula: C14H16N2OS. Mole weight: 260.4. Purity: >98%. IUPACName: 2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide. Canonical SMILES: O=C(NC1=NC=C(C(C)C)S1)CC2=CC=CC=C2. Product ID: ACM267654002. Alfa Chemistry ISO 9001:2015 Certified. | |
| BML 264 | BML 264 is a TPR channel blocker and phospholipase A2 (PLA2) inhibitor. It blocks the receptor-induced release of arachidonic acid and subsequent signaling cascades in the pancreas and the cardiovascular system. Synonyms: Benzoic acid, 2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-; 2-[[(2E)-1-Oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]benzoic acid; Benzoic acid, 2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propenyl]amino]-; Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propenyl]amino]-, (E)-; (E)-2-(3-(4-pentylphenyl)acrylamido)benzoic acid; BML264; BML-264. Grade: ≥95%. CAS No. 99196-74-4. Molecular formula: C21H23NO3. Mole weight: 337.41. | |
| BML-277 | BML-277 is a selective APT-competitive inhibitor of the DNA damage response signaling enzyme CHK2 ( IC50 =15 nM). Uses: A selective apt-competitive inhibitor. Synonyms: BML-277; BML 277; BML277; Chk2 Inhibitor II; 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide. Grade: ≥98%. CAS No. 516480-79-8. Molecular formula: C20H14ClN3O2. Mole weight: 363.80. | |
| BML-277 | BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Chk2 Inhibitor II. CAS No. 516480-79-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13946. | |
| BML-278 | BML-278 is a selective Sirt1 activator (EC150 = 1μM) structurally based on a dihydropyridine scaffold. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. Synonyms: BML 278; BML278. Grade: ≥95%. CAS No. 120533-76-8. Molecular formula: C24H25NO4. Mole weight: 391.5. | |
| BML-278 | BML-278 is a SIRT1 activator ( EC 150 : 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120533-76-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W025074. | |
| BML-278, SIRT1 Inhibitor (N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine) | A structurally novel activator of SIRT1 (EC150=1uM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50uM respectively). Cell permeable. Group: Biochemicals. Alternative Names: N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| BML-284 | BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 853220-52-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19987. | |
| BML-284 | BML-284 is potent, selective and cell-permeable Wnt signaling activator. It induces β-catenin and transcription factor (TCF)-dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro. Uses: Bml-284 may be a useful tool in the study of physiological processes that involve the wnt pathway. Synonyms: BML 284; 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine; 4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine. Grade: >98%. CAS No. 853220-52-7. Molecular formula: C19H18N4O3. Mole weight: 350.37. | |
| BML-286 | A small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways. Group: Biochemicals. Alternative Names: 2- [ [3- [ (2-phenylacetyl) amino] benzoyl] amino] benzoic Acid; 2- [ [3- [ (phenylacetyl) amino] benzoyl] amino] benzoic Acid. Grades: Highly Purified. CAS No. 294891-81-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| BML-287 | BML-287 is a selective inhibitor of secreted frizzled related protein-1 (sFRP-1). BML-287 is a useful tool for studying the Wnt signaling pathway. Group: Biochemicals. Alternative Names: N-[2- (3, 4-Dimethoxyphenyl) ethyl]-2-ethyl-5- (phenylsulfonyl) benzenesulfonamide. Grades: Highly Purified. CAS No. 915754-05-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BML-288 | BML-288. Group: Biochemicals. Alternative Names: 6,7-Dihydro-5-methyl-6-oxo-N-1,3,4-thiadiazol-2-yl-5H-furo[2,3-f]indole-7-carboxamide. Grades: Highly Purified. CAS No. 851681-89-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C14H10N4O3S. US Biological Life Sciences. | Worldwide |
| BMMCC | BMMCC. Pack Sizes: Milligram Quantities: 50 mg. Order Number: B111. |  www.prochemonline.com |
| BMN-673 8R,9S | BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Synonyms: Talazoparib (8R,9S); (8R,9S)-BMN-673; BMN673 (8R,9S); BMN 673 (8R,9S). Grade: >98%. CAS No. 1207456-00-5. Molecular formula: C19H14F2N6O. Mole weight: 380.35. | |
| BMP-10 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMP-11 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMP-12/GDF-7 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMP-13 human | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BMP-14 (GDF-5/CDMP-1) human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMP-22 | BMP-22 is an inhibitor of autotaxin with IC50 of 170 nM. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) in vitro in a concentration-dependent manner. MP-22 can decrease the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis. Synonyms: 4-pentadecylbenzylphosphonic acid; BMP22; BMP 22. Grade: ≥95%. CAS No. 1306684-90-1. Molecular formula: C22H39O3P. Mole weight: 382.52. | |
| BMP-2 Epitope (73-92) | BMP-2 Epitope (73-92) is the 73-92 amino acid residue of the knuckle epitope of bone morphogenetic protein-2 (BMP-2). BMP-2 promotes the formation and regeneration of bone and cartilage, and also participates in organogenesis, cell differentiation, cell proliferation, and apoptosis. Synonyms: BMP-2 Knuckle Epitope (73-92); H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-OH; L-lysyl-L-isoleucyl-L-prolyl-L-lysyl-L-alanyl-L-seryl-L-seryl-L-valyl-L-prolyl-L-threonyl-L-alpha-glutamyl-L-leucyl-L-seryl-L-alanyl-L-isoleucyl-L-seryl-L-threonyl-L-leucyl-L-tyrosyl-L-leucine. CAS No. 500719-13-1. Molecular formula: C97H164N22O30. Mole weight: 2118.5. | |
| BMP-3 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMP-4 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| BMP Inhibitor II, DMH1 (ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4- (6- (4-Isopropoxyphenyl) pyrazolo[1, 5-a]pyrimidin-3-yl) quinoline) | A cell-permeable pyrrazolopyrimidine compound that inhibits against R/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206711-16-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| BMP Inhibitor III, LDN-212854 (Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline) | A cell-permeable pyrazolopyrimidinyl quinoline that is superior to Dorsomorphin and DMH1 as an ATP-site-targeting, ALK1/2 inhibitor (IC50 = 2.40 and 1.30nM, respectively; [ATP] = 6uM) with respect to both potency and selectivity over ALK3/4/5 (IC50 = 0.858, 2.133, and 9.276uM, respectively). Also a potent RIPK2 inhibitor (IC50 = 6nM) with reduced potency against ABL1/c-abl, PDGFR-beta, ALK3, and PDGFR-alpha (IC50 = 40, 68, 85.8, and 650nM, respectively) and little inhibitory activity toward a panel of more than 190 kinases. Effectively inhibits ALK2- and ALK3-mediated C2C12 osteogenic differentiation (IC50 = 10 and 40.5nM, respectively) in vitro and prevents constitutively active ALK2 Q207D mutant-induced heterotopic ossification in mice (6mg/kg/12h via i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
| BMPO | BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BocMPO. CAS No. 387334-31-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121137. | |
| BMPR1A human | recombinant, expressed in Insect cells (Baculovirus), ?90% (SDS-PAGE), ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMPR2 (174-end), active, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| BMPS | BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Uses: Scientific research. Group: Signaling pathways. CAS No. 55750-62-4. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-42146. | |
| BMP signaling agonist sb4 | BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding,?Id1?and?Id3) canonical BMP signaling[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100874-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124697. | |
| BmPyPhB | BmPyPhB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,3-Bis[3,5-di(pyridin-3-yl)phenyl]benzene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1030380-38-1. Molecular formula: C38H26N4. Mole weight: 538.64 g/mol. Product ID: ACM1030380381. Alfa Chemistry ISO 9001:2015 Certified. | |
| BMS-002 | BMS-002 is a selective antogonist of lysophosphatidic acid (LPA) receptor-1 developed to treat diabetic nephropathy. In eNOS-/- db/db mouse model, BMS-002 significantly decreased the level of proteinuria. Uses: The potential treatment of diabetic nephropathy. Synonyms: BMS 002; BMS002. | |
| BMS-066 | BMS-066 is an inhibitor of IKKβ/Tyk2 pseudokinase, with IC50s of 9 and 72 nM, respectively. Synonyms: 2-Methoxy-N-((6-(1-methyl-4-(methylamino)-1,5-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide; Acetamide, N-((6-(1,6-dihydro-1-methyl-4-(methylamino)imidazo(4,5-d)pyrrolo(2,3-b)pyridin-7-yl)-2-pyridinyl)methyl)-2-methoxy-; N-((6-(1,6-Dihydro-1-methyl-4-(methylamino)imidazo(4,5-d)pyrrolo(2,3-b)pyridin-7-yl)-2-pyridinyl)methyl)-2-methoxyacetamide. Grade: ≥95%. CAS No. 914946-88-6. Molecular formula: C19H21N7O2. Mole weight: 379.42. | |
| BMS-1 | BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD-1/PD-L1 inhibitor 1. CAS No. 1675201-83-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19991. | |
| BMS-1001 | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with IC50 of 2.25 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Synonyms: BMS 1001; BMS1001. CAS No. 2113650-03-4. Molecular formula: C35H34N2O7. Mole weight: 594.65. | |
| BMS-1001 hydrochloride | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with IC50 of 2.25 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Synonyms: BMS-1001 HCl; (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride. Grade: 98%. CAS No. 2113650-04-5. Molecular formula: C35H35ClN2O7. Mole weight: 631.12. | |
| BMS-1166 | BMS-1166 is a novel and potent inhibitor of the PD-1/PD-L1 interaction with IC50 of 1.4 nM. Synonyms: BMS1166; BMS 1166. CAS No. 1818314-88-3. Molecular formula: C36H33ClN2O7. Mole weight: 641.11. | |
| BMS-1166 | BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1818314-88-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102011. | |
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