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| Product | Description | |
|---|---|---|
| BRD 4354 | BRD 4354 is an HDAC5 and HDAC9 inhibitor (IC50 = 0.85 and 1.88 μM, respectively) displaying >20-fold selectivity for HDAC5/9 over HDAC1/2/3. It also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Synonyms: BRD4354; BRD 4354; BRD-4354; 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol. Grade: ≥98% by HPLC. CAS No. 315698-07-8. Molecular formula: C21H23ClN4O. Mole weight: 382.89. |  |
| BRD 4354 ditrifluoroacetate | BRD 4354 ditrifluoroacetate is a moderately potent HDAC5 and HDAC9 inhibitor with IC50s of 0.85 and 1.88 μM, respectively. Synonyms: 8-Quinolinol, 5-chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-, 2,2,2-trifluoroacetate (1:2); 5-Chloro-7-[(4-ethyl-1-piperazinyl)(3-pyridinyl)methyl]-8-quinolinol trifluoroacetate (1:2). CAS No. 2444837-63-0. Molecular formula: C25H25ClF6N4O5. Mole weight: 610.93. | |
| BRD4 (49-170) GST tag human | recombinant, expressed in E. coli, ?82% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| BRD4 (49-170) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4770 | BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology. Synonyms: BRD4770; BRD-4770; BRD 4770. Grade: 0.98. CAS No. 1374601-40-7. Molecular formula: C25H23N3O3. Mole weight: 413.477. | |
| BRD4770 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4884 | BRD4884 is a selective HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3. It possesses preferential binding kinetics with seven-fold longer half-life. BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration. It acts by enhancing the learning and memory processes. Synonyms: BRD-4884; BRD 4884. Grade: ≥98%. CAS No. 1404559-91-6. Molecular formula: C18H19FN2O2. Mole weight: 314.4. | |
| BRD4, BD1, BD2 (49-460) GST tag human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4, BD1, BD2 (49-460) His tag human | recombinant, expressed in E. coli, ?75% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4/CK2-IN-1 | BRD4/CK2-IN-1 is an effective and orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC). Molecular formula: C29H30ClN5O5. Mole weight: 564.03. | |
| BRD4 degrader-3 | BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC 50 s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1]. PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413382-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136857. |  |
| BRD4-IN-4 | BRD4-IN-4 (Compound 1) is a BRD4 inhibitor ( IC 50 =6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 304685-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153751. | |
| BRD4 ligand 6 TFA | BRD4 ligand 6 TFA is the TFA salt form of BRD4 ligand 6 (HY-161651). BRD4 ligand 6 TFA is a BRD4 ligand and can be used for synthesis of BRD4 PROTACs, such as PROTAC BRD4 Degrader-26 (HY-161650) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763548-61-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161651A. | |
| BRD5018 | BRD5018 is an antimalarial agent. CAS No. 2245231-51-8. Molecular formula: C33H38N4O4. Mole weight: 554.68. | |
| BRD5529 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD5529 | BRD5529 is an effective dose-dependent CARD9-TRIM62 protein-protein interaction (PPI) inhibitor with an IC50 value of 8.6 ?M. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohns disease (CD) and ulcerative colitis (UC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1358488-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115497. | |
| BRD5648 | BRD5648 is the inactive enantiomer of rac-BRD0705, which is a potent, paralog selective and orally active inhibitor of GSK3α. Synonyms: (R)-BRD0705; (R)-4-Ethyl-7,7-dimethyl-4-phenyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-b]quinolin-5(4H)-one. Grade: 99%. CAS No. 2056261-42-6. Molecular formula: C20H23N3O. Mole weight: 321.42. | |
| BRD56491 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD6688 | BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 μM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1. It crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration. Synonyms: BRD-6688; BRD 6688. Grade: ≥98%. CAS No. 1404562-17-9. Molecular formula: C16H18N4O. Mole weight: 282.3. | |
| BRD-6929 | BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 849234-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100719. | |
| BRD6989 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 6989 | BRD 6989 is a small molecule inhibitor with high selectivity for CDK8 over CDK19. It is an analog of the natural product cortistatin A (dCA), which inhibits CDK8 and upregulates IL-10. BRD 6989 selectively binds a complex of CDK8 with an IC50 of 200 nM. It also inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs. It may be useful for inflammatory disorders. Synonyms: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile; BRD-6989; BRD6989. Grade: ≥98%. CAS No. 642008-81-9. Molecular formula: C16H16N4. Mole weight: 264.33. | |
| BRD7116 | BRD7116 is an inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM) but does not affect normal hematopoietic stem cells or AML cells. Synonyms: BRD-7116; 2,2,3,3-tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide. Grade: >98%. CAS No. 329059-55-4. Molecular formula: C28H36N2O4S. Mole weight: 496.66. | |
| BRD7116 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD7389 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 7389 | BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2, respectively). It upregulates insulin expression in mouse αTC1 pancreatic α cells. Synonyms: BRD7389; BRD-7389; BRD 7389; BAS 05532738; BAS05532738; BAS-05532738; 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione. Grade: ≥97% by HPLC. CAS No. 376382-11-5. Molecular formula: C24H18N2O2. Mole weight: 366.41. | |
| BRD 7389 | BRD 7389. Group: Biochemicals. Grades: Purified. CAS No. 376382-11-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| BRD73954 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD73954 | BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. Synonyms: BRD73954; BRD-73954; BRD 73954. Grade: >98%. CAS No. 1440209-96-0. Molecular formula: C16H16N2O3. Mole weight: 284.31. | |
| BRD7552 | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. Synonyms: BRD-7552; BRD 7552; BRD7552. Grade: 95%. CAS No. 1137359-47-7. Molecular formula: C33H33N3O15. Mole weight: 711.63. | |
| BRD7552 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD7552 | BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and ? cell function[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137359-47-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-19694. | |
| BRD 7552 | PDX1 transcription factor inducer; up regulates PDX1 expression in both primary human islets and ductal cells. Induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. Increases insulin expression in PANC-1 cells, primary human islets and human duct-derived cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1137359-47-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BRD7-IN-1 | BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) and binds to a VHL ligand via a linker to form a PROTAC VZ185. Synonyms: 4-[3,5-Dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-2,7-naphthyridin-1(2H)-one dihydrochloride; 2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-, hydrochloride (1:2). Grade: ≥95%. CAS No. 2448414-48-8. Molecular formula: C22H28Cl2N4O3. Mole weight: 467.39. | |
| BRD7-IN-1 free base | BRD7-IN-1 free base is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185. Synonyms: 2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-; 4-[3,5-Dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-2,7-naphthyridin-1(2H)-one. Grade: ≥95%. CAS No. 2305379-66-0. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| BRD9539 | BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) with an IC50 value of 6.3 μM. It is selective for G9a and PRC2 over SU39H1 and NDMT1 up to a concentration of 40 μM. BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. Synonyms: BRD-9539; BRD 9539. Grade: ≥98%. CAS No. 1374601-41-8. Molecular formula: C24H21N3O3. Mole weight: 399.4. | |
| BRD9539 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD9757 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 9757 | BRD9757 is a potent and selective histone deacetylases 6 (HDAC6) inhibitor with IC50 of 30 nM. It displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold). Synonyms: N-Hydroxy-1-cyclopentene-1-carboxamide; BRD9757; BRD-9757. Grade: ≥98%. CAS No. 1423058-85-8. Molecular formula: C6H9NO2. Mole weight: 127.14. | |
| BRD 9876 | BRD 9876. Group: Biochemicals. Grades: Purified. CAS No. 32703-82-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| BRD 9876 | BRD 9876 is an ATP non-competitive kinesin Eg5 inhibitor. It selectively inhibits microtubule-bound Eg5 leading to an arrest in G2/M phase. Synonyms: BRD9876; BRD-9876; BRD 9876; 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile; 6-Tert-Butyl-2,3-naphthalenedicarbonitrile. Grade: ≥99% by HPLC. CAS No. 32703-82-5. Molecular formula: C16H14N2. Mole weight: 234.3. | |
| Br-DIF-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD-IN-3 | BRD-IN-3, a highly potent inhibitor of PCAF bromodomain (BRD) (IC50 = 7 nM), has activity against GCN5 and FALZ. Synonyms: (R,R)-36n; 2-(((3R,5R)-5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-methylpiperidin-3-yl)amino)-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-[[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-3-piperidinyl]amino]-3,5-dihydro-3-methyl-; 2-{[(3R,5R)-5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-methyl-3-piperidinyl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one. Grade: ≥95%. CAS No. 2351938-32-2. Molecular formula: C21H25N5O3. Mole weight: 395.45. | |
| BRD-K98645985 | BRD-K98645985 is a BAF inhibitor that binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity. Synonyms: BRD K98645985; BRDK98645985; 1-Isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1,4,9]oxadiazacyclododecin-12-yl)urea. Grade: >98%. CAS No. 1357647-78-9. Molecular formula: C33H43N5O4. Mole weight: 573.73. | |
| BRD-K98645985 | BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 ?M. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357647-78-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-114268. | |
| BRDT (22-138) GST tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRDT (22-138) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRDT (257-382) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Breathable Membrane | Breathable Membrane. Group: Polymers. |  |
| Brecanavir | Brecanavir (GW640385) is a novel, potent HIV protease inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW640385. CAS No. 313682-08-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121240. | |
| Brecanavir | Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Brecanavir is by a substantial margin the most potent and broadly active antiviral agent among the PIs tested in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Brecanavir; GW-0385; GW-0385; GW0385; GW-640385; GW 640385; GW640385; GW-640385X; VX-385; VX 385; VX385. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82. Purity:>98%. IUPACName: [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Canonical SMILES: Cc1nc(cs1)COc2ccc(cc2)C[C@@H]([C@@H](CN(CC(C)C)S(=O)(=O)c3ccc4c(c3)OCO4)O)NC(=O)O[C@H]5CO[C@@H]6[C@H]5CCO6. Product ID: ACM313682085-1. Alfa Chemistry ISO 9001 |  |
| Brecanavir | Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Uses: Hiv-1 protease inhibitor. Synonyms: Brecanavir; UNII-E367I8C7FI; CHEMBL206031; GW-0385; GW-640385; GW-640385X; VX-385; GW0385; GW640385; GW640385X; VX385; GW 0385; GW 640385; GW 640385X; VX 385; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Grade: ≥98%. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82. | |
| Brefeldin a | Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NECTROLIDE;SYNERGISIDIN;4h-cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-de;cahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-;cyanaein;CYANEIN;DECUMBIN;GAMMA-4-DIHDYROXY-2-(6-HYDROXY-1-HEPTENYL)-4-CYCLOPENTANECROTONIC ACID LAMBDA-LACTONE. Product Category: Inhibitors. CAS No. 20350-15-6. Molecular formula: C16H24O4. Mole weight: 280.36. Purity: 0.9987. Product ID: ACM20350156. Alfa Chemistry ISO 9001:2015 Certified. | |
| Brefeldin A | Brefeldin is an antibiotic produced by Penicillum brefeldianum S-464, Pen. cyaneum S-ll, Pen. decumbens, Pen. simplicissimum S-543, etc. Brefeldin A has anti-candida, aspergillus and anti-tumor activity. Uses: Antiviral agents. Synonyms: Ascotoxin; Synergisidin; Decumbin; Nectrolide. Grade: >98%. CAS No. 20350-15-6. Molecular formula: C16H24O4. Mole weight: 280.36. | |
| Brefeldin A | 10mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C16H24O4. CAS No. 20350-15-6. Prepack ID 17689223-10mg. Molecular Weight 280.36. See USA prepack pricing. |  |
| Brefeldin A | Brefeldin A (BFA) is a fungal metabolite demonstrated to reversibly interfere with anterograde transport from the endoplasmic reticulumto the Golgi apparatus (1,2). While initially isolated as an antibiotic (3), and does have a wide range of antibiotic activity, it is primarily used as a biological research tool for studying protein transport. Treatment leads to a rapid accumulation of proteins within the ER and collapse of the Golgi stacks. Treatment with BFA can also inhibit protein secretion (4) and prolonged exposure can induce apoptosis (5). The main target of BFA appears to be ADP-ribosylation factor (ARF), which is responsible for association of coat protein to the Golgi membrane (6,7). Group: Biochemicals. Alternative Names: gamma-4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda -lactone; Ascotoxin; BFA; Cyanein; Decumbin;g-4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, ?-Lactone, BFA; Cyanein; Decumbin; Synergisidin; Nectrolide. Grades: Purified. CAS No. 20350-15-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H24O4, Molecular Weight: 280.36. US Biological Life Sciences. | Worldwide |
| Brefeldin A | Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus [1] [2]. Brefeldin A is also an autophagy and mitophagy inhibitor [3]. Brefeldin A is a CRISPR/Cas9 activator [5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity [5]. Uses: Scientific research. Group: Natural products. Alternative Names: BFA; Cyanein; Decumbin. CAS No. 20350-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16592. | |
| Brefeldin B | Brefeldin is an antibiotic produced by Penicillum brefeldianum S-464, Pen. cyaneum S-ll, Pen. decumbens, Pen. simplicissimum S-544, etc. Molecular formula: C15H22O4. Mole weight: 266.33. | |
| Brefeldin C | Brefeldin is an antibiotic produced by Penicillum brefeldianum S-464, Pen. cyaneum S-ll, Pen. decumbens, Pen. simplicissimum S-545, etc. Synonyms: (1S,2Z,7S,10Z,12R,13R)-12-hydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one; 4H-Cyclopent(f)oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1-hydroxy-6-methyl-, (1R-(1R*,2E,6S*,10E,11aS*,14aR*))-. Grade: 95%. CAS No. 73899-78-2. Molecular formula: C16H24O3. Mole weight: 264.36. | |
| Bremelanotide | Bremelanotide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Bremelanotide;Bremelanotide PT 141;Bremelanotide;Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH;PT-141. Product Category: Heterocyclic Organic Compound. CAS No. 189691-06-3. Molecular formula: C50H68N14O10. Mole weight: 1025.16. Density: 1.43. Product ID: ACM189691063. Alfa Chemistry ISO 9001:2015 Certified. | |
| Bremelanotide | Bremelanotide is a peptide melanocortin receptor agonist developed for the treatment of sexual dysfunction, hemorrhagic shock and reperfusion injury. Uses: Bremelanotide is a synthetic peptide drug that has generated a lot of interest in the drug development community due to its potential applications in sexual dysfunction and other conditions. this peptide is a synthetic analog of the natural hormone alpha-msh (melanocyte stimulating hormone) and acts as a non-selective agonist of the melanocortin receptors mc3-r and mc4-r. one of the main areas of. Synonyms: (Ac-Nle4, Asp5, D-Phe7, Lys10)-cyclo-α-MSH (4-10); PT 141; PT-141; PT141. CAS No. 189691-06-3. Molecular formula: C50H68N14O10. Mole weight: 1025.16. | |
| Bremelanotide Acetate | Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PT-141 Acetate. CAS No. 1607799-13-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18678A. | |
| Bremelanotide Acetate | Bremelanotide Acetate is a heptapeptide melanocortin agonist. Bremelanotide, formerly known as PT-141, employed in clinical trials for sexual dysfunction including both male erectile dysfunction (ED) and female sexual dysfunction or disorder (FSD), is a f. Synonyms: PT141 acetate. CAS No. 1607799-13-2. Molecular formula: C52H72N14O12. Mole weight: 1085.22. | |
| Bremelanotide Acetate Hydrate | Bremelanotide is a melanocortin receptor agonist shown to improve female sexual function in females suffering from sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 100mg. Molecular Formula: C52H74N14O13. US Biological Life Sciences. | Worldwide |
| Brensocatib | Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 ( DPP1 ) inhibitor with pIC 50 s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD7986; INS 1007. CAS No. 1802148-05-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101056. | |
| Brentuximab | Brentuximab is a monoclonal antibody targeting CD30. Brentuximab is conjugated with monomethyl auristatin E (MMAE) (HY-15162) to form the antibody-drug conjugate Brentuximab vedotin (HY-P99107), which can induce apoptosis in primary effusion lymphoma cells. Brentuximab vedotin exhibits antitumor activity with an IC 50 of 10 nM against human CD30+ cancer cells [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2088770-90-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99151. | |
| Brentuximab | Brentuximab is a chimeric antibody directed against CD30, a protein often found at high levels on classical Hodgkin lymphoma cells (called Reed-Sternberg cells). CAS No. 2088770-90-3. | |
| Brentuximab vedotin (solution) | Brentuximab vedotin (solution) is the solution form of Brentuximab vedotin (cAC10-vcMMAE) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 914088-09-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99107A. | |
| Brepocitinib | Brepocitinib (PF-06700841) is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC 50 s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC 50 s of 77 nM and 6.49 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06700841. CAS No. 1883299-62-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112708. | |
| Brequinar | Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical trials or closed clinical trials using this agent. Synonyms: DUP785; NSC 368390; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-; Biphenquinate. Grade: ≥98%. CAS No. 96187-53-0. Molecular formula: C23H15F2NO2. Mole weight: 375.37. | |
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