A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Cyclo (-Leu-Pro) is a cyclic dipeptide containing leucine and proline. Synonyms: cyclo(Leu-Pro); Cyclo(L-leucyl-L-prolyl). Grades: ≥95%. CAS No. 2873-36-1. Molecular formula: C11H18N2O2. Mole weight: 210.3.
Cyclo(-L-Leu-L-Pro) 99+% (HPLC)
Cyclo(-L-Leu-L-Pro) 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
Cyclo(L-Leu-L-Trp)
Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium. It is active against various bacteria and fungi, and it also inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 μM). Synonyms: 3S-(1H-indol-3-ylmethyl)-6S-(2-methylpropyl)-2,5-piperazinedione; Cyclo(L-leucyl-L-tryptophyl); Cyclo(leu-trp); Cyclo(L-Trp-L-Leu); 2,5-Piperazinedione, 3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)-, (3S-cis)-. Grades: ≥95%. CAS No. 15136-34-2. Molecular formula: C17H21N3O2. Mole weight: 299.37.
Cyclo(L-Leu-trans-4-hydroxy-L-Pro)
Cyclo(L-Leu-trans-4-hydroxy-L-Pro) is a natural compound isolated from Phellinus igniarius. It is a plant growth regulator. Synonyms: Cyclo(L-leucyl-trans-4-hydroxy-L-proline); Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-(2-methylpropyl)-, (3S,7R,8aS)-; L-hydroxyprolyl-L-leucine anhydride; cyclo[L-(4-hydroxyprolinyl)-L-leucine]; 7-Hydroxygancidin W. Grades: ≥95%. CAS No. 115006-86-5. Molecular formula: C11H18N2O3. Mole weight: 226.27.
Cyclo(L-Phe-L-Phe)
It is found in chicken essence, is a dual inhibitor of the serotonin transporter, and acetylcholinesterase. Synonyms: Cyclo(-Phe-Phe); (3s,6s)-3,6-Dibenzylpiperazine-2,5-Dione. Grades: ≥ 99% (TLC). CAS No. 2862-51-3. Molecular formula: C18H18N2O2. Mole weight: 294.35.
Cyclo(L-Phe-L-Phe)
Cyclo(L-Phe-L-Phe). Group: Biochemicals. Alternative Names: Cyclo(-Phe-Phe). Grades: Highly Purified. CAS No. 2862-51-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C18H18N2O2. US Biological Life Sciences.
Worldwide
Cyclo(L-Phe-L-Phe) 99+% (TLC)
Cyclo(L-Phe-L-Phe) 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 2862-51-3. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences.
Worldwide
Cyclo(-L-Phe-L-Ser)
An intermediate in the biosynthesis of gliotoxin. Synonyms: Cyclo(-Phe-Ser). Grades: ≥ 98% (HPLC). CAS No. 35591-00-5. Molecular formula: C12H14N2O3. Mole weight: 234.25.
Cyclo(-L-Phe-L-Ser)
Cyclo(-L-Phe-L-Ser). Group: Biochemicals. Alternative Names: Cyclo(-Phe-Ser). Grades: Highly Purified. CAS No. 35591-00-5. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences.
Worldwide
Cyclo(-L-Phe-L-Ser) 98+% (HPLC)
Cyclo(-L-Phe-L-Ser) 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
Cyclo(-L-Phe-L-Trp)
Cyclo(-L-Phe-L-Trp). Group: Biochemicals. Alternative Names: Cyclo(-Phe-Trp). Grades: Highly Purified. CAS No. 82597-82-8. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences.
Cyclo(-L-Phe-L-Trp) 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
cyclo(L-Pro-L-Tyr)
cyclo(L-Pro-L-Tyr) is a diketopiperazine formed by the fusion of tyrosine and proline, and is a secondary metabolite of fungi and bacteria. It can activate N-acyl homoserine lactone (ahls), and can also activate or counteract other luxr-based quorum sensing systems. Synonyms: Maculosin; Cyclo(-Pro-Tyr); (3S,8aS)-Hexahydro-3-[(4-hydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione; (3S-trans)-Hexahydro-3-[(4-hydroxyphenyl)methyl]-pyrrolo[1,2-a]pyrazine-1,4-dione; Cyclo L-Prolyl-L-tyrosine; Cyclo(L-tyrosyl-L-proline); L-Proline-L-tyrosine Anhydride; Maculosin 1; Maculosine; Maculosine 1. Grades: >98% by HPLC. CAS No. 4549-2-4. Molecular formula: C14H16N2O3. Mole weight: 260.29.
cyclo(L-Pro-L-Val)
A diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus. It is a secondary metabolite found in various marine fungi and bacteria. It is capable of activating N-acylhomoserine lactones (ahls), also capable of activating or antagonizing other luxr-based quorum-sensing systems. Synonyms: (3S-trans)-Hexahydro-3-(1-methylethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione; (S,S)-Hexahydro-3-isopropyl-pyrrolo[1,2-a]pyrazine-1,4-dione; (-)-(6S,9S)-Cyclo(prolylvalyl); Cyclo(L-Val-L-Pro); Cyclo(L-prolyl-L-valine); Cyclo(L-prolyl-L-valyl); L-Valyl-L-prolyl lactam; Maculosin 5. Grades: >98% by HPLC. CAS No. 2854-40-2. Molecular formula: C10H16N2O2. Mole weight: 196.25.
Cyclo(L-prolyl-L-leucyl)
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262. Group: Biochemicals. Alternative Names: (3S-trans)-Hexahydro-3-(2-methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione; 3-Isobutylhexa hydropyrrolo [1,2-a] pyrazine-1,4-dione; Cyclo(L-Leu-L-Pro); Cyclo(L-Pro-D-Leu); Cyclo(L-Pro-L-Leu); Cyclo(L-leucyl-L-prolyl); Cyclo(L-prolyl-L-leucyl); Cyclo(Pro-Leu); Cyclo(proline-leucine); Cyclo-L-prolyl-L-leucine; Gancidin W; L-Leucyl-L-proline lactam; L-Leucyl-L-prolyl lactam; Maculosin 6. Grades: Highly Purified. CAS No. 2873-36-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Cyclo(L-Ser-L-Ser)
Cyclo(L-Ser-L-Ser). Group: Biochemicals. Alternative Names: Cyclo(-Ser-Ser). Grades: Highly Purified. CAS No. 23409-30-5. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Cyclo(-L-Ser-L-Tyr). Group: Biochemicals. Alternative Names: Cyclo(-Ser-Tyr). Grades: Highly Purified. CAS No. 21754-31-4. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences.
Worldwide
Cyclo(-L-Ser-L-Tyr) 99+% (HPLC)
Cyclo(-L-Ser-L-Tyr) 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
Cyclo(L-Trp-L-Trp)
Cyclo(L-Trp-L-Trp). Group: Biochemicals. Alternative Names: Cyclo(-Trp-Trp). Grades: Highly Purified. CAS No. 20829-55-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
Cyclo(L-Trp-L-Trp)
Cyclo(L-Trp-L-Trp) is a cyclic dipeptide with antibacterial activity. It inhibits the growth of 41 out of 49 strains of multidrug resistant A. baumannii as well as B. subtilis, M. luteus, S. aureus, S. cerevisiae, A. niger and C. albicans. It has been used as a substrate for indole prenyltransferases in the synthesis of mono- and diprenylated indolines. Synonyms: Cyclo(-Trp-Trp). Grades: ≥98%. CAS No. 20829-55-4. Molecular formula: C22H20N4O2. Mole weight: 372.42.
Cyclo(L-Trp-L-Trp)
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii , as well as Candida albicans , Bacillus subtilis , Micrococcus luteus , Saccharomyces cerevisiae , Aspergillus niger , Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research [1]. Uses: Scientific research. Group: Peptides. CAS No. 20829-55-4. Pack Sizes: 50 mg; 100 mg. Product ID: HY-P2124.
Cyclo(L-Trp-L-Trp) 98+% (HPLC)
Cyclo(L-Trp-L-Trp) 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Cyclo(-L-Trp-L-Tyr). Group: Biochemicals. Alternative Names: Cyclo(-Trp-Tyr). Grades: Highly Purified. CAS No. 20829-53-2. Pack Sizes: 100mg, 250mg. US Biological Life Sciences.
Worldwide
Cyclo(-L-Trp-L-Tyr) 99+% (TLC)
Cyclo(-L-Trp-L-Tyr) 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
cyclo(L-Tyr-L-Val)
Cyclo(L-Tyr-L-Val) is a diketopiperazine metabolite isolated from marine actinomycetes (Nocardiopsis gilva). Synonyms: Cyclo(Tyr-Val). Grades: >95% by HPLC. CAS No. 21754-25-6. Molecular formula: C14H18N2O3. Mole weight: 262.3.
cyclo(L-tyrosyl-L-tyrosyl) synthase
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl). Group: Enzymes. Synonyms: Rv2275 (gene name); cYY synthase; cyclodityrosine synthase. Enzyme Commission Number: EC 2.3.2.21. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2295; cyclo(L-tyrosyl-L-tyrosyl) synthase; EC 2.3.2.21; Rv2275 (gene name); cYY synthase; cyclodityrosine synthase. Cat No: EXWM-2295.
Cyclo(L-Val-L-Val)
Cyclo(L-Val-L-Val). Group: Biochemicals. Alternative Names: Cyclo(-Val-Val); Val-Val diketopiperazine. Grades: Highly Purified. CAS No. 19943-16-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences.
Cyclo(L-Val-L-Val) 98+% (NMR). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
cyclomaltodextrinase
Also hydrolyses linear maltodextrin. Group: Enzymes. Synonyms: cycloheptaglucanase; cyclohexaglucanase; cyclodextrinase; cyclomaltodextrin dextrin-hydrolase (decyclizing). Enzyme Commission Number: EC 3.2.1.54. CAS No. 37288-41-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3917; cyclomaltodextrinase; EC 3.2.1.54; 37288-41-8; cycloheptaglucanase; cyclohexaglucanase; cyclodextrinase; cyclomaltodextrin dextrin-hydrolase (decyclizing). Cat No: EXWM-3917.
cyclomaltodextrin glucanotransferase
Cyclomaltodextrins (Schardinger dextrins) of various sizes (6,7,8, etc. glucose units) are formed reversibly from starch and similar substrates. Will also disproportionate linear maltodextrins without cyclizing (cf. EC 2.4.1.25, 4-α-glucanotransferase). Group: Enzymes. Synonyms: Bacillus macerans amylase; cyclodextrin glucanotransferase; α-cyclodextrin glucanotransferase; α-cyclodextrin glycosyltransferase; β-cyclodextrin glucanotransferase; β-cyclodextrin glycosyltransferas. Enzyme Commission Number: EC 2.4.1.19. CAS No. 9030-9-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2416; cyclomaltodextrin glucanotransferase; EC 2.4.1.19; 9030-09-5; Bacillus macerans amylase; cyclodextrin glucanotransferase; α-cyclodextrin glucanotransferase; α-cyclodextrin glycosyltransferase; β-cyclodextrin glucanotransferase; β-cyclodextrin glycosyltransferase; γ-cyclodextrin glycosyltransferase; cyclodextrin glycosyltransferase; cyclomaltodextrin glucotransferase; cyclomaltodextrin glycosyltransferase; konchizaimu; α-1,4-glucan 4-glycosyltransferase, cyclizing; BMA; CGTase; neutral-cyclodextrin glycosyltransferase; 1,4-α-D-glucan 4-α-D-(1,4-α-D-glucano)-transferase (cyclizing). Cat No: EXWM-2416.
Cyclomaltodextrin glucanotransferase
EC 2.4.1.19. CAS No. 9030-9-5. Product ID: 8-05218.
Cyclomaltoheptaose hydrate
Cyclomaltoheptaose hydrate, a cyclic oligosaccharide with vast potential for drug delivery and structural studies, has been shown to effectively inhibit the activity of various enzymes implicated in diseases such as cancer and Alzheimer's. Additionally, it displays remarkable chiral resolving properties, making it a highly useful tool for separating enantiomers. Its multifaceted nature is a valuable asset in advancing numerous scientific fields. Synonyms: b-Cyclodextrin hydrate. CAS No. 68168-23-0. Molecular formula: C42H70O35 xH2O. Mole weight: 1134.98 (anydrous basis).
Cyclomaltopentaose
Cyclomethicone 5
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Cyclomethicone 5
Pharmacopeia & Metrological Institutes Standards. Uses: For analytical and research use. Group: Reagents. CAS No. 541-02-6. Pack Sizes: 200MG.
Cyclomethicone 6
Pharmacopeia & Metrological Institutes Standards. Uses: For analytical and research use. Group: Reagents. CAS No. 540-97-6. Pack Sizes: 200MG.
Cyclomethicone 6
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Cyclo(Met-Pro) could be detected in grilled and stewed beef. The cyclopeptide seems to be an important component of beef flavor. Synonyms: cyclo(methionylpropyl); Cyclo(L-Pro-L-Met-); Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-[2-(methylthio)ethyl]-, (3S,8aS)-; Cyclo(-Met-Pro); (3S, 8aS) -3-[2- (Methylsulfanyl) ethyl]hexahydropyrrolo[1, 2-a]pyrazine-1, 4-dione; cyclo-(L-proline-L-methionine); cyclo(MP). Grades: ≥90%. CAS No. 53049-06-2. Molecular formula: C10H16N2O2S. Mole weight: 228.32.
Cyclononylprodiginine
Cyclononylprodiginine is a prodigiosin antibiotic. CAS No. 34852-35-2. Molecular formula: C23H29N3O. Mole weight: 363.49.
Cyclooctane-1,3-dione
Cyclooctane-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,3-Cyclooctanedione, SureCN2047984, CTK3G9579, 935-29-5. Product Category: Heterocyclic Organic Compound. CAS No. 935-29-5. Molecular formula: C8H12O2. Mole weight: 140.179680 [g/mol]. Purity: 0.96. IUPACName: cyclooctane-1,3-dione. Canonical SMILES: C1CCC(=O)CC(=O)CC1. Density: 1.039 g/cm³. Product ID: ACM935295. Alfa Chemistry ISO 9001:2015 Certified.
Cyclooctanone
Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level. Group: Biochemicals. Alternative Names: NSC 9475. Grades: Highly Purified. CAS No. 502-49-8. Pack Sizes: 25g. US Biological Life Sciences.
Worldwide
Cyclooctanone
Cyclooctanone. CAS No: 502-49-8
Sarchem Laboratories New Jersey NJ
cyclooctat-9-en-7-ol synthase
Requires Mg2+. Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase. Group: Enzymes. Synonyms: cetB2. Enzyme Commission Number: EC 4.2.3.146. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5160; cyclooctat-9-en-7-ol synthase; EC 4.2.3.146; cetB2. Cat No: EXWM-5160.
Cyclooctatin
It is produced by the strain of Sreptomyces melanosporofaciens M1614-43F2. It can inhibit the hemolysis phospholipase [EC 3.1.1.5] (Lyso-PL) activity. Terpentecin as substrates, it inhibits Lyso-PL, PL-A2, PL-C and PL-D with IC50 of 2.9 μg/mL, 65.0 μg/mL, 70.0 μg/mL and >100 μg/mL, respectively. Ki is 4.8 X 10-6 mol/L. Synonyms: Dicyclopenta(a,d)cyclooctene-3,4-diol,1,2,3,3a,4,5,7,8,9,9a,10,10a-dodecahydro-4,9a-dimethyl-1-(hydroxymethyl)-7-(1-methylethyl)-; 1-(Hydroxymethyl)-7-isopropyl-4, 9a-dimethyl-1, 2, 3, 3a, 4, 5, 7, 8, 9, 9a, 10, 10a-dodecahydrodicyclopenta[a, d]cyclooctene-3, 4-diol. CAS No. 139552-97-9. Molecular formula: C20H34O3. Mole weight: 322.49.
Cyclooctene oxide
Cyclooctene oxide. Group: Biochemicals. Alternative Names: 1,2-1,2-Epoxycyclooctane; 9-9-Oxabicyclo[6. 1. 0]nonane. Grades: Highly Purified. CAS No. 286-62-4. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C8H14O. US Biological Life Sciences.
Worldwide
Cyclooctyl acetate
Cyclooctyl acetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cyclooctyl acetate, Cyclooctanol, acetate, MolPort-003-909-204, CID69877, NSC75872, EINECS 212-252-0, ZINC04577181, 772-60-1. Product Category: Heterocyclic Organic Compound. CAS No. 772-60-1. Molecular formula: C10H18O2. Mole weight: 170.248720 [g/mol]. Purity: 0.96. IUPACName: cyclooctyl acetate. Canonical SMILES: CC(=O)OC1CCCCCCC1. ECNumber: 212-252-0. Product ID: ACM772601. Alfa Chemistry ISO 9001:2015 Certified.
Cyclooctylamine
Cyclooctylamine. Group: Biochemicals. Alternative Names: Aminocyclooctane. Grades: Highly Purified. CAS No. 5452-37-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C8H15NH2. US Biological Life Sciences.
Worldwide
Cyclooctyltrichlorosilane
Cyclooctyltrichlorosilane. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CYCLOOCTYLTRICHLOROSILANE; Trichlorsilylcyclooctan; 1-(Trichlorsilyl)cyclooctan. Product Category: Halosilane. Appearance: Transparent liquid. CAS No. 18290-59-0. Molecular formula: C8H15Cl3Si. Mole weight: 245.65. Purity: 95%+. IUPACName: trichloro(cyclooctyl)silane. Canonical SMILES: C1CCCC(CCC1)[Si](Cl)(Cl)Cl. Density: 1.19 g/cm³. Product ID: ACM18290590. Alfa Chemistry ISO 9001:2015 Certified.
Cyclooxygenase 1 from Human, Recombinant
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. COX-1. Mole weight: ~70 kDa. Activity: >20,000 units/mg. Stability: > 6 months. Storage: -80°C (as supplied); avoid freeze/thaw cycles by aliquoting protein. Form: 80 mM Tris, pH 8.0, containing 0.1% polysorbate 20, 300 uM DDC, and 10% glycerol. Source: Sf21 cells. Species: Human. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-1237.
Cyclooxygenase 2 from Human, Recombinant
Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. COX-2. Mole weight: 70 kDa. Activity: >8,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Human. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1238.
Cyclooxygenase 2 from Ovine, Recombinant
Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Purity: >80% estimated by SDS-PAGE. COX-2. Mole weight: ~70 kDa. Activity: >20,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Ovine. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1239.
Cyclopaldic acid
It is produced by the strain of Penicillum cyclopium var. album, Pen. cyclopium 77. Cyclopaldic acid of 2.5 μg/mL can inhibit the spore germination of Garlic botrytis spore 95%-100%. Synonyms: 3,5-dihydroxy-7-methoxy-6-methyl-1-oxo-1,3-dihydro-2-benzofuran-4-carbaldehyde; 1,3-Dihydro-3,5-dihydroxy-7-methoxy-6-methyl-1-oxo-4-isobenzofurancarboxaldehyde; Cyclopaldsaeure. CAS No. 477-99-6. Molecular formula: C11H10O6. Mole weight: 238.19.
Cyclopamine
Cyclopamine is a Hedgehog ( Hh ) pathway antagonist with an IC 50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Deoxojervine. CAS No. 4449-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17024.
Cyclopamine
Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched. Group: Biochemicals. Alternative Names: (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-. Grades: Highly Purified. CAS No. 4449-51-8. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Cyclopamine (11-Deoxyjervine)
Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumor suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle. Group: Biochemicals. Alternative Names: 11-Deoxyjervine. Grades: Highly Purified. CAS No. 4449-51-8. Pack Sizes: 25mg. US Biological Life Sciences.
A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay; 50nM in p2Ptch-/-cells; 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Group: Biochemicals. Grades: Purified. CAS No. 306387-90-6. Pack Sizes: 100ug. Molecular Formula: C??H??N?O?, Primary Target: Hh signaling in Shh-light2 assay. US Biological Life Sciences.
It is produced by the strain of Penicillum cyclopium and Pen. corymbiferum. Cyclopenin can inhibit the growth of plants. Cyclopenin acts as an inhibitor of acetylcholinesterase (AChE). Cyclopenin also has antibacterial activity against E. coli and M. pyogenes. Synonyms: (-)-Cyclopenine; (-)-Cyclopenin; Cyclopenine; (3S,3'R)-4-Methyl-3'-phenylspiro[3H-1,4-benzodiazepine-3,2'-oxirane]-2,5(1H,4H)-dione; Spiro(3H-1,4-benzodiazepine-3,2'-oxirane)-2,5(1H,4H)-dione, 4-methyl-3'-phenyl-, cis-(-)-(9CI)-. Grades: ≥99%. CAS No. 20007-87-8. Molecular formula: C17H14N2O3. Mole weight: 294.30.
Cyclopenin
Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicllium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of the tumor necrosis factor alpha (TNF)-induced replication of human immunodeficiency virus (HIV). Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite. Group: Biochemicals. Grades: Highly Purified. CAS No. 19553-26-5. Pack Sizes: 5mg. US Biological Life Sciences.