A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
CU-T12-9 is a potent small-molecule agonist of TLR1/2 (EC50 = 52.9 nM). Synonyms: Benzenamine, N-methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-; CU T12 9; CUT129; N-Methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]benzenamine; CU-T 12-9. Grades: ≥95%. CAS No. 1821387-73-8. Molecular formula: C17H13F3N4O2. Mole weight: 362.31.
Cutamesine
Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuroprotection and regeneration in the context of neurodegenerative disease. in vitro: reduced SOD1. Uses: Nootropic agents. Synonyms: 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (11C)SA4503 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride cutamesine SA 4503 SA-4503 SA4503. CAS No. 165377-43-5. Molecular formula: C23H32N2O2. Mole weight: 368.51.
cutinase
Cutin, a polymeric structural component of plant cuticles, is a polymer of hydroxy fatty acids that are usually C16 or C18 and contain up to three hydroxy groups. The enzyme from several fungal sources also hydrolyses the p-nitrophenyl esters of hexadecanoic acid. It is however inactive towards several esters that are substrates for non-specific esterases. Group: Enzymes. Enzyme Commission Number: EC 3.1.1.74. CAS No. 51377-41-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3502; cutinase; EC 3.1.1.74; 51377-41-4. Cat No: EXWM-3502.
Superoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. SOD plays a critical role in the defense of cells against the toxic effects of oxygen radicals. SOD competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice by preventing the conversion of NO to peroxynitrate, an inducer of apoptosis. Superoxide dismutase (sod?ec 1.15.1.1) deal with the superoxide radical byalternately adding or removing an electron from t...c arthritis, myocardial infarction, angiocardiopathy, cancer patients. Group: Enzymes. Synonyms: Superoxide dismutases; EC 1.15.1.1; superoxidase dismutase; copper-zinc superoxide dismutase; Cu-Zn superoxide dismutase; ferrisuperoxide dismutase; superoxide dismutase I; superoxide dismutase II; SOD; Cu,Zn-SOD; Mn-SOD; Fe-SOD; SODF; SODS; SOD-1; SOD-2; SOD-3; SOD-4; hemocuprein; erythrocuprein; cytocuprein; cuprein ; hepatocuprein; 9054-89-1. Enzyme Commission Number: EC 1.15.1.1. Purity: >90% (SDS-PAGE test). Mole weight: About 20kDa (SDS-PAGE detection). Activity: 21,186U/mg protein. Appearance: White powder, lyophilized. Storage: 4°C, store at -20°C for long-term preserva
CV-1
CV-1 is an antibiotic produced by Streptomyces sp. CO-1. It has anti-Escherichia coli activity in combination with spiramycin, and its mechanism is to inhibit lipopolysaccharide synthesis. Synonyms: 1,2-Diamino-1,2-N,N'-carbonyl-1,2-dideoxyglucose hydrate. CAS No. 108351-34-4. Molecular formula: C7H14N2O6. Mole weight: 222.20.
CV 1808
CV 1808 has been found to be an adenosine A2 receptor agonist and could probably be used as an antihypertensive as well as antipsychotic agent. Uses: Vasodilator agents. Synonyms: CV-1808; CV 1808; CV1808; 2-Phenylaminoadenosine; 2-Phenylamino Adenosine. Grades: ≥99% by HPLC. CAS No. 53296-10-9. Molecular formula: C16H18N6O4. Mole weight: 358.36.
CV 1808
CV 1808. Group: Biochemicals. Grades: Highly Purified. CAS No. 53296-10-9. Pack Sizes: 10mg. Molecular Formula: US Biological Life Sciences.
Competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation. Inhibits PAF induced hypotension and lethality. Group: Biochemicals. Alternative Names: 2-(2-Acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium Chloride. Grades: Highly Purified. CAS No. 100488-87-7. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
CV-6209 chloride
CV-6209 is a potent platelet-activating factor (PAF) receptor antagonist, which inhibits aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little effect on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo. Synonyms: 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium monochloride. Grades: ≥95%. CAS No. 100488-87-7. Molecular formula: C34H60N3O6·Cl. Mole weight: 642.3.
CVD Graphene on Copper Foil (Graphene Factory)
CVD Graphene on Copper Foil (Graphene Factory). Group: other nano materials.
CVD Graphene on Copper-PMMA Coated
CVD Graphene on Copper-PMMA Coated. Group: other nano materials.
CVD Graphene on Plastic Substrate
CVD Graphene on Plastic Substrate. Group: other nano materials.
CVD Graphene on Quartz
CVD Graphene on Quartz. Group: Single crystal substrates. CAS No. 25617-97-4. >99.9%.
CVD Graphene on Quartz Substrate
CVD Graphene on Quartz Substrate. Group: other nano materials. > 99.9%.
CVD Graphene on SiO2 Substrate. Group: other nano materials.
CVD Graphene on Si/SiO2 (Graphene Factory)
CVD Graphene on Si/SiO2 (Graphene Factory). Uses: 1) catalyst2) supercapacitors3) solar energy4) graphene semiconductor chips5) conductive graphene film6) graphene computer memory7) biomaterials8) transparent conductive coatings. Group: other nano materials.
CVD Method Monolayer MoS2
CVD Method Monolayer MoS2. Group: other nano materials.
CVD Method Monolayer MoS2 Film
CVD Method Monolayer MoS2 Film. Group: other nano materials.
CVD Method Monolayer WS2
The CVD method monolayer WS2 is a promising member of Alfa Chemistry's family of 2D graphene-like materials. Among 2D materials with tailored morphologies designed to enhance their performance in nanoelectronics, WS2 is a particularly promising candidate. Alfa Chemistry's high quality WS2 layer films can be used as CVD grown films on sapphire, Al2O3 or SiO2 substrates. Whatever your purpose, you will be impressed with the performance and consistent quality of the CVD method monolayer WS2 from us. Uses: Potential applications include transistors, sensors, and other electronic and photovoltaic devices. Group: other nano materials. Molecular formula: 247.98 g/mol. S=[W]=S. (6N) 99.9999% confirmed.
CVD Method Monolayer WSe2
Tungsten selenide is a member of the group VI transition metal dichalcogenides, an important class of inorganic two-dimensional materials for various applications including photovoltaics, lithium-ion batteries, and FETs. CVD monolayer WSe2 on SiO2 substrate is just one of many advanced 2D materials we prepare and offer. Find high quality monolayer CVD WSe2 at Alfa Chemistry. Trust us to meet all your advanced material needs. Uses: An excellent device material for studying the number of layers and fluorescence effects. Group: other nano materials. Alternative Names: Tungsten selenide, Tungsten diselenide, Tungsten (IV) selenide. Molecular formula: 341.76 g/mol. [Se]=[W]=[Se]. (6N) 99.9999% confirmed.
CVN424
CVN424 is an orally active and selective GPR6 inverse agonist with a K i of 9.4 nM and an EC 50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2254706-21-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134661A.
CVT10216
CVT10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50 value of 29nM, thereby inhibiting dopamine synthesis. It is active in suppressing alcohol and cocaine use, and anxiety. It has been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety. It increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents. It prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking. It also prevents alcohol-induced increases in NAc DA without changing basal levels. Uses: Cvt10216 is active in suppressing alcohol and cocaine use, and anxiety. Synonyms: CVT-10216; CVT 10216; CVT10216. 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic acid;GS 455534. Grades: >98 %. CAS No. 1005334-57-5. Molecular formula: C24H19NO7S. Mole weight: 465.48.
CVT 10216
Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models. Group: Biochemicals. Alternative Names: 3-[[[3-[4-[ (Methylsulfonyl) amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid. Grades: Highly Purified. CAS No. 1005334-57-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
CVT-12012
CVT-12012 is a bio-active chemical compound and is highly potent in a human cell-based (HEPG2) SCD assay with IC50 value of 6nM. Synonyms: CVT-12012; CVT 12012; CVT12012; 2-Hydroxy-N- (2- (3-methyl-2-oxo-7- ( ( (3- (trifluoromethyl) phenyl) methyl) amino) -1, 2-dihydroquinoxalin-1-yl) ethyl) acetamide. Grades: 95%. CAS No. 1018675-35-8. Molecular formula: C21H21F3N4O3. Mole weight: 434.41.
CVT-2551
CVT-2551, a piperazineacetamide derivative, could have been useful in some biological studies. Synonyms: CVT-2551; CVT 2551; CVT2551; RS-89961; RS 89961; RS89961; 1-Piperazineacetamide, 4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-N-(2-(hydroxymethyl)-6-methylphenyl)-. Grades: 98%. CAS No. 172430-44-3. Molecular formula: C24H33N3O5. Mole weight: 443.54.
CVT-2759
CVT-2759 is a potential partial agonist of A(1)-ADORs, may be used to slow AV nodal conduction. Uses: Adenosine a1 receptor agonists. Synonyms: CVT-2759; CVT 2759; CVT2759; UNII-42E8N8RC9Z. Adenosine, N-((3R)-tetrahydro-3-furanyl)-, 5'-(ethylcarbamate). Grades: ≥98%. CAS No. 342419-10-7. Molecular formula: C17H24N6O6. Mole weight: 408.17.
CVT-313
CVT-313 (Cdk2 Inhibitor III) is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 with IC 50 of 0.5 μM. CVT-313 inhibits CDC5L phosphorylation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cdk2 Inhibitor III. CAS No. 199986-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15339.
CVT-313
A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 μM for Cdk2/A and Cdk2/E; 4.2 μM for Cdk1/B; 215 μM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 μM) in vitro and prevent neointima formation in vivo. Synonyms: CVT 313; NG 26; CVT313; NG26; NG-26; NG26. Grades: 95%. CAS No. 199986-75-9. Molecular formula: C20H28N6O3. Mole weight: 400.47.
CVT-3248
CVT-3248, a piperazineacetamide derivative, could be probably effective in some biological studies. Synonyms: L58PM3303I; CVT-3248; CVT 3248; CVT3248; RS-101647; RS 101647; RS101647; 1-Piperazineacetamide, N-(2-(hydroxymethyl)-6-methylphenyl)-. Grades: 98%. CAS No. 172430-50-1. Molecular formula: C14H21N3O2. Mole weight: 263.34.
CVT-3369
CVT-3369 is an impurity of Ranolazine, which is a medication used to treat heart-related chest pain. Synonyms: RS-91347; 4-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetic Acid; Ranolazine Impurity 16; CVT 3369; CVT3369; RS 91347; RS91347; 1-Piperazineacetic acid, 4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-. Grades: 98%. CAS No. 172430-48-7. Molecular formula: C16H24N2O5. Mole weight: 324.37.
CVT5440
CVT5440 is a selective, high affinity A(2B) adenosine receptor antagonist. It may has the potential treatment of asthma and has good selectivity. Uses: Cvt5440 may has the potential treatment of asthma and has good selectivity. Synonyms: CVT-5440; CVT5440; CVT 5440; UNII-29S2U9DRGS;1H-Purine-2,6-dione, 3,7-dihydro-8-(4-((5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)-1,3-dipropyl-;8-[4-[[5-(3-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]methoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione. Grades: 98%. CAS No. 531506-64-6. Molecular formula: C27H28N6O5. Mole weight: 516.55.
CW 008
CW 008 is a cAMP/PKA/CREB pathway activator promoting osteogenic differentiation of human bone marrow derived MSCs in vitro, and it also increases bone mass and bone volume density in ovariectomized mice. Uses: Promoting osteogenic differentiation of human bone marrow. Synonyms: CW-008; 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide. Grades: >98%. CAS No. 1134613-19-6. Molecular formula: C21H14F2N6O2. Mole weight: 420.38.
CW-069 is a novel and allosteric inhibitor of the microtubule motor protein HSET, it shows statistically significant selectivity over KSP. Synonyms: CW069; CW-069; CW 069. Grades: >98%. CAS No. 1594094-64-0. Molecular formula: C23H21IN2O3. Mole weight: 500.33.
CWHM-1008
CWHM-1008 is a potent and orally active antimalarial agent, with EC 50 values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2362539-97-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111746.
CWHM 12 demonstrated high potency against all of the five possible β subunit binding partners (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) in in vitro ligand-binding assays, with somewhat less potency against αvβ5 than against the other αv integrins. Treated mice with CCl4 for 3 weeks to establish fibrotic disease and then treated with CWHM 12 or vehicle for the final 3 weeks of CCl4. CWHM12 significantly reduced liver fibrosis even after fibrotic disease had been established. Similar to our findings in the liver, administration of CWHM 12 significantly inhibited progression of pulmonary fibrosis. Synonyms: CWHM12; CWHM 12; CWHM-12. Grades: >98%. CAS No. 1564286-55-0. Molecular formula: C26H32BrN5O6. Mole weight: 590.47.
CX08005
CX08005 is a competitive inhibitor of PTP1B (IC50 = 0.781 μM). CX08005 binds catalytic P-loop of enzyme. It exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP. Synonyms: 2-[[[2- (Tetradecyl) phenyl]amino]carbonyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1256341-22-6. Molecular formula: C28H39N04. Mole weight: 453.61.
CX 4945 hydrochloride
CX 4945 hydrochloride is an orally bioactive and ATP-competitive casein kinase 2 (CK2) inhibitor. CX 4945 inhibits proliferation and migration in a panel of cancer cell lines which overexpresses CK2. Uses: Antitumor agent. Synonyms: CX 4945 hydrochloride; CX-4945 hydrochloride; CX4945 hydrochloride; Silmitasertib HCl; Silmitasertib hydrochloride. Grades: 98%. CAS No. 2108312-01-0. Molecular formula: C19H12ClN3O2.HCl. Mole weight: 386.23.
CX-4945 sodium salt
CX-4945 (Silmitasertib) sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively. Synonyms: Silmitasertib sodium salt; CX-4945 sodium salt; CX 4945 sodium salt; CX4945 sodium salt. Grades: >98%. CAS No. 1309357-15-0. Molecular formula: C19H11ClN3NaO2. Mole weight: 371.75.
CX-5011
CX-5011 is a very potent and selective CK2 inhibitor, which induces cell death in tumor cells. Synonyms: CX5011; CX 5011; Pyrimido[4,5-c]quinoline-8-carboxylic acid, 5-[(3-ethynylphenyl)amino]-. Grades: 98%. CAS No. 1009821-06-0. Molecular formula: C20H12N4O2. Mole weight: 340.34.
CX516
CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BDP 12. CAS No. 154235-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10933.
CX546
CX546 is a first-generation and selective benzamide-type positive AMPAR modulator. CX546 is a prototypical ampakine agent and has antipsychotic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 215923-54-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12505.
CX546
It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine drug that facilitates activation of glutamatergic AMPA receptors. Synonyms: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone; 1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbonyl]piperidine; CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; GR87; BDP17; BDP-17. Grades: >98%. CAS No. 215923-54-9. Molecular formula: C14H17NO3. Mole weight: 247.29.
CX 546
AMPA potentiator. Group: Biochemicals. Alternative Names: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone. Grades: Highly Purified. CAS No. 215923-54-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C14H17NO3. US Biological Life Sciences.
Worldwide
CX-5461
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. Synonyms: CX-5461; CX 5461; CX5461. CAS No. 1138549-36-6. Molecular formula: C27H27N7O2S. Mole weight: 513.62.
A positive allosteric modulator selective for the AMPA receptors. Used in studies related to Schizophrenia, neuroplasticity, Autism and neuronal differentiation. Group: Biochemicals. Grades: Highly Purified. CAS No. 215923-54-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CX 614
Positive allosteric modulator of AMPA receptors. Group: Biochemicals. Alternative Names: 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one. Grades: Highly Purified. CAS No. 191744-13-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C13H13NO4. US Biological Life Sciences.
Worldwide
CX 614
CX 614 has been found to be an AMPA modulator and has also been found to be an ampakine drug facilitating activation of glutamatergic AMPA receptors. Synonyms: CX614; CX 614; CX-614. 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one. Grades: ≥99% by HPLC. CAS No. 191744-13-5. Molecular formula: C13H13NO4. Mole weight: 247.25.
CX-6258
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. Synonyms: (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one; CX6258; CX-6258; CX 6258. CAS No. 1202916-90-2. Molecular formula: C26H24ClN3O3. Mole weight: 461.946.
CX-6258 Hydrochloride
CX-6258 shows antiproliferative activity against a panel of human cancer cell lines with IC50 of 0.02-3.7 μM, mostly sensitive to acute leukemia cell lines. Synonyms: CX-6258 HCl; CX 6258 hydrochloride; CX 6258 HCl; CX6258 HCl. Grades: >98%. CAS No. 1353859-00-3. Molecular formula: C26H25Cl2N3O3. Mole weight: 498.40.
CX-6258 hydrochloride hydrate
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC 50 s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1353858-99-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18095A.
CX-6258 hydrochloride hydrate
The hydrochloride hydrate salt form of CX-6258, a pan-Pim kinases inhibitor, has been found to have strong antiproliferative potencies against human solid tumors and hematological malignancies. It has already been discontinued for Solid tumours. IC50: 5 n. Uses: The hydrochloride hydrate salt form of cx-6258 is a pan-pim kinases inhibitor that has been found to have strong antiproliferative potencies against human solid tumors and hematological malignancies. it has already been discontinued for solid tumours. ic5. Synonyms: CX-6258 hydrochloride hydrate; CX 6258 hydrochloride hydrate; CX6258 hydrochloride hydrate; C26H24ClN3O3.ClH.H2O; 2121AH; HY-18095A; CS-1530; W-6143; CS 1530; W 6143; CS1530; W6143. Grades: 98%. CAS No. 1353858-99-7. Molecular formula: C26H27Cl2N3O4. Mole weight: 516.42.
CX 717
CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 867276-98-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139897.
CXCR2 antagonist 2
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC 50 value of 95 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2647464-91-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139873.
A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37°C). Group: Biochemicals. Grades: Highly Purified. CAS No. 473728-67-5. Pack Sizes: 2mg. US Biological Life Sciences.
Worldwide
CXCR2-IN-1
CXCR2-IN-1 is a CXCR2 antagonist (pIC50 = 9.3) with favorable central nervous system penetration property (Br/Bl>0.45). Synonyms: 1-(2-chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(1-methylpiperidin-4-yl)sulfonylphenyl]urea. CAS No. 1873376-49-8. Molecular formula: C19H20Cl2FN3O4S. Mole weight: 476.35.
CXCR3 Antagonist 6c
CXCR3 Antagonist 6c is a potent and selective chemokine CXCR3 antagonist (IC50 value of 60 nM in a calcium mobilization functional assay). It inhibits CXCR3 functional response to CXCL11 as measured by T-cell chemotaxis. Synonyms: 4-[2-[ (3-chlorobenzoyl) amino]-4-[2- (2, 4-dichlorophenyl) ethylcarbamoyl]phenyl]-N-ethyl-1, 4-diazepane-1-carboxamide. Grades: 99%. CAS No. 870998-13-3. Molecular formula: C30H32Cl3N5O3. Mole weight: 616.97.
An arylsulfonamide derivative that acts as a CXCR3 antagonist (IC50 = 192nM against CXCL10-induced chemotaxis of hCXCR3-overexpressing L1.2 cells) with good aqueous solubility (>100uM at pH 7.4). Shown to be orally available in mice (83% bioavailability; t1/2 = 1h; 10mg/kg p.o.) in vivo and display a medium intrinsic clearance (CIint = 17uL/min/mg) in in vitro mouse liver microsome stability test. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C??H??F?N6O?S. US Biological Life Sciences.
Worldwide
CXCR4 Antagonist III (Fusin Antagonist III, N2- (4- ( (3- (Cyclohexylamino) propylamino) methyl) benzyl) -N4- (piperidin-4-yl) quinazoline-2,4-diamine, 2HCl)
A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50=36.2nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10uM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50=100.1 and 41nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6mg/kg, s.c). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV)
A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1alpha/CXCL12 for CXCR4 binding (IC50 = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC50 = 56uM; 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???FN??O??S?. xH?O, Sequence: N alpha-4-fluorobenzoyl-Arg-Arg-Nal-Cys4-Tyr-Cit-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys¹3-Arg-NH2 (Disulfide bond: 4 ? 13; Nal = L-3-(2-naphthyl)alanine; Cit = L-citrulline). US Biological Life Sciences.
Worldwide
CXD101
CXD101 is a selective histone deacetylase (HDAC) inhibitor with IC50 of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. It exhibits antineoplastic activity. Synonyms: HDAC-IN-4; CXD-101; CXD 101; N-(2-Aminophenyl)-4-(1-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)benzamide. Grades: 99%. CAS No. 934828-12-3. Molecular formula: C24H29N5O. Mole weight: 403.52.
cXMP
cXMP, a highly potent biomolecular tool, serves as a remarkable resource in the field of biomedicine due to its diverse applications. Its immense value lies in its prowess as a cyclic nucleotide analog, granting researchers the ability to delve deep into the intricate web of signaling pathways associated with cellular responses, encompassing the realm of drugs and diseases. Pertaining to research and drug discovery, cXMP assumes a pivotal role in unraveling the intricacies of cyclic nucleotide involvement in the regulation of various biochemical processes. Synonyms: Xanthosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 31319-70-7. Molecular formula: C10H10N4O8P · Na. Mole weight: 368.2.
CY 208-243
CY 208-243 is a D1DR receptor agonist and has been found to show antiparkinsonian activity in animal models. Synonyms: CY 208-243; CY-208-243; CY208243; (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin. Grades: ≥95% by HPLC. CAS No. 100999-26-6. Molecular formula: C19H18N2. Mole weight: 274.36.
Cy3-11-dCTP
Cy3-11-dCTP is a highly acclaimed fluorescent nucleotide derivative extensively utilized in the thriving biomedical industry, emerging as an indispensable instrument for the purpose of effectively and precisely marking DNA or RNA molecules in diverse scientific investigations. Notably, this remarkable compound seamlessly facilitates fluorescent in situ hybridization (FISH) endeavors and empowers meticulous microarray analysis. Grades: ≥ 95%. Mole weight: 1635.