A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
(3-chloro-2-propyenyl)hydroxylamine HCl. CAS No. 96992-71-1. Categories: (e)-o-(3-chloroallyl)hydroxylamine hydrochloride.
Pennsylvania PA
E07LKK
E07LKK has antibacterial activity against S. aureus, E.coli.
E10KKL
E10KKL is a synthetic construct peptide. It has antibacterial activity.
E1231
E1231 is an orally active activator of Sirtuin 1 ( SIRT1 ) ( EC 50 =0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (K D =9.61 μM) and deacetylated liver X receptor-alpha ( LXRα ), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE -/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one. CAS No. 1031195-19-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117006.
E-1,2-Bis(4-hex-5-enyloxyphenyl)diazene
Other Crystal Monomers. Alternative Names: Diazene, 1,2-bis[4-(5-hexen-1-yloxy)phenyl]-, (1E)-. CAS No. 1007319-13-2. Molecular formula: C24H30N2O2. Mole weight: 378.51. Purity: 97%+. Catalog: ACM1007319132.
E12LLK
E12LLK is a synthetic construct peptide. It has antibacterial activity.
E14KKL
E14KKL is a synthetic construct peptide. It has antibacterial activity.
E14LKK / H14LKK
E14LKK / H14LKK is a synthetic construct peptide. It has antibacterial activity.
E17110
E17110 is an LXRβ agonist. E17110 shows a significant activation effect on LXRβ, with an EC50 of 0.72 μmol/L. Synonyms: E-17110; E 17110. Grades: ≥98% by HPLC. Molecular formula: C16H15FN2O5. Mole weight: 334.30.
E-1-Bromo-6,6-dimethyl-6-methylcarboxylate-2-en-4-yne. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
E-1-Methylthio-1-propene
E-1-Methylthio-1-propene. Group: Biochemicals. Alternative Names: (1E)-1-(Methylthio)-1-propene; (E)-Methyl 1-propenyl Sulfide. Grades: Highly Purified. CAS No. 42848-06-6. Pack Sizes: 10mg. Molecular Formula: C4H8S, Molecular Weight: 88.17. US Biological Life Sciences.
Worldwide
E1R
E1R is a positive allosteric modulator of sigma-1 receptors ( Sig1R PAM ) with cognition-enhancing activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1301211-78-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116463.
E1 ubiquitin-activating enzyme
Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step. Group: Enzymes. Synonyms: ubiquitin activating enzyme; E1; ubiquitin-activating enzyme E1. Enzyme Commission Number: EC 6.2.1.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5704; E1 ubiquitin-activating enzyme; EC 6.2.1.45; ubiquitin activating enzyme; E1; ubiquitin-activating enzyme E1. Cat No: EXWM-5704.
E 2012
E 2012, is a potent selective, orally bioavailable γ-secretase modulator without affecting Notch processing that can used to treat Alzheimer's Disease. Synonyms: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one; 870843-42-8; E 2012; (E)-1-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-3-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZYLIDENE]PIPERIDIN-2-ONE; UNII-3LSD4Y5F0F; 3LSD4Y5F0F; CHEMBL1224151; E-2012; (e)-1-((1s)-1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1h-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-((1S)-1-(4-Fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; GTPL7358; SCHEMBL1238634; SCHEMBL1238639; C25H26FN3O2; DTXSID30468614; PUOAETJYKQITMO-LANLRWRYSA-N; (S,E)-1-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; W-5462; J-501810; I14-15434; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylene]piperidin-2-one; 2-Piperidinone, 1-((1S)-1-(4-fluorophenyl)ethyl)-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)methylene)-, (3E)-. CAS No. 870843-42-8. Molecular formula: C25H26FN3O2. Mole weight: 419.49.
E 2012
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870843-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-10016.
E235 is an expression regulator of activates transcription factor 4 ( ATF4 ). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 891894-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153339.
E260 is a Fer/FerT kinase inhibitor with Kd of 0.85 uM, which selectively evokes metabolic stress and necrotic death in cancer cells. Synonyms: E260; E 260; E-260; 2-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]-6-(4-propan-2-ylphenyl)imidazo[2,1-b][1,3,4]thiadiazole. CAS No. 1241537-79-0. Molecular formula: C24H34N6S. Mole weight: 438.638.
E260
E260 is a Fer / FerT kinase inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1241537-79-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112097.
The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. Group: Enzymes. Synonyms: ubiquitin-carrier-protein E2; UBC (ambiguous); ubiquitin-conjugating enzyme E2. Enzyme Commission Number: EC 2.3.2.23. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2297; E2 ubiquitin-conjugating enzyme; EC 2.3.2.23; ubiquitin-carrier-protein E2; UBC (ambiguous); ubiquitin-conjugating enzyme E2. Cat No: EXWM-2297.
E3330
E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities. Group: Inhibitors. CAS No. 136164-66-4. Molecular formula: C21H30O6. Mole weight: 378.46. Appearance: Solid. Purity: 0.9934. Canonical SMILES: CCCCCCCCC/C (C (O)=O)=C\C1=C (C)C (C (OC)=C (OC)C1=O)=O. Catalog: ACM136164664.
E3330
E3330 is a potent and selective APE1 (Ref-1) inhibitor, which inhibits NF-κB DNA-binding activity. It blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines and has anticancer properties such as inhibiting the growth and migration of cancer cells. Synonyms: APX-3330; E-3330; E 3330; (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid; (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid; Undecanoic acid, 2-((4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene)-, (E)-. Grades: 98%. CAS No. 136164-66-4. Molecular formula: C21H30O6. Mole weight: 378.46.
E-3- (4-Benzyloxy) -1- (2. 4-bisbenzyloxy-6-hydroxy) phenyl) propenone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
E-3620
E-3620 is a potent 5-HT 3 receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 151213-86-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19199.
E 3810 dihydrochloride
E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, -2, and -3 and FGFR-1 and -2 kinases in the nanomolar range. Uses: Antitumor agent. Synonyms: E 3810 dihydrochloride; E3810 dihydrochloride; E-3810 dihydrochloride; Lucitanib dihydrochloride; 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide dihydrochloride. Grades: 99%. CAS No. 2108875-91-6. Molecular formula: C26H25N3O4.2HCl. Mole weight: 516.42.
E3 ligase Ligand 32
E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2300099-98-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W382038.
E3 ligase Ligand-Linker Conjugates 30
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47.
E-3-(Tributylstannyl)-2-propen-1-amine
E-3-(Tributylstannyl)-2-propen-1-amine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113559-13-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15551.
E-4031
E-4031, a benzenesulfonamide derivative, could be used as a Class III antiarrhythmic agent due to its effect of blocking the ERG potassium channels. Uses: E-4031 could be used as a class iii antiarrhythmic agent due to its effect of blocking the erg potassium channels. Synonyms: E-4031; E 4031; E4031; 113559-13-0; CHEMBL536480; E-4031dihydrochloride; E-4031; 1- (2- (6-Methyl-2-pyridyl) ethyl) -4- (4-methylsulfonylaminobenzoyl) piperidinedihydrochloride; N- [4- [ [1- [2- (6-methyl-2-pyridinyl) ethyl] -4-piperidinyl] carbonyl] phenyl] methanesulfonamidedihydrochloride. Grades: 95%. CAS No. 113559-13-0. Molecular formula: C21H29Cl2N3O3S. Mole weight: 474.44.
E-4031 dihydrochloride
E-4031 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 113559-13-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
E4CPG
E4CPG. Group: Biochemicals. Grades: Purified. CAS No. 170846-89-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
E4CPG
E4CPG is a group I/group II metabotropic glutamate receptor antagonist with higher potency than (RS)-MCPG. Synonyms: (RS)-α-Ethyl-4-carboxyphenylglycine; 4-(1-amino-1-carboxypropyl)benzoic acid. Grades: ≥99% by HPLC. CAS No. 170846-89-6. Molecular formula: C11H13NO4. Mole weight: 223.23.
E-5-(2-Carboxyvinyl)-2'-deoxyuridine hydroxysuccinimide ester. Group: Biochemicals. Grades: Highly Purified. CAS No. 869355-24-8. Pack Sizes: 100mg, 200mg, 500mg, 1g. Molecular Formula: C16H17N3O9. US Biological Life Sciences.
Worldwide
E-5-(2-Carboxyvinyl)uracil
E-5-(2-Carboxyvinyl)uracil. Group: Biochemicals. Grades: Highly Purified. CAS No. 57412-59-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
E 5555 hydrobromide
E 5555 hydrobromide is a potent and orally bioactive thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50 = 19 nM). It inhibits human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively. Synonyms: Atopaxar hydrobromide; ER 172594-06 HBr; E 5555 hydrobromide; E-5555 hydrobromide; E5555 hydrobromide. Grades: 99%. CAS No. 474550-69-1. Molecular formula: C29H38FN3O5.HBr. Mole weight: 608.54.
E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers. Synonyms: E6201; E 6201; E-6201; ER 806201; ER806201; ER-806201; LL-Z1640-2. CAS No. 603987-35-5. Molecular formula: C21H27NO6. Mole weight: 389.45.
E-64. Group: Biochemicals. Alternative Names: Trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat. Grades: Highly Purified. CAS No. 66701-25-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C15H27N5O5. US Biological Life Sciences.
Worldwide
E-64
5mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: C15H27N5O5. CAS No. 66701-25-5. Prepack ID 12170327-5mg. Molecular Weight 357.41. See USA prepack pricing.
E-64
E-64. CAS No: 66701-25-5
Sarchem Laboratories New Jersey NJ
E-64
E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC 50 of 9 nM for papain. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Proteinase inhibitor E 64. CAS No. 66701-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15282.