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| Product | Description | |
|---|---|---|
| Everolimus | Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that can prevent allograft rejection, and may demonstrate activity in both the prevention and treatment of PTLDs in transplant patients. Group: Biochemicals. Alternative Names: Afinitor, Certican, RAD-001, Zortress; 40-O- (2-Hydroxyethyl) rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; RAD; RAD 001; SDZ-RAD; XIENCE V. Grades: Highly Purified. CAS No. 159351-69-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Everolimus 27-O-Desmethyl Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 27-O-Desmethyl Everolimus. Grades: > 95%. Molecular formula: C52H81NO14. Mole weight: 944.22. |  |
| Everolimus 28-Ethylhydroxy Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 28-Ethylhydroxy Rapamycin. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus, Cyclosporine and Tacrolimus Mix Standard | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
| Everolimus-d4 | Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Alternative Names: 40-O-(2-Hydroxyethyl-d4)rapamycin; 42-O-(2-Hydroxy)ethyl-d4 Rapamycin; Afinitor-d4; Certican-d4; RAD-d4; RAD 001-d4; SDZ-RAD-d4; XIENCE V-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Everolimus-d4 | Everolimus-d 4 is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: RAD001-d4; SDZ-RAD-d4. CAS No. 1338452-54-2. Pack Sizes: 500 μg. Product ID: HY-10218S. |  |
| Everolimus-D4 solution | 100 ?g/mL in acetonitrile, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). |  |
| Everolimus Dehydrate Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Dehydro Seco Acid. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus EP Impurity B | Everolimus EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1062122-63-7. Molecular formula: C53H83NO14. Mole weight: 958.24. Catalog: APB1062122637. | |
| Everolimus EP Impurity E | Everolimus EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus EP Impurity E. CAS No. 1237826-25-3. Molecular formula: C52H79NO14. Mole weight: 942.18. Catalog: APB1237826253. | |
| Everolimus Hydrolized Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: seco Everolimus B; (2S)-1-[2-[(2R, 3R, 6S)-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 20S, 21R)-14, 20-Dihydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15-docosatetraen-1-yl]tetrahydro-. Grades: > 95%. CAS No. 769905-89-7. Molecular formula: C53H85NO15. Mole weight: 976.27. | |
| Everolimus Impurity 23 (Everolimus-13C2-D4) | Everolimus Impurity 23 (Everolimus-13C2-D4). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1661009-29-5. Molecular formula: C5113C2H79D4NO14. Mole weight: 964.25. Catalog: APB1661009295. | |
| Everolimus Impurity 24 (Everolimus-D4) | Everolimus Impurity 24 (Everolimus-D4). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1338452-54-2. Molecular formula: C53H79D4NO14. Mole weight: 962.26. Catalog: APB1338452542. | |
| Everolimus Impurity 6 | Everolimus Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1704711-12-5. Molecular formula: C54H85NO14. Mole weight: 972.27. Catalog: APB1704711125. | |
| Everolimus Isomer C | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 9,14-Deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-42-O-(2-hydroxyethyl)-14-oxorapamycin. Grades: 80%. CAS No. 908340-97-6. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus O-Desmethyl Impurity (Mixture of Diastereomers) | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 27-O-Desmethyl Everolimus. Grades: > 95%. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
| Everolimus O-ethyl impurity | Everolimus O-ethyl impurity. CAS No. 1704711-12-5. Product ID: 8-05125. Molecular formula: C54H85NO14. Mole weight: 972.28. |  |
| Everolimus O-Ethyl Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 7-O-Desmethyl-7-O-ethyl Everolimus. Grades: > 95%. CAS No. 1704711-12-5. Molecular formula: C54H85NO14. Mole weight: 972.28. | |
| Everolimus O-Silyl Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin; 42-O-[2-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]ethyl]rapamycin. Grades: > 95%. CAS No. 159351-68-5. Molecular formula: C59H97NO14Si. Mole weight: 1072.52. | |
| Everolimus Related Compound 1 | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: O-Desmethyl Everolimus. Grades: > 95%. CAS No. 745779-75-3. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
| Everolimus Related Compound 3 | Everolimus Ring-Opening Impurity. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid. Grades: 65%. CAS No. 147438-30-0. Molecular formula: C32H49NO9. Mole weight: 591.75. | |
| Everolimus Related Compound 4 | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[2-[(2R, 3R, 6S)-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 20S, 21R)-14, 20-Dihydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15-docosatetraen-1-yl]tetrahydro-2-hydroxy-3-methyl-. Grades: > 95%. Molecular formula: C57H91NO16. Mole weight: 1046.36. | |
| Everolimus Related Compound 5 | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Di-tert-butyl-4-methylene-2,5-cyclohexadienone; 2,6-Di-t-butyl-4-methylene-2,5-cyclohexadienone. Grades: > 95%. CAS No. 2607-52-5. Molecular formula: C15H22O. Mole weight: 218.34. | |
| Everolimus Ring-Opening Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Retroaldol Degradation Product. Grades: > 95%. CAS No. 1708118-13-1. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus solution | 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material. Group: Immunosuppressants. | |
| Evexomostat | Evexomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor. Synonyms: poly ({N-[ (2RS) -2-hydroxypropyl]methacrylamide}-co-[N-methacryloylgly-cyl-L-phenylalanyl-L-leucyl-N1- (trans-4-{[ ({ (3R, 4S, 5S, 6R) -5-methoxy-4-[ (2R, 3R) -2-methyl-3- (3-methylbut-2-en-1-yl) oxiran-2-yl]-1-oxaspiro[2. 5]-octan-6-yl}oxy) carbonyl]amino}cyclohexyl) glycinamide (~0.91:0.09 x)]); poly([N-(2-hydroxypropyl)methacrylamide]-co-{methacryloyl-Gly-Phe-Leu-Gly amide with O-[ (trans-4-aminocyclohexyl) carbamoyl]fumagillol}). CAS No. 2416263-67-5. Molecular formula: [(C7H13NO2)n(C46H68N6O10)]m. | |
| Evifacotrep | Evifacotrep is a short transient receptor potential channel 5 (TRPC5) antagonist. Synonyms: 4-chloro-5-{4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl}pyridazin-3(2H)-one. CAS No. 2413739-88-3. Molecular formula: C18H12ClF4N5O2. Mole weight: 441.77. | |
| Evinacumab | Evinacumab (REGN1500) is a human anti- ANGPTL3 ( angiopoietin-like protein 3 ) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN1500. CAS No. 1446419-85-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99194. | |
| Evinacumab | Evinacumab is a humanized anti-ANGPTL3 monoclonal antibody. Evinacumab has the potential therapeutic activity against homozygous familial hypercholesterolemia. Synonyms: Evkeeza; REGN1500. CAS No. 1446419-85-7. | |
| Evixapodlin | Evixapodlin is a human programmed cell death ligand 1 (PD-1/PD-L1) protein/protein interaction inhibitor with an IC50 of 0.213 nM. It has anticancer and antiviral functions. Synonyms: (12S,122S)-62,72-dichloro-53,86-dimethoxy-3,10-diaza-5,8(2,5)-dipyrazina-1,12(2)-dipyrrolidina-6,7(1,3)-dibenzenadodecaphane-15,125-dione; (5S, 5'S)-5, 5'- ( ( ( (5, 5'- (2, 2'-dichloro-[1, 1'-biphenyl]-3, 3'-diyl)bis (3-methoxypyrazine-5, 2-diyl))bis (methylene))bis (azanediyl))bis (methylene))bis (pyrrolidin-2-one); 2-Pyrrolidinone, 5, 5'-[ (2, 2'-dichloro[1, 1'-biphenyl]-3, 3'-diyl) bis[ (3-methoxy-5, 2-pyrazinediyl) methyleneiminomethylene]]bis-, (5S,5'S)-; PD-1/PD-L1-IN 7. Grades: ≥98%. CAS No. 2374856-75-2. Molecular formula: C34H36Cl2N8O4. Mole weight: 691.61. | |
| Evobrutinib | Evobrutinib (M2951) is an orally active, potent, highly selective and irreversibly covalent BTK inhibitor, with an IC 50 of 8.9 nM. Evobrutinib (M2951) can be used for the research of autoimmune diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: M2951; MSC2364447C. CAS No. 1415823-73-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101215. | |
| Evocalcet | Evocalcet (KHK7580) is an orally active calcium sensing receptor ( CaSR ) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KHK7580. CAS No. 870964-67-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17613. | |
| Evocalcet | Evocalcet is a calcium-sensing receptor agonist under the development of Kyowa Hakko Kirin. Phase III clinical trials for Secondary hyperparathyroidism are on-going in Japan. Uses: Secondary hyperparathyroidism. Synonyms: MT-4580; MT 4580; MT4580; KHK-7580; KHK7580; KHK 7580; Evocalcet;2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic acid. Grades: 98%. CAS No. 870964-67-3. Molecular formula: C24H26N2O2. Mole weight: 374.48. | |
| Evodenoson | Evodenoson is a selective A2A adenosine receptor agonist. Phase II clinical trials for the treatment of Glaucoma and Ocular hypertension were discontinued. Uses: Glaucoma;ocular hypertension. Synonyms: ATL313; ATL 313; ATL-313; DE-112; DE 112; DE112; methyl 4-[3-[6-amino-9-[(2R,3R,4S,5S)-5-(cyclopropylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]prop-2-ynyl]piperidine-1-carboxylate. Grades: 98%. CAS No. 844873-47-8. Molecular formula: C23H29N7O6. Mole weight: 499.53. | |
| Evodenoson | Evodenoson is a selective agonist of the A 2A adenosine receptor. Evodenosons primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenosons protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATL 313; DE 112. CAS No. 844873-47-8. Pack Sizes: 1 mg. Product ID: HY-105017. | |
| Evodiamine | Evodiamine - Product ID: NST-10-12. Category: Alkaloids. Alternative Names: d-Evodiamine. Purity: 98%. Test method: HPLC. CAS No. 518-17-2. Pack Sizes: 25g, 50g, 125g, 250g. Appearance: White to pale yellow powder. Molecular formula: C19H17N3O. Mole weight: 303.36. Storage: +2 +8 °C. |  |
| Evodiamine | A chemical extracted from Evodia plants, and has been shown to reduce fat uptake. Group: Biochemicals. Alternative Names: (13bS)-8, 13, 13b-14-Tetrahydro-14-methyl-indolo[2', 3':3, 4]pyrido[2, 1-b]quinazolin-5(7H)-one; d-Evodiamine; (+)-Evodiamine. Grades: Highly Purified. CAS No. 518-17-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Evodiamine | Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Evodiamine; d-Evodiamine. CAS No. 518-17-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-N0114. | |
| Evodiamine 98% HPLC | Evodiamine 98% HPLC. |  CA, FL & NJ |
| Evofosfamide | Evofosfamide (TH-302) is a hypoxia -activated proagent with IC 50 of 10 μM and 1000 μM in hypoxia (N 2 ) and normoxia (21% O 2 ), respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TH-302. CAS No. 918633-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10535. | |
| Evofosfamide | Evofosfamide is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. Synonyms: TH-302; TH 302; TH302; 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine. Grades: > 98%. CAS No. 918633-87-1. Molecular formula: C9H16Br2N5O4P. Mole weight: 449.04. | |
| Evogliptin | This active molecular is a selective dipeptidyl peptidase 4 (DPP4) inhibitor under the development of Dong-A. Evogliptin improves insulin resistance and delays the onset of diabetes. Evogliptin monotherapy improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. In Sep 1st 2016, preclinical trials in Type-2 diabetes mellitus (Combination therapy) in Russia was on-going. In Sep 12th 2016, Phase-I clinical trials in non-alcoholic steatohepatitis (Combination therapy) in USA was on-going. Uses: Type-2 diabetes mellitus. Synonyms: (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one;CHEMBL1779710; UNII-09118300L7; DA-1229; DA 1229; DA1229; 1222102-29-5; Evogliptin [INN];1246960-27-9 (HCl). Grades: 98%. CAS No. 1222102-29-5. Molecular formula: C19H26F3N3O3. Mole weight: 401.43. | |
| Evogliptin hydrochloride | Evogliptin is a DPP-4 inhibitor, for the treatment of type 2 diabetes mellitus in patients with inadequately controlled by diet and exercise alone, or in combination with metformin when diet and exercise plus metformin alone do not provide satisfactory glycaemic control. CAS No. 1246960-27-9. Molecular formula: C19H27ClF3N3O3. Mole weight: 401.42. | |
| Evogliptin tartrate | Evogliptin (DA-1229) tartrate is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA-1229 tartrate. CAS No. 1222102-51-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117985B. | |
| Evogliptin Tartrate | Evogliptin is an antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Synonyms: 2-Piperazinone, 4-[(3R)?-3-amino-1-oxo-4-(2,?4,?5-trifluorophenyl)?butyl]?-3-[(1,?1-dimethylethoxy)?methyl]?-, (3R)?-, (2R,?3R)?-2,?3-dihydroxybutanedioat?e (1:1). Grades: > 95%. CAS No. 1222102-51-3. Molecular formula: C19H26F3N3O3. C4H6O6. Mole weight: 401.43 150.09. | |
| Evogliptin Tartrate Impurity S1 | An isomer of Evogliptin. Evogliptin is an antidiabetic drug in the dipeptidyl peptidase-4 (DPP-6) inhibitor class of drugs. Synonyms: 2-Piperazinone, 4-[(3S)?-3-amino-1-oxo-4-(2,?4,?5-trifluorophenyl)?butyl]?-3-[(1,?1-dimethylethoxy)?methyl]?-, (3R)?-, (2R,?3R)?-2,?3-dihydroxybutanedioat?e (1:1). Grades: > 95%. Molecular formula: C19H26F3N3O3. C4H6O6. Mole weight: 401.43 150.09. | |
| Evogliptin Tartrate Impurity S2 | An isomer of Evogliptin. Evogliptin is an antidiabetic drug in the dipeptidyl peptidase-4 (DPP-5) inhibitor class of drugs. Synonyms: 2-Piperazinone, 4-[(3S)?-3-amino-1-oxo-4-(2,?4,?5-trifluorophenyl)?butyl]?-3-[(1,?1-dimethylethoxy)?methyl]?-, (3S)?-, (2R,?3R)?-2,?3-dihydroxybutanedioat?e (1:1). Grades: > 95%. Molecular formula: C19H26F3N3O3. C4H6O6. Mole weight: 401.43 150.09. | |
| Evogliptin Tartrate Impurity S3 | An isomer of Evogliptin. Evogliptin is an antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Synonyms: 2-Piperazinone, 4-[(3R)?-3-amino-1-oxo-4-(2,?4,?5-trifluorophenyl)?butyl]?-3-[(1,?1-dimethylethoxy)?methyl]?-, (3S)?-, (2R,?3R)?-2,?3-dihydroxybutanedioat?e (1:1). Grades: > 95%. Molecular formula: C19H26F3N3O3. C4H6O6. Mole weight: 401.43 150.09. | |
| Evolitrine | Evolitrine is an alkaloid isolated from Fructus Evodiae. Synonyms: Evolitrin; 4,7-dimethoxyfuro[2,3-b]quinoline. Grades: 98%. CAS No. 523-66-0. Molecular formula: C13H11NO3. Mole weight: 229.23. | |
| Evolocumab | Evolocumab is a monoclonal antibody as well as an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein targeting LDL receptors. Inhibition of PCSK9 could prevent LDL receptors from degradation and promote the removal of LDL-C from blood circulation. Evolocumab is used for the treatment of hyperlipidemia. Uses: The treatment of hyperlipidemia. Synonyms: AMG 145; AMG-145; AMG145. CAS No. 1256937-27-5. Molecular formula: C6242H9648N1668O1996S56. Mole weight: 141800. | |
| Evolocumab | Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H 2 O 2 -induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 145. CAS No. 1256937-27-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9930. | |
| Evolocumab | Evolocumab Inhibitor. Uses: Scientific use. Product Category: T9920. CAS No. 1256937-27-5. |  |
| Evomonoside | Evomonoside is a potent natural compound used for studying neurological diseases such as Alzheimer's and Parkinson's. Derived from natural sources, Evomonoside exhibits neuroprotective properties by preventing the formation of amyloid plaques in the brain. Synonyms: (3b,5b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxycard-20(22)-enolide; Digitoxigenin 3-rhamnoside; Digitoxigenin rhamnoside. CAS No. 508-93-0. Molecular formula: C29H44O8. Mole weight: 520.65. | |
| Evomonoside | Evomonoside. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-beta-card-20(22)-enolide,3-beta-((6-deoxy-alpha-l-mannopyranosyl)oxy)-14-bet;a-hydroxy-;digitoxigenin3-rhamnoside;digitoxigeninrhamnoside;evomonosid;EVOMONOSIDE;DIGITOXIGENIN-3-O-ALPHA-L-RHAMNOPYRANOSIDE;DIGITOXIGENIN-3-O-A-L-RHAMNOPYRANOSIDE. Product Category: Heterocyclic Organic Compound. CAS No. 508-93-0. Molecular formula: C29H44O8. Mole weight: 520.65. Product ID: ACM508930. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Evoxanthine | Evoxanthine is a furanoidone alkaloid isolated from Evodia xanthoxyloides. Evoxanthine is active against Gram-positive and Gram-negative bacteria, including Escherichia coli, Bacillus subtilis and Aspergillus flavus. It has antimalarial and anticancer activities. Synonyms: 11-Methoxy-5-Methyl-1,3-Dioxolo[4.5-B]Acridin-10(5H)-One; 1,3-Dioxolo[4.5-B]Acridin-10(5H)-One. Grades: >95% by HPLC. CAS No. 477-82-7. Molecular formula: C16H13NO4. Mole weight: 283.28. | |
| EVP-0015962 | EVP-0015962 is a selective Amyloid precursor protein secretase modulator under the development of FORUM Pharmaceuticals. Chronic treatment with EVP-0015962 can lower the production of Aβ42, attenuate memory deficits, and reduce Aβ plaque formation and inflammation in Tg2576 transgenic animals. EVP-0015962 shows a therapeutic alternative for disease modification in Alzheimer's disease. In Jun 2016, Phase-II for Alzheimer's disease in USA was discontinued. Uses: Alzheimer's disease. Synonyms: EVP-0015962; EVP 0015962; EVP0015962. SCHEMBL3660255; ZSERTYLZGRJLOO-UHFFFAOYSA-N; 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-3-cyclobutylpropanoic acid. Grades: 98%. CAS No. 1447811-26-8. Molecular formula: C22H19ClF6O3. Mole weight: 480.83. | |
| EVP4593 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| EVP-6124 | EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). It shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs and improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Synonyms: EVP-6124; EVP6124; EVP 6124; MT-4666; MT4666; MT 4666; Encenicline. Grades: >98%. CAS No. 550999-75-2. Molecular formula: C16H17ClN2OS. Mole weight: 320.84. | |
| Evunzekibart | Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ATOR-1017. CAS No. 2639688-77-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990067. | |
| Evuzamitide | Evuzamitide is a diagnostic imaging agent. Evuzamitide as a pan-amyloid radiotracer binding to amyloid deposits from multiple amyloidogenic proteins. Evuzamitide can be used for the research of early diagnosis of amyloid cardiomyopathy (CMP) and monitoring [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1420048-58-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10023. | |
| EW-7197 | EW-7197 is a potent and selective ALK5 inhibitor, displaying antimetastatic and anticancer effects. It inhibits TGF-β/Smad signaling, and abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung. EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice. Synonyms: Vactosertib; N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine. Grades: >98%. CAS No. 1352608-82-2. Molecular formula: C22H18FN7. Mole weight: 399.433. | |
| EX1314 | BMS-604992 is a selective and orally active growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (Ki = 2.3 nM) and strong functional activity (EC50 = 0.4 nM). It stimulates feeding in rodents. Synonyms: BMS-604992; Carbamic acid, (2-amino-2-oxoethyl)methyl-, (3-((1S)-1-((2-amino-2-methyl-1-oxopropyl)amino)-2-(phenylmethoxy)ethyl)-1,2,4-triazolo(4,3-a)pyridin-5-yl)methyl ester, monohydrochloride; (3-{(1S)-2-(Benzyloxy)-1-[(2-methylalanyl)amino]ethyl}[1, 2, 4]triazolo[4, 3-a]pyridin-5-yl)methyl (2-amino-2-oxoethyl)methylcarbamate hydrochloride (1:1). Grades: 98%. CAS No. 674343-47-6. Molecular formula: C24H32ClN7O5. Mole weight: 534.01. | |
| EX229 | EX229 (compound 991), also known as AMPK Activator 991, is a potent AMPK activator that displays 5-10-fold more potent than A769662 in activating AMPK. Synonyms: Compound 991; AMPK Activator 991; 5-[[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methylbenzoic acid. Grades: ≥98%. CAS No. 1219739-36-2. Molecular formula: C24H18ClN3O3. Mole weight: 431.87. | |
| Ex26 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Ex26 | Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 ( S1P 1 ) antagonist ( IC 50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P 1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S1P1-IN-Ex26. CAS No. 1233332-37-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117213. | |
| Ex 26 | Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM) with > 3,000-fold selectivity over S1P2, S1P3, S1P4 and S1P5. It causes lymphocyte sequestration in peripheral lymph nodes, and upregulates S1P1 receptor expression. Synonyms: 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1233332-37-0. Molecular formula: C28H28ClFN2O3. Mole weight: 494.98. | |
| EX 527 | EX 527. Group: Biochemicals. Grades: Purified. CAS No. 49843-98-3. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| EX-527 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| EX-527 | EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3. Synonyms: SEN0014196; EX-527; EX-527; EX-527; Selisistat. Grades: >98%. CAS No. 49843-98-3. Molecular formula: C13H13ClN2O. Mole weight: 248.71. | |
| EX-527 | EX-527 Inhibitor. Uses: Scientific use. Product Category: T6111. CAS No. 49843-98-3. | |
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