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An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L43) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-((trimethylsilyl)oxy)phenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one; 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone. Grades: > 95%. CAS No. 272778-12-8. Molecular formula: C39H46F2N2O5Si2. Mole weight: 716.98.
Ezetimibe Impurity B
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L14) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: methyl 5-(4-fluorophenyl)-5-hydroxypentanoate. Grades: > 95%. CAS No. 870634-36-9. Molecular formula: C12H15FO3. Mole weight: 226.25.
Ezetimibe Impurity C
Ezetimibe Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R,6S)-N,6-bis(4-fluorophenyl)-2-(4-hydroxyphenyl)tetrahydro-2H-pyran-3-carboxamide. CAS No. 1296129-15-1. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1296129151.
Ezetimibe Impurity D
Ezetimibe Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 204589-58-2. Molecular Formula: C24H21F2NO2. Mole Weight: 393.43. Catalog: APB204589582.
Ezetimibe Impurity E
Ezetimibe Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one. CAS No. 302781-98-2. Molecular Formula: C24H22FNO3. Mole Weight: 391.43. Catalog: APB302781982.
Ezetimibe Impurity F
Ezetimibe Impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 190595-66-5. Molecular Formula: C24H22FNO3. Mole Weight: 391.43. Catalog: APB190595665.
Ezetimibe Impurity G
Ezetimibe Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1700622-06-5. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1700622065.
Ezetimibe Impurity H
Ezetimibe Impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1798008-25-9 (racemic); (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(2-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 2743547-96-6. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB2743547966.
Ezetimibe Impurity I
Ezetimibe Impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-(p-tolyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1700622-07-6. Molecular Formula: C25H24FNO3. Mole Weight: 405.46. Catalog: APB1700622076.
Ezetimibe Impurity J
Ezetimibe Impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1700622-08-7. Molecular Formula: C24H21ClFNO3. Mole Weight: 425.88. Catalog: APB1700622087.
Ezetimibe Impurity L
Ezetimibe Impurity L. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-N,5-bis(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide. CAS No. 1510820-22-0. Molecular Formula: C24H23F2NO2. Mole Weight: 395.44. Catalog: APB1510820220.
Ezetimibe Impurity M
Ezetimibe Impurity M. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-((S)-5-hydroxy-5-phenylpentanoyl)-4-phenyloxazolidin-2-one. Molecular Formula: C20H21NO4. Mole Weight: 339.39. Catalog: APB05462.
Ezetimibe Impurity N
Ezetimibe Impurity N. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. CAS No. 404874-94-8. Molecular Formula: C20H20FNO4. Mole Weight: 357.38. Catalog: APB404874948.
Ezetimibe Impurity O
Ezetimibe Impurity O. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. CAS No. 1612153-32-8. Molecular Formula: C20H20FNO4. Mole Weight: 357.38. Catalog: APB1612153328.
Ezetimibe Impurity P
Ezetimibe Impurity P. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-(4-fluorophenyl)-5-oxopentanoic acid. CAS No. 149437-76-3. Molecular Formula: C11H11FO3. Mole Weight: 210.2. Catalog: APB149437763.
Ezetimibe Impurity Q1
Ezetimibe Impurity Q1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-((2R,5R)-5-(4-fluorophenyl)-5-hydroxy-2-((S)-hydroxy(4-hydroxyphenyl)methyl)pentanoyl)-4-phenyloxazolidin-2-one. Molecular Formula: C27H26FNO6. Mole Weight: 479.5. Catalog: APB05460.
Ezetimibe Impurity Q2
Ezetimibe Impurity Q2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-((2R,5R)-5-(4-fluorophenyl)-5-hydroxy-2-((R)-hydroxy(4-hydroxyphenyl)methyl)pentanoyl)-4-phenyloxazolidin-2-one. Molecular Formula: C27H26FNO6. Mole Weight: 479.5. Catalog: APB05461.
Ezetimibe Impurity R
Ezetimibe Impurity R. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-((R,E)-5-(4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzylidene)pentanoyl)-4-phenyloxazolidin-2-one. Molecular Formula: C27H24FNO5. Mole Weight: 461.48. Catalog: APB05459.
Ezetimibe Impurity S
Ezetimibe Impurity S. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. CAS No. 528565-93-7. Molecular Formula: C20H20FNO4. Mole Weight: 357.38. Catalog: APB528565937.
Ezetimibe Impurity (Tetrahydro-pyran-2-one)
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L35) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,6R)-6-(4-fluorophenyl)-3-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)tetrahydro-2H-pyran-2-one. Grades: > 95%. Molecular formula: C24H21F2NO3. Mole weight: 409.44.
Ezetimibe Intermediate
Used for lowering cholesterol. Group: Heterocyclic organic compound. Alternative Names: (4s)-3-[5-(4-fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone;3-[5-[(4-FLUOROPHENYL)-1-5-DIOXOPENTA]-YL-4-(S)-PHENYL OXNZOLIDINE-2-ONE;3-[5-(4-FLUOROPHENYL)-1,5-DIOXOPENTYL]-4-PHENYL-(4S)-2-OXAZOLIDINONE;2-OXAZOLIDINONE, 3-[5-(4-FLUOROPHENYL)-1,5-D. CAS No. 189028-93-1. Molecular formula: C20H18FNO4. Mole weight: 355.36. Appearance: Off-White Solid. Density: 1.288 g/cm³. Catalog: ACM189028931.
Ezetimibe ketone
Ezetimibe ketone. Group: Biochemicals. Alternative Names: (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone; EZM-K. Grades: Highly Purified. CAS No. 191330-56-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C24H19F2NO3. US Biological Life Sciences.
Worldwide
Ezetimibe ketone
Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 ( NPC1L1 ) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EZM-K. CAS No. 191330-56-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-133114.
Ezetimibe Ketone
Phase-I metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone. Grades: > 95%. CAS No. 191330-56-0. Molecular formula: C24H19F2NO3. Mole weight: 407.42.
Ezetimibe Lactam Cleaved Alcohol
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L23) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3'-Anhydro Ezetimibe Alcohol Impurity; (βR,γS)-γ-[(4-Fluorophenyl)amino]-β-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanol. Grades: > 95%. CAS No. 1374250-07-3. Molecular formula: C24H23F2NO2. Mole weight: 395.45.
Ezetimibe Phenexy Glucuronide
A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe phenoxy Glucuronide. Grades: > 95%. CAS No. 190448-57-8. Molecular formula: C30H29F2NO9. Mole weight: 585.55.
Ezetimibe phenoxy glucuronide
Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity [1]. Ezetimibe is a potent cholesterol absorption inhibitor [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ezetimibe glucuronide; Ezetimibe β-D-glucuronide. CAS No. 190448-57-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-135391.
Ezetimibe Phenoxy tert-Butyldiphenylsilyl Ether
Ezetimibe Phenoxy tert-butyldiphenylsilyl ether is a substituted Ezetimibe. Group: Biochemicals. Alternative Names: (3R, 4S) -1- (4-Fluorophenyl ) -3- [ (3S) -3- (4-fluorophenyl ) -3- hydroxypropyl ] -4- (4-tert-butyl diphenyl silyl oxyphenyl ) -2-azetidinone. Grades: Highly Purified. CAS No. 1042722-66-6. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Ezetimibe Related Impurity 6
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L40) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(3-fluorophenyl)-3-((S)-3-(3-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grades: > 95%. Molecular formula: C24H21F2NO3. Mole weight: 409.44.
Ezetimibe Related Impurity 7
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L41) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(3-fluorophenyl)-3-((E)-3-(3-fluorophenyl)allyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grades: > 95%. CAS No. 204589-68-4. Molecular formula: C24H19F2NO2. Mole weight: 391.42.
Ezetimibe Ring-Open Impurity
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L15) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide. Grades: > 95%. CAS No. 1197811-72-5. Molecular formula: C24H23FNO3. Mole weight: 411.45.
Ezetimibe ring-opening dehydrate impurity
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L31) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (αR,βS)-β-[(4-Fluorophenyl)amino]-α-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanoic Acid. Grades: > 95%. CAS No. 1292292-63-7. Molecular formula: C24H21F2NO3. Mole weight: 409.44.
Ezetimibe (RRR)-Isomer
Ezetimibe (RRR)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1593542-96-1. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1593542961.
Ezetimibe (RRS)-Isomer
Ezetimibe (RRS)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 163380-16-3. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB163380163.
Ezetimibe (RSR)-Isomer
Ezetimibe (RSR)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1376614-99-1. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1376614991.
Ezetimibe (RSS)-Isomer
Ezetimibe (RSS)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4S)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1478664-18-4. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1478664184.
Ezetimibe (SRR)-Isomer
Ezetimibe (SRR)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1478664-02-6. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1478664026.
Ezetimibe (SSR)-Isomer
Ezetimibe (SSR)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1593543-00-0. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1593543000.
Ezetimibe (SSS)-Isomer
Ezetimibe (SSS)-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1593543-07-7. Molecular Formula: C24H21F2NO3. Mole Weight: 409.43. Catalog: APB1593543077.
Ezetimibe Tetrahydropyran Impurity
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (2R,3R,6S)-N,6-Bis(4-fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-2H-pyran-3-carboxamide; SCH59566. Grades: > 95%. CAS No. 1296129-15-1. Molecular formula: C24H21F2NO3. Mole weight: 409.44.
Ezetimibe Triol Impurity
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L48) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R,5R)-3-(4-fluorophenyl)-5-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-((S)-2-hydroxy-1-phenylethyl)-4-(4-hydroxyphenyl)piperidine-2,6-dione. Grades: > 95%. Molecular formula: C33H30F2N2OS. Mole weight: 572.61.
EZH2-IN-14
EZH2-IN-14 is a selective EZH2 ( Histone Methyltransferase ) inhibitor with an IC 50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1979157-17-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148458.
Ezh2 Inhibitor II, EI1(Enhancer of Zested Homolog 2 Inhibitor II, HMTase Inhibitor XI, 6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide)
A cell-permeable indolocarboxamide compound that acts as a potent and selective inhibitor against Ezh2/PRC2 (Polycomb repressive complex 2; Ezh2 / SUZ12 / EED / AEBP2 / RbAP48) HMTase activity (IC50/substrate = 15nM/H3K27me021-44 and 13nM/H3K27me221-44, respectively, against human wt or Y641F Ezh2-containing PRC2; [SAM] = 1uM) in a cofactor SAM-competitive manner, while inhibiting Ezh1/PRC2 only at much higher concentrations (IC50 = 1.34uM) and exhibiting no potency toward CARM 1, Dot1L, G9a, MLL, NSD3, Set7/9, SETD2, SETD8, SmyD2, or Suv39H2 (IC50 >100uM). Shown to suppress cellular H3K27 dimethylation and trimethylation (1 to 10uM) in DLBCL cultures and exhibit antiproliferation activity against DLBCL cell lines with wt or mutant Ezh2 (3.3uM to 10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: Ezh2/PRC2. US Biological Life Sciences.
Worldwide
Ezlopitant
Ezlopitant, also known as CJ-11,974, is a NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Synonyms: CJ 11,974; CJ-11974; CJ11974; (7S,8S)-7-[di(phenyl)methyl]-N-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine. CAS No. 147116-64-1. Molecular formula: C31H38N2O. Mole weight: 454.66.
Ezomycin A1 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 39422-19-0. Molecular formula: C26H38N8O15S. Mole weight: 734.69.
Ezomycin A2
Ezomycin A2 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 54328-22-2. Molecular formula: C19H26N6O12. Mole weight: 530.44.
Ezomycin B2
Ezomycin B2 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 57973-16-7. Molecular formula: C19H25N5O13. Mole weight: 531.43.
Ezomycin D2
Ezomycin D2 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 57973-11-2. Molecular formula: C19H27N5O14. Mole weight: 549.44.
A cell-permeable, quinoline that binds directly to ezrin (=12.6uM) in a reversible manner, and inhibits PKC?-mediated ezrin phosphorylation at Thr567 (IC50=8.1uM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10uM. At 10uM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10uM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vitro at 2.26mg/kg/day. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
E,Z-trans-3-(2-Chloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is the photolysis product of Permethrin, which is a medication and an insecticide used to treat scabies and lice. Synonyms: E,Z-trans-3-(2-Chlorovinyl)-2,2-dimethylcyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 3-[(1E)-2-chloroethenyl]-2,2-dimethyl-, (1R,3S)-rel-; rel-(1R,3S)-3-((E)-2-chlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid; Cyclopropanecarboxylic acid, 3-(2-chloroethenyl)-2,2-dimethyl-, [1α,3β(E)]-. Grades: 98%. CAS No. 61914-45-2. Molecular formula: C8H11ClO2. Mole weight: 174.62.
Ezurpimtrostat
Ezurpimtrostat is a palmitoyl protein thioesterase 1 (PPT-1) inhibitor. Synonyms: 4-(4-(tert-butylamino)piperidin-1-yl)-N-(4-chlorobenzyl)quinolin-2-amine. CAS No. 1914148-72-3. Molecular formula: C25H31ClN4. Mole weight: 423.00.
Ezurpimtrostat hydrochloride
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GNS561 hydrochloride. CAS No. 1914148-73-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137978A.
Ezutromid
Ezutromid, also known as BMN-195 and SMTC-1100, is an orally bioavailable and non-toxic small molecule that transcriptionally upregulates the utrophin gene (EC50= 0.4 uM), increasing both utrophin mRNA and protein. It significantly reduces dystrophin-deficient muscle pathology in vivo. Synonyms: 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole; BMN-195; BMN 195; BMN195; SMTC-1100; SMTC1100; SMTC 1100; VOX-C1100; Ezutromid. CAS No. 945531-77-1. Molecular formula: C19H15NO3S. Mole weight: 337.39.