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EX-527 R-enantiomer is the R-enantiomer of EX-527, which is a potent and selective SIRT1 inhibitor and with no inhibition on SIRT3 and SIRT3. It is a negative control of the active form EX-527 S-enantiomer. Synonyms: Selisistat R-enantiomer; (R)-Selisistat; EX-527(R); EX 527(R); EX527(R). Grades: >98%. CAS No. 848193-69-1. Molecular formula: C13H13ClN2O. Mole weight: 248.71.
EX 527 (Selisistat, EX527, SIRT1 Inhibitor III)
EX 527 (Selisistat, EX527, SIRT1 Inhibitor III). Group: Biochemicals. Alternative Names: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide. Grades: Highly Purified. CAS No. 49843-98-3. Pack Sizes: 10mg. Molecular Formula: C13 H13 ClN 2, Molecular Weight: 248.7. US Biological Life Sciences.
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EX-527 S-enantiomer
EX-527 S-enantiomer is the S-enantiomer of EX-527, which is a potent and selective SIRT1 inhibitor and with no inhibition on SIRT3 and SIRT3. Synonyms: Selisistat S-enantiomer; EX-527(S); (S)-Selisistat; EX 527(S); EX527(S); EX-527S; EX527S. Grades: >98%. CAS No. 848193-68-0. Molecular formula: C13H13ClN2O. Mole weight: 248.71.
Selective SIRT1 inhibitor (IC50=98nM). Does not inhibit other HDACs or SIRT family members. Group: Biochemicals. Alternative Names: 6-Chloro-2,3,4,9-tetrahydro-1Hcarbazole- 1-carboxamide (racemic). Grades: Highly Purified. CAS No. 49843-98-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
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EX-A202
GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection. GSK2838232 is a betulin derivative. Synonyms: GSK2838232; GSK-2838232; GSK 2838232. Grades: 98%. CAS No. 1443461-21-9. Molecular formula: C48H73ClN2O6. Mole weight: 809.57.
Exalamide
Exalamide. Group: Biochemicals. Alternative Names: HBA, hyperan, 2-(hexyloxy)benzamide. Grades: Highly Purified. CAS No. 53370-90-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C13H19NO2. US Biological Life Sciences.
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Exalamide
Exalamide is a derivative of salicylamide used as an antifungal. Uses: Used as an antifungal. Synonyms: 2-(Hexyloxy)benzamide; 2-hexoxybenzamide. Grades: ≥95%. CAS No. 53370-90-4. Molecular formula: C13H19NO2. Mole weight: 221.3.
Exalamide
Exalamide (2-(Hexyloxy)benzamide), an arenecarboxamide, is a potent antifungal agent. Group: Inhibitors. Alternative Names: 2-(hexyloxy)-benzamid; 2-n-hexyloxybenzamide; h.p.216; o-hexyloxy-benzamid; 2-(HEXYLOXY)BENZAMIDE; HBA; HYPERAN; EXALAMIDE. CAS No. 53370-90-4. Molecular formula: C13H19NO2. Mole weight: 221.3. Appearance: White Solid. Purity: 0.9993. Canonical SMILES: O=C(N)C1=CC=CC=C1OCCCCCC. Density: 1.03 g/cm³. Catalog: ACM53370904.
Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Group: Inhibitors. Alternative Names: 10H,13H-BENZO[DE]PYRANO[3,4:6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT);exatecan alideximer;(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3,4:6,7)indolizino(1,2-b)quinoline-10,13-dione;Exatecan;DX 8951. CAS No. 171335-80-1. Molecular formula: C24H22FN3O4. Mole weight: 435.45. Purity: 0.994. Catalog: ACM171335801.
Exatecan
Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer. Uses: Topoisomerase i inhibitors. Synonyms: DX-8951; (1S, 9S)-1-Amino-9-ethyl-5-fluoro-1, 2, 3, 9, 12, 15-hexahydro-9-hydroxy-4-methyl-10H, 13H-benzo(de)pyrano(3', 4':6, 7)indolizino(1, 2-b)quinoline-10, 13-dione; 10H, 13H-Benzo(de)pyrano(3', 4':6, 7)indolizino(1, 2-b)quinoline-10, 13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-; NSC-829066. Grades: ≥95%. CAS No. 171335-80-1. Molecular formula: C24H22FN3O4. Mole weight: 435.45.
Exatecan
Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC 50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DX-8951. CAS No. 171335-80-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631.
Exatecan mesylate
Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC 50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DX8951f. CAS No. 169869-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-13631A.
Excess aluminum Ti3AlC2 MXene
Excessive aluminum Ti3AlC2 and rich aluminum lead to improved structural order and morphology of Ti3AlC2 grains, while also reducing oxygen activity, producing the highest stoichiometric MAX phase without affecting the quality of the obtained MXene. Uses: Hot press, mxene precursor. Group: Mxenes materials.
Exchange Reaction Buffer 10X
Exchange reaction buffer (10X) for P4410. Group: Molecular Biology. Alternative Names: For use with T4 polynucleotide kinase. Pack Sizes: 200ul, 1x1ml. US Biological Life Sciences.
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Exemestane
Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC 50 s of 30 nM and 40 nM for human placenta l and rat ovarian aromatase , respectively. Exemestane can be used for hormone-dependent breast cancer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FCE 24304; EXE. CAS No. 107868-30-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13632.
An antineoplastic (hormonal). Group: Biochemicals. Alternative Names: 6-Methyleneandrosta-1,4-diene-3,17-dione-19-d3;FCE 24304-19-d3; Aromasin-19-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
An antineoplastic (hormonal). Group: Biochemicals. Alternative Names: 6-Methyleneandrosta-1,4-diene-3,17-dione, FCE-24304, Aromasin. Grades: Highly Purified. CAS No. 107868-30-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Exemestane-D2
Exemestane-D2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C20H22D2O2. Mole Weight: 298.42. Catalog: APB07753.
Exemestane EP Impurity B
Exemestane EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 184972-09-6. Molecular Formula: C20H26O3. Mole Weight: 314.43. Catalog: APB184972096.
Exemestane EP Impurity C
Exemestane EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2130745-60-5. Molecular Formula: C21H24O2. Mole Weight: 308.42. Catalog: APB2130745605.
Exemestane EP Impurity E
Exemestane EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 19457-55-7. Molecular Formula: C20H26O2. Mole Weight: 298.43. Catalog: APB19457557.
Exemestane EP Impurity F
Exemestane EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,10R,13S,14S)-10,13-Dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,6,17-trione. CAS No. 72648-46-5. Molecular Formula: C19H22O3. Mole Weight: 298.38. Catalog: APB72648465.
Exemestane EP Impurity H
Exemestane EP Impurity H. Uses: For analytical and research use. Group: Impurity standards. CAS No. 122370-91-6. Molecular Formula: C20H26O2. Mole Weight: 298.43. Catalog: APB122370916.
Exemestane EP Impurity I
Exemestane EP Impurity I. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C21H26O3. Mole Weight: 326.44. Catalog: APB07754.
Exemestane Impurity 1
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 1,2-α-Epoxy Exemestane; (1α,2α)-1,2-Epoxy-6-methyleneandrost-4-ene-3,17-dione. Grades: > 95%. CAS No. 159354-61-7. Molecular formula: C20H24O3. Mole weight: 312.41.
Exemestane Impurity 1
Exemestane Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 159354-61-7. Molecular Formula: C20H24O3. Mole Weight: 312.41. Catalog: APB159354617.
Exemestane Impurity 10
Exemestane Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl 4-methylbenzenesulfonate. Molecular Formula: C27H32O5S. Mole Weight: 468.6. Catalog: APB05409.
Exemestane Impurity 10
Exemestane Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 881896-95-3. Molecular Formula: C21H28O3. Mole Weight: 328.45. Catalog: APB881896953.
Exemestane Impurity 11
Exemestane Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,10R,13S,14S)-6-(ethoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione. Molecular Formula: C22H32O3. Mole Weight: 344.49. Catalog: APB05407.
Exemestane Impurity 11
Exemestane Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 107868-36-0. Molecular Formula: C20H23ClO2. Mole Weight: 330.85. Catalog: APB107868360.
Exemestane Impurity 12
Exemestane Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-6-yl)methyl 4-methylbenzenesulfonate. Molecular Formula: C27H34O5S. Mole Weight: 470.62. Catalog: APB05408.
Exemestane Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 152764-29-9. Molecular Formula: C20H26O3. Mole Weight: 314.43. Catalog: APB152764299.
Exemestane Impurity 14
Exemestane Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,8S,9S,10R,13R,14S,17R)-17-((2R,5R)-5,6-dimethylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol. Molecular Formula: C28H48O. Mole Weight: 400.68. Catalog: APB05405.
Exemestane Impurity 15
Exemestane Impurity 15. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,8S,9S,10R,13R,14S,17R)-17-((2R,5S,E)-5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol. Molecular Formula: C29H48O. Mole Weight: 412.69. Catalog: APB05404.
Exemestane Impurity 15
Exemestane Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 67737-88-6. Molecular Formula: C27H40N2O. Mole Weight: 408.63. Catalog: APB67737886.
Exemestane Impurity 16
Exemestane Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,8S,9S,10R,13R,14S,17R)-17-((2R,5R)-5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol. CAS No. 83-46-5. Molecular Formula: C29H50O. Mole Weight: 414.71. Catalog: APB83465.
Exemestane Impurity 16
Exemestane Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 184972-11-0. Molecular Formula: C20H26O4. Mole Weight: 300.42. Catalog: APB184972110.
Exemestane Impurity 2
Exemestane Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2467590-81-2. Molecular Formula: C20H24O2. Mole Weight: 296.41. Catalog: APB2467590812.
Exemestane Impurity 3
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 6,16-Dimethylideneandrosta-1,4-diene-3,17-dione. Grades: > 95%. Molecular formula: C21H24O2. Mole weight: 308.42.
Exemestane Impurity 3
Exemestane Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1012054-48-6. Molecular Formula: C20H28O3. Mole Weight: 316.44. Catalog: APB1012054486.
Exemestane Impurity 4
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 16-methylideneandrosta-1,4-diene-3,17-dione. Grades: > 95%. Molecular formula: C20H24O2. Mole weight: 296.41.
Exemestane Impurity 5
Exemestane Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C20H24O2. Mole Weight: 296.41. Catalog: APB07755.
Exemestane Impurity 6
Exemestane Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1331732-05-8. Molecular Formula: C20H26O3. Mole Weight: 314.43. Catalog: APB1331732058.
Exemestane Impurity 8 (Testosterone Impurity 6)
Exemestane Impurity 8 (Testosterone Impurity 6). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1035-69-4. Molecular Formula: C19H24O2. Mole Weight: 284.4. Catalog: APB1035694.
Exemestane Impurity E
Exemestane Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2'R, 8R, 9S, 10R, 13S, 14S) -10, 13-dimethyl-7, 8, 9, 11, 12, 13, 15, 16-octahydrospiro [cyclopenta [a]phenanthrene-6, 2'-oxirane]-3, 17 (10H, 14H) -dione. CAS No. 152764-24-4. Molecular Formula: C20H24O3. Mole Weight: 312.4. Catalog: APB152764244.
Exemestane Impurity G
Exemestane Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2'S, 8R, 9S, 10R, 13S, 14S) -10, 13-dimethyl-7, 8, 9, 11, 12, 13, 15, 16-octahydrospiro [cyclopenta [a]phenanthrene-6, 2'-oxirane]-3, 17 (10H, 14H) -dione. CAS No. 152764-31-3. Molecular Formula: C20H24O3. Mole Weight: 312.4. Catalog: APB152764313.
Exemestane Impurity H
Exemestane Impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one. Molecular Formula: C20H26O2. Mole Weight: 298.42. Catalog: APB05414.
Exemestane Impurity I
Exemestane Impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-6-methylene-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl formate. Molecular Formula: C21H26O3. Mole Weight: 326.43. Catalog: APB05412.
Exemestane Impurity J
Exemestane Impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-6-methylene-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate. Molecular Formula: C22H28O3. Mole Weight: 340.46. Catalog: APB05413.
Exemestane Impurity JQ
Exemestane Impurity JQ. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,10R,13S,14S)-6-hydroxy-6,10,13-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione. Molecular Formula: C20H26O3. Mole Weight: 314.42. Catalog: APB05411.
Exemestane mesylate analogue. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl methanesulfonate. CAS No. 861395-77-9. Molecular Formula: C21H28O5S. Mole Weight: 392.51. Catalog: APB861395779.
Exemestane Metabolite 1
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 17β-Hydroxy Exemestane Sulfamate; (17β)-17-[(Aminosulfonyl)oxy]-6-methyleneandrosta-1,4-dien-3-one. Grades: > 95%. Molecular formula: C20H27NO4S. Mole weight: 377.51.
Exemestane Metabolite 2
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 6-Hydroxy-6-(methoxymethyl)-androsta-1,4-diene-3,17-dione. Grades: > 95%. Molecular formula: C21H28O4. Mole weight: 344.45.
Exemestane Related Compound
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 6α-(Methoxymethyl)androsta-1,4-dien-3,17-dione. Grades: > 95%. CAS No. 881896-95-3. Molecular formula: C21H28O3. Mole weight: 328.46.
Exemestane Related Compound 1
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 6β-(Formyl)androsta-1,4-dien-3,17-dione. Grades: > 95%. Molecular formula: C20H24O3. Mole weight: 312.41.
Exemestane Related Compound 2
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 17-hydroxy-8,10,13-trimethyl-3-oxo--decahydro-3H-cyclopenta[a]phenanthrene-6-carboxylic acid. Grades: > 95%. Molecular formula: C20H24O3. Mole weight: 312.41.
Exemestane Related Compound 2 (17-alpha isomer)
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 17-alpha-hydroxy-8,10,13-trimethyl-3-oxo--decahydro-3H-cyclopenta[a]phenanthrene-6-carboxylic acid. Grades: > 95%. Molecular formula: C20H24O3. Mole weight: 312.41.
Exemestane Related Compound 2 (17-beta isomer)
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 17-beta-hydroxy-8,10,13-trimethyl-3-oxo--decahydro-3H-cyclopenta[a]phenanthrene-6-carboxylic acid. Grades: > 95%. Molecular formula: C20H24O3. Mole weight: 312.41.
Exemestane Related Compound 3
Exemestane Related Compound 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 933455-73-3. Molecular Formula: C21H28O3. Mole Weight: 328.45. Catalog: APB933455733.
Exemestane Related Compound A
A metabolite of Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: 1,2-Dihydro Exemestane; 6-Methyleneandrost-4-ene-3,17-dione; 6-Methyleneandrost-4-en-3,17-dione. Grades: > 95%. CAS No. 19457-55-7. Molecular formula: C20H26O2. Mole weight: 298.43.
Exemestane Related Compound B
Isotope labelled Exemestane. Exemestaneis a third generation, irreversible steroidal aromatase inhibitor that induces aromatase degradation leading to a decrease in estrogen levels in plasma. Synonyms: Androsta-1,4-diene-3,17-dione, 6-(hydroxymethyl). Grades: > 95%. CAS No. 184972-09-6. Molecular formula: C20H26O3. Mole weight: 314.43.
Exemestane (Standard)
Exemestane (Standard) is the analytical standard of Exemestane. This product is intended for research and analytical applications. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC 50 s of 30 nM and 40 nM for human placenta l and rat ovarian aromatase , respectively. Exemestane can be used for hormone-dependent breast cancer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FCE 24304(Standard); EXE (Standard). CAS No. 107868-30-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13632R.
Exenatide
Exenatide, naturally occured in the saliva of the Gila monster, an incretin mimetic that has glucoregulatory effect. As a glucagon-like peptide-1 (GLP-1) receptor agonist, it stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways. Uses: Hypoglycemic agents. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-; L-Histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide; Exendin 3 (Heloderma horridum), 2-glycine-3-L-glutamic acid-; Exendin 4 (Heloderma suspectum); AC 2993; AC 2993A; AC 2993LAR; Bydureon; Byetta; DA 3091; EQW; Exatenide; Exenatide LAR; Exendin 4; Exendin-4; ITCA 650; LAEx4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. CAS No. 141758-74-9. Molecular formula: C184H282N50O60S. Mole weight: 4186.56.
Exenatide acetate
Exenatide acetate is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor with Ki value of 136 pM. It is a 39 amino acid peptide, which increases intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. It was first isolated from the venom of H. horridum and consequently synthesized. It stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1 receptor-dependent mechanism. It also stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells. It protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neurodegenerative diseases. It also has anxiolytic and anti-depressant effects and induces satiety. It is an incretin mimetic approved for type 2 diabetes mellitus treatment. It also has neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-, acetate (1:x); Exendin 4 (Heloderma suspectum), acetate; Exendin-4 acetate; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.CH3CO2H. Grades: >98%. CAS No. 914454-01-6. Molecular formula: C184H282N50O60S.C2H4O2. Mole weight: 4246.61.