A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Ezlopitant, also known as CJ-11,974, is a NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Synonyms: CJ 11,974; CJ-11974; CJ11974; (7S,8S)-7-[di(phenyl)methyl]-N-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine. CAS No. 147116-64-1. Molecular formula: C31H38N2O. Mole weight: 454.66.
EZM0414
EZM0414 is a first-in-class and oral SETD2 inhibitor, which is under research for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Synonyms: EZM0414; 2411748-50-8; KCY37T9RXU; EZM-0414; UNII-KCY37T9RXU; N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, N-((1R,3S)-3-(4-acetyl-1-piperazinyl)cyclohexyl)-4-fluoro-7-methyl-; N-((1R,3S)-3-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1H-indole-2-carboxamide; CHEMBL5095235; SCHEMBL21739955; GLXC-25885; BDBM50594406; NSC841441; AKOS040760023; AT34570; NSC-841441; MS-26809; CS-0435622; KS6. Molecular formula: C22H29FN4O2. Mole weight: 400.49.
EZM0414
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411748-50-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144858.
EZM0414 TFA
EZM0414 (SETD2-IN-1) TFA is the TFA salt form of EZM0414 (HY-144858). EZM0414 TFA is a potent, selective, orally active inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 TFA can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SETD2-IN-1 TFA. CAS No. 2411759-92-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136328.
EZM2302
EZM2302 is an inhibitor of CARM1 enzymatic activity in biochemical assays (IC50?=?6?nM) with broad selectivity against other histone methyltransferases. Synonyms: EZM 2302; EZM-2302; methyl (R)-2-(2-(2-chloro-5-(2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate. Grade: >98%. CAS No. 1628830-21-6. Molecular formula: C29H37ClN6O5. Mole weight: 585.1.
EZM 2302 is a potent and orally active CARM1 inhibitor with an IC50 value of 6 nM. EZM 2302 shows antiproliferative activity and anti-tumor activity. EZM 2302 inhibits PABP1 and SMB expression[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628830-21-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111109.
Ezomycin A1
Ezomycin A1 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 39422-19-0. Molecular formula: C26H38N8O15S. Mole weight: 734.69.
Ezomycin A2
Ezomycin A2 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 54328-22-2. Molecular formula: C19H26N6O12. Mole weight: 530.44.
Ezomycin B2
Ezomycin B2 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 57973-16-7. Molecular formula: C19H25N5O13. Mole weight: 531.43.
Ezomycin D2
Ezomycin D2 is an antifungal antibiotic produced by Streptomyces kitazawaensis 009. It is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on sclerotinia, botrytis and candidiasis of crops. CAS No. 57973-11-2. Molecular formula: C19H27N5O14. Mole weight: 549.44.
A cell-permeable, quinoline that binds directly to ezrin (=12.6uM) in a reversible manner, and inhibits PKC?-mediated ezrin phosphorylation at Thr567 (IC50=8.1uM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10uM. At 10uM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10uM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vitro at 2.26mg/kg/day. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
E,Z-trans-3-(2-Chloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is the photolysis product of Permethrin, which is a medication and an insecticide used to treat scabies and lice. Synonyms: E,Z-trans-3-(2-Chlorovinyl)-2,2-dimethylcyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 3-[(1E)-2-chloroethenyl]-2,2-dimethyl-, (1R,3S)-rel-; rel-(1R,3S)-3-((E)-2-chlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid; Cyclopropanecarboxylic acid, 3-(2-chloroethenyl)-2,2-dimethyl-, [1α,3β(E)]-. Grade: 98%. CAS No. 61914-45-2. Molecular formula: C8H11ClO2. Mole weight: 174.62.
Ezurpimtrostat
Ezurpimtrostat is a palmitoyl protein thioesterase 1 (PPT-1) inhibitor. Synonyms: 4-(4-(tert-butylamino)piperidin-1-yl)-N-(4-chlorobenzyl)quinolin-2-amine. CAS No. 1914148-72-3. Molecular formula: C25H31ClN4. Mole weight: 423.00.
Ezurpimtrostat hydrochloride
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GNS561 hydrochloride. CAS No. 1914148-73-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137978A.
Ezutromid
Ezutromid, also known as BMN-195 and SMTC-1100, is an orally bioavailable and non-toxic small molecule that transcriptionally upregulates the utrophin gene (EC50= 0.4 uM), increasing both utrophin mRNA and protein. It significantly reduces dystrophin-deficient muscle pathology in vivo. Synonyms: 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole; BMN-195; BMN 195; BMN195; SMTC-1100; SMTC1100; SMTC 1100; VOX-C1100; Ezutromid. CAS No. 945531-77-1. Molecular formula: C19H15NO3S. Mole weight: 337.39.