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| Product | Description | |
|---|---|---|
| Ezetimibe-d4 phenolic glucuronide | One of the isotope labelled impurities of Ezetimibe, which could be used as an antihyperlipoproteinemic agent. Synonyms: 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid-d4. Molecular formula: C30H25D4F2NO9. Mole weight: 589.58. |  |
| Ezetimibe Dehydoxy Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L16) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3-Dehydroxy Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone. Grade: > 95%. CAS No. 204589-58-2. Molecular formula: C24H21F2NO2. Mole weight: 393.44. | |
| Ezetimibe Deprotected Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L13) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((2R,5S)-5-(4-fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. Grade: 95%. CAS No. 1185883-40-2. Molecular formula: C33H30F2N2O5. Mole weight: 572.61. | |
| Ezetimibe Desfluoro Chloro Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L29) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe; (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H21ClFNO3. Mole weight: 425.89. | |
| Ezetimibe Desfluoro Dehydoxy Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L45) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-3-((S)-3-(benzyloxy)-3-(4-fluorophenyl)propyl)-1-(3-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H22FNO2. Mole weight: 375.45. | |
| Ezetimibe Desfluoro Methyl Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L30) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 4"DeFluoro-4"methyl-ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-hydroxy-3-(p-tolyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. CAS No. 1700622-07-6. Molecular formula: C25H24FNO3. Mole weight: 405.47. | |
| Ezetimibe-D-glucuronide-[d4] | Ezetimibe-D-glucuronide-[d4] is an esteemed compound in the biomedical field, aiding in the research of hypercholesterolemia and familial hypercholesterolemia. Manifesting as a remarkable cholesterol absorption inhibitor, it deftly curtails cholesterol levels through the hindrance of intestinal cholesterol assimilation and associated phytosterol uptake. Synonyms: Ezetimibe-d4 β-D-Glucuronide; Ezetimibe-D-glucuronide D4. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. | |
| Ezetimibe Diacetate | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L5) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-4-[4-(acetyloxy)phenyl]-1-(4-fluorophenyl)-2-azetidinone. Grade: > 95%. CAS No. 163380-20-9. Molecular formula: C28H25F2NO5. Mole weight: 493.51. | |
| Ezetimibe Diacetate | Protected Ezetimibe derivative. Group: Biochemicals. Alternative Names: (3R,4S)-. Grades: Highly Purified. CAS No. 163380-20-9. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Ezetimibe (Diacid Impurity) | An open-ringed diacid impurity of Ezetimibe. Group: Biochemicals. Alternative Names: (2R) -2- [ (S) - [ (4-Fluorophenyl) amino] [4- (phenylmethoxy) phenyl] methyl] pentanedioic Acid. Grades: Highly Purified. CAS No. 1013025-04-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ezetimibe Diacid Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: ((2R,3S)-2-[(4-Benzyloxyphenyl)-4-(4-Fluorophenylamino)methyl]pentanedioic acid). Grade: > 95%. CAS No. 1013025-04-1. Molecular formula: C25H24FNO5. Mole weight: 437.47. | |
| Ezetimibe diastereomers | An impurity of Ezetimibe. Ezetimibe is a selective cholesterol absorption inhibitor that targets the Niemann-Pick C1-Like 1 (NPC1L1) protein in the small intestine, blocking dietary and biliary cholesterol uptake. Synonyms: Ezetimibe R,R,R- and S,S,S-isomer; R,R,R-Ezetimibe and S,S,S-Ezetimibe; (3S,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one and (3R,4R)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; S,S,S-Ezetimibe and R,R,R-Ezetimibe. Grade: ≥95%. Molecular formula: C24H21F2NO3. Mole weight: 409.43. | |
| Ezetimibe Diol | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L22) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (1S,4R)-1-(4-Fluorophenyl)-4-[(S)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-1,5-pentanediol. Grade: > 95%. CAS No. 1374250-08-4. Molecular formula: C24H25F2NO3. Mole weight: 413.47. | |
| Ezetimibe Fluoro Isomer | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L9) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-; (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; Ezetimibe o-Fluorobenzene isomer; O-Fluorobenzene ezetimibe; Ezetimibe ortho-Fluorobenzene Isomer; 3'-(2-Fluorophenyl) Ezetimibe. Grade: ≥95%. CAS No. 2743547-96-6. Molecular formula: C24H21F2NO3. Mole weight: 409.43. | |
| Ezetimibe hydroxy-D-glucuronide-[d4] | Ezetimibe hydroxy-D-glucuronide-[d4] is a metabolite of stable isotope-labeled Ezetimibe, playing a profound role in illuminating the intricate mechanisms of Ezetimibe metabolism, pharmacokinetics and elimination pathways. Synonyms: Ezetimibe hydroxy-D-glucuronide D4. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. | |
| Ezetimibe Hydroxy Glucuronide | A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe Hydroxy β-D-Glucuronide; (1S)-1-(4-Fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-3-azetidinyl]propyl β-D-Glucopyranosiduronic Acid. Grade: > 95%. CAS No. 536709-33-8. Molecular formula: C30H29F2NO9. Mole weight: 585.55. | |
| Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether | Ezetimibe Hydroxy tert-butyldiphenylsilyl ether is a substituted Ezetimibe. Group: Biochemicals. Alternative Names: (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-tert-butyldiphenylsilyloxy-3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone. Grades: Highly Purified. CAS No. 1217748-67-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ezetimibe Impuriry 66 | Ezetimibe Impuriry 66. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1044664-24-5. Molecular formula: C26H23F2NO4. Mole weight: 451.47. Catalog: APB1044664245. |  |
| Ezetimibe Impuriry 74 | Ezetimibe Impuriry 74. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1683564-73-9. Molecular formula: C31H27F2NO3. Mole weight: 499.56. Catalog: APB1683564739. | |
| Ezetimibe Impuriry 75 | Ezetimibe Impuriry 75. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1416263-36-9. Molecular formula: C31H27F2NO3. Mole weight: 499.56. Catalog: APB1416263369. | |
| Ezetimibe Impuriry 82 | Ezetimibe Impuriry 82. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1683564-75-1. Molecular formula: C31H27F2NO3. Mole weight: 499.56. Catalog: APB1683564751. | |
| Ezetimibe Impurity 10 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L44) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C18H18FNO3. Mole weight: 315.35. | |
| Ezetimibe Impurity 2 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L17) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-oxo-3-phenylpropyl)azetidin-2-one. Grade: > 95%. Molecular formula: C31H26FNO3. Mole weight: 479.56. | |
| Ezetimibe Impurity 3 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L18) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-4-(4-(benzyloxy)phenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-1-phenylazetidin-2-one. Grade: > 95%. Molecular formula: C31H26FNO3. Mole weight: 479.56. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(R)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L38) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (4R)-4-Phenyl-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one. Grade: > 95%. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(R)-hydroxy-pentanoyl]-4-(S)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L36) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. Grade: > 95%. CAS No. 528565-93-7. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L37) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (4R)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one. Grade: > 95%. CAS No. 189028-95-3. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(S)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L39) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one. Grade: > 95%. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe Impurity 38 | Ezetimibe Impurity 38. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-((2R,5S)-5-((tert-butyldimethylsilyl)oxy)-2-((S)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one. CAS No. 1701462-59-0. Molecular formula: C45H58F2N2O5Si2. Mole weight: 801.12. Catalog: APB1701462590. | |
| Ezetimibe Impurity 39 | Ezetimibe Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-hydroxybenzaldehyde. CAS No. 123-08-0. Molecular formula: C7H6O2. Mole weight: 122.12. Catalog: APB123080. | |
| Ezetimibe Impurity 4 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L19) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3S,4R)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one. Grade: > 95%. Molecular formula: C31H25F2NO3. Mole weight: 497.55. | |
| Ezetimibe Impurity 49 | Ezetimibe Impurity 49. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: dihydro-2H-pyran-2,6(3H)-dione. CAS No. 108-55-4. Molecular formula: C5H6O3. Mole weight: 114.1. Catalog: APB108554. | |
| Ezetimibe Impurity 5 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L20) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one. Grade: > 95%. Molecular formula: C31H27F2NO3. Mole weight: 499.56. | |
| Ezetimibe Impurity 8 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L42) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. Grade: > 95%. CAS No. 189028-93-1. Molecular formula: C20H18FNO4. Mole weight: 355.37. | |
| Ezetimibe Impurity 8 Enantiomer | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L46) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone. Grade: > 95%. CAS No. 404874-93-7. Molecular formula: C20H18FNO4. Mole weight: 355.37. | |
| Ezetimibe Impurity 9 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L43) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-((trimethylsilyl)oxy)phenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one; 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone. Grade: > 95%. CAS No. 272778-12-8. Molecular formula: C39H46F2N2O5Si2. Mole weight: 716.98. | |
| Ezetimibe Impurity B | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L14) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: methyl 5-(4-fluorophenyl)-5-hydroxypentanoate. Grade: > 95%. CAS No. 870634-36-9. Molecular formula: C12H15FO3. Mole weight: 226.25. | |
| Ezetimibe Impurity G | Ezetimibe Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1700622-06-5. Molecular formula: C24H21F2NO3. Mole weight: 409.43. Catalog: APB1700622065. | |
| Ezetimibe Impurity I | Ezetimibe Impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-(p-tolyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1700622-07-6. Molecular formula: C25H24FNO3. Mole weight: 405.46. Catalog: APB1700622076. | |
| Ezetimibe Impurity J | Ezetimibe Impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. CAS No. 1700622-08-7. Molecular formula: C24H21ClFNO3. Mole weight: 425.88. Catalog: APB1700622087. | |
| Ezetimibe Impurity L | Ezetimibe Impurity L. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-N,5-bis(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide. CAS No. 1510820-22-0. Molecular formula: C24H23F2NO2. Mole weight: 395.44. Catalog: APB1510820220. | |
| Ezetimibe Impurity (Tetrahydro-pyran-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L35) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,6R)-6-(4-fluorophenyl)-3-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)tetrahydro-2H-pyran-2-one. Grade: > 95%. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ezetimibe ketone | Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 ( NPC1L1 ) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EZM-K. CAS No. 191330-56-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-133114. |  |
| Ezetimibe ketone | Ezetimibe ketone. Group: Biochemicals. Alternative Names: (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone; EZM-K. Grades: Highly Purified. CAS No. 191330-56-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C24H19F2NO3. US Biological Life Sciences. | Worldwide |
| Ezetimibe Ketone | A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone; EZM-K; Ezetimibe 3-Oxo Impurity; 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R-trans)-. Grade: >95%. CAS No. 191330-56-0. Molecular formula: C24H19F2NO3. Mole weight: 407.42. | |
| Ezetimibe Lactam Cleaved Alcohol | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L23) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3'-Anhydro Ezetimibe Alcohol Impurity; (βR,γS)-γ-[(4-Fluorophenyl)amino]-β-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanol. Grade: > 95%. CAS No. 1374250-07-3. Molecular formula: C24H23F2NO2. Mole weight: 395.45. | |
| Ezetimibe-[N-(4-fluorophenyl-d4)] | Ezetimibe-[N-(4-fluorophenyl-d4)] is the labelled analogue of Ezetimibe, which is a cholesterol absorption inhibitor. Synonyms: Ezetimibe-d4 [N-(4-fluorophenyl-d4)]; Ezetimibe-d4; Ezetimibe D4 (Fluoroaniline-d4); (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone-d4; (3R,4S)-1-(4-fluorophenyl-2,3,5,6-d4)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: ≥95%. CAS No. 1093659-90-5. Molecular formula: C24H17D4F2NO3. Mole weight: 413.45. | |
| Ezetimibe phenoxy glucuronide | Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity [1]. Ezetimibe is a potent cholesterol absorption inhibitor [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ezetimibe glucuronide; Ezetimibe β-D-glucuronide. CAS No. 190448-57-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-135391. | |
| Ezetimibe phenoxy glucuronide | A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl β-D-glucopyranosiduronic acid; Ezetimibe glucuronide; Sch 58235 glucuronide; Sch 60663; Ezetimibe β-D-Glucuronide; Ezetimibe phenoxy-β-D-glucuronide. Grade: >95%. CAS No. 190448-57-8. Molecular formula: C30H29F2NO9. Mole weight: 585.55. | |
| Ezetimibe Phenoxy Glucuronide-[d4] | Ezetimibe Phenoxy Glucuronide-[d4] is the labelled analogue of Ezetimibe Phenoxy Glucuronide, which is a metabolite of Ezetimibe. Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe D4 Phenoxy Glucuronide. Grade: 95% by HPLC; 98% atom D. CAS No. 1426174-41-5. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. | |
| Ezetimibe Phenoxy tert-Butyldiphenylsilyl Ether | Ezetimibe Phenoxy tert-butyldiphenylsilyl ether is a substituted Ezetimibe. Group: Biochemicals. Alternative Names: (3R, 4S) -1- (4-Fluorophenyl ) -3- [ (3S) -3- (4-fluorophenyl ) -3- hydroxypropyl ] -4- (4-tert-butyl diphenyl silyl oxyphenyl ) -2-azetidinone. Grades: Highly Purified. CAS No. 1042722-66-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ezetimibe Related Impurity 6 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L40) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(3-fluorophenyl)-3-((S)-3-(3-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ezetimibe Related Impurity 7 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L41) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(3-fluorophenyl)-3-((E)-3-(3-fluorophenyl)allyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. CAS No. 204589-68-4. Molecular formula: C24H19F2NO2. Mole weight: 391.42. | |
| Ezetimibe Ring-Open Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L15) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide. Grade: > 95%. CAS No. 1197811-72-5. Molecular formula: C24H23FNO3. Mole weight: 411.45. | |
| Ezetimibe ring-opening dehydrate impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L31) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (αR,βS)-β-[(4-Fluorophenyl)amino]-α-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanoic Acid. Grade: > 95%. CAS No. 1292292-63-7. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ezetimibe System Suitability Mixture | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Ezetimibe tetrahydropyran analog | An impurity of Ezetimibe. Ezetimibe is a cholesterol absorption inhibitor used to reduce low-density lipoprotein (LDL) cholesterol levels in the blood. It is commonly used alone or in combination with other cholesterol-lowering medications, such as statins, to manage hypercholesterolemia and related conditions. Synonyms: N,6-Bis(4-fluorophenyl)-2-(4-hydroxyphenyl)tetrahydro-2H-pyran-3-carboxamide; Ezetimibe Tetrahydropyran Impurity; Ezetimibe THP analog; Ezetimibe Cyclized Impurity; Ezetimibe Cyclic ether; Ezetimibe Cyclic Ether Impurity; N,6-Bis(4-fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-2H-pyran-3-carboxamide. Grade: ≥95%. CAS No. 1050631-82-7. Molecular formula: C24H21F2NO3. Mole weight: 409.43. | |
| Ezetimibe Triol Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L48) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R,5R)-3-(4-fluorophenyl)-5-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-((S)-2-hydroxy-1-phenylethyl)-4-(4-hydroxyphenyl)piperidine-2,6-dione. Grade: > 95%. Molecular formula: C33H30F2N2OS. Mole weight: 572.61. | |
| EZH1/EED/SUZ12 human | recombinant, expressed in baculovirus infected insect cells. Group: Fluorescence/luminescence spectroscopy. | |
| EZH1/EED/SUZ12/RbAp48/AEBP2 human | recombinant, expressed in baculovirus infected insect cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EZH2/EED inactive human | recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EZH2 / EED / SUZ12 human | recombinant, expressed in baculovirus infected insect cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EZH2/EED/SUZ12/RbAp48 active human | recombinant, expressed in baculovirus infected Sf9 cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EZH2/EED/SUZ12/RbAp48/AEBP2 human | recombinant, expressed in baculovirus infected insect cells. Group: Fluorescence/luminescence spectroscopy. | |
| EZH2 human | recombinant, expressed in baculovirus infected Sf9 cells, ?49% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EZH2-IN-14 | EZH2-IN-14 is a selective EZH2 ( Histone Methyltransferase ) inhibitor with an IC 50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1979157-17-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148458. | |
| EZH2-IN-5 | EZH2-IN-5 is a potent inhibitor of EZH2 with IC50s of 1.52 and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively. Synonyms: Benzamide, 5-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[[trans-4-(dimethylamino)cyclohexyl]ethylamino]-2-methyl-. CAS No. 1403258-69-4. Molecular formula: C26H37BrN4O2. Mole weight: 517.50. | |
| EZH2-IN-6 | EZH2-IN-6, an inhibitor of EZH2, has enhanced antitumor activity. Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, 1-[(1R)-1-[trans-4-[3-(cyclopropyloxy)-1-azetidinyl]cyclohexyl]ethyl]-N-[[1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl]methyl]-2-methyl-. CAS No. 2702269-27-8. Molecular formula: C31H41N5O3S. Mole weight: 563.75. | |
| Ezh2 Inhibitor II, EI1(Enhancer of Zested Homolog 2 Inhibitor II, HMTase Inhibitor XI, 6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide) | A cell-permeable indolocarboxamide compound that acts as a potent and selective inhibitor against Ezh2/PRC2 (Polycomb repressive complex 2; Ezh2 / SUZ12 / EED / AEBP2 / RbAP48) HMTase activity (IC50/substrate = 15nM/H3K27me021-44 and 13nM/H3K27me221-44, respectively, against human wt or Y641F Ezh2-containing PRC2; [SAM] = 1uM) in a cofactor SAM-competitive manner, while inhibiting Ezh1/PRC2 only at much higher concentrations (IC50 = 1.34uM) and exhibiting no potency toward CARM 1, Dot1L, G9a, MLL, NSD3, Set7/9, SETD2, SETD8, SmyD2, or Suv39H2 (IC50 >100uM). Shown to suppress cellular H3K27 dimethylation and trimethylation (1 to 10uM) in DLBCL cultures and exhibit antiproliferation activity against DLBCL cell lines with wt or mutant Ezh2 (3.3uM to 10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: Ezh2/PRC2. US Biological Life Sciences. | Worldwide |
| EZH2/SUZ12/RbAp48 human | recombinant, expressed in baculovirus infected Sf9 cells, ?88% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
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