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L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1). It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%). Synonyms: L-erythro-C18-Sphingosine; (E,2R,3S)-2-aminooctadec-4-ene-1,3-diol. Grades: ≥98%. CAS No. 6036-75-5. Molecular formula: C18H37NO2. Mole weight: 299.49.
L-Erythrulose
L-Erythrulose is a prominent compound widely used in the cosmetic industry for its self-tanning properties. This colorless ketose sugar reacts with the amino acids in the skin's outermost layer to produce a natural, long-lasting tan, making it a sought-after ingredient in self-tanning lotions and sprays. Synonyms: L-Erythrulose; 533-50-6; L-glycero-Tetrulose; L-(+)-Erythrulose; (3S)-1,3,4-trihydroxybutan-2-one; (3S)-1,3,4-Trihydroxy-2-butanone; UNII-WKK1W5B83O; WKK1W5B83O; (S)-1,3,4-Trihydroxybutan-2-one; 2-Butanone, 1,3,4-trihydroxy-, (3S)-; ERYTHRULOSE, L-; FM-MH; ERYTHRULOSE [INCI]; L-ERYTHRULOSE [MI]; ERYTHRULOSE, (+)-; SCHEMBL439347; CHEBI:27913; UQPHVQVXLPRNCX-VKHMYHEASA-N; DTXSID801019042; BCP10464; MFCD00004703; AKOS028108990; 2-Butanone,1,3,4-trihydroxy-,(3S)-; L-(+)-Erythrulose, >=85% (HPLC); CS-0436802; C02045; EN300-7592871; W-203014; Q27103403; Erythrulose, Pharmaceutical Secondary Standard; Certified Reference Material. CAS No. 533-50-6. Molecular formula: C4H8O4. Mole weight: 120.1.
L-erythrulose 1-phosphate isomerase
The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism. Group: Enzymes. Synonyms: eryH (gene name). Enzyme Commission Number: EC 5.3.1.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5473; L-erythrulose 1-phosphate isomerase; EC 5.3.1.33; eryH (gene name). Cat No: EXWM-5473.
L-erythrulose 4-kinase
The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol. Group: Enzymes. Synonyms: lerK (gene name). Enzyme Commission Number: EC 2.7.1.209. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3044; L-erythrulose 4-kinase; EC 2.7.1.209; lerK (gene name). Cat No: EXWM-3044.
L-erythrulose 4-phosphate epimerase
The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol. Group: Enzymes. Synonyms: lerI (gene name). Enzyme Commission Number: EC 5.1.3.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5426; L-erythrulose 4-phosphate epimerase; EC 5.1.3.39; lerI (gene name). Cat No: EXWM-5426.
Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body. Synonyms: 2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid; RDEA 594; Zurampic; [[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid; Lesinida. Grades: >98%. CAS No. 878672-00-5. Molecular formula: C17H14BrN3O2S. Mole weight: 404.28.
Lesinurad
Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with K m values of 0.85 and 2 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RDEA594. CAS No. 878672-00-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15258.
Lesinurad Impurity 11 is an intermediate of Lesinurad, a HEK293 cell-based inhibitor. Synonyms: Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate; [[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid methyl ester; Acetic acid, 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4h-1,2,4-triazol-3-yl]thio]-, methyl ester. Grades: >95%. CAS No. 1533519-85-5. Molecular formula: C18H17N3O2S. Mole weight: 339.42.
Lesinurad Impurity 15
an intermediate of Lesinurad. Synonyms: 1-cyclopropylnaphthalen. Grades: > 95%. CAS No. 25033-19-6. Molecular formula: C13H12. Mole weight: 168.24.
Lesinurad Impurity 16
An intermediate of Lesinurad, a urate transporter inhibitor used for the treatment of high blood uric acid levels associated with gout. Synonyms: Methyl 2-(5-broMo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate. Grades: > 95%. CAS No. 878671-99-9. Molecular formula: C18H16BrN3O2S. Mole weight: 418.32.
Lesinurad Impurity 18
an intermediate of Lesinurad. Synonyms: [[5-chlorine-4-(4-bromo-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid. Grades: > 95%. Molecular formula: C14H9BrClN3O2S. Mole weight: 398.67.
Lesinurad Impurity 19
an intermediate of Lesinurad. Synonyms: 5-Amino-1-(2-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol. Grades: > 95%. Molecular formula: C15H14N4S. Mole weight: 282.37.
an intermediate of Lesinurad. Synonyms: [[4-(4-bromo-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid. Grades: > 95%. Molecular formula: C14H10BrN3O2S. Mole weight: 364.22.
Lesinurad Impurity C
an intermediate of Lesinurad. Synonyms: [[4-(1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid. Grades: > 95%. CAS No. 1038366-57-2. Molecular formula: C14H11N3O2S. Mole weight: 285.33.
Lesinurad Impurity D
an intermediate of Lesinurad. Synonyms: [[5-bromo-4-(4-bromo-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid. Grades: > 95%. Molecular formula: C14H9Br2N3O2S. Mole weight: 443.12.
Lesinurad Impurity G
an intermediate of Lesinurad. Synonyms: 5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-hydroxy. Grades: > 95%. Molecular formula: C15H12BrN3O. Mole weight: 330.19.
Lesinurad Impurity H
an intermediate of Lesinurad. Synonyms: 5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole. Grades: > 95%. Molecular formula: C15H12BrN3. Mole weight: 314.19.
Lesinurad Impurity I
an intermediate of Lesinurad. Synonyms: [[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]oxo]-acetic Acid. Grades: > 95%. Molecular formula: C17H14BrN3O3. Mole weight: 388.22.
Lesinurad sodium
Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with K m values of 0.85 and 2 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RDEA-594 sodium. CAS No. 1151516-14-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15258A.
Lesinurad sodium
Lesinurad sodium is an once-daily inhibitor of URAT1, which is a transporter in the kidney that regulates uric acid excretion from the body. Synonyms: sodium 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate; sodium Lesinurad; RDEA594 sodium; RDEA 594 sodium; RDEA-594 sodium; Zurampic sodium; Acetic acid, 2-((5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl)thio)-, sodium salt (1:1). Grades: >98%. CAS No. 1151516-14-1. Molecular formula: C17H13BrN3NaO2S. Mole weight: 426.26.
Lesogaberan
Lesogaberan is a potent and selective GABAB receptor agonist that limit the clinical use of baclofen for the treatment of GERD. Uses: Gaba b receptor agonists. Synonyms: AZD-3355; AZD 3355; AZD3355; Lesogaberan.[(2R)-3-amino-2-fluoropropyl]-hydroxy-oxophosphanium. Grades: ≥98%. CAS No. 344413-67-8. Molecular formula: C3H9FNO2P. Mole weight: 141.03.
Lesogaberan hydrochloride
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and GABA A receptors, as measured by displacement of [ 3 H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan hydrochloride inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-3355 hydrochloride. CAS No. 2925644-17-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-10061B.
Lesopitron dihydrochloride
Lesopitron dihydrochloride is a full and selective 5-HT 1A receptor agonist with IC 50 of 125 nM in rat hippocampal membranes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E4424. CAS No. 132449-89-9. Pack Sizes: 1 mg. Product ID: HY-101609.
Lestaurtinib
Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC 50 s of 2, 25 and 0.9 nM for FLT3 , TrkA and JAK2 , respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CEP-701; KT-5555. CAS No. 111358-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-50867.
Lestaurtinib
It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML). Group: Biochemicals. Alternative Names: (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3,2,1-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;A 154475.0; CEP 701 ; KT 5555; SP 924. Grades: Highly Purified. CAS No. 111358-88-4. Pack Sizes: 500ug, 1mg, 2mg, 5mg. US Biological Life Sciences.
Worldwide
Lestaurtinib
Lesraurtinib, also known as CEP701, KT 5555, SP 924, is an orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. Synonyms: CEP-701; KT-5555; SP 924; (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one. Grades: ≥98%. CAS No. 111358-88-4. Molecular formula: C26H21N3O4. Mole weight: 439.46.
Letaxaban
Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma. TAK-442 inhibited in vitro reconstituted human prothrombinase (system included FXa, calcium, and washed platelets) with an IC(50) value of 51 nM. In a rat model of balloon injury, thrombin activity on the surface of injured vessels increased to 3.2-, 22-, and 5.8-fold the activity on the surface of the intact aorta at 5 minutes, 1 hour, and 24 hours after the injury, respectively. At approximately 1 hour after the injury, TAK-442 blocked platelet-associated thrombin generation on the surface of injured aortas with an IC(50) value of 19 nM. Uses: Factor xa inhibitors. Synonyms: TAK-442; TAK 442; TAK442; (S)-1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one. CAS No. 870262-90-1. Molecular formula: C22H26ClN3O5S. Mole weight: 479.98.
LETC
LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor with an EC 50 of 66 nM in transfected DH60.21 neuroblastoma cells. LETC can cross the blood-brain barrier. LETC can be used for the study of synucleinopathies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 951131-13-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163739.
Leteprinim potassium
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AIT-082. CAS No. 192564-13-9. Pack Sizes: 5 mg. Product ID: HY-120251A.
Leteprinim Potassium Salt
A synthetic purine derivative with neuroprotective effects. A cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism. Group: Biochemicals. Alternative Names: 4- [ [3- (1, 6-Dihydro-6-oxo-9H-purin-9-yl) -1-oxopropyl] amino] benzoic Acid Potassium Salt; AIT 082; Neotrofin. Grades: Highly Purified. CAS No. 192564-13-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Letermovir
Letermovir is a novel anti-CMV compound which targets the pUL56 (amino acid 230-370) subunit of the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. It has a novel mode of action targets the enzyme UL56 terminase and keep active to other drug-resistant virus. It has been approved in prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Uses: Antiviral agents. Synonyms: AIC246; AIC-246; AIC 246; MK-8828; MK 8828; MK8828. Grades: ≥98%. CAS No. 917389-32-3. Molecular formula: C29H28F4N4O4. Mole weight: 572.56.
Letermovir
Letermovir. Uses: For analytical and research use. Group: Impurity standards. CAS No. 917389-32-3. Molecular Formula: C29H28F4N4O4. Mole Weight: 572.56. Catalog: APB917389323.
Letermovir
Letermovir (AIC246) is a potent inhibitor of CMV , which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AIC246; MK-8228. CAS No. 917389-32-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15233.
Letermovir impurity 10
Letermovir impurity 10. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C32H32F2N4O5. Mole Weight: 590.63. Catalog: APB11703.
Letermovir Impurity 11
Letermovir Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: phenyl (2-fluorophenyl)carbamate. Molecular Formula: C13H10FNO2. Mole Weight: 231.07. Catalog: APB01520.
Letermovir impurity 12
Letermovir impurity 12. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H16FNO4. Mole Weight: 281.28. Catalog: APB11737.
Letermovir impurity 13
Letermovir impurity 13. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C22H22F4N4O3. Mole Weight: 466.44. Catalog: APB11738.
Letermovir impurity 14
Letermovir impurity 14. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C23H24F4N4O3. Mole Weight: 480.46. Catalog: APB11704.
Letermovir impurity 15
Letermovir impurity 15. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H12F4N2O3. Mole Weight: 380.3. Catalog: APB11706.
Letermovir impurity 16
Letermovir impurity 16. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H14F4N2O4. Mole Weight: 398.31. Catalog: APB11705.
Letermovir impurity 17
Letermovir impurity 17. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C40H42F4N6O4. Mole Weight: 746.81. Catalog: APB11707.
Letermovir impurity 18
Letermovir impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 917389-29-8. Molecular Formula: C30H30F4N4O4. Mole Weight: 586.59. Catalog: APB917389298.
Letermovir impurity 19
Letermovir impurity 19. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C29H28F4N4O4. Mole Weight: 572.56. Catalog: APB11709.
Letermovir Impurity 2
Letermovir Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate. Molecular Formula: C30H30F4N4O4. Mole Weight: 586.58. Catalog: APB01522.
Letermovir impurity 20
Letermovir impurity 20. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C29H28F4N4O4. Mole Weight: 572.56. Catalog: APB11735.
Letermovir impurity 21
Letermovir impurity 21. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C29H28F4N4O4. Mole Weight: 572.56. Catalog: APB11710.
Letermovir impurity 23
Letermovir impurity 23. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C29H28F4N4O4. Mole Weight: 572.56. Catalog: APB11711.
Letermovir impurity 24
Letermovir impurity 24. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H14F4N2O4. Mole Weight: 398.31. Catalog: APB11712.
Letermovir impurity 25
Letermovir impurity 25. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C8H6F3NO2. Mole Weight: 205.14. Catalog: APB11714.
Letermovir impurity 26
Letermovir impurity 26. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C8H8F3NO2. Mole Weight: 207.15. Catalog: APB11713.
Letermovir impurity 27
Letermovir impurity 27. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C11H17ClN2O. Mole Weight: 228.72. Catalog: APB11736.
Letermovir impurity 28
Letermovir impurity 28. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H25N3O2. Mole Weight: 315.42. Catalog: APB11716.
Letermovir impurity 29
Letermovir impurity 29. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C27H40N4O2. Mole Weight: 452.64. Catalog: APB11715.