A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Lilial 2-(4-tert-Butylbenzyl)propionaldehyde. CAS No. 80-54-6. Categories: 7439-96-5; manganese.
CA, FL & NJ
Lilodidine
Lilodidine. Group: Biochemicals. Alternative Names: 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline; 1,7-Trimethyleneindol; 1,8-Trimethyleneindole; 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline; 1,7-(1,3-Propanediyl)-indole. Grades: Highly Purified. CAS No. 5840-1-7. Pack Sizes: 250mg. Molecular Formula: C11H11N, Molecular Weight: 157.21. US Biological Life Sciences.
Worldwide
Lilotomab
Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HH1. CAS No. 1453362-55-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99707.
Lily aldehyde
Lily aldehyde. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Lilial solution. Product Category: Heterocyclic Organic Compound. Appearance: Liquid. CAS No. 80-54-6. Molecular formula: C14H20O. Mole weight: 204.31. Purity: 0.95. IUPACName: 3-(4-Tert-butylphenyl)-2-methylpropanal. Canonical SMILES: CC(CC1=CC=C(C=C1)C(C)(C)C)C=O. Density: 0.946 g/mL at 20 °C(lit.). Product ID: ACM80546. Alfa Chemistry ISO 9001:2015 Certified.
Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206. CAS No. 74397-12-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-B0683.
Limaprost
Limaprost is a potent platelet adhesion inhibitor and vasodilator that increases blood flow and inhibits platelet aggregation. It is an analog of prostaglandin E1 with structural modifications intended to give a prolonged half-life and greater potency. Synonyms: ONO 1206; ONO 1206; ONO 1206; OP 1206; Limaprost; 17α,20-dimethyl-Δ2-PGE1; 17α,20-dimethyl-Δ2-Prostaglandin E1. Grades: >98%. CAS No. 74397-12-9. Molecular formula: C22H36O5. Mole weight: 380.52.
Limaprost-d3
Labeled Limaprost. Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal. Group: Biochemicals. Alternative Names: (2E, 11α, 13E, 15S, 17S)-11, 15-Dihydroxy-17-(methyl-d3), 20-methyl-9-oxoprosta-2, 13-dien-1-oic Acid. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Limbwood 109289 H
Limbwood 109289 H. CAS No. MIXTURE. VIGON Item # 507715. Categories: Speciality Ingrdients Suppliers.
America & Internationally
Lime
Our wide distribution network, with locations coast-to-coast, helps guarantee fast, reliable service to Univar's customers.
Lime Concentrate
Juice. Uses: Beverage Design. Group: Juice Concentrates. Grade: Food. Pack Sizes: Pails to Drums.
Lime Oxide. CAS No. 73018-51-6. Kosher: Y. VIGON Item # 500912. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
limertinib
limertinib (ASK120067) is a potent and orally active inhibitor of EGFR T790M ( IC 50 :0.3 nM) with selectivity over EGFR WT (IC 50 :6.0 nM). limertinib is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASK120067. CAS No. 1934259-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138751.
Limestone, dolomitic
Limestone, dolomitic. Uses: For analytical and research use. Group: Process materials, geological, cement & soils. Catalog: APS009439. Shipping: Room Temperature.
Lime Terpenes
Lime Terpenes. CAS No. MIXTURE. Kosher: Y. VIGON Item # 507201. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Limetol
Limetol. Group: Biochemicals. Alternative Names: 2-Ethenyltetrahydro-2,6,6-trimethyl-2H-pyran; Tetrahydro-2,2,6-trimethyl-6-vinyl-2H-pyran; 2,2,6-Trimethyl-6-vinyltetrahydropyran; 2,2,6-Trimethyl-6-vinyltetrahydropyrane; 2,6,6-Trimethyl-2-vinyltetrahydro-2H-pyran; 2,6,6-Trimethyl-2-vinyltetrahydropyran; Bois de Rose oxide. Grades: Highly Purified. CAS No. 7392-19-0. Pack Sizes: 100mg. Molecular Formula: C10H18O, Molecular Weight: 154.25. US Biological Life Sciences.
Worldwide
Limetol
Limetol. CAS No. 7392-19-0. FEMA No. 3735. Kosher: Y. VIGON Item # 500913. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Limetol
Limetol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,2,6-TRIMETHYL-6-VINYLTETRAHYDROPYRAN;FEMA 3735;LIMETOL;2,2,6-Trimethyl-6-vinyltetrahydro-2H-pyran;2,6,6-trimethoxy-2-vinyltetrahydropyran;2,6,6-trimethyl-2-ethenyltetrahydro-2H-pyran;2,6,6-trimethyl-2-ethenyltetrahydropyran;2,6,6-Trimethyl-2-vinyltetra. Product Category: Heterocyclic Organic Compound. CAS No. 7392-19-0. Molecular formula: C10H18O. Mole weight: 154.25. Product ID: ACM7392190. Alfa Chemistry ISO 9001:2015 Certified. Categories: Limetown.
Lime USP. CAS No. 1305-78-8. Molecular formula: CaO.
Lime Water, Laboratory Grade, 3.8 L
Storage Code: Green; general chemical storage. Grades: chem-grade laboratory. Product ID: 872443. -- SOLD FOR EDUCATIONAL USE ONLY --
Lime Water, Laboratory Grade, 500 mL
Storage Code: Green; general chemical storage. Notes: 140 mg calcium hydroxide per 100 mL of solution. Grades: chem-grade laboratory. Product ID: 872441. -- SOLD FOR EDUCATIONAL USE ONLY --
Limiglidole
Limiglidole is used as a antihyperglycaemic drug candidate. It shows antiplatelet activity 2-fold exceeded activity of antiplatelet agent acetylsalicylic acid in the mouse model of systemic collagen-epinephrine thrombosis. It significantly decreased the relative and mean area of blood clots in the sections of mouse lungs. Uses: Limiglidole is used as a antihyperglycaemic drug candidate. Synonyms: 2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-N,N-diethylethanamine. Grades: 98%. CAS No. 64644-54-8. Molecular formula: C15H22N4. Mole weight: 258.37.
limit dextrin α-1,6-maltotetraose-hydrolase
This bacterial enzyme catalyses a reaction similar to EC 3.2.1.33, amylo-α-1,6-glucosidase (one of the activities of the eukaryotic glycogen debranching enzyme). However, while EC 3.2.1.33 removes single glucose residues linked by 1,6-α-linkage, and thus requires the additional activity of 4-α-glucanotransferase (EC 2.4.1.25) to act on limit dextrins formed by glycogen phosphorylase (EC 2.4.1.1), this enzyme removes maltotriose and maltotetraose chains that are attached by 1,6-α-linkage to the limit dextrin main chain, generating a debranched limit dextrin without a need for another enzyme. Group: Enzymes. Synonyms: glgX (gene name); glycogen debranching enzyme (ambiguous). Enzyme Commission Number: EC 3.2.1.196. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3880; limit dextrin α-1,6-maltotetraose-hydrolase; EC 3.2.1.196; glgX (gene name); glycogen debranching enzyme (ambiguous). Cat No: EXWM-3880.
limit dextrinase
Plant enzymes with little or no action on glycogen. Action on amylopectin is incomplete, but action on α-limit dextrins is complete. Maltose is the smallest sugar it can release from an α-(1?6)-linkage. Group: Enzymes. Synonyms: R-enzyme; amylopectin-1,6-glucosidase; dextrin α-1,6-glucanohydrolase. Enzyme Commission Number: EC 3.2.1.142. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3825; limit dextrinase; EC 3.2.1.142; R-enzyme; amylopectin-1,6-glucosidase; dextrin α-1,6-glucanohydrolase. Cat No: EXWM-3825.
LIMK1 inhibitor BMS 4
LIMK1 inhibitor BMS 4 is a potent LIM kinase 1 (LIMK1; IC50 = 22nM) inhibitor devoid of any cytotoxic side effects. Synonyms: 1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea. Grades: 99%. CAS No. 905298-84-2. Molecular formula: C23H23N7O2S. Mole weight: 461.54.
LIMKi 3
LIMKi 3. Group: Biochemicals. Grades: Purified. CAS No. 1338247-35-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
LIMK-IN-1
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK) , with IC 50 s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116571-01-7. Pack Sizes: 2 mg. Product ID: HY-14227.
LIM Kinase Inhibitor I, LIMKi 3 (N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide)
A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~1uM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10uM in A549 proliferation & colony formation assays). Shown to effectively destabilize F-actin structure in MDA-MB-231 breast cancer cells (3 to 10uM) with concomitant blockage of invasion (by 93% at 10uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1338247-35-0. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?F?N?OS. US Biological Life Sciences.
Worldwide
Limnonectin-1Fa
Limnonectin-1Fa is an antibacterial peptide isolated from Limnonectes fujianensis. It has activity against gram-negative bacteria. Synonyms: Ser-Phe-Pro-Phe-Phe-Pro-Pro-Gly-Ile-Cys-Lys-Arg-Leu-Lys-Arg-Cys. Grades: 97.0%. Molecular formula: C89H136N24O18S2. Mole weight: 1898.3.
Limnonectin-1Fb
Limnonectin-1Fb is an antibacterial peptide isolated from Limnonectes fujianensis. It has activity against gram-negative bacteria. Synonyms: Ser-Phe-His-Val-Phe-Pro-Pro-Trp-Met-Cys-Lys-Ser-Leu-Lys-Lys-Cys. Grades: 97.9%. Molecular formula: C91H134N22O19S3. Mole weight: 1936.3.
Limocrocin
It is produced by the strain of Str. limosus. It has anti-gram-positive bacterial effect. Synonyms: (2E,4E,6E,8E,10E,12E,14E)-N1,N16-bis(2-hydroxy-5-oxocyclopent-1-en-1-yl)hexadeca-2,4,6,8,10,12,14-heptaenediamide; N,N'-Bis(2-hydroxy-5-oxo-1-cyclopentenyl)-2,4,6,8,10,12,14-hexadecaheptene-1,16-diamide; 2,4,6,8,10,12,14-Hexadecaheptaenediamide, N,N'-bis(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (2E,4E,6E,8E,10E,12E,14E)-. CAS No. 24112-57-0. Molecular formula: C26H26N2O6. Mole weight: 462.49.
While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate. Group: Enzymes. Synonyms: NAD+-dependent limonene-1,2-diol dehydrogenase. Enzyme Commission Number: EC 1.1.1.297. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0206; limonene-1,2-diol dehydrogenase; EC 1.1.1.297; NAD+-dependent limonene-1,2-diol dehydrogenase. Cat No: EXWM-0206.
limonene-1,2-epoxide hydrolase
Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. The enzyme hydrolyses several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. It differs from the previously described epoxide hydrolases [EC 3.3.2.4 (trans-epoxysuccinate hydrolase), EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase) and EC 3.3.2.10 (soluble epoxide hydrolase)] as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl dicarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline. Both enantiomers of menth-8-ene-1,2-diol [i.e. (1R,2R,4S)-menth-8-ene-1,2-diol and (1S,2S,4R)-menth-8-ene-1,2-diol] are metabolized. Group: Enzymes. Synonyms: limonene oxide hydrolase. Enzyme Commission Number: EC 3.3.2.8. CAS No. 216503-88-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4005; limonene-1,2-epoxide hydrolase; EC 3.3.2.8; 216503-88-7; limonene oxide hydrolase. Cat No: EXWM-4005.
limonene 1,2-monooxygenase
A flavoprotein (FAD). Limonene is the most widespread terpene and is formed by more than 300 plants. Rhodococcus erythropolis DCL14, a Gram-positive bacterium, is able to grow on both (S)-limonene and (R)-limonene as the sole source of carbon and energy. NADPH can act instead of NADH, although more slowly. It has not been established if the product formed is optically pure or a mixture of two enantiomers. Group: Enzymes. Enzyme Commission Number: EC 1.14.13.107. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0706; limonene 1,2-monooxygenase; EC 1.14.13.107. Cat No: EXWM-0706.
Limonene C10H16
100g Pack Size. Group: Aroma Chemicals, Biochemicals, Building Blocks, Flavours and Fragrance Materials. Formula: C10H16. CAS No. 138-86-3. Prepack ID 90027016-100g. Molecular Weight 136.23. See USA prepack pricing.
Limonenoxide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 8,9-Epoxy-p-menth-1-en. Product Category: Heterocyclic Organic Compound. CAS No. 28098-68-2. Molecular formula: C10H16O. Mole weight: 36.46094;g/mol. Purity: 0.96. IUPACName: chlorane. Canonical SMILES: Cl. ECNumber: 231-595-7. Product ID: ACM28098682. Alfa Chemistry ISO 9001:2015 Certified.
Limonin
Limonin inhibits HIV-1 with an EC 50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC 50 of 54.74 μM. Limonin has antiviral and antitumor activities [1] [2] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Limonoic acid 3,19:16,17 dilactone. CAS No. 1180-71-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17411.
Limonin
Limonin - Product ID: NST-10-13. Category: Terpenes. Alternative Names: Citrolimonin, Dictamnolactone, Evodin, Limonine, Obaculactone, Obakulactone. Purity: 98%. Test method: HPLC. CAS No. 1180-71-8. Pack Sizes: 1g, 2g, 5g, 10g. Appearance: White Powder. Molecular formula: C26H30O8. Mole weight: 470.51. Storage: +2 +8 °C.
100mg Pack Size. Group: Aroma Chemicals, Building Blocks, Flavours and Fragrance Materials. Formula: C26H30O8. CAS No. 1180-71-8. Prepack ID 24406022-100mg. Molecular Weight 470.51. See USA prepack pricing.
Limonin
Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.IC50 Value:Target: HIV; anticancerLimonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. Limonin is chemically induced carcinogenesis inhibitor and HIV-1 replication inhibitor. Limonin has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. Limonin also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Evodia lactone. Product Category: Inhibitors. Appearance: Powder. CAS No. 1180-71-8. Molecular formula: C26H30O8. Mole weight: 470.51. Purity: 98%+. IUPACName: (1R,2R,7S,10R,13R,14R,16S,19S,20S)-19-(Furan-3-yl)-9,9,13,20-tetramethyl-4,8,15,18-tetraoxahexacyclo[11.9.0.02,7.02,10.014,16.014,20]docosane-5,12,17-trione. Canonical SMILES: CC1(C2CC(=O)C3(C(C24COC(=O)CC4O1)CCC5(C36C(O6)C(=O)OC5C7=COC=C7)C)C)C. Density: 1.39±0.1 g/cm³. Product ID: ACM1180718. Alfa Chemistry ISO 9001:2015 Certified.
limonin-D-ring-lactonase
Limonoate is a triterpenoid. Group: Enzymes. Synonyms: limonin-D-ring-lactone hydrolase; limonin lactone hydrolase. Enzyme Commission Number: EC 3.1.1.36. CAS No. 9031-17-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3462; limonin-D-ring-lactonase; EC 3.1.1.36; 9031-17-8; limonin-D-ring-lactone hydrolase; limonin lactone hydrolase. Cat No: EXWM-3462.
limonoid glucosyltransferase
The enzyme purified from navel orange albedo tissue also acts on the related tetranortriterpenoid nomilin. Group: Enzymes. Synonyms: uridine diphosphoglucose-limonoid glucosyltransferase. Enzyme Commission Number: EC 2.4.1.210. CAS No. 195836-82-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2438; limonoid glucosyltransferase; EC 2.4.1.210; 195836-82-9; uridine diphosphoglucose-limonoid glucosyltransferase. Cat No: EXWM-2438.
limulus clotting enzyme
From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: clotting enzyme. Enzyme Commission Number: EC 3.4.21.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4178; limulus clotting enzyme; EC 3.4.21.86; clotting enzyme. Cat No: EXWM-4178.
limulus clotting factor B
From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor B is activated by limulus clotting factor C. In peptidase family S1 (trypsin family). Group: Enzymes. Enzyme Commission Number: EC 3.4.21.85. CAS No. 848851-53-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4177; limulus clotting factor B; EC 3.4.21.85; 848851-53-6. Cat No: EXWM-4177.
limulus clotting factor C
From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin. Inhibited by antithrombin III. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: factor C; limulus factor C. Enzyme Commission Number: EC 3.4.21.84. CAS No. 115743-27-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4176; limulus clotting factor C; EC 3.4.21.84; 115743-27-6; factor C; limulus factor C. Cat No: EXWM-4176.
Lin28 1632
Lin28 1632 is an RNA binding protein Lin28 inhibitor with IC50 value of 8 μM. It can inhibit growth of tumor cell lines and tumor-sphere formation in vitro. Synonyms: Lin28 1632; Lin-28 1632; Lin 28 163; Lin281632; Lin-281632; Lin 281632. N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide. Grades: ≥98% by HPLC. CAS No. 108825-65-6. Molecular formula: C15H15N5O. Mole weight: 281.31.
LIN28 inhibitor LI71 enantiomer
LIN28 inhibitor LI71 enantiomer is the enantiomer of LIN28 inhibitor LI71 with less active. LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC 50 of 7 uM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956189-58-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-123905A.
Lin28-TAT human
recombinant, expressed in E. coli, ?90% (SDS-PAGE), ?90% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Linaclotide
Linaclotide is a peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well. Synonyms: Constella; Linzess; L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide); L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1->6),(2->10),(5->13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13). Grades: ≥95%. CAS No. 851199-59-2. Molecular formula: C59H79N15O21S6. Mole weight: 1526.74.
Linaclotide
Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4nM in a radioligand binding assay using mouse intestinal mucosa).1 Luminal exposure to 5ug of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor null mice. Linaclotide (100ug/kg) increases intestinal transit in wild-type mice. It also reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis.2 Formulations containing linaclotide have been used for the treatment of constipation and pain associated with irritable bowel syndrome. Group: Biochemicals. Alternative Names: L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1?6),(2?10),(5?13)-Tris(disulfide). Grades: Highly Purified. CAS No. 851199-59-2. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N??O??S?, Molecular Weight: 1526.74. US Biological Life Sciences.