A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
L-Pyroglutamic acid 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg, 5Kg. US Biological Life Sciences.
Worldwide
L-Pyroglutamic acid beta-naphthylamide
100mg Pack Size. Group: Amino Acids, Biochemicals, Building Blocks. Formula: C15H14N2O2. CAS No. 22155-91-5. Prepack ID 16763199-100mg. Molecular Weight 254.28. See USA prepack pricing.
L-Pyroglutamic acid-β-naphthylamide
Substrate for the determination of pyrrolidonylpeptidase. Synonyms: L-Pyr-βNA. Grade: ≥ 99% (HPLC). CAS No. 22155-91-5. Molecular formula: C15H14N2O2. Mole weight: 254.3.
L-Pyroglutamic acid-beta-naphthylamide
L-Pyroglutamic acid-beta-naphthylamide. Group: Biochemicals. Alternative Names: L-Pyr-bNA. Grades: Highly Purified. CAS No. 22155-91-5. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
L-Pyroglutamic acid-b-naphthylamide 99+% (HPLC)
L-Pyroglutamic acid-b-naphthylamide 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 22155-91-5. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences.
A substrate for pyroglutamate aminopeptidase. Used for colorimetric determination of pyrrolidonyl peptidase activity in bacteria. Group: Biochemicals. Alternative Names: (S)-N-(2-Naphthyl)-5-oxopyrrolidine-2-carboxamide. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
L-Pyroglutamic acid-[d5]
L-Pyroglutamic acid-[d5] is the isotope labelled analog of L-Pyroglutamic Acid. L-Pyroglutamic acid is an amino acid that is used in the synthesis of peptides and a metabolite in the glutathione cycle. Synonyms: L-2-Pyrrolidinone-3,3,4,4,5-d5-5-carboxylic Acid; H-L-Pyr-OH-d5; 5-Oxo-L-proline-d5. Grade: 98% by CP; 98% atom D. CAS No. 1086136-22-2. Molecular formula: C5H2D5NO3. Mole weight: 134.15.
L-Pyroglutamic acid pentachlorophenyl ester. Group: Biochemicals. Alternative Names: L-Pyr-OPcp. Grades: Highly Purified. CAS No. 28990-85-4. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
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L-Pyroglutamic acid pentachlorophenyl ester 99+%
L-Pyroglutamic acid pentachlorophenyl ester 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g. US Biological Life Sciences.
Worldwide
L-Pyroglutamic acid (Standard)
L-Pyroglutamic acid (Standard) is the analytical standard of L-Pyroglutamic acid. This product is intended for research and analytical applications. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid standard can be used as a biomarker for systemic lupus erythematosus (SLE) [1]. Uses: Scientific research. Group: Natural products. CAS No. 98-79-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-76082R.
L-Pyroglutamyl-L-alanine
L-Pyroglutamyl-L-alanine. Group: Biochemicals. Alternative Names: Pyr-L-Ala-OH. Grades: Highly Purified. CAS No. 21282-08-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
L-Pyroglutamyl-L-alanine 99+% (HPLC)
L-Pyroglutamyl-L-alanine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences.
Worldwide
L-Pyroglutamyl-L-histidyl-L-prolinamide
L-Pyroglutamyl-L-histidyl-L-prolinamide. Group: Biochemicals. Alternative Names: Protirelin; Thyrotropin-Releasing Hormone. Grades: Highly Purified. CAS No. 24305-27-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C16H22N6O4. US Biological Life Sciences.
Worldwide
L-Pyrohomoglutamic acid
L-Pyrohomoglutamic acid is an amino acid building block. L-Pyrohomoglutamic acid can be used to synthesize ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 34622-39-4. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W017542.
L-Pyrrolidine-2-carboxylic acid
L-Pyrrolidine-2-carboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Azetidinecarboxylic Acid;DL-H-Aze-OH. Product Category: Heterocyclic Organic Compound. CAS No. 2517-4-6. Molecular formula: C4H7NO2. Mole weight: 101.1039. Density: 1.186g/cm³. Product ID: ACM2517046. Alfa Chemistry  ISO 9001:2015 Certified. Categories: L-proline.
L-Pyrrolidonecarboxyl-L-Alanine
Intermediate for peptides. Synonyms: Pyr-Ala-OH; 5-oxo-L-prolyl-L-alanine. Grade: ≥ 99% (HPLC). CAS No. 21282-08-6. Molecular formula: C8H12N2O4. Mole weight: 200.2.
L-Pyrrolysine
L-Pyrrolysine. Uses: L-pyrrolysine is a unique and interesting amino acid that shows great potential in the field of drug discovery due to its remarkable properties and applications. this specific amino acid is not present in the standard genetic code of organisms, but is instead incorporated into proteins by certain enzymes in response to specific codons in the genetic code. this unusual property of l-pyrrolysine has. CAS No. 448235-52-7. Molecular formula: C12H21N3O3. Mole weight: 255.31.
L-Quebrachitol
L-Quebrachitol. Group: Biochemicals. Grades: Highly Purified. CAS No. 642-38-6. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C7H14O6. US Biological Life Sciences.
Worldwide
L-Quebrachitol
100mg Pack Size. Group: Aroma Chemicals, Biochemicals, Building Blocks, Chiral Compounds. Formula: C7H14O6. CAS No. 642-38-6. Prepack ID 43189539-100mg. Molecular Weight 194.19. See USA prepack pricing.
L-Quebrachitol
1g Pack Size. Group: Aroma Chemicals, Biochemicals, Building Blocks, Chiral Compounds. Formula: C7H14O6. CAS No. 642-38-6. Prepack ID 43189539-1g. Molecular Weight 194.19. See USA prepack pricing.
L-Quebrachitol.
L-Quebrachitol. Group: Biochemicals. Grades: Plant Grade. CAS No. 642-38-6. Pack Sizes: 20mg. Molecular Formula: C7H14O6, Molecular Weight: 194.18. US Biological Life Sciences.
Worldwide
L-Quisqualic acid
L-Quisqualic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL)-L-ALANINE;L(+)-QUISQUALIC ACID;L-QUISQUALIC ACID;L-(+)-A-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID;(L)-(+)-ALPHA-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID;BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-. Product Category: Heterocyclic Organic Compound. Appearance: Off-White Solid. CAS No. 52809-07-1. Molecular formula: C5H7N3O5. Mole weight: 189.13. Purity: >99 %. Density: 1.679g/cm³. Product ID: ACM52809071. Alfa Chemistry  ISO 9001:2015 Certified.
L-Quisqualic acid
L-Quisqualic acid. Group: Biochemicals. Grades: Purified. CAS No. 52809-07-1. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences.
Worldwide
LQZ-7I
LQZ-7I is a malarial protease PfSUB1 inhibitor. LQZ-7I showed significantly improved activity and is the focus of this work. LQZ-7 when given orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors. The data obtained utilizing LQZ-7I in both in vitro and in vivo studies highlights its potential as a lead for further development, which may yield a potential cancer therapeutic by targeting the survivin protein directly. Uses: Designed for use in research and industrial production. Additional or Alternative Names: LQZ-7I; LQZ 7I; LQZ7I. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 195822-23-2. Molecular formula: C20H14F2N4. Mole weight: 348.36. Purity: >98%. IUPACName: 2,3-Quinoxalinediamine, N,N'-bis(4-fluorophenyl)-. Canonical SMILES: FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1. Product ID: ACM195822232. Alfa Chemistry  ISO 9001:2015 Certified. Categories: N2,N3-bis(4-fluorophenyl)quinoxaline-2,3-diamine.
L-R
L-R is a vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM). Synonyms: L-R4W2. Grade: >98%. CAS No. 206350-79-0. Molecular formula: C46H71N21O6. Mole weight: 1014.2.
L-R4W2
L-R4W2. Group: Biochemicals. Grades: Purified. CAS No. 206350-79-0. Pack Sizes: 1mg. US Biological Life Sciences.
LRGILS-NH is a control peptide for SLIGRL-NH2, a protease-activated receptor-2 (PAR2) agonist that facilitates gastrointestinal transit in vivo. Synonyms: L-leucyl-L-arginylglycyl-L-isoleucyl-L-leucyl-L-serinamide. Grade: ≥95% by HPLC. CAS No. 245329-01-5. Molecular formula: C29H56N10O7. Mole weight: 656.83.
LRGILS-NH2
LRGILS-NH2. Group: Biochemicals. Grades: Purified. CAS No. 245329-01-5. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
LRH-1, GST tagged human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
LRH-1 human
recombinant, expressed in insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
L-rhamnonate dehydratase
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in fructose and mannose metabolism. Group: Enzymes. Synonyms: L-rhamnonate hydro-lyase. Enzyme Commission Number: EC 4.2.1.90. CAS No. 99533-47-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5074; L-rhamnonate dehydratase; EC 4.2.1.90; 99533-47-8; L-rhamnonate hydro-lyase. Cat No: EXWM-5074.
L-rhamnono-1,4-lactonase
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is L-rhamnono-1,4-lactone lactonohydrolase. Other names in common use include L-rhamno-gamma-lactonase, L-rhamnono-gamma-lactonase, and L-rhamnonate dehydratase. This enzyme participates in fructose and mannose metabolism. Group: Enzymes. Synonyms: L-rhamno-γ-lactonase; L-rhamnono-γ-lactonase; L-rhamnonate dehydratase. Enzyme Commission Number: EC 3.1.1.65. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3493; L-rhamnono-1,4-lactonase; EC 3.1.1.65; L-rhamno-γ-lactonase; L-rhamnono-γ-lactonase; L-rhamnonate dehydratase. Cat No: EXWM-3493.
L-rhamnose-[1-13C] monohydrate
Labelled L-Rhamnose Monohydrate. L-Rhamnose Monohydrate is a composition of plum leaf polysaccharides. L-Rhamnose is a part of plant cell wall polysaccharides, rhamnogalacturonan I and rhamnogalacturonan. Synonyms: L-[1-13C]rhamnose monohydrate; 6-deoxy-L-[1-13C]mannose monohydrate; L-rhamnose-1-13C monohydrate. CAS No. 478511-48-7. Molecular formula: C5[13C]H14O6. Mole weight: 183.16.
L-rhamnose 1-dehydrogenase
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-rhamnofuranose:NAD+ 1-oxidoreductase. This enzyme participates in fructose and mannose metabolism. Group: Enzymes. Enzyme Commission Number: EC 1.1.1.173. CAS No. 52227-67-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0076; L-rhamnose 1-dehydrogenase; EC 1.1.1.173; 52227-67-5. Cat No: EXWM-0076.
L-rhamnose 1-dehydrogenase (NADP+)
The enzyme from the archaeon Thermoplasma acidophilum is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+. Group: Enzymes. Enzyme Commission Number: EC 1.1.1.377. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0295; L-rhamnose 1-dehydrogenase (NADP+); EC 1.1.1.377. Cat No: EXWM-0295.
L-rhamnose 1-dehydrogenase [NAD(P)+]
The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC 1.1.1.377, L-rhamnose 1-dehydrogenase (NADP+). Group: Enzymes. Enzyme Commission Number: EC 1.1.1.378. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0296; L-rhamnose 1-dehydrogenase [NAD(P)+]; EC 1.1.1.378. Cat No: EXWM-0296.
L-rhamnose-[2-13C] monohydrate
Labelled L-Rhamnose Monohydrate. L-Rhamnose Monohydrate is a composition of plum leaf polysaccharides. L-Rhamnose is a part of plant cell wall polysaccharides, rhamnogalacturonan I and rhamnogalacturonan. Synonyms: L-[2-13C]rhamnose monohydrate; 6-deoxy-L-[2-13C]mannose monohydrate; L-rhamnose-2-13C monohydrate. CAS No. 478511-51-2. Molecular formula: C5[13C]H14O6. Mole weight: 183.16.
L-rhamnose-[3-13C] monohydrate
Labelled L-Rhamnose Monohydrate. L-Rhamnose Monohydrate is a composition of plum leaf polysaccharides. L-Rhamnose is a part of plant cell wall polysaccharides, rhamnogalacturonan I and rhamnogalacturonan. Synonyms: L-[3-13C]rhamnose monohydrate; 6-deoxy-L-[3-13C]mannose monohydrate; L-rhamnose-3-13C monohydrate. CAS No. 478511-54-5. Molecular formula: C5[13C]H14O6. Mole weight: 183.16.
L-rhamnose isomerase
Contains two divalent metal ions located at different metal-binding sites within the active site. The enzyme binds the closed ring form of the substrate and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. Isomerization proceeds via a hydride-shift mechanism. While the enzyme from the bacterium Escherichia coli is specific for L-rhamnose, the enzyme from the bacterium Pseudomonas stutzeri has broad substrate specificity and catalyses the interconversion of L-mannose and L-fructose, L-lyxose and L-xylulose, D-ribose and D-ribulose, and D-allose and D-psicose. Group: Enzymes. Synonyms: rhamnose isomerase; L-rhamnose ketol-isomerase. Enzyme Commission Number: EC 5.3.1.14. CAS No. 9023-84-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5455; L-rhamnose isomerase; EC 5.3.1.14; 9023-84-1; rhamnose isomerase; L-rhamnose ketol-isomerase. Cat No: EXWM-5455.
L-Rhamnose monohydrate
100g Pack Size. Group: Biochemicals, Carbohydrates, Sugars. Formula: C6H12O5 ·H2O. CAS No. 10030-85-0. Prepack ID 28953701-100g. Molecular Weight 182.17. See USA prepack pricing.
L-Rhamnose monohydrate
25g Pack Size. Group: Biochemicals, Carbohydrates, Sugars. Formula: C6H12O5 ·H2O. CAS No. 10030-85-0. Prepack ID 28953701-25g. Molecular Weight 182.17. See USA prepack pricing.
The enzyme is specific for L-rhamnopyranose. Group: Enzymes. Synonyms: rhamnose 1-epimerase; type-3 mutarotase; YiiL. Enzyme Commission Number: EC 5.1.3.32. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5419; L-rhamnose mutarotase; EC 5.1.3.32; rhamnose 1-epimerase; type-3 mutarotase; YiiL. Cat No: EXWM-5419.
L-Ribose
25g Pack Size. Group: Biochemicals, Carbohydrates. Formula: C5H10O5. CAS No. 24259-59-4. Prepack ID 23543542-25g. Molecular Weight 150.13. See USA prepack pricing.
L-Ribose
5g Pack Size. Group: Biochemicals, Carbohydrates. Formula: C5H10O5. CAS No. 24259-59-4. Prepack ID 23543542-5g. Molecular Weight 150.13. See USA prepack pricing.
L-Ribose
L-Ribose. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2R,3S,4R,5S)-5-(hydroxymethyl)oxolane-2,3,4-triol. Appearance: White to almost white powder to crystal. CAS No. 24259-59-4. Molecular formula: C5H10O5. Mole weight: 150.13. Purity: 0.98. IUPACName: (2S,3S,4S)-2,3,4,5-tetrahydroxypentanal. Canonical SMILES: C([C@@H]([C@@H]([C@@H](C=O)O)O)O)O. Product ID: ACM24259594-1. Alfa Chemistry  ISO 9001:2015 Certified.
L-Ribose
L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. Many anticancer and antiviral drugs are synthesized based on a backbone of L-Ribose and its derivatives [1]. Uses: Scientific research. Group: Natural products. CAS No. 24259-59-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-W008351.
L-ribose-[1-13C]
Labelled analogue of L-Ribose, which is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate. Synonyms: L-[1-13C]ribose; L-ribose-1-13C. Molecular formula: C4[13C]H10O5. Mole weight: 151.12.
L-ribose-[UL-13C5]
Labelled analogue of L-Ribose, which is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate. Synonyms: L-[UL-13C5]ribose; L-ribose-U-13C5. Molecular formula: [13C]5H10O5. Mole weight: 155.09.
L-Ribulose
L-Ribulose, an isomer of L-ribose, is an important precursor for other rare sugars and L-nucleoside analogue synthesis [1]. Uses: Scientific research. Group: Natural products. CAS No. 2042-27-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-121305A.
L-ribulose-5-phosphate 3-epimerase
Along with EC 4.1.1.85, 3-dehydro-L-gulonate-6-phosphate decarboxylase, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli. Group: Enzymes. Synonyms: L-xylulose 5-phosphate 3-epimerase; UlaE; SgaU. Enzyme Commission Number: EC 5.1.3.22. CAS No. 1114425-98-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5408; L-ribulose-5-phosphate 3-epimerase; EC 5.1.3.22; 1114425-98-7; L-xylulose 5-phosphate 3-epimerase; UlaE; SgaU. Cat No: EXWM-5408.
L-ribulose-5-phosphate 4-epimerase
Requires a divalent cation for activity. Group: Enzymes. Synonyms: phosphoribulose isomerase; ribulose phosphate 4-epimerase; L-ribulose-phosphate 4-epimerase; L-ribulose 5-phosphate 4-epimerase; AraD; L-Ru5P. Enzyme Commission Number: EC 5.1.3.4. CAS No. 9024-19-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5427; L-ribulose-5-phosphate 4-epimerase; EC 5.1.3.4; 9024-19-5; phosphoribulose isomerase; ribulose phosphate 4-epimerase; L-ribulose-phosphate 4-epimerase; L-ribulose 5-phosphate 4-epimerase; AraD; L-Ru5P. Cat No: EXWM-5427.
LRRK2-IN-1
LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC 50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1234480-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10875.
LRRK2-IN-1
LRRK2-IN-1 is a benzodiazepine based derivative and is known as a selective inhibitor of the Parkinson's disease kinase LRRK2. Group: Biochemicals. Alternative Names: 5, 11-Dihydro-2- [ [2-methoxy-4- [ [4- (4-methyl-1-piperazinyl) -1-piperidinyl] carbonyl] phenyl] amino] -5, 11-dimethyl-6H-pyrimido [4, 5-b] [1, 4] benzodiazepin-6-one. Grades: Highly Purified. CAS No. 1234480-84-2. Pack Sizes: 10mg. US Biological Life Sciences.
An orally bioavailable fluoro-diaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of LRRK2 activity (IC50=4.76 and 6.87nM for hr-wt-LRRK2 and G2019S-LRRK2 mutant, respectively) with selectivity over PLK4, GAK, TNK1, CAMKK2, and PIP4K2C (IC50 <300nM) in a 185-kinase panel. Does neither exert cytotoxicity nor block neuronal development of human or rat cortical neurons at 1uM. Shown to prevent GS-LRRK2-induced neuronal injury (EC50 ~4nM) and G2019S- or R1441C-LRRK2-mediated neuronal death in both rat and human cortical neurons (EC50 ~100nM). Even though exhibits favorable pharmacokinetic profile and metabolic stability, and yet suffers from limited blood brain barrier penetration (~4%). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
LRRK2 Inhibitor III, HG-10-102-01 (Leucine-Rich Repeat Kinase 2 Inhibitor III, Mixed-Lineage Kinase 1 Inhibitor I, MLK1 Inhibitor I, MNK Inhibitor III, (4- (5-Chloro-4- (methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl) (morpholino)methanone)
A cell-permeable 2,4-diaminopyrimidinyl compound that acts as a potent, ATP-competitive LRRK2-selective inhibitor (IC5050 = 20.3, 3.2, 153.7 and 95.9nM, respectively,against human wt LRRK2 and G2019S, A2016T, G2019S/A2016T LRRK2 mutant; [ATP] = 100uM), displaying much reduced potency against MNK2 and MLK1 (IC50 = 0.6 and 2.1uM, respectively; [ATP] = 100uM) and little activity toward a panel of 136 other kinases. Although both HG-10-102-01 and LRRK2-In-1 inhibit cellular wt and G20195 LRRK2 phosphorylation (Optimal conc. 1 to 3uM), only HG-10-102-01 is effective against cellular A2016T and G2019S/A2016T LRRK2 phosphorylations (IC50 <3uM). And only HG-10-102-01, but not LRRK2-In-1 or CZC-25146, can cross blood-brain-barrier for LRRK2 phosphorylation inhibition in mice (30mg/kg to 50mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences.
Worldwide
LS-102
LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 ?M. LS-102 has the potential for rheumatoid arthritis treatment[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456891-34-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-135844.
L-saccharopine oxidase
The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD). Group: Enzymes. Synonyms: FAP2. Enzyme Commission Number: EC 1.5.3.18. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1545; L-saccharopine oxidase; EC 1.5.3.18; FAP2. Cat No: EXWM-1545.
LSAT - Lanthanum Strontium Aluminum Tantalum Oxide or (La,Sr)(Al,Ta)O3 is an optically transparent perovskite ceramic. LSAT crystals are grown via the Czochralski method and typically used as a substrate for epitaxial growth of thin films in ferroelectric and hHigh temperature superconductor devices. Group: Single crystal substrates. Molecular formula: 3996g/mol. Mole weight: (La0.3Sr0.7)(Al0.65Ta0.35)O3. >99.9%.
LsbA
LsbA is an antibacterial peptide isolated from Lactococcus lactis. It has activity against gram-positive bacteria and fungi. Synonyms: Phe-Lys-Lys-Lys-Lys-Arg-Asn-Ile-Gly-Thr-Phe-Val-Phe-Phe-Ala-Ile-Ala-Leu-Phe-Cys-Thr-Val-Met-Phe-Ala-Tyr-Leu-Leu-Leu-Thr-Asn-Gln-Tyr-Val-Pro-Ile-Asp-Tyr-Asn-Val-Pro-Arg-Tyr-Ala. Molecular formula: C253H380N58O58S2. Mole weight: 5226.27.
LsbB
LsbB is an antibacterial peptide isolated from Lactococcus lactis. It has activity against gram-positive bacteria and fungi. Synonyms: Met-Lys-Thr-Ile-Leu-Arg-Phe-Val-Ala-Gly-Tyr-Asp-Ile-Ala-Ser-His-Lys-Lys-Lys-Thr-Gly-Gly-Tyr-Pro-Trp-Glu-Arg-Gly-Lys-Ala. Molecular formula: C156H246N44O40S. Mole weight: 3410.
LSD1 Active human
recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.