A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5. Group: Biochemicals. Alternative Names: 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) . Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase. Uses: Designed for use in research and industrial production. Additional or Alternative Names: STK763743, necrotatin-7, Necrostatin-7, AC1LOGUN, Nec-7, CHEMBL514242, HMS621M06, MolPort-002-708-930, ZINC20587175, AKOS001738191, A2363/0099838, 5-[3-(4-Fluoro-phenyl)-1H-pyrazol-4-ylmethylene]-2-imino-[2,3]bithiazolyl-4-one, (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one, (5Z)-5-{[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one, 351062-08-3, 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone. Product Category: Inhibitors. Appearance: Solid. CAS No. 351062-08-3. Molecular formula: C16H10FN5OS2. Mole weight: 371.41. Purity: 0.96. IUPACName: (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one. Canonical SMILES: C1=CC(=CC=C1C2=C(C=NN2)C=C3C(=O)N(C(=N)S3)C4=NC=CS4)F. Product ID: ACM351062083. Alfa Chemistry ISO 9001:2015 Certified.
Necrostatin-7
Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC 50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-7. CAS No. 351062-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117200.
Necrostatin-7 (Nec-7)
Necroptosis inhibitor. Does not inhibit RIP1 kinase. Group: Biochemicals. Alternative Names: Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg. US Biological Life Sciences.
A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in the pathway. Group: Biochemicals. Alternative Names: (Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
Necrosulfonamide
Necrosulfonamide, a necroptosis and gasdermin D inhibitor, selectively targets (MLKL). Necrosulfonamide prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a key substrate of RIP3 in the induction of necrosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1360614-48-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100573.
Necrosulfonamide
Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway. Group: Biochemicals. Alternative Names: N-[4-[[ (3-Methoxypyrazinyl) amino]sulfonyl]phenyl]-3- (5-nitro-2-thienyl) -2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Necrosulfonamide-d4
Labeled Necrosulfonamide. Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway. Group: Biochemicals. Alternative Names: N-[4-[[ (3-Methoxypyrazinyl) amino]sulfonyl] (phenyl]-d4) -3- (5-nitro-2-thienyl) -2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl](phenyl-d4)]-3-(5-nitrothiophene-2-yl)acrylamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 874374-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-103316A.
Nedaplatin
Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 375101D. CAS No. 95734-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13700.
Ne-Dimethyl-L-lysine hydrochloride. Group: Biochemicals. Alternative Names: L-Lys(Me)2-OH·HCl. Grades: Highly Purified. CAS No. 2259-86-1. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences.
Worldwide
Ne-Dimethyl-L-lysine hydrochloride 98+% (NMR)
Ne-Dimethyl-L-lysine hydrochloride 98+% (NMR). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
Nedisertib
Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Peposertib; M3814. CAS No. 1637542-33-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101570.
Nedizantrep
GDC-6599 is an orally active TRPA1 inhibitor, with IC 50 values of 5.3 nM in humans, 6.6 nM in rats, 9.3 nM in dogs, 7.2 nM in monkeys, and 15 nM in guinea pigs. GDC-6599 can be used in the research of neuropathic pain and respiratory diseases such as asthma and chronic cough [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-6599. CAS No. 2376824-99-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-156684.
Needle Mushroom Powder contains a large quantity of a protein, designated Five, which helps to regulate the immune system. Animal testing indicated possible uses for vaccines and cancer immunotherapy. Needle Mushroom Powder also contains flammutoxin, a cytolytic and cardiotoxic protein that may possibly be poorly absorbed orally. Group: Others. Needle Mushroom Powder; Flammulina Velutipes. Cat No: EXTC-074.
Neem
This product contains essential fatty acids and vitamin E to work double time on hydrating and plumping the skin, for a healthy look and feel. Pack Sizes: 1 kg. Product ID: CDC10-0556. Category: Anti-Acne Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Anti-Acne Ingredients; Neem; CDC10-0556.
NEEM OIL*
NEEM OIL*. Uses: Designed for use in research and industrial production. Additional or Alternative Names: clarified;clarifiedhydrophobicextractof;clarifiedhydrophobicextractofneemoil;clarifiedhydrophobicextractofneemoilchemical;clarifiedhydrophobicneemoil;margosaoil;nim-76;nimoil. Product Category: Heterocyclic Organic Compound. CAS No. 8002-65-1. Molecular formula: W99. Product ID: ACM8002651. Alfa Chemistry ISO 9001:2015 Certified.
Nefazodone
Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT 2A receptors , and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 83366-66-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119209.
Nefazodone hydrochloride
Nefazodone hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 82752-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Nefazodone hydrochloride
Nefazodone hydrochloride. CAS No: 82752-99-6
Sarchem Laboratories New Jersey NJ
Nefazodone hydrochloride
Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A ( K i =5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake ( IC 50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMY-13754; MJ-13754-1. CAS No. 82752-99-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B1396.
A selective serotonin 5-HT2 receptor antagonist. An antidepressant. Group: Biochemicals. Alternative Names: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
A potent 5-HT2A receptor antagonist (Kd = 26nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48nM) and 5-HT1A receptor (Kd = 80nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 82752-99-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Nefazodone Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Nefazodone Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Neferine
Neferine. Group: Biochemicals. Grades: Plant Grade. CAS No. 2292-16-2. Pack Sizes: 20mg. Molecular Formula: C38H44N2O6, Molecular Weight: 624.77. US Biological Life Sciences.
A cell-permeable diphenylpyrazolo compound that disrupts HIV accessary protein Nef dimerization (IC50 = 3uM in HEK293T cells) and prevents Nef-mediated Src family kinase Hck activation (IC50 = 2.8uM) without directly affecting the catalytic activity of c-Src, Hck, Lck, or Lyn. Shown to suppress HIV and SIV viral replication (IC50/strain/culture = 1uM/SIV deltaB670/CEM-174 and <0.3uM/HIV-1 NL4-3/CEM-T4) and infectivity, being ineffective against the replication of Nef-defective HIV-1 mutant. Molecular docking and in vitro binding studies reveal a high-affinity B9-targeting site formed at the Nef dimerization interface and a low-affinity binding site on each Nef monomer at the dimer interface periphery. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?S, Primary Target: Nef. US Biological Life Sciences.
Nefiracetam. Group: Biochemicals. Grades: Purified. CAS No. 77191-36-7. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Nefiracetam
Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DM9384; DZL-221. CAS No. 77191-36-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0340.
Neflamapimod
Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC 50 for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-745. CAS No. 209410-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10328.
Ne-Fmoc-L-lysine
Ne-Fmoc-L-lysine. Group: Biochemicals. Alternative Names: L-Lys(Fmoc)-OH. Grades: Highly Purified. CAS No. 84624-28-2. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Ne-Fmoc-L-lysine 99+% (HPLC)
Ne-Fmoc-L-lysine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Ne-Fmoc-L-lysine methyl ester hydrochloride
Ne-Fmoc-L-lysine methyl ester hydrochloride. Group: Biochemicals. Alternative Names: L-Lys(Fmoc)-OMe·HCl. Grades: Highly Purified. CAS No. 201009-98-5. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Ne-Fmoc-L-lysine methyl ester hydrochloride 99+%
Ne-Fmoc-L-lysine methyl ester hydrochloride 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Nefopam
Nefopam is a non-opioid non-steroidal centrally acting analgesic. Group: Biochemicals. Grades: Highly Purified. CAS No. 13669-70-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C17H19NO, Molecular Weight: 253.34. US Biological Life Sciences.
Worldwide
Nefopam-[d3]
Nefopam-[d3] is the labelled analogue of Nefopam. Nefopam is a centrally acting, non-opioid analgesic drug that is primarily used to treat moderate to severe pain. Synonyms: Nefopam D3; 3,4,5,6-Tetrahydro-5-(methyl-d3)-1-phenyl-1H-2,5-benzoxazocine; (+/-)-Nefopam-d3; Fenazoxine-d3. Grade: >95%; ≥99% atom D. CAS No. 1346747-15-6. Molecular formula: C17H16D3NO. Mole weight: 256.37.
Nefopam hydrochloride
Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs. Uses: Analgesics, non-narcotic. Synonyms: Nefopam Hydrochloride. Grade: >98%. CAS No. 23327-57-3. Molecular formula: C17H19NO.HCl. Mole weight: 289.8.
Nefopam hydrochloride
Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fenazoxine hydrochloride. CAS No. 23327-57-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B1057.
Nefopam Hydrochloride
?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardspharmaceutical toxicology. Alternative Names: Fenazoxine, Acupan, Nefopam hydrochloride,1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1), 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (8CI,9CI), Fenazoxine hydrochloride, R 738, Ajan, (+/-)-Nefopam hydrochloride.
Nefopam Hydrochloride
A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant. Group: Biochemicals. Alternative Names: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine Hydrochloride; (+/-)-Nefopam Hydrochloride; Acupan; Ajan; Fenazoxine; Fenazoxine hydrochloride; R 738. Grades: Highly Purified. CAS No. 23327-57-3. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Nefopam Impurity 6
Nefopam Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-benzoyl-N-(2-hydroxyethyl)benzamide. CAS No. 108941-80-6. Molecular formula: C16H15NO3. Mole weight: 269.11. Catalog: APB108941806.
Nefopam N-oxide. Group: Biochemicals. Alternative Names: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine 5-oxide. Grades: Highly Purified. CAS No. 66091-32-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H19NO2. US Biological Life Sciences.
Worldwide
Nefopam N-Oxide-[d3]
Nefopam N-Oxide-[d3] is the labelled analogue of Nefopam N-Oxide, which is a metabolite of Nefopam. Synonyms: Nefopam-d3 N-Oxide; 3,4,5,6-Tetrahydro-5-(methyl-d3)-1-phenyl-1H-2,5-benzoxazocine 5-Oxide. Grade: >95%. CAS No. 1346603-50-6. Molecular formula: C17H16D3NO2. Mole weight: 272.36.
Negamycin
Negamycin is a peptide antibiotic that has broad-spectrum antibacterial activity. Synonyms: L-threo-Hexonic acid, 3,6-diamino-2,3,4,6-tetradeoxy-, 2-(carboxymethyl)-2-methylhydrazide; BRN 4687658. Grade: >98% by HPLC. CAS No. 33404-78-3. Molecular formula: C9H20N4O4. Mole weight: 248.28.
Negative Ion Nanopowder / Nanoparticles
Negative Ion Nanopowder / Nanoparticles. Group: Polymers nano materials. 99%.
Negative resist developer I
Negative resist developer I. Group: Self assembly and lithography.
Negative resist remover I
Available as part of Negative Photoresist kit 654892. Group: Self assembly and lithography. Pack Sizes: 250 mL in glass bottle.
Negletein
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 29550-13-8. Molecular formula: C16H12O5. Mole weight: 284.26. Purity: 0.99. Product ID: ACM29550138. Alfa Chemistry ISO 9001:2015 Certified.
Negsehisandrin G
Negsehisandrin G is a lignan isolated from the fruits of Schisandra neglecta A. C. Smith. Synonyms: Angeloyl-(+)-gomisin K3. Grade: >98%. CAS No. 1023744-69-5. Molecular formula: C28H36O7. Mole weight: 484.589.
Negsehisandrin G
Negsehisandrin G. Group: Biochemicals. CAS No. 1023744-69-5. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
n-Eicosane
100g Pack Size. Group: Building Blocks, Organics. Formula: C20H42. CAS No. 112-95-8. Prepack ID 45515231-100g. Molecular Weight 282.54. See USA prepack pricing.
Neihulizumab
Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1) , leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab). CAS No. 2158362-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99378.
Neihumicin
Neihumicin is produced by the strain of Micromonospora neihuensis Wu, sp. nov. Neihumicin is resistant to beer saccharomyces yeast and Penicillium italium Wehmer, but not to bacteria. Synonyms: Neihumycin; 3,6-Dibenzylidene-2-methoxy-3,6-dihydropyrazin-5-one; NSC617674; (Z,Z)-3,6-Dihydro-5-methoxy-3,6-bis(phenylmethylene)-2(1H)-pyrazinone. CAS No. 111451-12-8. Molecular formula: C19H16N2O2. Mole weight: 304.34.