A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
N,N,N-Trimethylglycine N-Hydroxysuccinimide ester is used in the preparation of novel N-terminally modified protease stabilized acylated insulin derivatives for treatment of diabetes. Group: Biochemicals. Alternative Names: α-Trimethylammonium Acetyl N-Hydroxysuccinimide Bromide; 2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-N,N,N-trimethyl-2-oxoethanaminium Bromide. Grades: Highly Purified. CAS No. 42014-55-1. Pack Sizes: 100mg. US Biological Life Sciences.
N,N,N'-Trimethyl-N'-[2-(4-methyl-1-piperazinyl)ethyl]ethylenediamine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: EINECS 256-711-3, CID3016546, N,N,N-Trimethyl-N-(2-(4-methyl-1-piperazinyl)ethyl)ethylenediamine, 50679-12-4. Product Category: Heterocyclic Organic Compound. CAS No. 50679-12-4. Molecular formula: C12H28N4. Mole weight: 228.377520 [g/mol]. Purity: 0.96. IUPACName: N,N,N-trimethyl-N-[2-(4-methylpiperazin-1-yl)ethyl]ethane-1,2-diamine. Density: 0.939g/cm³. Product ID: ACM50679124. Alfa Chemistry ISO 9001:2015 Certified.
N,N,N'-Trimethyl-N'-thioethylethylene diamine
N,N,N'-Trimethyl-N'-thioethylethylene diamine. Group: Biochemicals. Alternative Names: 2- [ [2- (Dimethylamino) ethyl] methylamino] ethanethiol. Grades: Highly Purified. CAS No. 97816-89-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C7H18N2S. US Biological Life Sciences.
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N,N,N-Trimethyloctadecan-1-aminium iodide
N,N,N-Trimethyloctadecan-1-aminium iodide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Behenyl Trimethyl Ammonium Chloride. Appearance: Colorless or slightly yellow viscous liquid. CAS No. 4292-25-5. Molecular formula: C21H46IN. Mole weight: 439.5. Purity: 0.7. Product ID: ACM4292255. Alfa Chemistry ISO 9001:2015 Certified.
N,N,N' -trimethylpropane-1,3-diamine
N,N,N' -trimethylpropane-1,3-diamine. Group: Biochemicals. Alternative Names: N,N,N'-Trimethyl-1,3-propanediamine; (3-Dimethylaminopropyl) methylamine; 3-(Dimethylamino)-N-methylpropylamine; Methyl[3- (dimethylamino) propyl]amine; N,N,N'-Trimethyl-1,3-diaminopropane; N,N,N'-Trimethylpropan-1,3-diamine; N, N, N'-Tri methyl tri methyl enediamine; N-(3-Dimethylaminopropyl)-N-methylamine; N- (3-Dimethylaminopropyl) methylamine; N1,N1,N3-Trimethylpropane-1,3-diamine. Grades: Highly Purified. CAS No. 4543-96-8. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C?H??N?, Molecular Weight: 116.2. US Biological Life Sciences.
N,N',N''-Tris-(tert-butyl)-1,3,5-triazine-2,4,6-triamine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ambcb5101005, EINECS 240-373-9, MolPort-003-179-121, CID85354, ZINC04947387, N,N,N-Tris(tert-butyl)-1,3,5-triazine-2,4,6-triamine, 16268-98-7. Product Category: Heterocyclic Organic Compound. CAS No. 16268-98-7. Molecular formula: C15H30N6. Mole weight: 294.439 g/mol. Purity: 0.96. IUPACName: 2-N,4-N,6-N-tritert-butyl-1,3,5-triazine-2,4,6-triamine. Product ID: ACM16268987. Alfa Chemistry ISO 9001:2015 Certified.
N-(N-Octadecyl)acrylamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-OCTADECYL ACRYLAMIDE;N-(N-OCTADECYL)ACRYLAMIDE;N-Octadecyl-2-propenamide;N-Octadecylpropenamide;N-Stearylacrylamide;N-octadecylprop-2-enamide. Product Category: Polymer/Macromolecule. CAS No. 1506-54-3. Molecular formula: H3C(CH2)17NHCOCH=CH2. Mole weight: 323.6. Product ID: ACM1506543. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-Octadecylacrylamide.
N-N-Octadecylurea
N-N-Octadecylurea. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-n-Octadecylurea;Stearylurea. Product Category: Heterocyclic Organic Compound. CAS No. 2158-8-9. Molecular formula: C19H40N2O. Product ID: ACM94455. Alfa Chemistry ISO 9001:2015 Certified.
1g Pack Size. Group: Building Blocks, Carbohydrates. Formula: C14H31NO5. CAS No. 23323-37-7. Prepack ID 32310080-1g. Molecular Weight 293.4. See USA prepack pricing.
N-n-Octyl-D-glucamine
N-n-Octyl-D-glucamine. CAS No. 23323-37-7. Product ID: 3-00292. Molecular formula: C14H31O5N. Mole weight: 293.4. Properties: bp 89°C 89 d 0.92.
N-n-Octyl-D-glucamine
N-n-Octyl-D-glucamine (CAS# 23323-37-7) is used in the preparation of Dexketoprofen Trometamol. Synonyms: (2R,3R,4R,5S)-6-(octylamino)hexane-1,2,3,4,5-pentol; (2R,3R,4R,5S)-6-(octylamino)hexane-1,2,3,4,5-pentol. CAS No. 23323-37-7. Molecular formula: C14H31NO5. Mole weight: 293.40.
N-Nonadecanophenone
N-Nonadecanophenone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PHENYL N-OCTADECYL KETONE;N-OCTADECYL PHENYL KETONE;N-NONADECANOPHENONE;N-nonadecanphenone. Product Category: Heterocyclic Organic Compound. CAS No. 103044-68-4. Molecular formula: C25H42O. Mole weight: 358.6. Product ID: ACM103044684. Alfa Chemistry ISO 9001:2015 Certified.
n-Nonane
n-Nonane. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nonyl hydride. Product Category: Heterocyclic Organic Compound. CAS No. 111-84-2. Molecular formula: C9H20. Mole weight: 128.25. Product ID: ACM111842. Alfa Chemistry ISO 9001:2015 Certified.
N-NONANE-D20
N-NONANE-D20. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nonane-d20, 456314_ALDRICH, 121578-11-8. Product Category: Heterocyclic Organic Compound. CAS No. 121578-11-8. Molecular formula: C9D20. Mole weight: 148.38. Purity: 98 atom % D. IUPACName: 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-icosadeuteriononane. Canonical SMILES: CCCCCCCCC. Density: 0.837g/cm³. Product ID: ACM121578118. Alfa Chemistry ISO 9001:2015 Certified.
N-Nonanoylmorpholine
Liquid. CAS No. 5299-64-9. Pack Sizes: 1g, 5g. Product ID: FR-0947. B.P. 125-130/0.5 mm. Mole weight: 227.35.
MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins. The hydrophilic head groups offer ample strength to extract proteins while still providing the capability to stabilize proteins in solution and promote crystal growth. It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes. Synonyms: MEGA-9; 1-deoxy-1-[methyl(1-oxononyl)amino]-D-glucitol; nonanoyl-n-methylglucamine; Nonanoyl-N-methylglucamide; 1-Deoxy-1-[methyl(nonanoyl)amino]hexitol. Grades: >99%. CAS No. 85261-19-4. Molecular formula: C16H33NO6. Mole weight: 335.44.
N-Nonyldeoxygalactonojirimycin
N-Nonyldeoxygalactonojirimycin, a remarkable biomedical compound, emerges as a paramount solution in the realm of treating diverse ailments. Renowned for its unrivaled efficacy, it showcases immense potential as a therapeutic agent within enzyme replacement therapies targeting Fabry diseasean intricate lysosomal storage disorder. Synonyms: N-Nonyldeoxygalactonojirimycin; N-(n-Nonyl)deoxygalactonojirimycin; 223771-83-3; (2R,3S,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol; NN-DGJ; SCHEMBL3324203; N-Nonyl-deoxy-galactonojirimycin; W-201929; (2R,3S,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol; (2R,3S,4R,5S)-2-(hydroxymethyl)-1-nonyl-piperidine-3,4,5-triol. CAS No. 223771-83-3. Molecular formula: C15H31NO4. Mole weight: 289.41.
N-Nonyldeoxynojirimycin
N-Nonyldeoxynojirimycin. Group: Biochemicals. Grades: Purified. CAS No. 81117-35-3. Pack Sizes: 10mg. US Biological Life Sciences.
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N-Nonyldeoxynojirimycin
N-Nonyldeoxynojirimycin, an efficacious hindrance of glycosidase enzymes, finds practical application in the biomedicine domain to alleviate and mitigate lysosomal storage disorders, namely Gaucher's disease, Fabry disease, and Tay-Sachs disease. Uses: Glycoside hydrolase inhibitors. Synonyms: NN-DNJ. CAS No. 81117-35-3. Molecular formula: C15H31NO4. Mole weight: 289.41.
N-Nonyl triphenylphosphonium bromide
N-Nonyl triphenylphosphonium bromide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (1-NONYL)TRIPHENYLPHOSPHONIUM BROMIDE;N-NONYLTRIPHENYLPHOSPHONIUM BROMIDE;NONYLTRIPHENYLPHOSPHONIUM BROMIDE;(1-NONYL)TRIPHENYLPHOSPHONIUM BROMIDE, 98+%;N-NONYL TRIPHENYLPHOSPONIUM BROMIDE;Triphenylnonylphosphonium·bromide;n-Nonyltriphenylphosphonium brom. Product Category: Heterocyclic Organic Compound. Appearance: white powder. CAS No. 60902-45-6. Molecular formula: C27H34BrP. Mole weight: 469.44. Purity: 0.98. Product ID: ACM60902456. Alfa Chemistry ISO 9001:2015 Certified.
N,N-O-Phenylenedimaleimide
N,N-O-Phenylenedimaleimide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N,N-(1,2-PHENYLENE)BISMALEIMIDE;N,N-(1,2-PHENYLENE)DIMALEIMIDE;N,N-O-PHENYLENEDIMALEIMIDE;O-PHENYLENE DIMALEIMIDE;n,n'-2-phenylenedimaleimide;1,2-DIMALEIMIDOBENZENE;1,2-PHENYLENE-BIS-MALEIMIDE;1,2-PDM. Product Category: Polymer/Macromolecule. CAS No. 13118-04-2. Molecular formula: C14H8N2O4. Mole weight: 268.22. Purity: 0.96. IUPACName: 1-[2-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione. Canonical SMILES: C1=CC=C(C(=C1)N2C(=O)C=CC2=O)N3C(=O)C=CC3=O. Density: 1.567g/cm³. ECNumber: 236-046-5. Product ID: ACM13118042. Alfa Chemistry ISO 9001:2015 Certified.
N-Norbimatoprost
N-Norbimatoprost is a useful reagent for developing methods for treating epithelial-related conditions including hair loss. Group: Biochemicals. Grades: Highly Purified. CAS No. 155205-89-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C23H33NO4, Molecular Weight: 387.51. US Biological Life Sciences.
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N-Nornuciferine
N-Nornuciferine. Group: Biochemicals. Alternative Names: 1,2-Dimethoxynoraporphine; N-Nornuciferine; N-Desmethylnuciferine; Sanjoinine Ia; Daechualkaloid E. Grades: Plant Grade. CAS No. 4846-19-9. Pack Sizes: 10mg. Molecular Formula: C18H19NO2, Molecular Weight: 281.349. US Biological Life Sciences.
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nNOS Inhibitor I
nNOS inhibitor I is a cell-permeable nNOS inhibitor with Ki value of 120 nM. It displays >2,500-fold and 320-fold selectivity for nNOS over eNOS and iNOS, respectively. Synonyms: NOS I; ncNOS; N-[(4S)-4-Amino-5-[(2-aminoethyl]amino]P; N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt. Grades: ≥95%. CAS No. 357965-99-2. Molecular formula: C8H21N7O2·3CF3COOH. Mole weight: 589.4.
A cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction uponnMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30min 10uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15min before ischemia; 1.5mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated nMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5mg/kg i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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N,N,O-Tribenzyl-D-serine
Protected D-serine. Group: Biochemicals. Alternative Names: (R)-2-[Bis (phenylmethyl)amino]-3- (phenylmethoxy)-1-propanoic Acid Phenylmethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
N,N'-[(Perfluoropropane-2,2-diyl)bis(6-hydroxy-3,1-phenylene)]bis(1,3-dioxo-1,3-dihydroisobenzofuran-5-carboxamide). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-FAP-ATA; N,N'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(6-hydroxy-3,1-phenylene)]bis[1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxamide]. Product Category: Tetracarboxylic Dianhydride Monomers. Appearance: White to Light Yellow to Green Powder to Crystal. CAS No. 223255-30-9. Molecular formula: C33H16F6N2O10. Mole weight: 714.49 g/mol. Purity: 98.0%(T)(HPLC). Product ID: ACM-MO-223255309. Alfa Chemistry ISO 9001:2015 Certified.
N,N'-Propane-1,3-diylbis[3-(3,5-dI-tert-butyl-4-hydroxyphenyl)propionamide]. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N,N'-1,3-Propanediylbis(3,5-di-tert-butyl-4-hydroxyhydrocinnamamide). Product Category: Heterocyclic Organic Compound. CAS No. 69851-61-2. Molecular formula: C37H58N2O4. Mole weight: 594.9. Purity: 95%+. IUPACName: 3-(3,5-Ditert-butyl-4-hydroxyphenyl)-N-[3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoylamino]propyl]propanamide. Canonical SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCC(=O)NCCCNC(=O)CCC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C. Density: 1.036±0.06 g/cm3. Product ID: ACM69851612-1. Alfa Chemistry ISO 9001:2015 Certified.
N-(N-Propyl)ethylenediamine
N- (N-Propyl) ethylenediamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 111-39-7. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C5H14N2. US Biological Life Sciences.
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N, N-S-Tri methyl isothiouronium Iodide
N, N-S-Tri methyl isothiouronium Iodide. Group: Biochemicals. Grades: Highly Purified. CAS No. 6966-83-2. Pack Sizes: 100mg. US Biological Life Sciences.
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N,N,s-Tris(carboxymethyl)cysteamine monohydrate
N,N,s-Tris(carboxymethyl)cysteamine monohydrate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 81877-53-4, N,N,S-Tris(carboxymethyl)cysteamine, N-[2-(Carboxymethylthio)ethyl]iminodiacetic acid monohydrate, CTK5E9172, Glycine,N-(carboxymethyl)-N-[2-[(carboxymethyl)thio]ethyl]-, monohydrate (9CI). Product Category: Heterocyclic Organic Compound. CAS No. 81877-53-4. Molecular formula: C8H15NO7S. Mole weight: 269.27. Purity: 0.96. IUPACName: 2-[carboxymethyl-[2-(carboxymethylsulfanyl)ethyl]amino]acetic acid;hydrate. Canonical SMILES: C(CSCC(=O)O)N(CC(=O)O)CC(=O)O.O. Density: 1.516g/cm³. Product ID: ACM81877534. Alfa Chemistry ISO 9001:2015 Certified.
N,N'-((sulfonylbis(4,1-phenylene))bis(ethane-2,1-diyl))bis(5-chloro-2-methoxybenzamide). Group: Biochemicals. Alternative Names: Sulphonamide Sulfone Dimer. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C32H30Cl2N2O6S, Molecular Weight: 641.559999999999. US Biological Life Sciences.
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N,N'-Sulfonyldiimidazole (SDI)
N,N'-Sulfonyldiimidazole (SDI). Group: Biochemicals. Grades: Highly Purified. CAS No. 7189-69-7. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
N,N'-Terephthalylidene-bis(4-fluoroaniline)
N,N'-Terephthalylidene-bis(4-fluoroaniline). Uses: Designed for use in research and industrial production. Product Category: Phenols. CAS No. 17866-84-1. Molecular formula: C8H9FN2O. Mole weight: 320.34. Product ID: ACM17866841-1. Alfa Chemistry ISO 9001:2015 Certified.
1, 1-Thiocarbonyl diimidazole can be used to deoxygenate carboxylic monosaccharide analogues. Group: Biochemicals. Grades: Highly Purified. CAS No. 6160-65-2. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C?H?N?S, Melting Point: 96-103°C. US Biological Life Sciences.
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N, N'-Thiocarbonyl diimidazole ≥95%
N, N'-Thiocarbonyl diimidazole ≥95%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
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NNV-009
NNV-009 is an antibody labeled with 177Lu that has the potential use to treat non-Hodgkin's lymphoma and chronic lymphocytic leukemia (CLL). Uses: The potential treatment of non-hodgkin's lymphoma and chronic lymphocytic leukemia (cll). Synonyms: NNV 009; NNV009.
NNZ 2591
NNZ 2591 is a synthetic analogue of a small peptide of cyclic glycine proline (cGP). NNZ 2591 shows orally active and cross the blood-brain barrier. NNZ 2591 shows neuroprotective after ischemic brain injury. NNZ 2591 improves motor function in a rat model of Parkinson's disease. NNZ 2591 has the potential for the research of ischemic brain injury and angelman syndrome [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 847952-38-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148195.
No. 17927 D
No. 17927 D is a beta-lactam antibiotic produced by Streptomyces fulvoviridis SANK 61278, SANK 60183 and SANK 69283. The antibacterial activity is weak. Molecular formula: C13H19N2O5SNa. Mole weight: 338.35.
NO-1886
NO-1886 is a lipoprotein lipase (LPL) activator that increases the level of high-density lipoprotein cholesterol and reduces plasma triglycerides. It was shown to prevent fat accumulation in high fat-fed rats, suggesting its potential use as an antidiabetic agent. Synonyms: Ibrolipim; Lipoprotein Lipase Activator; LPL Activator; OPF 009; N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide. Grades: ≥98%. CAS No. 133208-93-2. Molecular formula: C19H20BrN2O4P. Mole weight: 451.3.
NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development. Group: Biochemicals. Alternative Names: 2-Acetyloxybenzoic acid 3-nitrooxymethylphenyl ester; 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate; NCX 4016. Grades: Highly Purified. CAS No. 175033-36-0. Pack Sizes: 25mg, 50mg. US Biological Life Sciences.
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Nobiletin
Nobiletin. Group: Biochemicals. Alternative Names: 3'4'5,6,7,8-Hexamethoxyflavone. Grades: Plant Grade. CAS No. 478-01-3. Pack Sizes: 20mg. Molecular Formula: C21H22O8, Molecular Weight: 402.394999999999. US Biological Life Sciences.
Worldwide
Nobiletin
Nobiletin is a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin has anti-hemagglutination, anti-thrombosis, anti-fungal, anti-allergic, anti-cholinesterase and anti-epileptic effects. It is a carbohydrate metabolism promoter. Uses: Anticancer. Synonyms: Hexamethoxyflavone. Grades: >98%. CAS No. 478-01-3. Molecular formula: C21H22O8. Mole weight: 402.39.
Nobiletin
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 478-01-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0155.
Nobiletin
Nobiletin - Product ID: NST-10-23. Category: Flavonoids. Alternative Names: 3',4',5,6,7,8-Hexamethoxyflavone. Purity: 98%. Test method: HPLC. CAS No. 478-01-3. Pack Sizes: 0,5g, 1g, 2,5g, 5g. Appearance: White to beige colored powder. Molecular formula: C21H22O8. Mole weight: 402.39. Storage: +2 +8 °C.
N,O-Bis-acetyl-L-tyrosine
N,O-Bis-acetyl-L-tyrosine. Group: Biochemicals. Alternative Names: Ac-L-Tyr(Ac)-OH. Grades: Highly Purified. CAS No. 17355-23-6. Pack Sizes: 10g. US Biological Life Sciences.